Genome-wide associations spanning 194 in-hospital drug dosage change phenotypes highlight diverse genetic backgrounds in concurrent drug therapy by Alexander Pil Henriksen, Cristina Leal Rodríguez, Hannah Currant, Ioannis Louloudis, Jorge Hernansanz Biel, Maria Herrero-Zazo, Ewan Birney, Thomas Folkmann Hansen, Gianluca Mazzoni, Amalie Dahl Haue, Henning Bundgaard, Christian Erikstrup, Khoa Manh Dinh, Liam Quinn, Mie Topholm Bruun, Henrik Hjalgrim, Erik Sørensen, Christina Mikkelsen, Michael Schwinn, Ole Birger Vestager Pedersen, Henrik Ullum, Sisse Rye Ostrowski, Karina Banasik, Søren Brunak

“…As populations get older and medicine consumption rises, the rate of concurrent drug use and polypharmacy among patients is increasing. …”
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Understanding barriers and opportunities for fresh produce access in eThekwini Metro, Durban, South Africa by Scott Drimie, Mieke Faber, Lisanne du Plessis

“… South Africa faces a triple burden of malnutrition – undernutrition, hidden hunger and increasing rates of overweight and obesity driven by poor dietary choices. …”
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The Fracture Ankle Implant Review (FAIR) study: a national multicentre retrospective review of practice in implant choice, fixation methods, and outcomes in fixation of the fibula... by William G. Fishley, Thomas Baldock, Alan J. Hilley, Rory Morrison, Paul Baker, Dave Townshend, FAIR Study Collaborating Authors

“…A local pilot service evaluation previously identified variance in use of locking plates in all patterns with significant cost implications. The Fracture Ankle Implant Review (FAIR) study aimed to evaluate current practice and implant use across the UK, and review outcomes and complication rates between different fibula fixation methods. …”
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Urban cycling-specific active transportation behaviour is sensitive to the fresh start effect: triangulating observational evidence from real world data by Isaak Fast, Shamsia Sobhan, Nika Klaprat, Tyler George, Nils Vik, Dan Prowse, Jacqueline Collett, Jonathan McGavock

“…This observation could be used to inform policies for increasing cycling rates in urban centres.…”
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The Stabilization Mechanism of a Stable Landslide Dam on the Eastern Margin of the Tibetan Plateau, China: Insights from Field Investigation and Numerical Simulation by Liang Song, Yanjun Shang, Yunsheng Wang, Tong Li, Zhuolin Xiao, Yuchao Zhao, Tao Tang, Shicheng Liu

“…Additionally, the step-pool system formed in the spillway of the Conaxue Co landslide dam contributes to the protection of the dam structure by dissipating 68% of the river’s energy (energy dissipation rate η = 0.68). Understanding the formation mechanisms of the Conaxue Co landslide dam can provide critical insights into managing future landslide dams that may form in the QTP, both in emergency response and long-term strategies.…”
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Epidemiological characterization of chronic myeloid leukaemia patients at an oncologic centre: A retrospective observational study by Ana Maria Meireles, Rita Calisto, Maria José Bento, Pedro Martinho Gouveia, Susana Bizarro, Manuel Teixeira, Cláudia Moreira, Ana Espírito Santo, Mário Mariz

“…At three months, the early molecular response rate was 77 %. At 12 months of treatment, of the 67 patients with response evaluation, 93 % achieved complete cytogenetic response and 49 % major molecular response. …”
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Outcomes of different steroid dosing regimens in critical Covid-19 pneumonia at a Kenyan hospital: A retrospective cohort study. by John Otieno Odhiambo, Jasmit Shah, Nancy Kunyiha, Charles Makasa, Felix Riunga

“…Fifty-eight percent of patients received a standard dose (6mg) of steroids. The mortality rate was higher in the high-dose group compared to the standard-dose group; however, the difference was not statistically significant (47.9% vs 43.7% p = 0.549). …”
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Impact of Dietary Glutamate on Growth Performance and Flesh Quality of Largemouth Bass by Bo Zhao, Ju Zhao, Haifeng Liu, Hailong Zhang, Hongying Shan, Jiali Zong, Quanquan Cao, Jun Jiang

“…The FBW, percent weight gain (PWG), specific growth rate (SGR), feed efficiency (FE), and protein efficiency ratio (PER) initially increased and then decreased with elevating dietary Glu levels. …”
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Fine-scale variability in iceberg velocity fields and implications for an ice-associated pinniped by L. M. Kaluzienski, J. M. Amundson, J. N. Womble, A. K. Bliss, L. E. Pearson

“…To better understand how pinnipeds respond to changes in iceberg habitat, we combine (i) iceberg velocity fields over hourly to monthly timescales, derived from high-rate time-lapse photogrammetry of Johns Hopkins Glacier and Inlet, Alaska, with (ii) aerial photographic surveys of harbor seals (<i>Phoca vitulina richardii</i>) conducted during the pupping (June) and molting (August) seasons. …”
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Kinetics of silicon extraction into alloy from a mixture of amorphous rocks by V.M. Shevko, N.M. Mirkayev, A.D. Badikova

“…It was established that when the melting the amorphous rocks, with an increase in the degree of silicon extraction into the alloy, the apparent activation energy decreases, that is a manifestation of diffusion processes, obviously associated with the formation of a silicon carbide layer on the coke surface. The rate of silicon extraction into the alloy when the melting the amorphous rocks is higher than when the melting quartzite. …”
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Early Dynamics of Circulating Tumor DNA Following Curative Hypofractionated Radiotherapy Related to Disease Control in Lung Cancer by Kyungmi Yang, Jae Myoung Noh, Yeon Jeong Kim, Hongryull Pyo

“…The Dmax showed better disease control rate with marginal significance (<i>p</i> = 0.081). …”
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Breaking barriers: targeted delivery of resveratrol in lung cancer using folate-integrated and pH-responsive hybrid nanocarriers by Sanjoy Das, Malay K. Das, Taison Jamatia, Nayan Ranjan Ghose Bishwas, Dhritiman Roy, Emdormi Rymbai

“…Finally, in vivo targeting and anticancer studies demonstrated that FOL-RSV-LPHNCs selectively internalized to the cancerous region and suppressed the tumor volume with an 8.66-fold higher rate in the xenograft mouse model. The folate receptor-mediated uptake mainly facilitates this superior therapeutic response which was further confirmed by in silico molecular docking and dynamic simulation. …”
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Physiological insights into the responses of tea plants to aluminum through an integrated transcriptomic and metabolomic analysis by Xinwan Zhang, Shijie Luo, Xiali Ye, Lin Liu, Xinxin Jia, Deyuan Jiang, Weiwei Wen

“…Compared to 0 mM Al treatment, low Al concentrations (0.4 mM) enhanced root vitality by 8.91%, while higher Al concentrations (10 and 100 mM) reduced root vigor by 19.31% and 76.81%, respectively. In a similar pattern, the electron transfer rate in leaves remained stable under low Al levels but significantly decreased under high Al conditions. …”
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Impact of Malaria Diagnostic Technologies on the Disease Burden in the Sub-Saharan Africa by Josephine Wambani, Patrick Okoth

“…However, in certain areas, the rate of decline has slowed or even reversed the gains made so far. …”
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Identification of endothelial INSR as an osteosarcoma-related biomarker and therapeutic target based on weighted gene co-expression network analysis by Xu Yingkai, Jiang Jianfeng, Hu Zhiyong, Zhou Zhifeng, Wang Lei

“…Abstract Background Osteosarcoma (OS) is the most common primary malignant bone tumor characterized by a high rate of metastasis. The clinical efficacy of current targeted drugs for OS is limited, highlighting the urgent need to identify novel therapeutic targets. …”
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Evaluation and optimization simulation of land suitability for village construction in the urban rural integration zone empirical test based on 49 administrative villages in Chuzho... by Shuping Fan, Yuntao Zhu, Huimin Guo, Qi Wang, Yishi Mi, Xin Gao, Yangbing Liu, Zihao Su

“…The results show that: (1) the village collective income and land use intensity have a great impact on the potential of village construction land, the proportion of permanent basic farmland, the distance from the organized town and the population loss rate have a great impact on the binding force of village construction land; (2) The proportion of suitable, unsuitable and suitable areas of village construction land is 38.63%, 27.56% and 15.60% respectively, the overall distribution pattern of suitability is “high in the east and southwest, South-Northeast Low”; (3) The eastern high-suitable area adopts the rural urbanization mode and optimizes the layout in a “group” style, The central low suitable area adopts the mode of “teng village and land reduction” and continuously improves the level of intensive land use, In the southwest, it is suitable for villages to form a “central village” layout mode based on location and economic development. …”
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Effects of Bt Rice Straw Extract on Seed Germination and Plant Growth of Pakchoi: Novel Variables of Cropping System by Chenning Zhang, Wenfang Suo, Yongfang Pan, Yuanjiao Feng

“…The 40 g·L⁻¹ heterozygous Bt extract increased leaf and root POD activity but inhibited germination rate and leaf SOD activity. The 10 g·L⁻¹ extract promoted root length and seedling POD activity but suppressed leaf POD activity. …”
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Dr Papineau Meets Dr Masquelet—Management of Open Calcaneal Fractures, Combining Two Techniques: A Case Report by Shuvendu P Roy, Yogendra Gupta, Gurinder Bedi, Vishwadeep Sharma

“…Aim and background: Open fractures of the calcaneum are often the source of significant morbidity due to the high rate of wound infection and significant morbidity, ranging from malunion to amputation. …”
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Fluid–solid coupling productivity analysis of multi-stage fractured horizontal wells in shale reservoirs by Qian QI, Ming YUE, Weiyao ZHU, Wenjiang MA

“…The simulation results of the model align with actual field data, showing that gas production follows an “L-shaped” decline pattern with a coincidence rate exceeding 70%, verifying the model’s accuracy.…”
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Safety and efficacy of prone position ventilation in patients with severe pneumonia in neurosurgical intensive care units by CHENG Longyang，LI Jun，LI Shaoya，LI Chuanqing，XU Manman，WANG Rong，ZHAO Penglai

“…Changes in blood gas analysis［pH，arterial partial pressure of oxygen（PaO2），arterial partial pressure of carbon dioxide（PaCO2），oxygenation index］and hemodynamics［heart rate（HR），mean arterial pressure（MAP）］were compared before prone positioning，and at 1 day，3 days，5 days，and 7 days after resuming supine position following prone position treatment. …”
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