Dynamics of cerebral blood flow following sertraline treatment in adolescent depression by Wenyu Ren, Wenyu Ren, Xiao Liu, Zhiwei Zhang, Xiaoqin Zhang, Wei Wu, Xingyu Wang, Zhihui Yu, Chuan Liu, Renqiang Yu

“…Furthermore, Pearson correlation analysis was employed to examine associations between changes in regional CBF and clinical improvement, as measured by changes in the 17-item Hamilton Depression Rating Scale (HAMD-17) scores.ResultsAt baseline, adolescents with depression exhibited increased CBF in the posterior cuneus and decreased CBF in the middle temporal gyrus (MTG), right middle orbitofrontal gyrus, and the left middle frontal gyrus (MFG), compared to healthy controls. …”
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Real-Time, Risk-Based Clinical Trial Quality Management in China: Development of a Digital Monitoring Platform by Min Jiang, Shuhua Zhao, Yun Mei, Zhiying Fu, Yannan Yuan, Jie Ai, Yuan Sheng, Ying Gong, Jingjing Chen

“…Quality findings from the early-stage, interim-stage, and conclusion-stage QC rounds of clinical trials were rated by using 3 severity grades (minor, major, or critical) and classified into 5 categories (with 4 taxonomy levels under each category). …”
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Criminal legal penalties, substance use, and overdose: a concept mapping study examining Colorado’s criminal legal penalties by Katherine LeMasters, Samantha K. Nall, Cole Jurecka, Betsy Craft, Paul J. Christine, Ryan Goodman, Jessie Henderson, Robert Haywood-James, Angela Williams, Grace Wittner, Joshua A. Barocas

“…Participants — recruited from community-based organizations — identified, rated, sorted, and categorized factors affecting criminal legal involvement, substance use, and/or overdose in their community. …”
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Shedding light on pharmacoepidemiology of eye diseases: a cohort study in Western Iran by Zeinab Mousavi, Masood Bagheri, Farid Najafi, Mahsa Yavari, Omid Bahiraee, Mehdi Moradinazar

“…The present study seeks to specifically evaluate the prescribing patterns of the ophthalmic drugs in Kermanshah province. …”
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Hepatitis B virus seroepidemiology data for Africa: Modelling intervention strategies based on a systematic review and meta-analysis. by Anna L McNaughton, José Lourenço, Phillip Armand Bester, Jolynne Mokaya, Sheila F Lumley, Uri Obolski, Donall Forde, Tongai G Maponga, Kenneth R Katumba, Dominique Goedhals, Sunetra Gupta, Janet Seeley, Robert Newton, Ponsiano Ocama, Philippa C Matthews

“…Region-specific differences were present, with estimated CHB prevalence in Northern Africa typically 30% to 40% lower (p = 0.007) than in Southern Africa for statistically similar exposure rates, demonstrating the need for intervention strategies to be tailored to individual settings. …”
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An integrative review of new nurse practitioners’ experiences in rural healthcare practice by Candace Stidolph, Jennifer Kawi, Catherine Dingley, Ann Marie Hart, Jarod Giger, Rebecca Benfield, Andrew Thomas Reyes

“…Data were iteratively compared, and significant patterns were extracted and organized into thematic clusters. …”
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Functioning in patients with major depression treated with duloxetine or a selective serotonin reuptake inhibitor in East Asia by Novick D, Montgomery W, Haro JM, Moneta MV, Zhu G, Yue L, Hong J, Duenas H, Brugnoli R

“…Depression severity was assessed using the 16-item Quick Inventory of Depressive Symptomatology-Self Report. PPS were rated using the modified Somatic Symptom Inventory. …”
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Developing self-efficacy and ‘communities of practice’ between community and institutional partners to prevent suicide and increase mental health in under-resourced communities: ex... by Lisa Wexler, Lauren White, Joel Ginn, Tara Schmidt, Suzanne Rataj, Caroline C. Wells, Katie Schultz, Eleni A. Kapoulea, Diane McEachern, Patrick Habecker, Holly Laws

“…Abstract Background Suicide is a serious and growing health inequity for Alaska Native (AN) youth (ages 15–24), who experience suicide rates significantly higher than the general U.S. youth population. …”
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Modeling the relationships among technological properties of sheep individual animal factors, milk composition, and minerals using generalized additive mixed models by Giorgia Stocco, Claudio Cipolat-Gotet, Andrea Summer, Francesco Tiezzi, Simone Blotta, Alessio Negro, Bianca Castiglioni, Stefano Biffani

“…Longer RCT increased the water retained in the curd and reduced the recovery of TS and the individual recovery rates of the main milk components in both breeds. …”
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Distinct Roles of HHLA2 and PD-L1 in the Immune Cell and Prognosis of Hepatocellular Carcinoma by Wang CH, Chen SL, Yang X, Wu T, Liu LL, Yun JP

“…Hematoxylin and eosin (H&E) staining was utilized to quantify TILs (percentage/area), while IHC was used to measure the densities of CD3+, CD4+, and CD8+ TILs (cells/mm²).Results: HHLA2 and PD-L1 exhibited similar positivity rates. HHLA2 positivity was associated with older age, lower alpha-fetoprotein (AFP) levels, well-differentiated tumors, and improved overall survival (OS). …”
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Long‐Term Trends in Incidence and Risk Factors for Hemorrhagic Stroke Subtypes Over 24 Years: The South London Stroke Register by Xianqi Li, Lu Liu, Ajay Bhalla, Matthew D. L. O'Connell, Charles D. A. Wolfe, Yanzhong Wang

“…We assessed the 24‐year trends in incidence, prestroke risk factors, medications, and demographic patterns in a multiracial and multiethnic population. …”
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Multicenter Study Examining Temporal Trends in Traumatic Intracranial Hemorrhage Over Six Years Using Joinpoint Regression by Timbre Backen, Kristin Salottolo, David Acuna, Carlos H. Palacio, Gina Berg, Andrea Tsoris, Robert Madayag, Kaysie Banton, David Bar-Or

“…The aging US population has altered the epidemiology of traumatic injury, but there are few studies examining changing patterns of traumatic intracranial hemorrhage (tICH). …”
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Post-marketing safety surveillance of pneumococcal vaccines: a real-world pharmacovigilance study using the U.S. vaccine adverse event reporting system (VAERS) database by Xinkuo Zheng, Meishen Liu, Aili Ding, Shihong Zhang, Ling Wu, Fanli Kong, Weijia Sun, Yuchen Peng, Yalin Xi

“…Females showed higher AE reporting rates (54.29%) compared to males (36.88%), with the majority of cases (38.20%) occurring in individuals aged < 18 years. …”
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Effect of planting geometry and chemical fertilizers on growth characteristics, essential oil yield and composition of Inula racemosa under cold desert conditions of western Himala... by Sakshi Vishvamitera, Sidharth Baghla, Varun Parmar, Romika Thakur, Sanatsujat Singh, Sachin Vashisath, Dinesh Kumar, Satbeer Singh, Ramesh Chauhan

“…A field experiment was carried out in the cold desert region of the western Himalayas comprising three planting geometries 30 × 30 cm (G1), 30 × 45 cm (G2) and 45 × 45 cm (G3) and four fertilizer doses (NPK) at the rates of 0 (F1), 90:60:30 kg ha−1 (F2), 120:75:40 kg ha−1 (F3), and 150:90:50 kg ha−1 (F4) from 2021 and 2022. …”
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Palliative Radiotherapy Near the End of Life: An Analysis of Factors Influencing the Administration of Radiotherapy in Advanced Tumor Disease by Nguyen-Son Le, Asli Zeybek, Klaus Hackner, Cornelia Gallauner, Josef Singer, Felix Schragel, Petra Georg, Sandra Gottsauner-Wolf, Martin Pecherstorfer, Gudrun Kreye

“…Furthermore, RT near the EOL was more likely administered at multiple sites (OR, 2.08 [95% CI, 1.00 to 4.29]) and with ≤5 fractions (OR, 2.37 [95% CI, 1.23 to 4.57]), while being associated with lower response rates (OR, 0.43 [95% CI, 0.21 to 0.86]) and increased therapy discontinuation (OR, 4.40 [95% CI, 1.45 to 13.37]).CONCLUSIONThese findings highlight varying RT patterns influenced by specific factors, demonstrating the complexity of EOL treatment decisions in advanced cancer care. …”
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Biomechanical stability and stress distribution before talus prosthesis design: effects of ligament removal and cartilage overlay thickness using finite element analysis by Gang Zeng, Yujun Sun, Min Liang, Wenzhou Liu, Yanbo Chen, Jionglin Wu, Jiayuan Zheng, Taolue Zhou, Huiying Zhao, Weidong Song, Yue Ding

“…Recent advancements, including patient-specific implants and improved biomaterials, show promise in enhancing long-term outcomes and reducing complication rates. Aim This study investigates the mechanical stability and stress distribution changes in a talus prosthesis after the sequential removal of surrounding ligaments and the application of varying thicknesses of cartilage overlays. …”
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Changes in influenza-associated excess mortality in China between 2012–2019 and 2020–2021: a population-based statistical modelling study by Xiaowei Deng, Jiangmei Liu, Minghan Wang, Nana Chen, Feiran Hao, Juan Yang, Maigeng Zhou, Hongjie Yu

“…Distinct pattern was observed for the AC and P&I outcomes. …”
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Neural signatures underlying the effect of social structure on empathy and altruistic behaviors by Xia Tian, Zixin Zheng, Renhui Li, Yue-Jia Luo, Chunliang Feng

“…Afterwards, participants rated the pain experienced by these innocents and shared money with other innocents. …”
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Development of lactation and breast/chestfeeding adverse event terminology (LaBAET) through a Delphi consensus approach by Katarzyna M. Maksym, Kinga Kalita-Kurzyńska, Diane Spatz, Melinda Boss, Maria Carmen Collado, Anna Gonciarz-Dytman, Bei Han, Asma Khalil, Joanna Kozakiewicz, Ernest Kuchar, Karolina Morze, Rebecca Powell, Natalie Shenker, Sławomir Wątroba, Anna L. David, Aleksandra Wesołowska

“…Oversupply of milk and other changes in lactation/feeding patterns were mapped to existing MedDRA terms. Grading for all five definitions was developed and agreed upon through consensus. …”
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Effect of transport stress on apoptosis and autophagy in goat lung cells by Yu Zhuo, Yunhai Hu, Yangshan Jin, Tian Ye, Yanzhen Yang, Ben Liu, Ben Liu, Ben Liu, Wenya Zheng, Wenya Zheng, Songlin Ding, Xue Yang, Xue Yang, Lucheng Zheng, Lucheng Zheng, Wei Hu, Wei Hu, Manxin Fang, Manxin Fang, Wanting Yi, Wenjing Xing

“…IntroductionRoad transportation exposes goats to thermal, mechanical, and microbial stressors that can compromise their welfare by triggering pulmonary apoptosis and autophagy processes associated with tissue damage and immunosuppression.MethodsTo explore potential biomarkers for transport-related welfare assessment, this study analyzed lung tissues from nine Ganxi goats (n = 9; 0 h control, 2 h/6 h transport groups) through an integrated experimental approach: TUNEL assays quantified apoptosis rates, immunohistochemistry mapped protein localization, Western blotting analyzed protein expression levels, and qPCR profiled gene expression of apoptotic regulators (Bax, Bcl-2) alongside autophagy-related markers (LC3B, p62, PINK1, Parkin).ResultsResults indicated time-dependent cellular stress patterns, where the 2 h group displayed elevated apoptosis rates, while the 6 h group exhibited upregulated Parkin expression (p < 0.05) and altered regulation of apoptotic [Bcl-2-associated X-protein (Bax)/B-cell lymphoma-2 (Bcl-2)] and autophagy-related genes (Microtubule-associated protein 1 light chain 3B (LC3B), p62, PTEN-induced putative kinase 1 (PINK1)/Parkin). …”
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