Ten-year trends in opioid prescribing and vaso-occlusive crises in sickle cell disease: a population-based national cohort study (2011–2022)Research in context by Kevin Y. Xu, Terri V. Newman, Lakeya S. McGill, Enrico M. Novelli, Cheryl A. Hillery, Joanna L. Buss, Lisa Gong, Ruizhi Huang, Fanghong Dong, Dustin Stwalley, Joanne Salas, Shiyuan A. Liu, Jeffrey F. Scherrer, Tashalee R. Brown, Tae Woo Park, Marc R. LaRochelle, Richard A. Grucza, Charles R. Jonassaint

“…Primary outcomes were monthly rates of outpatient opioid prescriptions and VOC-related acute care encounters. …”
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TS-InSAR assessment of groundwater overexploitation-land subsidence linkage: Hengshui case study by Yan An, Qiang Shen, C.K. Shum, Fan Gao, Xu Zhang, Liming Jiang, Hansheng Wang

“…New hydrological insights for the region: Results show subsidence dominates in Hengshui City, with rates up to 141 mm/year (2017–2024), mainly due to falling confined aquifer heads and delayed aquitard drainage. …”
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Effect of nonpharmaceutical interventions on the epidemic trends of scarlet fever in China: a population-based surveillance and modelling study by Xiaojuan Zhang, Yuanhai You, Jie Liu, Lu Sun, Haijian Zhou, Xingxing Zhang, Bike Zhang

“…Findings: During 2005-2024, 876,680 cases were reported (crude annual incidence: 3.22/100 000). The annual morbidity rates for three periods were 3.56, 1.58, and 3.25/100 000. …”
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Optimizing Effects of Organic Farming and Moderately Low Nitrogen Levels on Soil Carbon and Nitrogen Pools by Guanghua Wang, Yu Yang, Yuqi Chen, Shilong Yu, Xiaomin Huang, Min Jiang, Zujian Zhang, Lifen Huang

“…Therefore, a field trial was conducted to elucidate the impacts of different cultivation patterns and nitrogen application rates on soil carbon and nitrogen pools, especially on how these factors affect the components of soil organic carbon. …”
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Role of TRP channels and HSPs in thermal stress response in the aphid parasitoid Aphelinus asychis (Hymenoptera: Aphelinidae) by Xiang LIU, Zhi-wei KANG, Xing-lin YU, Fan LI, Tong-xian LIU, Qiang LI

“…The results showed that the maximum temperature that allowed A. asychis survival was approximately 41°C; females had higher survival rates than that of the males at 40 and 41°C. Short-term heat-shock resulted in increased expression of Aasyshsp in males, and Aasyhsp40, Aasyhsp68, Aasyhsp70-4, Aasyhsp70-5 and Aasyhsp90 were upregulated and then downregulated, whereas Aasyhsp70-3 was upregulated at 41°C. …”
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Association between social participation and medical care utilization among rural older adults in China: a longitudinal study based on the CLHLS (2011–2018) by Dianrui Yao, Le Yang, Naoki Kondo

“…Subjective economic status, self-rated health, and the number of chronic diseases significantly predicted social participation transition patterns (P < 0.05). …”
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Characterizing Breast Tumor Heterogeneity Through IVIM-DWI Parameters and Signal Decay Analysis by Si-Wa Chan, Chun-An Lin, Yen-Chieh Ouyang, Guan-Yuan Chen, Chein-I Chang, Chin-Yao Lin, Chih-Chiang Hung, Chih-Yean Lum, Kuo-Chung Wang, Ming-Cheng Liu

“…Evaluation using 3D-ROC analysis also indicated that the DNN was the best detector based on metrics like target detection rate and overall effectiveness. The DNN model further exhibited the capability to identify tumor heterogeneity, differentiating high- and low-cellularity regions. …”
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A Permutation Entropy Method for Sleep Disorder Screening by Cristina D. Duarte, Marcos M. Meo, Francisco R. Iaconis, Alejandro Wainselboim, Gustavo Gasaneo, Claudio Delrieux

“…<b>Conclusions:</b> The advantages of this approach, including compatibility with single-channel EEG (enabling potential wearable applications), independence from sleep-stage annotations, and generalizability across recording montages and sampling rates, stablish a framework for non-specific sleep pathology detection. …”
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Laboratory based antimicrobial resistance surveillance for Pseudomonas aeruginosa blood isolates from South Africa by Ashika Singh-Moodley, Adriano Duse, Preneshni Naicker, Ranmini Kularatne, Trusha Nana, Ruth Lekalakala, Nontombi Mbelle, Halima Dawood, Khine Swe Swe Han, Praksha Ramjathan, Prathna Bhola, Andrew Whitelaw, Olga Perovic

“…Pseudomonas aeruginosa is an opportunistic healthcare-associated pathogen with high rates of morbidity and mortality and an extensive range of resistance mechanisms. …”
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Hemotropic pathogens in aborted fetuses of domestic ruminants: transplacental transmission and implications for reproductive loss by Daria Jurković Žilić, Šimun Naletilić, Željko Mihaljević, Ema Gagović, Silvio Špičić, Irena Reil, Sanja Duvnjak, Maja Zdelar Tuk, Adnan Hodžić, Relja Beck

“…The highest infection rates were observed in cattle (17.27%) and sheep (15.85%), while goats showed significantly lower prevalence (5.3%). …”
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Effects of Physiological Loading from Patient-Derived Activities of Daily Living on the Wear of Metal-on-Polymer Total Hip Replacements by Benjamin A. Clegg, Samuel Perry, Enrico De Pieri, Anthony C. Redmond, Stephen J. Ferguson, David E. Lunn, Richard M. Hall, Michael G. Bryant, Nazanin Emami, Andrew R. Beadling

“…The results indicate that jogging significantly increased wear rates compared to the ISO walking gait waveform, with wear increasing from 15.24 ± 0.55 to 28.68 ± 0.87 mm³/Mc. …”
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Regulation of high-temperature microstructure evolution and recrystallization by pre-strain accumulation in Al–Zn–Mg–Cu alloys by Dejin Wei, Guoqun Zhao, Luyi Han, Kunpeng Deng

“…The deformation characteristics were examined under specific conditions: deformation temperature of 440 °C, strain rates of 0.001 s−1 and 0.1 s−1, and a deformation degree of 60 %. …”
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Socioeconomic disparities in incidence, treatment, and survival of intrahepatic cholangiocarcinoma: insights from a nationwide cohort study in SwedenResearch in context by Juan Vaz, Hannes Hagström, Per Sandström, Malin Sternby Eilard, Magnus Rizell, Ulf Strömberg

“…Household income– categorised as low (lowest national quartile), medium, or high (highest quartile)–was used as the SES indicator. Incidence rates (IRs), treatment patterns, and survival were analysed across income strata. …”
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Impact of Age and Menopausal Status on T-DM1 (Ado-Trastuzumab Emtansine) Treatment Outcomes in HER2-Positive Breast Cancer by Heves Surmeli, Deniz Isik, Oguzcan Kinikoglu, Yunus Emre Altintas, Ugur Ozkerim, Sıla Oksuz, Tugba Basoglu, Hatice Odabas, Nedim Turan

“…<b>Results</b>: The postmenopausal patients showed higher rates of lung metastasis (42.2% vs. 20.8%) and mortality (60.0% vs. 39.6%) than premenopausal patients. …”
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The Global Burden of Multidrug-Resistant Bacteria by Andrea Marino, Antonino Maniaci, Mario Lentini, Salvatore Ronsivalle, Giuseppe Nunnari, Salvatore Cocuzza, Federica Maria Parisi, Bruno Cacopardo, Salvatore Lavalle, Luigi La Via

“…We evaluate the effectiveness of various antimicrobial stewardship programs, documenting success rates and implementation challenges across different healthcare settings. …”
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Machine learning-based source apportionment and source-oriented probabilistic ecological risk assessment of heavy metals in urban green spaces by Jun Li, Jia-Yi Lu, Xin-Ying Tuo, Chao Wang, Jun-Zhuo Liu, Zhan-Dong Gao, Cun-Hao Yu, Fei Zang

“…Results showed that the average concentrations of Cd (0.38 mg kg−1), Cu (35.51 mg kg−1), Hg (0.07 mg kg−1), Pb (34.59 mg kg−1), and Zn (130.58 mg kg−1) exceeded local soil background values, except for As (8.56 mg kg−1), Cr (62.77 mg kg−1), and Ni (27.68 mg kg−1). Notably, exceedance rates for Cd, Hg, Pb, and Zn were 90.91 %, 94.95 %, 80.81 %, and 87.88 %, respectively. …”
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The role of JPT1 in hepatocellular carcinoma: tumor progression, microtubule dynamics regulation, and potential mechanisms within the immune microenvironment by Yipin Lu, Peng Xu, Sha Li, Jie Yao

“…A pan-cancer analysis was performed to evaluate JPT1 expression patterns and prognostic value across multiple cancer types. …”
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Prediction efficiency and incremental processing strategy during spoken language comprehension in autistic children: an eye-tracking study by Zihui Hua, Tianbi Li, Ruoxi Shi, Ran Wei, Li Yi

“…However, autistic children exhibited reduced prediction efficiency compared to neurotypical peers, evidenced by significantly lower proportions of and slower growth rates in fixations to target objects relative to unrelated distractors, and delayed onset of predictive looking. …”
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Inflammatory markers mediate the association between alternative adiposity indices and mortality in patients with rheumatoid arthritis: data from NHANES 1999–2018 by Feng Luo, Jia-jie Guo, Xue-mei Yuan, Heng Zhou, Qiu-yi Wang, Chang-ming Chen, Xue-ming Yao, Wu-kai Ma

“…Conclusions This study revealed a potential clinical value of a new obesity index, specifically the ABSI, in predicting the survival rates among individuals with RA. Inflammatory markers appear to play a partial mediating role in this relationship. …”
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Spatial distribution and predictors of early childbearing among Ethiopian women: evidence from the 2016 Ethiopian Demographic and Health Survey by Amare Teshome Tefera, Fanuel Gashaw, Martha Solomon, Nebiyu Bekele, Shegaye Shumet, Tigist Mulugeta, Araya Mesfin Nigatu, Solomon Gedlu Nigatu

“…Abstract Background Age at first birth is a crucial factor in understanding fertility patterns within a population. Ethiopia reports high rates of maternal and child mortality alongside elevated fertility levels. …”
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