Molecular mechanism and biological pathway of high-expressed RAD51 in regulating cell adhesion and potentially affecting oral squamous cell carcinoma by Yu-Xing Tang, Yu-Yan Pang, Yan Cui, Guo-Jiao Wu, Lin-Qing Huang, Chang-Zhan Zhou, Bin Li, Qi Li, Bang-Teng Chi, Rong-Quan He, Di-Yuan Qin, Jian-Di Li, Gang Chen, Dong-Ming Li, Yi-Wu Dang

“…However, its multi-platform expression patterns and functional role in cell adhesion within the context of OSCC have not yet been comprehensively validated. …”
Get full text

Enhancing the accuracy of mental health assessments through the integration of self-report and objective measures: A convergence study utilizing biosignals and 14-day wearable data by Nayeon Kwon, Dongwon Lee, Soree Hwang, Soomin Yang, Inchan Youn, Hyuk-June Moon, Sungmin Han

“…Participants performed a laboratory-based mental arithmetic task designed to induce acute stress while their electrocardiogram (ECG) was recorded to extract heart rate variability (HRV) features. Additionally, they wore a smartwatch for 14 consecutive days to monitor stress levels multiple times daily, as well as continuous sleep and activity patterns. …”
Get full text

Differential Cortical Responses of Functional and Sensory Electrical Stimulation in Closed-Loop Tremor Suppression for Parkinson’s Disease by Xiaoqi Zhao, Tinglan Huang, Mengyue Jin, Hongbo Zhao, Yu Shi, Yanlin Wang, Xiao Shen, Zhen Li, Qingqing Shi, Xiaodong Zhu, Lin Meng

“…Both FES and SES significantly reduced tremor amplitude, with FES showing overall greater suppression (hand suppression rate: 60.72% vs. 48.31%, p >0.05; forearm suppression rate: 62.25% vs. 54.41%, p >0.05) where substantial inter-individual variability was observed. …”
Get full text

Timing of Surgery and Preoperative Predictors of Surgical Site Infections for Patients with Depressed Skull Fractures in a Sub-Saharan Tertiary Hospital: A Prospective Cohort Study by Hervé Monka Lekuya, Jelle Vandersteene, Larrey Kasereka Kamabu, Rose Nantambi, Ronald Mbiine, Anthony Kirabira, Fredrick Makumbi, Stephen Cose, David Patrick Kateete, Mark Kaddumukasa, Edward Baert, Moses Galukande, Jean-Pierre Okito Kalala

“…The outcome variables were the incidence risk of SSI, types of SSI, microbial culture patterns of wound isolates, and hospital length of stay. …”
Get full text

Annual dialysis data report 2022, Japanese Society for Dialysis Therapy (JSDT) Renal Data Registry by Norio Hanafusa, Masanori Abe, Nobuhiko Joki, Junichi Hoshino, Masatomo Taniguchi, Kan Kikuchi, Takeshi Hasegawa, Shunsuke Goto, Tetsuya Ogawa, Eiichiro Kanda, Shigeru Nakai, Toshihide Naganuma, Kenichiro Miura, Atsushi Wada, Yoshiaki Takemoto

“…The results obtained for each condition provide evidence for developing more clinically effective practice patterns for these conditions.…”
Get full text

Clinicopathological characterization of Switch/Sucrose-non-fermentable (Swi/Snf) complex (ARID1A, SMARCA2, SMARCA4)-deficient endocervical adenocarcinoma by Chao Cao, Zi-Yun Wu, Wei Liao, Li-Jun Wei, Hao-Yu Liang, Xia Yang, Rong-Zhen Luo, Li-Li Liu

“…Defining Swi/Snf deficiency as loss of any subunit, the overall deficiency rate was 5.96% (36/604). Swi/Snf-deficient ECA tended to advanced FIGO stage (III-IV, P = 0.041), larger tumor size (P < 0.001), deeper stromal invasion (≥ 1/3, P = 0.046), and higher lymph node metastasis rate (P = 0.037). …”
Get full text

Identification of galectin-9 and its antibacterial function in Yellow River carp (Cyprinus carpio haematopterus) by Li Wang, Li Wang, Li Wang, Yuanyuan Hu, Xudong Li, Ziyan Zhang, Nan Wang, Limin Chao, Chengfei Li, Pei Gao, Jinyou Ma, Jinyou Ma, Lei Wang, Xiaojing Xia, Xiaojing Xia

“…IntroductionGalectin-9 is a β-galactoside-binding lectin that functions as a critical pattern recognition receptor (PRR) in the host immune system, initiating immune defense responses by recognizing and binding to pathogen-associated molecular patterns (PAMPs) on the surface of microorganisms. …”
Get full text

Optimization of bovine oocyte cryopreservation: membrane fusion competence and cell death of linoleic acid-in vitro matured oocytes subjected to vitrification by Glenda L. Ríos, María Florencia Suqueli García, María Florencia Suqueli García, Rodrigo J. Manrique, Jorgelina Buschiazzo

“…Zona pellucida-free oocytes co-incubated with sperm demonstrated that 43 μM LA better preserved the original sperm adhesion and fusion pattern post-vitrification, although fertilization rate was not improved. …”
Get full text

Dynamic brain-heart-gut coupling during sleep: a continuous physiological signal analysis by Guojing Wang, Guojing Wang, Guojing Wang, Hongyun Liu, Hongyun Liu, Shijing Wu, Shijing Wu, Xiaohua Yu, Xiaohua Yu, Weidong Wang, Weidong Wang

“…In terms of heart-gut coupling (HGC), the coupling strength between the very low frequency (VLF) band of heart rate variability (HRV) and all BS-derived power sequences was significantly lower than other HRV frequency bands. …”
Get full text

Aberrant Histone Methylation in Patients with Graves’ Disease by Ni Yan, Kaida Mu, Xiao-fei An, Ling Li, Qiu Qin, Rong-hua Song, Qiu-ming Yao, Xiao-qing Shao, Jin-an Zhang

“…The rate (degree) of H3K4 and H3K9 methylation and the expressions of histone-modifying genes were investigated. …”
Get full text

A bibliometric analysis of research trends in mesenchymal stem cell therapy for neonatal bronchopulmonary dysplasia: 2004–2024 by Lu Bai, Yue Xin

“…Despite the growing body of preclinical evidence, visualization of publication patterns reveals significant gaps between laboratory findings and clinical applications, with only 8.2% of publications reporting clinical outcomes. …”
Get full text

Dynamics of cerebral blood flow following sertraline treatment in adolescent depression by Wenyu Ren, Wenyu Ren, Xiao Liu, Zhiwei Zhang, Xiaoqin Zhang, Wei Wu, Xingyu Wang, Zhihui Yu, Chuan Liu, Renqiang Yu

“…Furthermore, Pearson correlation analysis was employed to examine associations between changes in regional CBF and clinical improvement, as measured by changes in the 17-item Hamilton Depression Rating Scale (HAMD-17) scores.ResultsAt baseline, adolescents with depression exhibited increased CBF in the posterior cuneus and decreased CBF in the middle temporal gyrus (MTG), right middle orbitofrontal gyrus, and the left middle frontal gyrus (MFG), compared to healthy controls. …”
Get full text

Efficacy and Safety of Tofacitinib in Patients with Polymyalgia Rheumatica (EAST PMR): An open-label randomized controlled trial. by Xinlei Ma, Fan Yang, Jinzhi Wu, Bei Xu, Mengdi Jiang, Yiduo Sun, Chuanying Sun, Ye Yu, Danyi Xu, Lanlan Xiao, Chunyun Ren, Chunyan Chen, Zi Ye, Junyu Liang, Jin Lin, Weiqian Chen

“…Secondary endpoints: PMR-AS score, c-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) at weeks 12 and 24. Thirty-nine patients with newly diagnosed PMR received tofacitinib, and 37 patients received glucocorticoid. …”
Get full text

Real-Time, Risk-Based Clinical Trial Quality Management in China: Development of a Digital Monitoring Platform by Min Jiang, Shuhua Zhao, Yun Mei, Zhiying Fu, Yannan Yuan, Jie Ai, Yuan Sheng, Ying Gong, Jingjing Chen

“…Quality findings from the early-stage, interim-stage, and conclusion-stage QC rounds of clinical trials were rated by using 3 severity grades (minor, major, or critical) and classified into 5 categories (with 4 taxonomy levels under each category). …”
Get full text

Loss of Reduction in Pediatric Distal Radius Fractures: Risk Factors From a Prospective Multicenter Registry by Apurva S. Shah, MD, MBA, Zoe E. Belardo, BA, Mark L. Miller, MD, Michael C. Willey, MD, Susan T. Mahan, MD, MPH, Divya Talwar, PhD, MPH, Donald S. Bae, MD

“…On multivariate analysis, metaphyseal bicortical fracture pattern (OR = 2.3), prereduction translation of ≥51% (OR = 2.3), and nonanatomic closed reductions (OR = 1.9) independently increased the odds of LOR. …”
Get full text

Criminal legal penalties, substance use, and overdose: a concept mapping study examining Colorado’s criminal legal penalties by Katherine LeMasters, Samantha K. Nall, Cole Jurecka, Betsy Craft, Paul J. Christine, Ryan Goodman, Jessie Henderson, Robert Haywood-James, Angela Williams, Grace Wittner, Joshua A. Barocas

“…Participants — recruited from community-based organizations — identified, rated, sorted, and categorized factors affecting criminal legal involvement, substance use, and/or overdose in their community. …”
Get full text

Analysis of influencing factors for primary membranous nephropathy complicated with atherosclerotic cardiovascular disease and establishment of a nomogram prediction model by Mirixiatijiang· Maimaiti, Zhu Guo-qiang, Su Ming-jie, Halinuer· Shadekejiang, Zhang Xue-qin, Lu Chen

“…They also had significantly higher systolic blood pressure ［130（120， 142） mmHg（1 mmHg=0.133 kPa） <italic>vs</italic> 122.0（113.5， 135.5） mmHg］， higher diastolic blood pressure ［80 （75， 90） mmHg <italic>vs</italic> 80（70， 85.5） mmHg］， higher prevalence of hypertension［142（64.8%） <italic>vs</italic> 67 （32.7%）］， and higher proportion of manual workers［60（27.4%） <italic>vs</italic> 28（13.7%）］ Additionally， lymphocyte count （LYM）， platelet count （PLT）， blood sodium concentration （Na）， blood urea nitrogen （BUN）， blood creatinine （Cr）， estimated glomerular filtration rate （eGFR）， 24-hour quantitative urine protein， glutamic transaminase， urinary occult blood， number of urinary hyaline and pathological tubular patterns， C-reactive protein （CRP）， complement C4， plasma fibrinogen， D-dimer， and centrocyte-lymphocyte ratio were all significantly different between the two groups （<italic>P</italic>&lt;0.05）. …”
Get full text

A data-driven approach to forest health assessment through multivariate analysis and machine learning techniques by Raja Waqar Ahmed Khan, Hamayun Shaheen, Muhammad Ejaz Ul Islam Dar, Tariq Habib, Muhammad Manzoor, Syed Waseem Gillani, Abeer Al-Andal, John Oluwafemi Ayoola, Muhammad Waheed

“…RF-based feature importance analysis showed tree DBH, height, regeneration rate, soil erosion, and tree density as key ecological drivers of forest health. …”
Get full text

Digital learning resource use among Swedish medical students: insights from a nationwide survey by Martin F. Bjurström, Emma Lundkvist, Louise W. Sturesson, Ola Borgquist, Robin Lundén, Malin Jonsson Fagerlund, Miklós Lipcsey, Thomas Kander

“…Several background factors influence usage patterns. These data may support institutions, program directors and teachers in their efforts to guide and improve use of digital learning tools in medical schools.…”
Get full text

Citronella oil-loaded electro-spun single and core-shell nano fibers as sustained repellent systems against Aedes aegypti by Samali Udara Liyanaarachchi, Sanjeewa K. Rodrigo, Nilwala Kottegoda, Veranja Karunaratne, Menaka Hapugoda, Tharaka Ranathunge, Lahiru Udayanga, Dushmantha Adikari

“…It was found that maintaining the outer:inner flow rate ratio at 5:2 in coaxial process is imperative to produce good fibers. …”
Get full text