Distinctive lung cancer incidence trends among men and women attributable to the period effect in Shanghai: An analysis spanning 42 years by Li Xie, Ying Qian, Yishan Liu, Yixuan Li, Sinong Jia, Herbert Yu, Chunfang Wang, Biyun Qian, Pingping Bao

“…Methods Data were obtained from Shanghai Cancer Registry. Age‐standardized rates were calculated and average annual percent changes (AAPCs) were evaluated by Joinpoint regression. …”
Get full text

Genetic and clinical characteristics of catecholaminergic polymorphic ventricular tachycardia in a Taiwanese nationwide cohort by Grace Chia-Yen Hsu, Mei-Hwan Wu, Jing-Yuan Chuang, Shuenn-Nan Chiu, Ming-Tai Lin, Ling-Ping Lai, Shih-Fan Sherri Yeh, Sheng-Fu Liu, Ting-Tse Lin, Fu-Tien Chiang, Jyh-Ming Jimmy Juang

“…Among the 29 Taiwanese patients with CPVT-related gene mutations, 55% had RYR2 mutations, a rate similar to other ethnicities. Three out of 12 RYR2 variants were unreported. …”
Get full text

Treatment response in relation to subthreshold bipolarity in patients with major depressive disorder receiving antidepressant monotherapy: a post hoc data analysis (KOMDD study) by Park Y, Lee B

“…The Beck Depression Inventory (BDI), Hamilton Depression Rating Scale (HAMD), Hamilton Anxiety Scale, and Beck Scale for Suicide Ideation were applied at baseline, 1 week, 3 weeks, 2 months, 3 months, and 6 months. …”
Get full text

Anthropogenic Activities Dominate Vegetation Improvement in Arid Areas of China by Yu Guo, Xinwei Wang, Hongying Cao, Qin Peng, Yunshe Dong, Yunchun Qi, Jian Liu, Ning Lv, Feihu Yin, Xiujin Yuan, Mei Zeng

“…The results indicated that (1) overall vegetation cover was low (averaged peak FVC = 0.191), showing a spatial pattern of higher values in the northwest and lower values in the southeast; high FVC values were primarily observed in mountainous areas and river corridors; (2) the annual peak FVC increased significantly at a rate of 0.0508 yr⁻¹, with 33.72% of the region showing significant improvements and 5.49% degradation; (3) the spatial pattern of FVC was shaped by the distribution of land use types (59.46%), while the temporal dynamics of FVC were driven by land use changes (16.37%) and the land use intensity (37.56%); (4) both the spatial pattern and the temporal dynamics were limited by the environmental conditions. …”
Get full text

Impact of post-transplant cyclophosphamide with bendamustine on immune reconstitution in young patients undergoing T-cell replete haploidentical bone marrow transplantation: result... by Forrest L. Baker, Forrest L. Baker, Forrest L. Baker, Jessica Stokes, Megan J. Cracchiolo, Dan Davini, Richard J. Simpson, Richard J. Simpson, Richard J. Simpson, Richard J. Simpson, Emmanuel Katsanis, Emmanuel Katsanis, Emmanuel Katsanis, Emmanuel Katsanis

“…Multi-parameter flow cytometry and TCR β sequencing of genomic DNA was performed on isolated PBMCs on PT days +30, +60, +100, +180, and +365.ResultsOverall, the PT-CY/BEN (n=14) regimen was associated with earlier neutrophil and platelet engraftment, reduced transfusion requirements, and comparable clinical outcomes to PT-CY (n=10), including survival and relapse rates. PT-CY/BEN patients exhibited distinct immune reconstitution patterns, characterized by earlier CD4+ T-cell recovery, impaired CD8+ T-cell engraftment, and reduced NK-cell counts. …”
Get full text

Geospatial Analytics of Urban Bus Network Evolution Based on Multi-Source Spatiotemporal Data Fusion: A Case Study of Beijing, China by Xiao Li, Shaohua Wang, Liang Zhou, Yeran Sun, Jiayi Zheng, Chang Liu, Junyuan Zhou, Cheng Su, Dachuan Xu

“…By analyzing spatial coverage rates of transit stations using road network and administrative division data, the study reveals the convenience of bus networks in different regions. …”
Get full text

RNAi-mediated suppression of toll-like receptor NlToll1 enhances Nilaparvata lugens susceptibility to entomopathogenic fungal infection by Zhu-Long Shao, Chen-Ping Lan, Xiao-Ping Yu, Zheng-Liang Wang

“…Toll-like receptors (TLRs) are a family of crucial pattern recognition proteins that are responsible for the immunologic recognition of invading pathogen in insects. …”
Get full text

The association between four dietary indices and mortality risk in cardiovascular disease patients by Mengshan Pan, Tongle Yin, Ying Yang, Feiyun Zhu, Jiamin Xu, Rucheng Chen, Weijun Zheng

“…Abstract Background The Planetary Healthy Diet Index-United States, the Healthy Diet Index, the Mediterranean Diet, and the Dietary Inflammation Index were linked to mortality rates in cardiovascular patients. This study investigated the relationship between these dietary patterns and all-cause mortality risk in U.S. cardiovascular patients from 2005 to 2006 to 2017–2018. …”
Get full text

Statistics and behavior of clinically significant extra-pulmonary vein atrial fibrillation sources: machine-learning-enhanced electrographic flow mapping in persistent atrial fibri... by Peter Ruppersberg, Steven Castellano, Philip Haeusser, Kostiantyn Ahapov, Melissa H. Kong, Stefan G. Spitzer, Stefan G. Spitzer, Georg Nölker, Andreas Rillig, Tamas Szili-Torok

“…Our machine learning approach established an activity threshold, above which divergent wavefront patterns—termed “significant sources”—predicted AF recurrence. …”
Get full text

Integrative single‐cell transcriptomic analysis deciphers heterogeneous characteristics of gastrointestinal tract cancer by Chuwen Sun, Tong Li, Xin Jin, Zhihui Xiu, Hang Su, Huanming Yang, Ming Liu, Kui Wu

“…Abstract Background Gastrointestinal tract cancer (GIC), including oesophageal cancer (EC), gastric cancer (GC) and colorectal cancer (CRC), is characterised with high global incidence and mortality rates, with similar tumourigenic processes. However, the common and heterogeneous molecular features among GIC at single‐cell level remain poorly characterised. …”
Get full text

Pitfalls in the diagnosis of apparent homozygous mutations: two cases of IL10RA deficiency inflammatory bowel disease and a literature review by Xiu Shi, Ziqing Ye, Lai Qian, Wenhui Hu, Ye Yang, Chunmeng He, Zhiheng Huang, Bingbing Wu, Ying Huang

“…Abstract Background In East Asia, IL10RA is the predominant pathogenic gene in patients with very early-onset inflammatory bowel disease (VEO-IBD), frequently characterised by refractory diarrhoea and severe perianal disease, resulting in elevated death rates. IL10RA-deficient IBD, an autosomal recessive genetic disorder, has been documented to be inherited through the conventional compound heterozygous or homozygous mutation patterns from both parents. …”
Get full text

Multimorbidity frailty index and clinical outcomes among 42,989 older heart failure patients directly discharged from emergency departments: A nationwide retrospective cohort study by Wan-Ju Liao, Hsi-Yu Lai, Liang-Yi Lin, Cheng-Hsueh Wu, Fei-Yuan Hsiao, Liang-Kung Chen

“…Readmission rates showed similar patterns. The severely frail group had higher risks of mortality (aHR 1.44, 95 % CI 1.33–1.55), all-cause readmissions (sHR 1.69, 95 % CI 1.62–1.76), and HF-related readmissions (sHR 1.59, 95 % CI 1.48–1.71). …”
Get full text

Farm households’ livelihood adaptive capacity under multiple pressures of small watershed management by Yaru Sun, Yilin Gan, Jing Luo, Tingting Han, Hafo Wang, Ruirui Yang, Lingling Tian

“…However, the FHLAC remains predominantly low to moderate in the small watershed. The contribution rates of livelihood pressure, livelihood capital, and willingness to adapt to FHLAC are 22.24 %, 28.69 %, and 49.07 %, respectively. …”
Get full text

Response of the Invasive Cyanobacterium <i>Raphidiopsis raciborskii</i> to Iron and Phosphorus Concentrations in the Habitat: Effects on Growth and Cellular Phosphorus Distribution by Wenting Shen, Han Yang, Gaibian Ding, Bo Li, Xin Gan, Zijie Yuan, Liqing Wang, Wei Zhang

“…The results revealed that under conditions of sufficient inorganic phosphorus, there was a logarithmic relationship between ferric ammonium citrate (Fe³⁺) and the specific growth rate of <i>R. raciborskii</i>. Fe³⁺ > 2 mg/L enhanced IPS enrichment and biomass accumulation. …”
Get full text

Extreme Oncoplastic Surgery for Multifocal/Multicentric and Locally Advanced Breast Cancer by Chaitanyanand B. Koppiker, Aijaz Ul Noor, Santosh Dixit, Laleh Busheri, Gautam Sharan, Upendra Dhar, Hari Kiran Allampati, Smeeta Nare

“…EO followed by RT results in acceptable local-regional control, low rate of complications, and high patient satisfaction. …”
Get full text

Predictive value of D-Dimer and thromboplastin time as coagulation indicators for COVID-19 patients by Marwan Alshipli, Thamer A Altaim, Ammar A Oglat, Samira Ahmed Alsenany, Osama Khodrog, Hanan Hasan, Sally Mohammed Farghaly Abdelaliem, A Matrieh, Bassam Z Shakhreet, Riziq Allah Gaowgzeh

“…Within the two groups of patients, the rate of coagulation disorders was as follows: mild = 8.8 % within coagulation disorders, 4.8% within the two Groups; severe = 91.2 % within coagulation disorders, 77.8 % within the two Groups. …”
Get full text

Geospatial analysis of cholera outbreak in Lusaka, Zambia, between 2023 and 2024 by William Ngosa, Tadatsugu Imamura, Nyuma Mbewe, Joseph Seriki, Oscar Nzila, Fred Mfune, Godfrey Zulu, Chomba Mulando, Tizha Chiluba, Luo Miyanda, Agness Phiri, Lucy Sichone, Galion Mwape, Kapambwe Mulenga, Charles Chileshe, Nawa Mabuku, Dabwiso Banda, Fangyu Yan, Taro Kamigaki, Roma Chilengi, Nyambe Sinyange

“…Results Over the study period, 4,591 suspected cholera cases with geocoordinate data were identified, with incidence rates varying across the constituencies. Median cholera incidence (IQR) was 0.55 (0.27–1.44) in Lusaka, with higher incidence rates observed in unplanned residential areas. …”
Get full text

Molecular and genomic investigation of an urban outbreak of dengue virus serotype 2 in Angola, 2017-2019. by Zoraima Neto, Pedro A Martinez, Sarah C Hill, Domingos Jandondo, Julien Thézé, Marinela Mirandela, Renato Santana Aguiar, Joilson Xavier, Cruz Dos Santos Sebastião, Ana Luísa Micolo Cândido, Filipa Vaz, Gisel Reyes Castro, Joana Paula Paixão, Nicholas J Loman, Philippe Lemey, Oliver G Pybus, Jocelyne Vasconcelos, Nuno Rodrigues Faria, Joana de Morais

“…<h4>Background</h4>The transmission patterns and genetic diversity of dengue virus (DENV) circulating in Africa remain poorly understood. …”
Get full text

Dynamic parking space allocation at urban scale: Problem formulation and resolution by Hanae Errousso, Jihane El Ouadi, El Arbi Abdellaoui Alaoui, Siham Benhadou

“…To do this, we consider both solicitation rates in these areas and coverage ratios of received parking demands. …”
Get full text

The characteristics of new-onset myasthenia gravis after COVID-19 outbreak: a cross-sectional study by Yanzhen Huang, Yu Wu, Shaodan Zhou, Xianting Que, Ailing Jiang, Danli Shi, Ting Lu, Yanlan Chen, Ziqun Lin, Chao Liu, Yishuang Wen, Shuyi Zhang, Wen Huang

“…After COVID-19 outbreak, there was an increase in new-onset MG patients, with more cases occurring within the first three months. The rates of pulmonary inflammation (40.28%), COVID-19 vaccination (88.14%), and treatment with tacrolimus (15.98%) and MG duration (15 weeks, IQR: 5.75, 32) were higher, while rates of thymectomy (13.92%), baseline MG-ADL (3, IQR: 3, 6), and QMGS (7, IQR: 5,8) were lower compared to new-onset MG patients before COVID-19 outbreak. …”
Get full text