Synergistic ideas in oncology: prospects for practical implementation by E. S. Evstratova, V. G. Petin

“…Synergism depends on the intensity of the factors used — the current temperature, the dose rate of ionizing radiation or the concentration of chemical agents. …”
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Multicenter study correlating molecular characteristics and clinical outcomes of cancer cases with patient-derived organoids by Paloma Navarro, Tatiana P. Grazioso, Arantzazu Barquín, Maria Barba, Mónica Yagüe, Carlos Millán, Irene López, Elena Sevillano, Miguel Quiralte, Paloma Fernández, Diego Losada, Eduardo Caleiras, Julia Calzas, Beatriz Jiménez, Sergio Ruiz-Llorente, Juan Justo, Félix Guerrero, Vital Hevia, Raquel Martín, Francisco José Pérez-Rodriguez, Julia Tejerina, Mario Prieto, Paula Comune, Juan Francisco Rodriguez-Moreno, Jesús García-Donás

“…Results From 184 patients (17 tumor types), 249 samples were collected: 149 (59.8%) from tumor tissue, 61 (24.5%) from peritoneal fluids, 39 (15.7%) from peripheral blood. Success rates for PDO establishment were 39.5%, 34.4%, and 25.6%, respectively. …”
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Inversion Study of Maize Leaf Physiological Information Under Light–Temperature Stress Using Visible–Near Infrared Spectroscopy by Siyao Gao, Jianlei Qiao, Lina Zhou, Shuang Liu, Limei Chen, Yue Yu, Lijuan Kong

“…This study focuses on maize during the seedling stage and investigates the response patterns of maize leaf net photosynthetic rate, relative chlorophyll content (SPAD value), and visible–near-infrared spectral data under eight light–temperature stress conditions. …”
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Genomic epidemiology and phylodynamics of Acinetobacter baumannii bloodstream isolates in China by Qixia Luo, Mengru Chang, Ping Lu, Qian Guo, Xiaoqing Jiang, Tingting Xiao, Haoyu Zhang, Yingying Ma, Yan Zhang, Wei Yu, Erjia Zhang, Yunbo Chen, Ping Shen, Jinru Ji, Chaoqun Ying, Zhiying Liu, the BRICS Working Group, Huaiqiu Zhu, Yonghong Xiao

“…Abstract In recent decades, Acinetobacter baumannii has become a major global nosocomial pathogen, with bloodstream infections (BSIs) exhibiting mortality rates exceeding 60% and imposing substantial economic burdens. …”
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Variation in physiological host range in three strains of two species of the entomopathogenic fungus Beauveria. by Clara Rohrlich, Isabelle Merle, Issa Mze Hassani, Manon Verger, Michel Zuin, Samantha Besse, Isabelle Robène, Samuel Nibouche, Laurent Costet

“…We performed laboratory mortality bioassays to assess their pathogenicity and virulence against nine insect pests, belonging to three orders: Lepidoptera, Coleoptera and Diptera. Mortality rate, mean survival time and mycosis rate were used to estimate virulence. …”
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Performance and limitations of linkage-disequilibrium-based methods for inferring the genomic landscape of recombination and detecting hotspots: a simulation study by Raynaud, Marie, Gagnaire, Pierre-Alexandre, Galtier, Nicolas

“…False positive and false negative hotspots considerably confound fine-scale patterns of inferred recombination under a wide range of conditions, particularly when Ne is small and the mutation/recombination rate ratio is low, to the extent that maps inferred from populations sharing the same recombination landscape appear uncorrelated. …”
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Timing matters! Academic assessment changes throughout the day by Carmelo M. Vicario, Michael A. Nitsche, Chiara Lucifora, Pietro Perconti, Mohammad A. Salehinejad, Mohammad A. Salehinejad, Mohammad A. Salehinejad, Francesco Tomaiuolo, Simona Massimino, Alessio Avenanti, Alessio Avenanti, Massimo Mucciardi

“…Our results demonstrate a Gaussian distribution of passing rates throughout the day, with a significant peak at midday. …”
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Human growth and development across time and space by Michael Hermanussen, Christiane Scheffler, Jana Fritsch, Piotr Fedurek, Joanna Nieczuja-Dwojacka, Maria Kaczmarek, Sylvia Kirchengast, Dominik Hagmann, Birgit Bühler, Katarzyna Górka, Sylwia Bartkowiak, Başak Koca Özer, Esin Köksal Babacan, Kübra Baran, Martin Musalek, Takashi Satake, Roshan Peiris, Toshie Hirohara, Komei Hattori, Natalia Nowak-Szczepanska, Anna Apanasewicz-Grzegorczyk, Aleksandra Gomula, Slawomir Koziel

“…Taking a decolonial view on the historical well-being of the Xavante, the overall health status of this Brazilian population has significantly worsened despite changes in the administrative frameworks, including reductions in mortality rates and increased hospital service usage. In addition to height, the alterations in body weight, the effects of fat mass on physical fitness, lifestyle, sports, and general health in Polish, Czech, and Turkish populations were discussed. …”
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Modeling of Photochemical and Photothermal Effects in Soft Tissue Subjected to Laser Irradiation by Marek Jasiński, Maria Zadoń

“…The connection between bioheat transfer and PDT models is taken into account through the respective relationships between perfusion rate, capillary blood velocity, and the maximum oxygen supply rate. …”
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Resolving contiguous vowels across word boundaries in Spanish: L2 learners, levels, and tasks by Erik W. Willis, D. Eric Holt, Carly Carver

“…The intermediate learners increased the frequency of linking contiguous vowels to 49% in the narrative-retell task, whereas the advanced L2 speakers slightly reduced their linking rate to 68%. The Mexican monolingual speaker comparison group produced linked speech in a narrative-retell task at a rate of 93%. …”
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Air Entrainment and Gas Transfer in Wave Breaking Events by S. Di Giorgio, S. Pirozzoli, A. Iafrati

“…We show that the volume of gas transferred across the air‐water interface increases significantly with the amount of air entrained due to wave breaking, peak values in the transfer velocity being concurrent with peaks in energy dissipation rate and air entrainment. The gas transfer velocity is observed to scale approximately as the one‐fourth power of the energy dissipation rate, consistent with previous theoretical predictions. …”
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Size and impact of the Brussels knowledge economy by Tom Van Puyenbroeck, Johan Eyckmans, Peter Teirlinck, André Spithoven, Gilles Van Hamme

“…Over the period 2008-2020, the compound annual growth rate of knowledge-intensive employment was highest in the surrounding Brussels functional metropolitan area. …”
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Evaluating the predictive power of combined gene expression dynamics from single cells on antibiotic survival by Razan N. Alnahhas, Virgile Andreani, Mary J. Dunlop

“…We first identified relationships between growth rate and reporter levels based on auto- and cross-correlation analysis, revealing consistent patterns where changes in growth rate were anticorrelated with fluorescence following a delay. …”
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Trends in prescription opioid use in Europe: A DARWIN EU® multinational cohort study including seven European countries by Junqing Xie, Mike Du, Yuchen Guo, Cesar Barboza, James T. Brash, Antonella Delmestri, Talita Duarte-Salles, Talita Duarte-Salles, Jasmine Gratton, Romain Griffier, Raivo Kolde, Wai Yi Man, Núria Mercadé-Besora, Marek Oja, Sarah Seager, Katia Verhamme, Dina Vojinovic, Edward Burn, Daniel Prieto-Alhambra, Daniel Prieto-Alhambra, Martí Català, Annika M. Jödicke

“…Annual period prevalence and incidence rates of opioid prescriptions were estimated, and long-term trends were quantified as the percent change from 2012 to 2019. …”
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Molecular Evolutionary Analyses of the RNA-Dependent RNA Polymerase (<i>RdRp</i>) Region and <i>VP1</i> Gene in Sapovirus GI.1 and GI.2 by Fuminori Mizukoshi, Ryusuke Kimura, Tatsuya Shirai, Asumi Hirata-Saito, Eri Hiraishi, Kosuke Murakami, Yen Hai Doan, Hiroyuki Tsukagoshi, Nobuhiro Saruki, Takeshi Tsugawa, Kana Kidera, Yoshiyuki Suzuki, Naomi Sakon, Kazuhiko Katayama, Tsutomu Kageyama, Akihide Ryo, Hirokazu Kimura

“…Further, the MRCAs of the <i>RdRp</i> region and <i>VP1</i> gene in HuSaV GI.2 diverged in 1960 and 1943, respectively. The evolutionary rates were higher for <i>VP1</i> gene in HuSaV GI.1 than that in HuSaV GI.2, furthermore, were higher in GI.1 Cluster B than GI.1 Cluster A. …”
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Barriers and facilitators to implementing a task-sharing mental health intervention for Sickle Cell Disease populations in low- and middle-income countries: a qualitative analysis... by John Patena, Leah Elster, Tania Hameed, Sumedha Kulkarni, Alden Yuanhong Lai, Annika C. Sweetland, Joyce Gyamfi, Temitope Ojo, Angela Odoms-Young, Charmaine Royal, Emmanuel Peprah

“…BackgroundPeople living with Sickle Cell Disease (SCD) experience higher rates of common mental disorders (CMD). There is an alarming treatment gap in the provision of adequate mental health services for CMDs in low- and middle-income countries (LMIC). …”
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Triatoma dimidiata, domestic animals and acute Chagas disease: a 10-year follow-up after an eco-bio-social intervention by Jose G. Juarez, Andrea M. Moller-Vasquez, María Granados-Presa, Pamela Pennington, Norma Padilla, Sujata Balasubramanian, Lisa D. Auckland, Elsa Berganza, Estuardo Alvarado Liberato, Henry Esquivel, Ranferi Trampe, Louisa A. Messenger, Celia Cordón-Rosales, Gabriel L. Hamer, Sarah A. Hamer

“…Results Persistent household infestation by T. dimidiata was observed across all four communities, with infestation rates ranging from 17% to 38% and colonization levels ranging from 9% to 29%. …”
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Spatio-Temporal Characteristics and Driving Forces of Landscape Ecological Risks in Highly Urbanized Areas: A Case Study of Suzhou City by Lingyue LU, Dawei SHAO, Dianming WU

“…However, relatively little attention has been given to urbanized areas characterized by high rates of population growth and land development. …”
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A longitudinal qualitative study of clinical nurses caring for hospitalized adults during the first fifteen months of COVID-19: lessons in professional survival and leadership by Elizabeth M. Norman, Mildred Ortu Kowalski, Roxanne Sabatini, Carol S. Jones, Wendy Silverstein

“…At the time of this April surge, nurses were exposed to a virus with no standard treatments and high mortality rates. Using a longitudinal qualitative design, the team hoped to answer questions about what compelled these nurses to continue to come to work? …”
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The system of atmosphere, land, ice and ocean in the region near the 79N Glacier in northeast Greenland: synthesis and key findings from the Greenland Ice Sheet–Ocean Interaction (... by T. Kanzow, T. Kanzow, A. Humbert, A. Humbert, T. Mölg, M. Scheinert, M. Braun, H. Burchard, F. Doglioni, P. Hochreuther, M. Horwath, O. Huhn, M. Kappelsberger, J. Kusche, E. Loebel, K. Lutz, B. Marzeion, B. Marzeion, R. McPherson, M. Mohammadi-Aragh, M. Mohammadi-Aragh, M. Möller, M. Möller, C. Pickler, M. Reinert, M. Rhein, M. Rhein, M. Rückamp, M. Rückamp, J. Schaffer, J. Schaffer, M. Shafeeque, M. Shafeeque, S. Stolzenberger, R. Timmermann, J. Turton, J. Turton, C. Wekerle, O. Zeising

“…Observations and models employed in this study are consistent in terms of melt rates occurring below the floating ice tongue. Our results suggest that the multidecadal warming of Atlantic Intermediate Water flowing into the cavity below the ice tongue – supplied by the recirculating branch of the West Spitsbergen Current in Fram Strait – is the main driver of the recent major increase in basal melt rates. …”
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