Landau–Kleffner Syndrome Can Herald the Diagnosis of GRIN2A Gene Mutation by Ayman Khalil Ebrahim, Jaafar Jawad Makhlooq, Maryam Yusuf Busehail

“…N-methyl-D-aspartate receptors (NMDARs) are glutamate-gated channels that are essential for synaptic transmission and plasticity in the central nervous system. …”
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Differences in Kinematic and Muscle Activity Between ACL Injury Risk and Healthy Players in Female Football: Influence of Change of Direction Amplitude in a Cross-Sectional Case–Co... by Loreto Ferrández-Laliena, Lucía Vicente-Pina, Rocío Sánchez-Rodríguez, Graham J Chapman, Jose Heredia-Jimenez, César Hidalgo-García, José Miguel Tricás-Moreno, María Orosia Lucha-López

“…<i>Background and Objectives</i>: Anterior cruciate ligament (ACL) injury rates remain high and have a significant impact on female football players. …”
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Renal prognostic value of serum monoclonal immunoglobulin in cryoglobulinemic glomerulonephritis by Lei Ma, Yuanyuan Xia, Yun Fan, Dan Zhou, Xinchen Yao, Yongzhong Zhong, Fan Yang, Feng Xu, Shaoshan Liang, Yujie Wang, Xiaodong Zhu, Dacheng Chen, Rong Tan, Zhengyun Zhu, Dandan Liang, Caihong Zeng

“…The MIg group had significantly lower eGFR levels, higher cryoglobulin levels, and higher rates of abnormal serum-free light chain ratios than the MIg/HBV/HCV negative group. …”
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Nucleus accumbens functional connectivity changes underlying alcohol expectancies in bipolar disorder and prospective alcohol outcomes: a within-subject randomized placebo-controll... by Elizabeth T. C. Lippard, Elizabeth T. C. Lippard, Elizabeth T. C. Lippard, Elizabeth T. C. Lippard, Elizabeth T. C. Lippard, Dylan E. Kirsch, Dylan E. Kirsch, Dylan E. Kirsch, Dylan E. Kirsch, Vanessa Le, Vanessa Le, Skyler Lee, Nadia Bibb, Kaitlyn Meek, Raquel Kosted, Ansley Huffman, J. R. C. Almeida, Kim Fromme, Kim Fromme, Stephen M. Strakowski, Stephen M. Strakowski, Stephen M. Strakowski

“…IntroductionAlcohol use disorder (AUD) occurs at higher rates in individuals with bipolar disorder compared to the general population. …”
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A novel deep learning-based 1D-CNN-optimized GRU approach for heart disease prediction by Jini Mol G., Ajith Bosco Raj T.

“…To identify the irregularities in the cardiac data pattern, a gated recurrent unit (GRU) classifier and a one-dimensional convolutional neural network (1D-CNN) are introduced. …”
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Classification of finger movements through optimal EEG channel and feature selection by Murside Degirmenci, Yilmaz Kemal Yuce, Matjaž Perc, Matjaž Perc, Matjaž Perc, Matjaž Perc, Matjaž Perc, Yalcin Isler

“…This study design may result in an increasing number of false positives and a significant decrease in the prediction rates and classification performance. Moreover, recent studies have focused on improving prediction performance using complex feature extraction and machine learning algorithms while ignoring comprehensive EEG channels and feature investigation in the prediction of finger movements from EEGs. …”
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Applying energy efficiency strategies to university buildings using Design Builder program "Case study of the Faculty of Commerce building at Sohag University as a case study" تطبي... by Heba Talah Anwar khelef, Ahmed A Farghaly, Mohamed H ElHafnawy

“…University buildings consume a large percentage of energy rates in buildings in general due to their occupants, their activities and their occupancy pattern, as the higher education sector constitutes a small but important part of the existing global buildings sector, which is 20% of the non-residential horizontal area. …”
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Red cell distribution width-to-platelet ratio (RPR) as a predictor of prolonged stay at hospital for COVID-19 inpatients by Martha Fors, Santiago J. Ballaz

“…One exemption was the red cell distribution width-to-platelet ratio (RPR) index, which can increase the probability of a longer hospital stay by up to ten times (HR(IC95%) = 0.092(0.03-0.29); p < 0.001).Conclusion The most effective biomarker to identify COVID-19 patients at high risk for extended hospital stay was RPR.Highlights IntroductionDetermining hospital Length of Stay (LoS) is vital for resource management, especially for future COVID-19 outbreaks.Previous studies have primarily focused on sociodemographic and clinical attributes, along with resource availability, but have not accounted for other factors like routine laboratory tests, which can significantly impact LoS predictions.This study examines novel hematology scores as predictors of LoS, emphasizing their importance in resource-limited settings like Ecuador.MethodsThis retrospective cohort study analyzed 2,930 COVID-19 patients admitted to Hospital IESS Quito Sur in Ecuador focusing on confirmed cases with complete blood count (CBC) values to assess LoS.The study explored various hematological ratios, such as the neutrophil-to-lymphocyte ratio (NLR) and red cell distribution width-to-lymphocyte ratio (RLR), as potential predictors of LoS and in-hospital outcomes for COVID-19 patients, using a combination of univariate and multivariable Cox proportional hazards regression models.Kaplan-Meier survival estimates and log-rank tests were used to analyze survival and discharge probabilities over time, highlighting sex-dependent effects and the significant association between selected hematological indices and patient outcomes.ResultsThe mean LoS for survivors was significantly shorter compared to those who died (p < 0.001), indicating that longer hospitalization was associated with higher mortality risk.Women had a shorter average LoS (with lower mortality risk (p < 0.001), suggesting an asymmetrical hospitalization pattern based on sex.While most hematological markers had minimal clinical relevance for LoS, the red cell distribution width-to-platelet ratio (RPR) stood out, increasing the likelihood of a longer hospital stay by up to tenfold, making it a critical factor in predicting prolonged hospitalization.DiscussionMen had longer hospital stays and higher mortality rates than women, likely due to differing inflammatory responses, though hyperinflammation markers like NLR, PLR, and Leu-CPR had minimal clinical impact.RPR had the strongest link to longer hospital stays, indicating a higher risk of extended hospitalization in severe COVID-19 cases.Elevated RPR is tied to oxidative stress and coagulation issues, suggesting early identification could help reduce prolonged stays and complications.ConclusionResearch generally points to clinical complications from COVID-19 as the main factor behind prolonged hospitalizations, underlining the importance of early identification and management of these issues.…”
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Regulation of Nav1.7: A Conserved SCN9A Natural Antisense Transcript Expressed in Dorsal Root Ganglia. by Jennifer Koenig, Robert Werdehausen, John E Linley, Abdella M Habib, Jeffrey Vernon, Stephane Lolignier, Niels Eijkelkamp, Jing Zhao, Andrei L Okorokov, C Geoffrey Woods, John N Wood, James J Cox

“…The Nav1.7 voltage-gated sodium channel, encoded by SCN9A, is critical for human pain perception yet the transcriptional and post-transcriptional mechanisms that regulate this gene are still incompletely understood. …”
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Adjuvant melatonin therapy during exercise prescription in breast cancer survivors on physical and anthropometric parameters, quality of life, and hormonal response. A randomized c... by Ana M. Celorrio San Miguel, Luis M. Cacharro, Gema Santamaría, Manuel Garrosa, Manuel Garrosa, Marta Celorrio San Miguel, Enrique Roche, Enrique Roche, Enrique Roche, Enrique Roche, Evelina Garrosa, Diego Fernández-Lázaro, Diego Fernández-Lázaro, Diego Fernández-Lázaro

“…Both MEL and CG exhibited a significant reduction (p &lt; 0.05) in the Borg Rating of Perceived Exertion (RPE) when comparing the beginning (T1) and end (T2) of the study Additionally, statistically significant differences (p = 0.018) were observed overtime between T1 and T2 in the MEL and CG in RPE, with a moderate effect size (η2p = 0.347). …”
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Differences in the inflammatory response and outcome among hospitalized patients during different waves of the COVID-19 pandemic by Violeta Briciu, Violeta Briciu, Daniel-Corneliu Leucuta, Monica Muntean, Monica Muntean, Amanda Radulescu, Amanda Radulescu, Cristina Cismaru, Cristina Cismaru, Adriana Topan, Adriana Topan, Lucia Herbel, Melinda Horvat, Melinda Horvat, Mirela Flonta, Mihai Calin, Roxana Dobrota, Mihaela Lupse, Mihaela Lupse

“…Leukocytes and neutrophils increased in their median values from the Wuhan to Delta wave and decreased in the Omicron wave, while an inverse pattern can be observed for lymphocytes, monocytes, and basophils. …”
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Trends in the molecular epidemiology of human papillomavirus in males from the plateau region of Southwest China: an 11-year retrospective analysis (2014–2024) by Jian-Peng Hu, Jun-Ling Wang, Yun Li, Mei Yang, Jing Li, Hong-Ying Li, Na Qiao, Chao-Fu Yue, Hong-Xia Liu, Xiu-Ping Li, Jin-Si Yang, Qian Xiong, Zhe-Wei Fang, Jian-Dong Zhang, Ting Ji, Zong-Sheng Wu, Rui Zhu, Yin-Yu Zhou, Fan Zhang, Shu-Min Li, Hong-Na Li, Chun-Ju Yang, Zheng-Fu Zhang, Fei He, Yan-Liang Zhang, Yong Sun, Hong-Wei Li

“…The coverage rates of the currently available bivalent, quadrivalent, and nonavalent HPV vaccines were 5.18%, 66.84%, and 73.17%, respectively. …”
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How plausible is it that PEP would be cost‐effective in sub‐Saharan Africa? by Geoffrey Peter Garnett, Peter Godfrey‐Faussett

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Quantum behaved Intelligent Variant of Gravitational Search Algorithm with Deep Neural Networks for Human Activity Recognition by Sonika Jindal, Monika Sachdeva, Alok K. S. Kushwaha

“…The addition of quantum computing based attributes (such as quantum bits, their superposition, and quantum gates, etc.) ensures the better diversity of discrete optimized features. …”
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Assessment of Preserved Ratio Impaired Spirometry (PRISm) Based on Different Definitions in the Early COPD Cohort by Dai C, Tang G, Yang H, Wu F, Deng Z, Zheng Y, Zhao N, Lu L, Wan Q, Wang Z, Peng J, Wu X, Zhou K, Cai G, Xiao S, Wen X, Yang C, Chen S, Yu S, Sun R, Zhou Y, Ran P

“…Furthermore, the prevalence of PRISm varied from 2.0% to 12.5% depending on the definitions and predicted equations, with the Chinese equation, LLN definition in Chinese equation and fixed definition in GLI equation yielding higher prevalence rates.Conclusion: Our findings highlight concerns about the comparability of studies and the interchangeability of various definitions and reference equations for PRISm.Keywords: PRISm, definitions, clinical features, prevalence, reference equations…”
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Tratamento de sequelas de queimadura de face com laser de CO2 fracionado em pacientes com fototipos III a VI Treatment of facial burn sequelae using fractional CO2 lasers in patien... by Alessandra Grassi Salles, Adelina Fátima do Nascimento Remigio, Valéria Berton Liguori Zacchi, Marcus Castro Ferreira

“…Two months after the session, 5 patients developed punctiform hypochromia in a checkerboard pattern corresponding to the points of laser ablation. …”
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Investigation of Population Changes and Determination of the Bean Pod Borer Helicoverpa armigera (Lepidoptera:Noctuidae) Peak in Bean Phaseolus vulgaris Linnaeus Fields by Pheromon... by Sedighe Ashtari

“…The investigation of the distribution and damage level of bean pod borer in important bean-growing areas of Markazi province over two years in five bean-growing regions (Arak, Khomain, Shazand, Milajerd, and Khondab) showed that Khomain and Khondab had the highest and lowest infestation rates, respectively. Red pods showed more sensitivity to this pest compared to green and white pods. …”
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Inwardly rectifying potassium channels: Critical insights for insect species and Apis mellifera by Fabien Sourisseau, Craig A. Doupnik, Pierre Charnet, Mohamed Chahine

“…The dKir channels are essential for various developmental processes, such as wing patterning, by modulating bone morphogenetic protein signaling pathways. …”
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THE IMPACT OF ADEQUATE PSYCHOPHARMACOTHERAPY ON THE EFFICIENCY OF TREATMENT IN PATIENTS WITH RHEUMATOID ARTHRITIS by A. A. Abramkin, T. A. Lisitsyna, D. Yu. Veltishchev, O. F. Seravina, O. B. Kovalevskaya, E. L. Nasonov

“…The diagnosis of MDs was based on the ICD-10 codes, by applying a semi-structured interview and the Hospital Anxiety and Depression Scale. Changes in the pattern and severity of ADS were evaluated using the Hamilton Anxiety Scale and the Montgomery–Asberg Depression Rating Scale. …”
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Calculation Model of Multi-roll Straightening Process Based on Bilinear Hardening and Power Hardening by ZHU Xiaoyu, CHENG Zixing, WANG Xiaogang, HAN Peisheng

“…To evaluate the applicability of different material models, five straightening schemes were designed, corresponding to plasticity rates of 33.4%, 50.0%, 66.7%, 75.0%, and 80.0%. The influence of various hardening coefficients on curvature and plasticity during straightening was investigated. …”
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