Rational strategies for improving the efficiency of design and discovery of nanomedicines by Xiaoting Shan, Ying Cai, Binyu Zhu, Lingli Zhou, Xujie Sun, Xiaoxuan Xu, Qi Yin, Dangge Wang, Yaping Li

“…This transition facilitates the enhancement of efficiency in the preclinical discovery pipeline of nanomaterials, particularly in improving the hit rate of nanomaterials and the optimization efficiency of promising candidates. …”
Get full text

The regulatory role of ZmSTOMAGEN1/2 in maize stomatal development is elucidated via gene editing and metabolic profiling. by Juan-Juan Xu, Qing-Yun Chen, Li-Fang Qin, Yuan Liu, You-Zhi Li, Xian-Wei Fan

“…The mutant displayed a lower stomatal density and index, leading to reduced net photosynthetic rate, transpiration rate, and stomatal conductance but increased water-use efficiency (WUE). …”
Get full text

Approximate Thermal Calculation of the Superheated Steam Condenser of Heat Pumps by V. I. Volodin, S. V. Zditovetskaya

“…In the first approach, the flow rate and temperature of the heated water are limited by the saturation temperature of the condensing refrigerant, regardless of the flow pattern of the working media. …”
Get full text

Analysis of factors, associated with the probability of antihypertensive medication in the population of patients with arterial hypertension by V. S. Kaveshnikov, V. N. Serebryakova, I. A. Trubacheva

“…The highest medication rate was found at very high CVR. Men with high CVR have showed lower medication rate than expected. …”
Get full text

Infant rat ultrasonic vocalizations in the neurodevelopmental model of schizophrenia by Agnieszka Potasiewicz, Zuzanna Mincikiewicz, Piotr Popik, Agnieszka Nikiforuk

“…Unlike controls, which showed an increasing USV rate associated with proper vocal development, MAM-exposed pups displayed a stable emission rate across days and emitted fewer USVs on the 12th PND. …”
Get full text

Crop yield and water productivity modeling using nonlinear growth functions by Iman Hajirad, Khaled Ahmadaali, Abdolmajid Liaghat

“…Furthermore, the absolute growth rate followed a bell-shaped pattern in the Logistic model and a right-skewed distribution in the Gompertz model. …”
Get full text

Mechanistic computational modeling of sFLT1 secretion dynamics. by Amy Gill, Karina Kinghorn, Victoria L Bautch, Feilim Mac Gabhann

“…Comparison between simulation predictions and additional experimental data of the outcomes of chemical inhibitors and genetic perturbations suggest that intermediate values of the secretion rate constant best match the simulation with experiments, which would completely constrain the model. …”
Get full text

Seroprevalence of scrub typhus among patients with acute febrile illness: A study from northern districts of West Bengal by Santanu Hazra, Arpita P. Dutta, Sumana Moitra, Shampa Das, Sanjoy K. Mallick, Arunabha Sarkar, Binita Pradhan, Ayan Chakraborty, Debapriya Bhowmick, Arnab Saha

“…Background: Scrub typhus is a re-emerging acute febrile illness with a high case fatality rate. Early clinical features are nonspecific and resemble any acute febrile illness, with or without skin rash creating clinical dilemmas. …”
Get full text

Influence of bulking materials on the organic matter degradation during composting of cattle manure by Md. Mukhlesur Rahman

“…This study aimed to understand the degradation pattern of cattle manure with different types of bulking materials during composting. …”
Get full text

Evaluation of Artesunate-mefloquine as a Novel Alternative Treatment for Schistosomiasis in African Children (SchistoSAM): protocol of a proof-of-concept, open-label, two-arm, indi... by Emmanuel Bottieau, Achilleas Tsoumanis, Yven Van Herrewege, Diana Arango, Christophe Burm, Badara Cisse, Souleymane Mboup, Clémentine Roucher, Isabel Brosius, Moustapha Mbow, Babacar Thiendella Faye, Annelies De Hondt, Bart Smekens, Linda Paredis, Idzi Potters, Katja Polman

“…The trial’s primary endpoints are the efficacy (cure rate (CR), assessed by microscopy) and safety (frequency and pattern of drug-related adverse events) of one AM course versus PZQ at 4 weeks after treatment. …”
Get full text

Interface evolution of microdroplets in flow-focusing channels with varying aspect ratios by Luyao He, Bo Wang, Qingquan Liu, Xiaodong Chen

“…It is found that the scaling exponent of the minimum neck thickness increases with the continuous phase flow rate. Numerical simulations are carried out to illustrate the shape evolution of a droplet in three-dimensional space, allowing the calculation of the curvature distribution of the interface. …”
Get full text

Spatiotemporal Change in Climate Variables and Resources of Wind， Solar Radiation and Precipitation in Qinghai Province from 1961 to 2021 by Meixia DUAN, Miaoni GAO, Han JIANG, Runhong XU, buda SU, Tong JIANG

“…In order to evaluate the potential of wind， solar radiation and precipitation in guaranteeing the development of clean energy comprehensively， this study analyzed the temporal and spatial changes in climate variables and resources of wind speed， solar radiation and precipitation in Qinghai Province throughout the year and four seasons from 1961 to 2021 based on the observation data of daily 10-meter-height wind speed， sunshine duration and precipitation at 51 meteorological stations.The results are as follows： （1） The annual average wind speed， solar radiation and precipitation in Qinghai Province are 2.67 m·s-1， 6084.2 MJ·m-2， and 299.7 mm， respectively.Wind speed tends to be higher in the western regions and lower in the east， which exceeds 3 m/s and reaches the standard for wind energy resource development in western Qinghai.The annual solar radiation in the entire Province exceeds 5040 MJ·m-2， and reaches the "very rich" level according to China Solar energy GB Standards.The solar radiation of Qaidam Basin is at its highest abundance level， which is ideal for solar energy resource development.Precipitation generally decreases from southeast to northwest.The resources of wind， solar radiation， and precipitation in Qinghai Province exhibits seasonal complementarity， characterized by a pattern of “strong winds， good sunlight， and less water in spring， whereas weak winds， good sunlight， and abundant water in summer”.（2） Under climate change， the annual average wind speed and total solar radiation in Qinghai Province show a significant decrease at rates of 0.16 m·s-1·10a-1and 29.04 MJ·m-2·（10a）-1， respectively.The western and central parts of Haixi are most affected by these changes， but the wind speed and solar radiation still remain within the acceptable range for wind energy and photovoltaic resource development.Meanwhile， precipitation increases significantly at a rate of 8.85 mm·（10a）-1， with the largest increase observed in western Yushu， eastern Haixi and northern Guoluo.The most significant decrease in wind speed is observed in spring， while summer solar radiation decreases at the fastest rate but with a substantial increase in precipitation.The changes in solar radiation and precipitation could be ascribed to the increased cloud cover in this region.（3） The changes in the areas where wind speed and solar radiation meet suitable development standards in Qinghai Province are not significant with reduced variabilities， which could ensure the stable development of clean energy.Wind energy resources in western Qinghai （such as Tanggula Mountains）， solar energy resources in the Qaidam Basin， and water energy resources in the three major river basins of the Yangtze River， Yellow River， and Lancang River have great potential for development.Overall， the results provide a theoretical foundation for the development of a balanced clean energy system encompassing wind， solar and hydropower.This contributes to achieving national "dual carbon" goals and enhancing the high-quality development of Qinghai Province.…”
Get full text

COVID-19 global risk evaluation: rankings, reducing surveillance bias, and infodemic by Michał P. Michalak, Elżbieta Węglińska, Agnieszka Kulawik, Jack Cordes, Michał Lupa, Andrzej Leśniak

“…Conversely, the case fatality rate exhibited only a weak positive correlation with probabilistic metrics, though these correlations were not consistently statistically significant. …”
Get full text

Glycolysis/gluconeogenesis specialization in microbes is driven by biochemical constraints of flux sensing by Severin Josef Schink, Dimitris Christodoulou, Avik Mukherjee, Edward Athaide, Viktoria Brunner, Tobias Fuhrer, Gary Andrew Bradshaw, Uwe Sauer, Markus Basan

“…Moreover, decreasing both lag times simultaneously comes at the cost of reduced growth rate or higher futile cycling between metabolic enzymes. …”
Get full text

Preparation of Porous F-WO3/TiO2 Films with Visible-Light Photocatalytic Activity by Microarc Oxidation by Chung-Wei Yeh, Kee-Rong Wu, Chung-Hsuang Hung, Hao-Cheng Chang, Chuan-Jen Hsu

“…Owing to the high specific surface area from the porous microstructure, the mTiO2 film shows a 61% and 50% rate increase in the photocatalytic dye degradation, as compared with the N,C-codoped TiO2 films under UV and Vis irradiation, respectively.…”
Get full text

Epigenetics in Plant Response to Climate Change by Wei Zhou, Min Wang, Lishan Wang, Yinghui Liu, Zaimin Tian, Linan Xie, Yu Wang

“…Given the unprecedented rate of contemporary climate change, epigenetic mechanisms may exert a more immediate and flexible influence than genetic modifications. …”
Get full text

Peltophorum pterocarpum flower mediated synthesis of silver nanoparticles and its catalytic degradation of Acid Blue 113 dye by Ramesh Vinayagam, Stuthi A. Shetty, Gokulakrishnan Murugesan, Louella Concepta Goveas, Thivaharan Varadavenkatesan, Raja Selvaraj

“…Catalytic studies showed rapid degradation of Acid Blue 113 dye in the presence of NaBH4, achieving a rate constant of 0.247 min−1 at 30 mg/L. These results demonstrate the environmental remediation potential of biogenically synthesized AgNPs and underscore the benefits of sustainable green synthesis approaches for industrial wastewater treatment.…”
Get full text

Features of Investment Activity in Agriculture in the South of Russia and Ways of its Activation by Vladimir Ivanovich Trukhachev, Igor Yurievitch Sklyarov, Yuliya Mikhailovna Sklyarova, Vitaliy Zelimkhanovich Mazloev, Anna Vladimirovna Volkogonova

“…The fall in the rouble exchange rate to foreign currencies made foreign agricultural products and food too expensive on the Russian market and sales fell sharply in Russia. …”
Get full text

Acute Pesticide Poisoning in Children: Hospital Review in Selected Hospitals of Tanzania by Elikana Lekei, Aiwerasia V. Ngowi, Leslie London

“…The annual APP incidence rate was 1.61/100,000. Conclusion. APP is common among children in this region of Tanzania. …”
Get full text

A robust and adaptive framework for interaction testing in quantitative traits between multiple genetic loci and exposure variables. by Julian Hecker, Dmitry Prokopenko, Matthew Moll, Sanghun Lee, Wonji Kim, Dandi Qiao, Kirsten Voorhies, Woori Kim, Stijn Vansteelandt, Brian D Hobbs, Michael H Cho, Edwin K Silverman, Sharon M Lutz, Dawn L DeMeo, Scott T Weiss, Christoph Lange

“…Using extensive simulation studies, we demonstrate that RITSS controls the type 1 error rate in a wide range of scenarios, and we show how the screening strategy influences statistical power. …”
Get full text