Clinical Features of Liver Injury Induced by Immune Checkpoint Inhibitors in Japanese Patients by Koji Imoto, Motoyuki Kohjima, Tomonobu Hioki, Tomoyuki Kurashige, Miho Kurokawa, Shigeki Tashiro, Hideo Suzuki, Akifumi Kuwano, Masatake Tanaka, Seiji Okada, Masaki Kato, Yoshihiro Ogawa

“…Immune checkpoint inhibitors (ICIs) have improved the survival rate of patients carrying various malignant neoplasms. …”
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The Role of Intestinal Translocation in the Pathogenesis of Pneumonia in Acute Poisoning and the Contribution of Intestinal Lavage to Its Prevention and Resolution by V. A. Matkevich, T. T. Tkeshelashvili, A. G. Vorobyova, N. E. Stolbova, M. M. Potskhveriya, Yu. S. Goldfarb

“…Mortality among the patients with PPD poisoning decreased by 7 times, and with M and CS poisoning, as well as with AlD, there were no deaths, while in the respective comparison groups, the mortality rate for pneumonia was 5.1, 7.4, and 17.4 %, respectively. …”
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Smart Grid Intrusion Detection for IEC 60870-5-104 With Feature Optimization, Privacy Protection, and Honeypot-Firewall Integration by Pedamallu Sai Mrudula, Rayappa David Amar Raj, Archana Pallakonda, Yanamala Rama Muni Reddy, K. Krishna Prakasha, V. Anandkumar

“…The experimental results demonstrate the framework’s operational capability and effectiveness for SCADA network security, achieving 99.29% accuracy, 94.8% recall and 4.1% false positive rates.…”
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Maize leaves salt-responsive genes revealed by comparative transcriptome of salt-tolerant and salt-sensitive cultivars during the seedling stage by Mingfang Ji, Sirui Xu, Zhongxian Ma, Chengnan Xiao, Jiangting Xu, Yanfang Zhu, Ronghao Cai, Chen Bo

“…The ST cultivar demonstrated superior seedling survival rates, higher relative water content, and lower electrolyte leakage and malondialdehyde levels in its leaves after both 3-day and 7-day salt treatments, when compared to the SS cultivar. …”
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Whole-Genome Sequence-Based Diversity of <i>Mycobacterium tuberculosis</i> Strains Isolated from a Central Western Region of Mexico by Andrea Monserrat Negrete-Paz, Gerardo Vázquez-Marrufo, Adrián Rodríguez-Carlos, Bruno Rivas-Santiago, Ma. Soledad Vázquez-Garcidueñas

“…Tuberculosis remains a significant health issue in Mexico, which has one of the highest incidence rates in the Americas. This study aimed to analyze the circulating sublineages, spoligotypes, drug resistance, and transmission patterns of <i>Mycobacterium tuberculosis</i> in Mexico’s Central Western region using whole-genome sequencing. …”
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Near-Unity Nitrate to Ammonia conversion via reactant enrichment at the solid-liquid interface by Wanru Liao, Jun Wang, Yao Tan, Xin Zi, Changxu Liu, Qiyou Wang, Li Zhu, Cheng-Wei Kao, Ting-Shan Chan, Hongmei Li, Yali Zhang, Kang Liu, Chao Cai, Junwei Fu, Beidou Xi, Emiliano Cortés, Liyuan Chai, Min Liu

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Weekly Image Guidance in Patients With Cervical Cancer Treated With Intensity‐Modulated Radiation Therapy: Results of a Large Cohort Study by Zheng Zeng, Weiping Wang, Junfang Yan, Dingchao Liu, Fuquan Zhang, Ke Hu

“…Results The median follow‐up periods were 63.4 months. The incidence rates of loco‐regional and distant failure were 9.9% and 13.6%. …”
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Mycobacteria Presence and Anti-Tuberculosis Drug Resistance Profile in Düzce Region: 18 Years of Experience by Emel Akbaş, Emel Çalışkan, Cihadiye Elif Öztürk, İdris Şahin, Şükrü Öksüz, Banu Hümeyra Keskin

“…Aim: The aim of this study was to determine the frequency of Mycobacterium tuberculosis complex (MTBC) and non-tuberculous mycobacteria (NTM) growth among mycobacterial isolates collected over 18 years from patients suspected of having tuberculosis, and to evaluate the resistance rates of MTBC strains to first-line anti-tuberculosis drugs.Material and Methods: A total of 17,199 clinical specimens, sent to the Mycobacteriology Laboratory, Department of Medical Microbiology, at Düzce University Health Application and Research Centre between 2004 and 2021 for suspected tuberculosis, were retrospectively analyzed in this study. …”
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Nitrogen fertilizer reduction based on bioorganic fertilizer improves the yield and quality of fresh leaves of alpine tea in summer by Rui Shi, Ying Wang, Fangyu Zhou, Sadam Hussain, Xingyu Lei, Enxiang Chen, Cong Wang, Juan Bai, Chunmei Gong

“…The effects of annual N fertilization rates viz. control, inorganic N at 300, 600, and 900 kg N hm−2 along with sole and combined bioorganic fertilizer application at 450 kg N hm−2 on soil characteristics, yield, quality, and resistance of fresh tea leaves were studied in summer. …”
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Prevalence and Antibiotic Resistance of Bacteria Isolated from Cerebrospinal Fluid of Neurosurgical Patients in Malang, Indonesia by Tommy Alfandy NAZWAR, Bagus Ramanto SAPUTRA, Dewi RETNONINGSIH, Farhad BAL'AFIF, Donny Wisnu WARDHANA

“…Conclusions: The sensitivity rates of ceftriaxone and meropenem were found to be 0% and 100%, respectively. …”
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Sex determination and stature estimation using logistic and linear regression models: A population-specific study of tibia and Fibula in Northeastern Thais by Suthat Duangchit, Chanasorn Poodendaen, Phetcharat Phetnui, Pornpimol Tasu, Worrawit Boonthai, Nareelak Tangsrisakda, Sitthichai Iamsaard

“…Results: For sex determination, the results showed that univariate logistic regression models achieved the accuracy rates up to 87.50 %, with maximum proximal epiphyseal breadth of the tibia demonstrating highest discriminatory power. …”
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Association of cancer and outcomes of patients hospitalized for COVID-19 between 2020 and 2023 [version 2; peer review: 1 approved, 2 approved with reservations, 1 not approved] by Robert F Terry, Rugiatu Z Kamara, Robert J Samuels, Donald S Grant, Sulaiman Lakoh, Mustapha Kabba, Innocent Nuwagira, Yusuf Sheku Tejan, Sia Morenike Tengbe, Ibrahim Franklyn Kamara, Shermarke Hassan, Abdulai Tejan Jalloh, Divya Nair, Laura Merson

“…Conclusions This study's findings underscore the heightened vulnerability of hospitalized COVID-19 patients with cancer, revealing a higher mortality rate, longer hospital stays, and an unstructured pattern of care that reflects the complexity of managing severely ill patients during a public health crisis like the COVID-19 pandemic.…”
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Effect of transport stress on apoptosis and autophagy in goat lung cells by Yu Zhuo, Yunhai Hu, Yangshan Jin, Tian Ye, Yanzhen Yang, Ben Liu, Ben Liu, Ben Liu, Wenya Zheng, Wenya Zheng, Songlin Ding, Xue Yang, Xue Yang, Lucheng Zheng, Lucheng Zheng, Wei Hu, Wei Hu, Manxin Fang, Manxin Fang, Wanting Yi, Wenjing Xing

“…IntroductionRoad transportation exposes goats to thermal, mechanical, and microbial stressors that can compromise their welfare by triggering pulmonary apoptosis and autophagy processes associated with tissue damage and immunosuppression.MethodsTo explore potential biomarkers for transport-related welfare assessment, this study analyzed lung tissues from nine Ganxi goats (n = 9; 0 h control, 2 h/6 h transport groups) through an integrated experimental approach: TUNEL assays quantified apoptosis rates, immunohistochemistry mapped protein localization, Western blotting analyzed protein expression levels, and qPCR profiled gene expression of apoptotic regulators (Bax, Bcl-2) alongside autophagy-related markers (LC3B, p62, PINK1, Parkin).ResultsResults indicated time-dependent cellular stress patterns, where the 2 h group displayed elevated apoptosis rates, while the 6 h group exhibited upregulated Parkin expression (p &lt; 0.05) and altered regulation of apoptotic [Bcl-2-associated X-protein (Bax)/B-cell lymphoma-2 (Bcl-2)] and autophagy-related genes (Microtubule-associated protein 1 light chain 3B (LC3B), p62, PTEN-induced putative kinase 1 (PINK1)/Parkin). …”
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Habit-learning and decision-making circuits are susceptible to glycemic variability in type 2 diabetes: a longitudinal study by Carolina Moreno, Carolina Moreno, Carolina Moreno, Otília C. d’Almeida, Otília C. d’Almeida, Joana Crisóstomo, Nádia Canário, Leonor Gomes, Leonor Gomes, Leonor Gomes, Miguel Castelo-Branco, Miguel Castelo-Branco

“…Linear regression analysis showed that, for each increase of 1 mmol/L in MAGE value, the SPC of the temporal lobe decreases on average by 1.2% (higher atrophy rate).ConclusionThe relationship between longitudinal GM atrophy and GV has a regionally specific pattern, suggesting localized brain susceptibility to intra-daily glucose fluctuations. …”
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Wild Ungulate Prey Size and Feeding Group Demographic Structure Affect Interactions and Per Capita Food Intake of African Pride Lions in East African Maasai Steppe by Thobias Oddo Tomeka, Bernard M. Kissui, Ifura Godfrey Ukio, Frank R. Mushi, Rudolf F. Mremi, Nathan J. Roberts, Marcel Holyoak, Guangshun Jiang

“…However, subadults increased their per capita intake rates when feeding together with both cubs and adult females. …”
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Toll-like receptor 4 promotes proliferation and apoptosis resistance in human papillomavirus–related cervical cancer cells through the Toll-like receptor 4/nuclear factor-κB pathwa... by Ninghong Jiang, Feng Xie, Qisang Guo, Ming-Qing Li, Jingjing Xiao, Long Sui

“…Proliferation of HeLa and Caski cells was promoted in lipopolysaccharide-stimulated groups but suppressed in short hairpin RNA–transfected groups. Apoptosis rates were lower in lipopolysaccharide-stimulated groups relative to short hairpin RNA–transfected groups. …”
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Global, regional, and national burden of sudden infant death syndrome and the impact of COVID-19: a trend and health inequality analysis based on the global burden of disease study... by Xinkuo Zheng, Meishen Liu, Xingwei Zhao, Xiuqi Xu, Wei Tao, Ling Wu, Weijia Sun, Yuhang Dong, Yalin Xi

“…Age-standardized DALY rates (ASDR; per 100,000 population) with 95% uncertainty intervals (UIs) were calculated for 204 countries and territories, stratified by age, location, and socio-demographic index (SDI).ResultsIn 2021, the ASDR of SIDS accounted for 44.16 (95% UI: 25.70–59.26) per 100,000 population globally, which was a 58.97% decrease from 1990. …”
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Differences found in patient characteristics of migrant tuberculosis sub-populations within low TB incidence European countries, 2014–2020 by Sarah Jackson, Barbara Hauer, Jean-Paul Guthmann, Mary O´Meara, Vinciane Sizaire, Karine Nordstrand, Anders Koch, Brit Häcker, Gerard de Vries, Jerker Jonsson, Kristina Langholz Kristensen, Wouter Arrazola de Oñate, Hanna Soini, Teresa Domaszewska

“…Compared to all patients, patients arriving from the 10 countries with the highest crude incidence rates were on average 9 years younger (median age 25 vs 34) and more often male (M:F ratio 2.6 vs. 1.8). …”
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Spectrum and epidemiology of rare diseases in a Chinese natural population of 14.31 million residents, 2012–2023 by Ming-Jia Li, Qi Li, Miao-Miao Zhao, Hanna Kim, Ruo-Qi Feng, Mo-Ning Guo, Jian-Peng heng, Jin-Kui Yang, Chang Liu

“…Age-standardized incidence rates (ASIR) were calculated per 100,000 person-years with 95% confidence intervals. …”
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Global burden of osteoarthritis among postmenopausal women in 204 countries and territories: a systematic analysis for the Global Burden of Disease Study 2021 by Jing Wang, Chenggang Jin, Lingling Sun, Lilu Ding, Dan Zhou, Yingjun Li, Wenfeng Xiao, Huadong Xu, Chan Ding, Jiarong Zou

“…Four subtypes of OA affecting the hip, knee, hand, and other joints among postmenopausal women were included. Age-standardised rates (ASRs) were derived with reference to the global age standard, and temporal patterns were scrutinised through estimated annual percentage change (EAPC) assessments. …”
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