Trends in Antihypertensive Drug Use and Irrational Prescriptions Among Elderly Patients in China (2016–2023): A Nationwide Multi-Center Cross-Sectional Survey Study by Hong D, Chen W, Du S, Ren J, Lv D, Shan W, Lu X, Zhao Q

“…The overall proportion of first-line antihypertensive prescriptions was 97.47% but showed a slight declining trend (APC=− 0.66%, P=0.004). The rates of inappropriate combination medication and overall irrational prescriptions decreased, while the rate of contraindicated medication prescriptions increased (P< 0.001). …”
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Bridging micro and macroevolution: insights from chromosomal dynamics in plants by Carmen Benítez-Benítez, Ashwini V. Mohan, Rogelio Sánchez-Villegas, Inés Gómez-Ramos, Ana Valdés-Florido, Kay Lucek, Marek Slovák, Marek Slovák, Filip Kolář, Filip Kolář, Ilia J. Leitch, Modesto Luceño, Isabel Larridon, Angelino Carta, Angelino Carta, Joan Cuscó-Borràs, Enrique Maguilla, Alegría Montero-Ramírez, Patrick G. Meirmans, Alison Dawn Scott, Santiago Martín-Bravo, Marcial Escudero

“…Here, we address the following questions: Are macroevolutionary patterns of chromosome evolution the result of accumulated microevolutionary changes, or do chromosomal dynamics drive larger shifts along the speciation continuum? …”
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Comprehensive assessment of adverse event profiles associated with bispecific antibodies in multiple myeloma by Mobina Golmohammadi, Shahzad Raza, Maram Albayyadhi, Hossein Sholehrasa, Jack Khouri, Louis Williams, Doris K. Hansen, Azam Moradi, Xuan Xu, Moath Albliwi, Ali Hajj Ali, Danai Dima, Faiz Anwer, Barry Paul, Majid Jaberi-Douraki

“…PCA revealed agents with all grades and grade 3/4 showed similar clustering patterns except for three agents. Overall, our findings demonstrated the excellent efficacy on the use of BsAbs in MM; however, these agents have been linked to a unique AE profile. …”
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Role of myostatin promoter mutations in growth and molting regulation of Macrobrachium rosenbergii by Qiyao Su, Qiyao Su, Jie Wei, Yakun Wang, Bai Liufu, Bai Liufu, Huarong Li, Huarong Li, Zhuang Mai, Zhuang Mai, Kunhao Hong, Kunhao Hong, Qiaoyan Zhou, Tianhui Jiao, Tianhui Jiao, Xidong Mu, Lingyun Yu

“…Knockdown experiments targeting two genotypes within the Mstn promoter region significantly reduced growth rates and extended molting cycles compared to control group. …”
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Characteristics of Anemia in Children Aged 6 Months to 5 Years Attending External Consultations at a Pediatric Hospital in Lisbon, Portugal by Réka Maulide Cane, Sérgio Chicumbe, Youssouf Keita, Anaxore Casimiro, Bárbara Martins Saraiva, Joana Vasconcelos, Beatriz Luzio Vaz, Afonso Sousa, Mafalda Cabral, Francisco Branco Caetano, Luís Varandas, Isabel Craveiro

“…Five children (6.8%) had normal hemoglobin but abnormal red-cell indices, with microcytic (60.0%; 3/5) or normocytic (40.0%; 2/5) patterns. Anemia rates were higher in males (55.1%), children aged 24–59 months, those residing in the Metropolitan Lisbon Area (82.6%), children whose caregivers had only basic or secondary education (58.0%), and those whose mothers were born in foreign countries (48.4%). …”
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ChatGPT-Assisted Deep Learning Models for Influenza-Like Illness Prediction in Mainland China: Time Series Analysis by Weihong Huang, Wudi Wei, Xiaotao He, Baili Zhan, Xiaoting Xie, Meng Zhang, Shiyi Lai, Zongxiang Yuan, Jingzhen Lai, Rongfeng Chen, Junjun Jiang, Li Ye, Hao Liang

“…MethodsILI positivity rate data spanning from 2014 to 2024 were obtained from the Chinese National Influenza Center (CNIC) database. …”
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Effects of Live and Peptide-Based Antimicrobiota Vaccines on <i>Ixodes ricinus</i> Fitness, Microbiota, and Acquisition of Tick-Borne Pathogens by Apolline Maitre, Lourdes Mateos-Hernandez, Myriam Kratou, Natalia Egri, Jennifer Maye, Manel Juan, Adnan Hodžić, Dasiel Obregón, Lianet Abuin-Denis, Elianne Piloto-Sardinas, Andrea C. Fogaça, Alejandro Cabezas-Cruz

“…The vaccination altered the feeding patterns and fitness of the ticks, with the Live vaccine group showing a higher weight and faster feeding time. …”
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Effects of Regulated Deficit Irrigation on Leaf Nutrients, Enzyme Activities, and Root Zone Soil Nutrients during Fruit Expansion and Coloration-Sugar Accumulation Stages of Citrus... by ZHONG Yun, HUANG Zhikun, ZHU Shijiang, HAO Kun, ZHU Zirong, ZHANG Wei, CHEN Hongde

“…The aim was to explore the response patterns of soil nutrients, citrus leaf nutrients, antioxidant enzyme activities, and root-zone soil nutrients to water stress under drip irrigation across different growth stages. …”
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Global burden of tuberculosis among adults aged 60 years and older, 1990-2021: Findings from the global burden of disease study 2021 by Junping Liu, Yue Zhou, Juan Guan, Yaping Liu, Weijian Song, Wei Liu, Xinle Yin, Yuqin Liu, Ting Li, Long Jin, Lihan Zhang, Yunkai Li, Lin Wu, Nan Wang, Zhaoyue Liu, Xinru Liu, Yanfu Wang, Qunhong Wu, Libo Liang

“…Results: A decreasing trend in age-standardized incidence rate, age-standardized mortality rate, and disability-adjusted life-years rates for TB and drug-susceptible TB was observed among the elderly population worldwide, whereas an upward trend was noted for MDR-TB and XDR-TB. …”
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Effects of intravenous immunoglobulin on the negatively transformed subpopulations of neutrophilic granulocytes in newborns with congenital pneumonia and neonatal sepsis by I. V. Nesterova, S. V. Kovaleva, G. A. Chudilova, L. V. Lomtatidze, T. V. Smerchinskaya, V. N. Chapurina

“…Testing of NG population included the following parameters: counting the numbers of NG subpopulations which simultaneously expressed CD11b CD64, CD32, CD16, as well as their phenotypic patterns, with regard of the receptor expression density (MFI) using flow cytometric techniques. …”
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Genotypic profile of Staphylococcus spp., Enterococcus spp., and E. coli colonizing dogs, surgeons, and environment during the intraoperative period: a cross-sectional study in a v... by Mareliza Possa de Menezes, Marita Vedovelli Cardozo, Natália Pereira, Mariana Bugov, Newton Valerio Verbisck, Vanessa Castro, Alessandra Figueiredo de Castro Nassar, Paola Castro Moraes

“…Twenty-four PFGE banding patterns were observed in CoNS (24/24), 15 in S. pseudintermedius (15/24), 4 in E. coli (4/8), and 7 in Enterococcus spp. (7/19). …”
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Prevalence and determinants of hypertension in rwanda: a secondary data analysis using the WHO STEPS survey 2022 by Jean Damascene Hagenimana, Kagisha Divine Pascaline, Felix K. Rubuga, Kelly Mwiza, Sabine Musange F., Nathalie Umutoni, Caroline Mudereri, Jocelyne Uwitonze, Emmanuel Christian Nyabyenda, Piero I. Mazimpaka, Olivier N. Wane, Eric remera, Uwimana Aline, Marie Rosette NAHIMANA, Jeanine Condo, Gashaija Absolomon

“…While previous national surveys have documented its burden, updated analysis of current prevalence patterns and determinants is needed to inform contemporary prevention strategies. …”
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Path to full immunisation coverage, role of each vaccine and their importance in the immunisation programme: a cross-sectional analytical study of India by Gunjan Taneja, Pawan Kumar, Disha Agarwal, Ajay Kumar Verma, Pritu Dhalaria, Sanjay Kapur, Ajeet Kumar Singh, Bhupendra Tripathi

“…The prevalence of absolute zero-dose children, antigen-wise zero dose, co-coverage rates and cascade levels for vaccine combinations are assessed. …”
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Improving Performance of Motor Imagery-Based Brain&#x2013;Computer Interface in Poorly Performing Subjects Using a Hybrid-Imagery Method Utilizing Combined Motor and Somatosensory... by Sangin Park, Jihyeon Ha, Laehyun Kim

“…The phenomena of brain-computer interface-inefficiency in transfer rates and reliability can hinder development and use of brain-computer interface technology. …”
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Timing matters! Academic assessment changes throughout the day by Carmelo M. Vicario, Michael A. Nitsche, Chiara Lucifora, Pietro Perconti, Mohammad A. Salehinejad, Mohammad A. Salehinejad, Mohammad A. Salehinejad, Francesco Tomaiuolo, Simona Massimino, Alessio Avenanti, Alessio Avenanti, Massimo Mucciardi

“…Our results demonstrate a Gaussian distribution of passing rates throughout the day, with a significant peak at midday. …”
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Body mass change over winter is consistently sex-specific across roe deer (Capreolus capreolus) populations by Hewison, A.J. Mark, Bonnot, Nadège C., Gaillard, Jean-Michel, Kjellander, Petter, Lemaitre, Jean-François, Morellet, Nicolas, Pellerin, Maryline

“…We suggest that allocation to antler growth and territory establishment drives this pattern, providing a likely explanation to account for the lower rates of male adult survival that are consistently reported in this weakly dimorphic species.…”
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Planned Liver Stereotactic Body Radiotherapy for Residual Colorectal Cancer Liver Metastases After Surgery: A Single-Arm Retrospective Study by Sixuan Li, Dezuo Dong, Xuan Zheng, Hongzhi Wang, Kun Wang, Baocai Xing, Weihu Wang

“…The 1-, and 2-year cumulative incidence rates of LF after SBRT were 7.7%, and 9.6%, respectively. …”
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Designing for Engagement in Primary Health Education Through Digital Game-Based Learning: Cross-National Behavioral Evidence from the iLearn4Health Platform by Evgenia Gkintoni, Emmanuella Magriplis, Fedra Vantaraki, Charitini-Maria Skoulidi, Panagiotis Anastassopoulos, Alexandra Cornea, Begoña Inchaurraga, Jaione Santurtun, Ainhoa de la Cruz Mancha, George Giorgakis, Kleri Kouppas, Stella Timotheou, Maria Jose Moreno Juan, Miren Muñagorri, Marta Harasiuk, Alfredo Garmendia Lopez, Efi Skoulidi, Apostolos Vantarakis

“…The study employed multiple statistical approaches—descriptive analysis, correlation analysis, ANOVA, regression modeling, and cluster analysis—to identify design engagement patterns and their predictors, tracking completion rates, progress trajectories, and interaction time as indicators of design effectiveness. …”
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Clinical features of patients with dysthymia in a large cohort of Han Chinese women with recurrent major depression. by Wenqing Wu, Zhoubing Wang, Yan Wei, Guanghua Zhang, Shenxun Shi, Jingfang Gao, Youhui Li, Ming Tao, Kerang Zhang, Xumei Wang, Chengge Gao, Lijun Yang, Kan Li, Jianguo Shi, Gang Wang, Lanfen Liu, Jinbei Zhang, Bo Du, Guoqing Jiang, Jianhua Shen, Ying Liu, Wei Liang, Jing Sun, Jian Hu, Tiebang Liu, Xueyi Wang, Guodong Miao, Huaqing Meng, Yi Li, Chunmei Hu, Yi Li, Guoping Huang, Gongying Li, Baowei Ha, Hong Deng, Qiyi Mei, Hui Zhong, Shugui Gao, Hong Sang, Yutang Zhang, Xiang Fang, Fengyu Yu, Donglin Yang, Tieqiao Liu, Yunchun Chen, Xiaohong Hong, Wenyuan Wu, Guibing Chen, Min Cai, Yan Song, Jiyang Pan, Jicheng Dong, Runde Pan, Wei Zhang, Zhenming Shen, Zhengrong Liu, Danhua Gu, Xiaoping Wang, Xiaojuan Liu, Qiwen Zhang, Yihan Li, Yiping Chen, Kenneth S Kendler, Jonathan Flint, Zhen Zhang

“…<h4>Conclusions</h4>There are increased rates of stressful life events in MDD with dysthymia, but the impact of life events on susceptibility to dysthymia with MDD differs from that seen for MDD alone. …”
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Toxicokinetics, tissue distribution, and toxic potency of PFOS alternative OBS in adult zebrafish (Danio rerio) based on flow-through exposure system by Yilong Zou, Yu Zhou, Xianglian Wang, Guiqing Gao, Gang Chen, Zhanmeng Liu, Mi Deng, Xueping Huang, Yongming Wu

“…Our findings indicate that OBS accumulated rapidly in zebrafish, with log kinetic bioconcentration factor (logBCFk) values ranging from 2.48 to 2.70 and slow elimination rates (ke = 0.0490–0.0643 d−1). The blood, liver, and muscle were responsible for over 50 % of the total body burden of OBS, with tissue concentrations decreasing in the following order: blood > liver > intestine > gills > gonad > brain > muscle, suggesting a tissue-specific accumulation pattern. …”
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