Antitumor power of oncolytic HSV engineered with IL-12 and IL-15 by Lei Zhang, Yanbin Zhu, Kunpeng Zheng, Xinyu Zhang, Chunxue Fu, Dan Wang, Xinqiang Zhang, Tong Wu, Shuxin Han, Zhenghai Ma

“…Treatment with RG2006 significantly reduced tumor growth and extended survival rates compared to other forms of oHSV-1. Analyses indicated a marked elevation in T cell and NK cell activation in mice receiving RG2006. …”
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<i>SHROOM3</i> Deficiency Aggravates Adriamycin-Induced Nephropathy Accompanied by Focal Adhesion Disassembly and Stress Fiber Disorganization by Li-Nan Xu, Ying-Ying Sun, Yan-Feng Tan, Xin-Yue Zhou, Tian-Chao Xiang, Ye Fang, Fei Li, Qian Shen, Hong Xu, Jia Rao

“…Clinically, the glomerular <i>SHROOM3</i> expression positively correlated with glomerular filtration rates in focal segmental glomerulosclerosis patients. …”
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Satellite-Based Prediction of Water Turbidity Using Surface Reflectance and Field Spectral Data in a Dynamic Tropical Lake by Elsa Pereyra-Laguna, Valeria Ojeda-Castillo, Enrique J. Herrera-López, Jorge del Real-Olvera, Leonel Hernández-Mena, Ramiro Vallejo-Rodríguez, Jesús Díaz

“…In this study, we utilized Landsat satellite imagery in conjunction with near-synchronous in situ reflectance measurements to monitor spatial and seasonal turbidity patterns between 2023 and 2025. The surface reflectance was radiometrically corrected and validated using spectroradiometer data collected across eight sampling sites in the eastern sector of the lake, the area where the highest rates of horizontal change in turbidity occur. …”
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Overweight and Helicobacter pylori infection: a correlation in metabolic dysfunction-associated fatty liver disease by Xu Chen, Jiayue Fu, Jiayue Fu, Kejia Jin, Kejia Jin, Zixuan Yang, Zixuan Yang, Yidan Qian, Yidan Qian, Kehan Mei, Yihan Wang, Jialei Min, Yilin Du, Zaisheng Zhu, Zaisheng Zhu, Shengcun Li, Shengcun Li

“…Therefore, eradication of H. pylori infection may have positive implications for reducing the incidence rate of overweight MAFLD.…”
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Nutritional status, body indices, and somatotype in Aymara and Quechua children from high Andean areas of Peru by Lidia Sofia Caballero Gutiérrez, Rodolfo Adrian Núñez Postigo, Juber Chávez Dominguez, Vilma Lucrecia Tapia Aguirre, José Oscar Alberto Begazo Miranda

“…Among the findings, most children presented normal nutritional status according to BMI-for-age and height-for-age Z-scores. However, high rates of overweight and obesity were observed in Aymara (39%) and Quechua (28.4%) children, with differences in fat content between ethnic groups at the 5th, 10th, 50th, and 75th percentiles. …”
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Relevance of Cellular Homeostasis-Related Gene Expression Signatures in Distinct Molecular Subtypes of Breast Cancer by Sharda P. Singh, Chathurika S. Dhanasekara, Michael W. Melkus, Chhanda Bose, Sonia Y. Khan, Flavia Sardela de Miranda, Maria F. Mahecha, Prrishti J. Gukhool, Sahil S. Tonk, Se-Ran Jun, Sahra Uygun, Rakhshanda Layeequr Rahman

“…Demographic factors such as age, race/ethnicity, menopausal status, and body mass index have been correlated with variations in incidence, mortality, and survival rates. Over the past decade, comprehensive genomic profiling has been widely used to identify molecular biomarkers and signatures to develop novel therapeutic strategies for patients. …”
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Multi-omics derivation of a core gene signature for predicting therapeutic response and characterizing immune dysregulation in inflammatory bowel disease by Mingming Wang, Liping Liang, Zibo Tang, Jimin Han, Lele Wu, Le Liu, Le Liu, Ye Chen, Ye Chen

“…Nomogram-based risk stratification effectively predicted biologic treatment responses across multiple therapeutic classes using four independent treatment datasets (GSE16879, GSE92415, GSE73661, GSE206285): low-risk patients demonstrated superior response rates to golimumab (63.3%), infliximab (54.8%), and vedolizumab (29% vs. 15% in high-risk group). …”
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CONCOMITANT CARDIOVASCULAR DISEASES AND ANTIHYPERTENSIVE TREATMENT IN OUTPATIENT PRACTICE (BY THE RECVASA REGISTRY DATA) by M. M. Loukianov, S. A. Boytsov, S. S. Yakushin, S. Yu. Martsevich, A. N. Vorobyev, A. V. Zagrebelnyy, N. N. Nikulina, K. G. Pereverzeva, E. A. Pravkina, A. D. Deev, E. V. Kudryashov, E. N. Belova

“…The mean number of prescribed AHDs was 1.73. The mean incidence rate of target blood pressure achievement was 26.1%. …”
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Burden of pulmonary arterial hypertension in Asia from 1990 to 2021: Findings from Global Burden of Disease Study 2021 by Shenshen Huang, Jiayong Qiu, Anyi Wang, Yuejiao Ma, Peiwen Wang, Dong Ding, Luhong Qiu, Shuangping Li, Mengyi Liu, Jiexin Zhang, Yimin Mao, Yi Yan, Xiqi Xu, Zhicheng Jing, Rongman Jia

“…Moreover, higher SDI and UHC levels were linked to reduced incidence, but higher prevalence rates. Conclusions:. Although progress has been made in reducing PAH-related mortality and DALYs, the disease continues to impose a substantial burden in Asia, particularly among older adults and young children. …”
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Mutation Profiling of Premalignant Colorectal Neoplasia by Jakub Karczmarski, Krzysztof Goryca, Jacek Pachlewski, Michalina Dabrowska, Kazimiera Pysniak, Agnieszka Paziewska, Maria Kulecka, Malgorzata Lenarcik, Andrzej Mroz, Michal Mikula, Jerzy Ostrowski

“…HGD adenomas had significantly higher mutation rates than LGD adenomas, while LGD-H adenomas exhibited mutation frequencies similar to those of LGD adenomas. …”
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Unravelling molecular transformation of dissolved organic matter in the full quantization treatment of landfill leachate concentrate by ZHONG Quanfa, ZHONG Lin, XU Guohui, JIN Qinghai, YU Jin, XU Fei, HE Di

“…The transfer station employed a full quantization treatment process of “biochemical process+advanced oxidation process+biochemical process”, resulting in the significant reduction of the concentrate color, with COD and DOC removal rates exceeding 90%. Ultraviolet-visible spectrophotometry results indicated aromaticity of DOM was slightly increased after biochemical treatment and significantly reduced after UV/Fenton treatment. …”
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Real-world effectiveness and safety of CDK4/6i in elderly and BIPOC patients with HR+/HER2- advanced/metastatic breast cancer: an updated systematic literature review by Nadia Harbeck, Adam Brufsky, Chloe Grace Rose, Beata Korytowsky, Connie Chen, Krista Tantakoun, Endri Jazexhi, Do Hoang Vien Nguyen, Meaghan Bartlett, Imtiaz A. Samjoo, Timothy Pluard

“…Key outcomes for synthesis were effectiveness, treatment patterns, and safety.ResultsThis review included 23 unique studies. …”
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Improvement of Oral Anticoagulant Prescription and Long‐Term Clinical Outcomes of Patients With Atrial Fibrillation After Implementation of a Clinical Decision Support System in Ou... by Po‐Tseng Lee, Mu‐Hsiang Huang, Ting‐Chun Huang, Pi‐Shan Sung, Chi‐Hui Hsu, Ya‐Ling Huang, Sheng‐Hsian Lin, Ping‐Yen Liu

“…Results OAC prescription rates increased from 47.3% to 67.5% after CDSS implementation. …”
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Exploring mobility data for enhancing HIV care engagement in Black/African American and Hispanic/Latinx individuals: a longitudinal observational study protocol by Katherine P Theall, Lisa Hightow-Weidman, Xiaoming Li, Sean Young, Lidia Flores, Seungjun Kim, Maryam Hassani, Cristina De Haro, Mohamed Emish, Zeyad Kelani, Dominic Arjuna Ugarte, Amanda Castel

“…Mobility data that measure individuals’ movements over time in combination with sociostructural data (eg, crime, census) can potentially identify barriers and facilitators to HIV care engagement and can enhance public health surveillance and inform interventions.Methods and analysis The proposed work is a longitudinal observational cohort study aiming to enrol 400 Black/African American and Hispanic/Latinx individuals living with HIV in areas of the USA with high prevalence rates of HIV. Each participant will be asked to share at least 14 consecutive days of mobility data per month through the study app for 1 year and complete surveys at five time points (baseline, 3, 6, 9 and 12 months). …”
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Lignin Unlocks Stealth Carbon Sinks in Cold Seeps via Microbial Enzymatic Gatekeeping by Jialing Li, Jingchun Feng, Pandeng Wang, Mengzhuo Zhu, Yongji Huang, Ying Wu, Junning Fan, Junlin Hu, Xiyang Dong, Yingli Zhou, Xuanyu Tao, Si Zhang

“…Our findings establish 3 paradigm shifts: (a) The turnover rates of terrestrial organic carbon are likely underestimated in deep-sea ecosystems; (b) microbial consortia employ combinatorial enzymatic strategies distinct from terrestrial decomposition regimes; (c) methyl shunting from lignin breakdown primes methanogenic precursors, revealing cryptic linkages between refractory carbon cycling and greenhouse gas reservoirs.…”
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Dietary supplementation with L-carnitine elevates intracellular carnitine levels and affects gene expression of SLC25A20 and COX4I1, as well as non-mitochondrial respiration of bov... by Leonie Seemann, Susanne Kersten, Susanne Bühler, Fabian Billenkamp, Ulrich Meyer, Christian Visscher, Korinna Huber, Erika Most, Klaus Eder, Sven Dänicke, Jana Frahm

“…The same applied for PBMC mitochondrial functionality and metabolic activity as assessed by ex vivo approaches, whereas non-mitochondrial respiration rate was significantly affected by L-carnitine supplementation over time. …”
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Cigarette Use, Lung Cancer Screening Eligibility and Completion Among Persons With Poor Mental Health by Monica Hernandez, Anastasia Rogova, Lorraine R. Reitzel, Lisa M. Lowenstein, Robert J. Volk

“…Mechanisms to increase LCS rates among adults with mental health conditions are discussed.…”
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Sex differences in the course of schizophrenia across diverse regions of the world by Novick D, Montgomery W, Treuer T, Moneta MV, Haro JM

“…Overall, females had slightly higher rates of clinical remission (58.0% vs 51.8%), functional remission (22.8% vs 16.0%), and recovery (16.5% vs 16.0%) at 36&amp;nbsp;months (P&amp;lt;0.001 for all). …”
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Trends in visits to a 24-hour walk-in crisis mental health centre during the COVID-19 pandemic by Jocelyne Lemoine, Depeng Jiang, Tanvi Vakil, James M. Bolton, Jennifer M. Hensel

“…Mean weekly visits had the pandemic not occurred were predicted with an autoregressive integrated moving average model and compared with observed rates.ResultsTotal pre-pandemic CRC visits (14,280) decreased 22.1%–11,122 total post-pandemic CRC visits. …”
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Clinical and radiographical analysis of percutaneous kyphoplasty with multi-point cement anchoring technique for preventing bone cement displacement in Kümmell’s disease of stage I... by Heng Wu, Xiao Dai, Hao Liu, Xiang Yang, Shenao Liu, Shuang Xu, Hao Chi, Yuquan Chen, Song Wang

“…The operation time, volume of cement, VAS score, ODI score, cement distribution pattern and score, bone cement leakage, adjacent vertebra fracture, and bone cement displacement were compared between the two groups. …”
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