Impact of post-transplant cyclophosphamide with bendamustine on immune reconstitution in young patients undergoing T-cell replete haploidentical bone marrow transplantation: result... by Forrest L. Baker, Forrest L. Baker, Forrest L. Baker, Jessica Stokes, Megan J. Cracchiolo, Dan Davini, Richard J. Simpson, Richard J. Simpson, Richard J. Simpson, Richard J. Simpson, Emmanuel Katsanis, Emmanuel Katsanis, Emmanuel Katsanis, Emmanuel Katsanis

“…Multi-parameter flow cytometry and TCR β sequencing of genomic DNA was performed on isolated PBMCs on PT days +30, +60, +100, +180, and +365.ResultsOverall, the PT-CY/BEN (n=14) regimen was associated with earlier neutrophil and platelet engraftment, reduced transfusion requirements, and comparable clinical outcomes to PT-CY (n=10), including survival and relapse rates. PT-CY/BEN patients exhibited distinct immune reconstitution patterns, characterized by earlier CD4+ T-cell recovery, impaired CD8+ T-cell engraftment, and reduced NK-cell counts. …”
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Multimorbidity frailty index and clinical outcomes among 42,989 older heart failure patients directly discharged from emergency departments: A nationwide retrospective cohort study by Wan-Ju Liao, Hsi-Yu Lai, Liang-Yi Lin, Cheng-Hsueh Wu, Fei-Yuan Hsiao, Liang-Kung Chen

“…Readmission rates showed similar patterns. The severely frail group had higher risks of mortality (aHR 1.44, 95 % CI 1.33–1.55), all-cause readmissions (sHR 1.69, 95 % CI 1.62–1.76), and HF-related readmissions (sHR 1.59, 95 % CI 1.48–1.71). …”
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Farm households’ livelihood adaptive capacity under multiple pressures of small watershed management by Yaru Sun, Yilin Gan, Jing Luo, Tingting Han, Hafo Wang, Ruirui Yang, Lingling Tian

“…However, the FHLAC remains predominantly low to moderate in the small watershed. The contribution rates of livelihood pressure, livelihood capital, and willingness to adapt to FHLAC are 22.24 %, 28.69 %, and 49.07 %, respectively. …”
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Antitumor power of oncolytic HSV engineered with IL-12 and IL-15 by Lei Zhang, Yanbin Zhu, Kunpeng Zheng, Xinyu Zhang, Chunxue Fu, Dan Wang, Xinqiang Zhang, Tong Wu, Shuxin Han, Zhenghai Ma

“…The engineered oHSV-1 demonstrated growth patterns comparable to wild-type HSV-1. The viral titers exhibited consistency within the same tumor cells. …”
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<i>SHROOM3</i> Deficiency Aggravates Adriamycin-Induced Nephropathy Accompanied by Focal Adhesion Disassembly and Stress Fiber Disorganization by Li-Nan Xu, Ying-Ying Sun, Yan-Feng Tan, Xin-Yue Zhou, Tian-Chao Xiang, Ye Fang, Fei Li, Qian Shen, Hong Xu, Jia Rao

“…Clinically, the glomerular <i>SHROOM3</i> expression positively correlated with glomerular filtration rates in focal segmental glomerulosclerosis patients. …”
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Satellite-Based Prediction of Water Turbidity Using Surface Reflectance and Field Spectral Data in a Dynamic Tropical Lake by Elsa Pereyra-Laguna, Valeria Ojeda-Castillo, Enrique J. Herrera-López, Jorge del Real-Olvera, Leonel Hernández-Mena, Ramiro Vallejo-Rodríguez, Jesús Díaz

“…In this study, we utilized Landsat satellite imagery in conjunction with near-synchronous in situ reflectance measurements to monitor spatial and seasonal turbidity patterns between 2023 and 2025. The surface reflectance was radiometrically corrected and validated using spectroradiometer data collected across eight sampling sites in the eastern sector of the lake, the area where the highest rates of horizontal change in turbidity occur. …”
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Identify suitable artificial groundwater recharge zones using hybrid deep learning models by Navaz Khalillollahi, Mohsen Isari, Hamed Faroqi, Kaywan Othman Ahmed, Kamran Nobakht Vakili, Miklas Scholz, Saad Sh. Sammeng

“…This study evaluated four deep learning models for delineating groundwater recharge zones: Artificial Neural Network (ANN), Convolutional Neural Network (CNN), Gated Recurrent Unit (GRU), and hybrid deep learning Convolutional Neural Network-Gated Recurrent Unit (CNN-GRU). …”
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Geospatial analysis of cholera outbreak in Lusaka, Zambia, between 2023 and 2024 by William Ngosa, Tadatsugu Imamura, Nyuma Mbewe, Joseph Seriki, Oscar Nzila, Fred Mfune, Godfrey Zulu, Chomba Mulando, Tizha Chiluba, Luo Miyanda, Agness Phiri, Lucy Sichone, Galion Mwape, Kapambwe Mulenga, Charles Chileshe, Nawa Mabuku, Dabwiso Banda, Fangyu Yan, Taro Kamigaki, Roma Chilengi, Nyambe Sinyange

“…Results Over the study period, 4,591 suspected cholera cases with geocoordinate data were identified, with incidence rates varying across the constituencies. Median cholera incidence (IQR) was 0.55 (0.27–1.44) in Lusaka, with higher incidence rates observed in unplanned residential areas. …”
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Molecular and genomic investigation of an urban outbreak of dengue virus serotype 2 in Angola, 2017-2019. by Zoraima Neto, Pedro A Martinez, Sarah C Hill, Domingos Jandondo, Julien Thézé, Marinela Mirandela, Renato Santana Aguiar, Joilson Xavier, Cruz Dos Santos Sebastião, Ana Luísa Micolo Cândido, Filipa Vaz, Gisel Reyes Castro, Joana Paula Paixão, Nicholas J Loman, Philippe Lemey, Oliver G Pybus, Jocelyne Vasconcelos, Nuno Rodrigues Faria, Joana de Morais

“…<h4>Background</h4>The transmission patterns and genetic diversity of dengue virus (DENV) circulating in Africa remain poorly understood. …”
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Dynamic parking space allocation at urban scale: Problem formulation and resolution by Hanae Errousso, Jihane El Ouadi, El Arbi Abdellaoui Alaoui, Siham Benhadou

“…To do this, we consider both solicitation rates in these areas and coverage ratios of received parking demands. …”
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The characteristics of new-onset myasthenia gravis after COVID-19 outbreak: a cross-sectional study by Yanzhen Huang, Yu Wu, Shaodan Zhou, Xianting Que, Ailing Jiang, Danli Shi, Ting Lu, Yanlan Chen, Ziqun Lin, Chao Liu, Yishuang Wen, Shuyi Zhang, Wen Huang

“…After COVID-19 outbreak, there was an increase in new-onset MG patients, with more cases occurring within the first three months. The rates of pulmonary inflammation (40.28%), COVID-19 vaccination (88.14%), and treatment with tacrolimus (15.98%) and MG duration (15 weeks, IQR: 5.75, 32) were higher, while rates of thymectomy (13.92%), baseline MG-ADL (3, IQR: 3, 6), and QMGS (7, IQR: 5,8) were lower compared to new-onset MG patients before COVID-19 outbreak. …”
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Multi-Objective Optimization of Off-Grid E-Bikes Charging Stations Powered by PhotoVoltaics by Fabio Corti, Gabriele Maria Lozito, Davide Astolfi, Salvatore Dello Iacono, Antony Vasile, Marco Pasetti, Alberto Reatti, Alessandra Flammini

“…A Genetic Algorithm is employed to determine the most appropriate rated power of the installed PhotoVoltaic (PV) systems and of the energy storage, by incorporating statistical methods to estimate the daily number of e-bikes requiring charging, hence making the optimization process more reflective of actual usage patterns. …”
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Nutritional status, body indices, and somatotype in Aymara and Quechua children from high Andean areas of Peru by Lidia Sofia Caballero Gutiérrez, Rodolfo Adrian Núñez Postigo, Juber Chávez Dominguez, Vilma Lucrecia Tapia Aguirre, José Oscar Alberto Begazo Miranda

“…Infants born at high altitudes, such as in the Puno region, typically exhibit higher birthweights than those born at low altitudes; however, the influence of ethnicity on childhood anthropometric patterns in high-altitude settings remains poorly understood. …”
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Conserved missense variant pathogenicity and correlated phenotypes across paralogous genes by Tobias Brünger, Alina Ivaniuk, Eduardo Pérez-Palma, Ludovica Montanucci, Stacey Cohen, Lacey Smith, Shridhar Parthasarathy, Ingo Helbig, Michael Nothnagel, Patrick May, Dennis Lal

“…For the gene family of voltage-gated sodium channels, where variants and expert-curated clinical phenotypes are available, we also assess whether phenotype patterns of multiple disorders for each gene are conserved across variant positions within the gene family. …”
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MCM3 promotes hepatocellular carcinoma progression via Epithelial-mesenchymal Transition through AKT/Twist signaling pathway by Wei-Guo Tang, Jin-Feng Feng, Xian Li, Qi-Man Sun, Jin-Wu Hu, Xiao-Lu Ma, Yan-Yan Nie, Yang Xu, Jian Sun, Qi-Meng Chang

“…Introduction and Objectives: Hepatocellular carcinoma (HCC), a leading cause of cancer fatalities, challenges clinicians with high recurrence and metastasis rates, urging the need for novel prognostic markers and therapeutic avenues. …”
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Regional variations in Mediterranean diet adherence: a sociodemographic and lifestyle analysis across Mediterranean and non-Mediterranean regions within the MEDIET4ALL project by Mohamed Ali Boujelbane, Mohamed Ali Boujelbane, Achraf Ammar, Achraf Ammar, Achraf Ammar, Atef Salem, Atef Salem, Mohamed Kerkeni, Mohamed Kerkeni, Khaled Trabelsi, Khaled Trabelsi, Bassem Bouaziz, Bassem Bouaziz, Liwa Masmoudi, Juliane Heydenreich, Christiana Schallhorn, Gabriel Müller, Ayse Merve Uyar, Hadeel Ali Ghazzawi, Adam Tawfiq Amawi, Bekir Erhan Orhan, Giuseppe Grosso, Osama Abdelkarim, Osama Abdelkarim, Tarak Driss, Kais El Abed, Kais El Abed, Piotr Zmijewski, Frédéric Debeaufort, Frédéric Debeaufort, Nasreddine Benbettaieb, Nasreddine Benbettaieb, Clément Poulain, Laura Reyes, Amparo Gamero, Marta Cuenca-Ortolá, Antonio Cilla, Nicola Francesca, Concetta Maria Messina, Enrico Viola, Björn Lorenzen, Stefania Filice, Aadil Bajoub, El-Mehdi Ajal, El-Mehdi Ajal, El Amine Ajal, Majdouline Obtel, Sadjia Lahiani, Taha Khaldi, Nafaa Souissi, Omar Boukhris, Omar Boukhris, Haitham Jahrami, Haitham Jahrami, Waqar Husain, Evelyn Frias-Toral, Evelyn Frias-Toral, Walid Mahdi, Walid Mahdi, Hamdi Chtourou, Wolfgang I. Schöllhorn

“…Sleep quality was poorer in MC (45% below recommended duration vs. 40% in NMC), while NMC reported higher insomnia rates. Mental health symptoms were comparable (33%–35% moderate depression/anxiety in both), reflecting post-pandemic global trends. …”
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Mutation Profiling of Premalignant Colorectal Neoplasia by Jakub Karczmarski, Krzysztof Goryca, Jacek Pachlewski, Michalina Dabrowska, Kazimiera Pysniak, Agnieszka Paziewska, Maria Kulecka, Malgorzata Lenarcik, Andrzej Mroz, Michal Mikula, Jerzy Ostrowski

“…HGD adenomas had significantly higher mutation rates than LGD adenomas, while LGD-H adenomas exhibited mutation frequencies similar to those of LGD adenomas. …”
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Intraspecific and Intracolonial Variation in the Profile of Venom Alkaloids and Cuticular Hydrocarbons of the Fire Ant Solenopsis saevissima Smith (Hymenoptera: Formicidae) by Eduardo Gonçalves Paterson Fox, Adriana Pianaro, Daniel Russ Solis, Jacques Hubert Charles Delabie, Bruno Cunha Vairo, Ednildo de Alcântara Machado, Odair Correa Bueno

“…Some fire ant species are top-rated pests spreading throughout the world by trade vessels. …”
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Unravelling molecular transformation of dissolved organic matter in the full quantization treatment of landfill leachate concentrate by ZHONG Quanfa, ZHONG Lin, XU Guohui, JIN Qinghai, YU Jin, XU Fei, HE Di

“…To investigate the removal and transformation patterns of dissolved organic matter(DOM) in the full quantization treatment of landfill leachate concentrate, this study centered on the landfill leachate concentrate derived from a waste transfer station in Shenzhen. …”
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Real-world effectiveness and safety of CDK4/6i in elderly and BIPOC patients with HR+/HER2- advanced/metastatic breast cancer: an updated systematic literature review by Nadia Harbeck, Adam Brufsky, Chloe Grace Rose, Beata Korytowsky, Connie Chen, Krista Tantakoun, Endri Jazexhi, Do Hoang Vien Nguyen, Meaghan Bartlett, Imtiaz A. Samjoo, Timothy Pluard

“…Key outcomes for synthesis were effectiveness, treatment patterns, and safety.ResultsThis review included 23 unique studies. …”
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