Breaking barriers: targeted delivery of resveratrol in lung cancer using folate-integrated and pH-responsive hybrid nanocarriers by Sanjoy Das, Malay K. Das, Taison Jamatia, Nayan Ranjan Ghose Bishwas, Dhritiman Roy, Emdormi Rymbai

“…Finally, in vivo targeting and anticancer studies demonstrated that FOL-RSV-LPHNCs selectively internalized to the cancerous region and suppressed the tumor volume with an 8.66-fold higher rate in the xenograft mouse model. The folate receptor-mediated uptake mainly facilitates this superior therapeutic response which was further confirmed by in silico molecular docking and dynamic simulation. …”
Get full text

Physiological insights into the responses of tea plants to aluminum through an integrated transcriptomic and metabolomic analysis by Xinwan Zhang, Shijie Luo, Xiali Ye, Lin Liu, Xinxin Jia, Deyuan Jiang, Weiwei Wen

“…Compared to 0 mM Al treatment, low Al concentrations (0.4 mM) enhanced root vitality by 8.91%, while higher Al concentrations (10 and 100 mM) reduced root vigor by 19.31% and 76.81%, respectively. In a similar pattern, the electron transfer rate in leaves remained stable under low Al levels but significantly decreased under high Al conditions. …”
Get full text

Impact of Malaria Diagnostic Technologies on the Disease Burden in the Sub-Saharan Africa by Josephine Wambani, Patrick Okoth

“…However, in certain areas, the rate of decline has slowed or even reversed the gains made so far. …”
Get full text

Determination of Carbapenemase-Producing OXA- 48 and KPC Genes in Antibiotic-Resistant Gram-Negative Bacilli Isolated from Infectious Samples of Cardiovascular Patients Hospitalize... by Mina Owrang, Ebrahim Taheri Hossein Abad, Shakiba Shafaie

“…Additionally, highest rates of bacterial resistance were observed against ceftazidime (100%) and imipenem (96.72%). …”
Get full text

Identification of endothelial INSR as an osteosarcoma-related biomarker and therapeutic target based on weighted gene co-expression network analysis by Xu Yingkai, Jiang Jianfeng, Hu Zhiyong, Zhou Zhifeng, Wang Lei

“…Abstract Background Osteosarcoma (OS) is the most common primary malignant bone tumor characterized by a high rate of metastasis. The clinical efficacy of current targeted drugs for OS is limited, highlighting the urgent need to identify novel therapeutic targets. …”
Get full text

Evaluation and optimization simulation of land suitability for village construction in the urban rural integration zone empirical test based on 49 administrative villages in Chuzho... by Shuping Fan, Yuntao Zhu, Huimin Guo, Qi Wang, Yishi Mi, Xin Gao, Yangbing Liu, Zihao Su

“…The results show that: (1) the village collective income and land use intensity have a great impact on the potential of village construction land, the proportion of permanent basic farmland, the distance from the organized town and the population loss rate have a great impact on the binding force of village construction land; (2) The proportion of suitable, unsuitable and suitable areas of village construction land is 38.63%, 27.56% and 15.60% respectively, the overall distribution pattern of suitability is “high in the east and southwest, South-Northeast Low”; (3) The eastern high-suitable area adopts the rural urbanization mode and optimizes the layout in a “group” style, The central low suitable area adopts the mode of “teng village and land reduction” and continuously improves the level of intensive land use, In the southwest, it is suitable for villages to form a “central village” layout mode based on location and economic development. …”
Get full text

Effects of Bt Rice Straw Extract on Seed Germination and Plant Growth of Pakchoi: Novel Variables of Cropping System by Chenning Zhang, Wenfang Suo, Yongfang Pan, Yuanjiao Feng

“…The 40 g·L⁻¹ heterozygous Bt extract increased leaf and root POD activity but inhibited germination rate and leaf SOD activity. The 10 g·L⁻¹ extract promoted root length and seedling POD activity but suppressed leaf POD activity. …”
Get full text

Dr Papineau Meets Dr Masquelet—Management of Open Calcaneal Fractures, Combining Two Techniques: A Case Report by Shuvendu P Roy, Yogendra Gupta, Gurinder Bedi, Vishwadeep Sharma

“…Aim and background: Open fractures of the calcaneum are often the source of significant morbidity due to the high rate of wound infection and significant morbidity, ranging from malunion to amputation. …”
Get full text

Fluid–solid coupling productivity analysis of multi-stage fractured horizontal wells in shale reservoirs by Qian QI, Ming YUE, Weiyao ZHU, Wenjiang MA

“…The simulation results of the model align with actual field data, showing that gas production follows an “L-shaped” decline pattern with a coincidence rate exceeding 70%, verifying the model’s accuracy.…”
Get full text

Safety and efficacy of prone position ventilation in patients with severe pneumonia in neurosurgical intensive care units by CHENG Longyang，LI Jun，LI Shaoya，LI Chuanqing，XU Manman，WANG Rong，ZHAO Penglai

“…PaO2 values followed a similar pattern：（79.63±4.81）mmHg，（89.90±6.83）mmHg，（106.98±12.26）mmHg，（130.40±12.03）mmHg and（135.68±13.95）mmHg，also demonstrating a significant increase（F=219.963，P<0.01）. …”
Get full text

Clinical characteristics and outcomes of non-tuberculous mycobacterial pulmonary infections after hematopoietic stem cell transplantation: A retrospective cohort study by Zahia Esber, Hamza Salam, Shefali Godara, Ayman Soubani

“…The most common radiologic pattern was nodular infiltrates in 15 (29.4%) patients. …”
Get full text

Phytol nanoemulsions encapsulated alginate hydrogel beads for the protection and management of alcohol-induced gastric ulcer via nitric oxide synthase and NF-κB/IL-6/TGF-β modulati... by Tamer I M Ragab, Abdulsalam M Kassem, Heba M I Abdallah, Sally A El Awdan, Naglaa M Ammar, Abd El-Nasser G El Gendy, Basma Emad Aboulhoda, Sherif M Afifi, Tuba Esatbeyoglu, Enayat A Omara, Abdelsamed I Elshamy

“…Alginate beads showed a pH-dependent release pattern. The release behavior showed a higher release rate at pH 6.8 than at pH 1.2. …”
Get full text

Cutis verticis gyrata in a Patient with Familial presenile sebaceous hyperplasia Presenting as &amp;ldquo;Leonine facies&amp;rdquo;: A Rare Case by Sutedja EK, Sutedja E, Ruchiatan K, Faldian Y, Yogya Y, Dwiyana RF, Maharani RH, Budiarsa M

“…Familial presenile sebaceous hyperplasia (FPSH), a rare variant of sebaceous hyperplasia, follows an autosomal dominant inheritance pattern with incomplete penetrance and variable severity among family members. …”
Get full text

Isokinetic knee strength as a predictor of cardiorespiratory responses during loaded aerobic capacity test in elite athletes by Bekir Çar, Ahmet Kurtoğlu, Özdemir Atar, Musa Türkmen, Özgür Eken, Mehmet Soyler, Monira I. Aldhahi

“…Cardiorespiratory parameters—average breath volume (ABV), average breath frequency (ABF), auxiliary oxygen density (AOD), and heart rate (HR)—were recorded during the Bruce Protocol conducted under two conditions: unloaded and with a 10 kg loaded vest. …”
Get full text

Exploring adolescents’ indirect financial and non-financial barriers to dental care non-attendance: the role of payment methods by Alla T. Alsharif, Saba Kassim

“…., brushing teeth, dental attendance pattern) and barriers to non-dental attendance. Logistic regression identified factors associated with non-attendance for dental care. …”
Get full text

Energy Dissipation and Failure Characteristics of Layered Composite Rocks under Impact Load by Wenjie Liu, Ke Yang, Wei Zhen, Xiaolou Chi, Rijie Xu, Xin Lv

“…The energy dissipation pattern of composite rock had an obvious strain rate effect. …”
Get full text

Neuroendocrine tumors of the digestive system: pathologic and molecular characteristics by V. V. Delektorskaya

“…In contrast, poorly differentiated neuroendocrine carcinomas have diffuse growth pattern, high-grade nuclear atypia and cellular proliferation, necrosis. …”
Get full text

Network meta-analysis of erlotinib, gefitinib, afatinib and icotinib in patients with advanced non-small-cell lung cancer harboring EGFR mutations. by Wenhua Liang, Xuan Wu, Wenfeng Fang, Yuanyuan Zhao, Yunpeng Yang, Zhihuang Hu, Cong Xue, Jing Zhang, Jianwei Zhang, Yuxiang Ma, Ting Zhou, Yue Yan, Xue Hou, Tao Qin, Xiaoxiao Dinglin, Ying Tian, Peiyu Huang, Yan Huang, Hongyun Zhao, Li Zhang

“…Pooled data on objective response rate (ORR), progression free survival (PFS), overall survival (OS) were calculated. …”
Get full text

Demographic and clinical characteristics of patients with benign bone tumors: Evidence of bimodal age distribution in a Hispanic population by Blake C. Martin, Mohammad Khalil, Juan Lopez-Alvarenga, Michael Sander

“…This indicates an incidence rate of 0.00018 per person-year. The average age was 38.8 years (SD 24.0), with females representing 58 % of the sample. …”
Get full text

Reduced Inter-Element Interference mmWave MIMO Antenna and Its Application in WBAN by Jawad Ahmad, Mohammad Hashmi

“…A specific absorption rate (SAR) analysis confirmed that the design complies with safety standards for both 1g and 10g tissue models. …”
Get full text