Distinct Roles of HHLA2 and PD-L1 in the Immune Cell and Prognosis of Hepatocellular Carcinoma by Wang CH, Chen SL, Yang X, Wu T, Liu LL, Yun JP

“…Hematoxylin and eosin (H&E) staining was utilized to quantify TILs (percentage/area), while IHC was used to measure the densities of CD3+, CD4+, and CD8+ TILs (cells/mm²).Results: HHLA2 and PD-L1 exhibited similar positivity rates. HHLA2 positivity was associated with older age, lower alpha-fetoprotein (AFP) levels, well-differentiated tumors, and improved overall survival (OS). …”
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Long‐Term Trends in Incidence and Risk Factors for Hemorrhagic Stroke Subtypes Over 24 Years: The South London Stroke Register by Xianqi Li, Lu Liu, Ajay Bhalla, Matthew D. L. O'Connell, Charles D. A. Wolfe, Yanzhong Wang

“…We assessed the 24‐year trends in incidence, prestroke risk factors, medications, and demographic patterns in a multiracial and multiethnic population. …”
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Multicenter Study Examining Temporal Trends in Traumatic Intracranial Hemorrhage Over Six Years Using Joinpoint Regression by Timbre Backen, Kristin Salottolo, David Acuna, Carlos H. Palacio, Gina Berg, Andrea Tsoris, Robert Madayag, Kaysie Banton, David Bar-Or

“…The aging US population has altered the epidemiology of traumatic injury, but there are few studies examining changing patterns of traumatic intracranial hemorrhage (tICH). …”
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Post-marketing safety surveillance of pneumococcal vaccines: a real-world pharmacovigilance study using the U.S. vaccine adverse event reporting system (VAERS) database by Xinkuo Zheng, Meishen Liu, Aili Ding, Shihong Zhang, Ling Wu, Fanli Kong, Weijia Sun, Yuchen Peng, Yalin Xi

“…Females showed higher AE reporting rates (54.29%) compared to males (36.88%), with the majority of cases (38.20%) occurring in individuals aged < 18 years. …”
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Effect of planting geometry and chemical fertilizers on growth characteristics, essential oil yield and composition of Inula racemosa under cold desert conditions of western Himala... by Sakshi Vishvamitera, Sidharth Baghla, Varun Parmar, Romika Thakur, Sanatsujat Singh, Sachin Vashisath, Dinesh Kumar, Satbeer Singh, Ramesh Chauhan

“…A field experiment was carried out in the cold desert region of the western Himalayas comprising three planting geometries 30 × 30 cm (G1), 30 × 45 cm (G2) and 45 × 45 cm (G3) and four fertilizer doses (NPK) at the rates of 0 (F1), 90:60:30 kg ha−1 (F2), 120:75:40 kg ha−1 (F3), and 150:90:50 kg ha−1 (F4) from 2021 and 2022. …”
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Palliative Radiotherapy Near the End of Life: An Analysis of Factors Influencing the Administration of Radiotherapy in Advanced Tumor Disease by Nguyen-Son Le, Asli Zeybek, Klaus Hackner, Cornelia Gallauner, Josef Singer, Felix Schragel, Petra Georg, Sandra Gottsauner-Wolf, Martin Pecherstorfer, Gudrun Kreye

“…Furthermore, RT near the EOL was more likely administered at multiple sites (OR, 2.08 [95% CI, 1.00 to 4.29]) and with ≤5 fractions (OR, 2.37 [95% CI, 1.23 to 4.57]), while being associated with lower response rates (OR, 0.43 [95% CI, 0.21 to 0.86]) and increased therapy discontinuation (OR, 4.40 [95% CI, 1.45 to 13.37]).CONCLUSIONThese findings highlight varying RT patterns influenced by specific factors, demonstrating the complexity of EOL treatment decisions in advanced cancer care. …”
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Biomechanical stability and stress distribution before talus prosthesis design: effects of ligament removal and cartilage overlay thickness using finite element analysis by Gang Zeng, Yujun Sun, Min Liang, Wenzhou Liu, Yanbo Chen, Jionglin Wu, Jiayuan Zheng, Taolue Zhou, Huiying Zhao, Weidong Song, Yue Ding

“…Recent advancements, including patient-specific implants and improved biomaterials, show promise in enhancing long-term outcomes and reducing complication rates. Aim This study investigates the mechanical stability and stress distribution changes in a talus prosthesis after the sequential removal of surrounding ligaments and the application of varying thicknesses of cartilage overlays. …”
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Changes in influenza-associated excess mortality in China between 2012–2019 and 2020–2021: a population-based statistical modelling study by Xiaowei Deng, Jiangmei Liu, Minghan Wang, Nana Chen, Feiran Hao, Juan Yang, Maigeng Zhou, Hongjie Yu

“…Distinct pattern was observed for the AC and P&I outcomes. …”
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Development of lactation and breast/chestfeeding adverse event terminology (LaBAET) through a Delphi consensus approach by Katarzyna M. Maksym, Kinga Kalita-Kurzyńska, Diane Spatz, Melinda Boss, Maria Carmen Collado, Anna Gonciarz-Dytman, Bei Han, Asma Khalil, Joanna Kozakiewicz, Ernest Kuchar, Karolina Morze, Rebecca Powell, Natalie Shenker, Sławomir Wątroba, Anna L. David, Aleksandra Wesołowska

“…Oversupply of milk and other changes in lactation/feeding patterns were mapped to existing MedDRA terms. Grading for all five definitions was developed and agreed upon through consensus. …”
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Neural signatures underlying the effect of social structure on empathy and altruistic behaviors by Xia Tian, Zixin Zheng, Renhui Li, Yue-Jia Luo, Chunliang Feng

“…Afterwards, participants rated the pain experienced by these innocents and shared money with other innocents. …”
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Child-therapist acoustic synchrony and response trajectories in autism intervention: an AI-based automated analysis using dynamic systems theory and affective computing by Giulio Bertamini, Silvia Perzolli, Arianna Bentenuto, Cesare Furlanello, Mohamed Chetouani, David Cohen, Paola Venuti

“…However, quantitatively studying fine-grained aspects such as the child-clinician synchrony patterns poses challenges, limiting translational research. …”
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Research on the Protection Status and Development Strategies for New Varieties of Lychee and Longan in China by Yingjie WEN, Zhixian TANG, Fachao SHI, Hailun LIU, Yonghua JIANG, Qian YAN

“…Of these, 21 litchi and 5 longan varieties were granted protection, yielding authorization rates of 33.3% and 19.2%. The average duration for examination and authorization was 30.5 months. …”
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Precision public health alliances as a model and method for community engagement by Margaret L. McGladrey, Mary Elizabeth Lacy, Kristen McQuerry, Rachel Hogg-Graham, Svetla Slavova, Emily R. Clear, Kory Heier, Caitline Phan, Megan Hall, Ryan Parker, Mindy Keeton, Jennifer Sword, Thomas Ard, Charbel Salem

“…Using precision analytics approaches with population health data helps identify localized patterns of social determinants and comorbidities, supporting the design of tailored interventions. …”
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A platform for multisite immune profiling of premetastatic pancreatic cancer at single-cell resolution by Elishama N. Kanu, Ashley A. Fletcher, Jiayin Bao, Ethan S. Agritelley, Julia Button, Austin M. Eckhoff, Karrie Comatas, Tao Wang, Bin-Jin Hwang, Michael E. Lidsky, Sabino Zani, Dan G. Blazer, Peter J. Allen, Zhicheng Ji, Frank J. Lowery, Sri Krishna, Nicholas D. Klemen, Daniel P. Nussbaum, Erika J. Crosby

“…Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is characterized by exceedingly high rates of metastatic progression, with the liver representing the most common site of distant spread. …”
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Quality of life and clinical data in hemodialysis patients with different degrees of pruritus by Sebastián Mas Fontao, Paula Manso, Julia Audije-Gil, David Hernán Gascueña, Fabiola Dapena, Nuria Aresté, Emilio Sánchez-Álvarez, Pablo Molina, Raquel Ojeda, Marian Goicoechea, Vicent Esteve Simó, Guillermo Alcalde Bezhold, Mario Prieto-Velasco, María Jesús Lloret, Ana Blanco Santos, Juan Manuel Buades, Carlos Narváez, Rafael Sánchez-Villanueva, Rosa Elena Pérez-Morales, María Dolores Arenas Jiménez, Fundación Renal Española Working Group, Prurito Working Group

“…Each reporting period (morning, midday, evening, and night) revealed distinct patterns in pruritus prevalence and severity (p < 0.05). …”
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Prevalence and sequence of chronic conditions in older people with dementia: a multi-province, population-based cohort study by Susan E. Bronskill, Azmina Artani, Laura C. Maclagan, Xuesong Wang, Hannah Chung, J. Michael Paterson, Andrea Gruneir, Karen A. Phillips, Rasaq Ojasanya, Xibiao Ye, Kayla McLean, Fernanda Ewerling, Claire Godard-Sebillotte, Victoria Massamba, Louis Rochette, Isabelle Vedel, Larry Shaver, Catherine Pelletier, Colleen J. Maxwell

“…While there is evidence demonstrating a strong association between coping and PMH, less is known about how coping patterns differ across age groups. Given that age can impact coping ability, addressing this knowledge gap is warranted. …”
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Clinical, epidemiological, and virological features of Mpox in Beijing, China – May 31–June 21, 2023 by Xiangfeng Dou, Fu Li, Zhenyong Ren, Daitao Zhang, Jia Li, Dan Li, Yulan Sun, Haoyuan Jin, Renqing Li, Weihong Li, Xin Zhang, Yang Yang, Lei Jia, Yu Han, Wai Li, Yang Pan, Wenjie Tan, Peng Yang, Quanyi Wang

“…There were high oropharyngeal swab (75.8%) and blood (84.6%) positivity rates. All MPXV strains belonged to the B.1.3 branch of the West African lineage. …”
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A low-cost mitigation system for ammonia removal from broiler house exhaust air by Jingjing Luo, Jinsheng Rong, Shizhen Zhou, Haoliang Wang, Miao Li, Xiliang Yan, Yingbao Wu, Yan Wang

“…In this study, we utilized computational fluid dynamics (CFD) simulations to model a broiler house and analyzed airflow patterns at varying screen distances to assess their effect on indoor ventilation. …”
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Infrared Compositional Measurements in Comet C/2017 K2 (Pan-STARRS) at Heliocentric Distances Beyond 2.3 au by Chemeda Ejeta, Erika Gibb, Michael A. DiSanti, Hideyo Kawakita, Boncho P. Bonev, Neil Dello Russo, Nathan X. Roth, Younas Khan, Adam J. McKay, Michael R. Combi, Lori Feaga, Mohammad Saki, Ronald J. Vervack Jr, Yinsi Shou

“…Comet C/2017 K2 (Pan-STARRS) provided a rare opportunity to investigate the evolution of coma composition and outgassing patterns over a transitional heliocentric distance ( R _h ) range where activity drivers in comets are thought to change from “hypervolatile” (CO, CH _4 , C _2 H _6 , and/or CO _2 )-dominated to H _2 O-dominated. …”
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Dynamic immune response to Avian Pathogenic Escherichia coli infection in broiler chickens: Insights into pro-inflammatory and anti-inflammatory cytokine regulation by Xin Ye, Chuan-Yu Hsu, Linan Jia, Xue Zhang, Christopher Magee, Stephanie Whitham, Spencer Leigh, Jeffrey D. Evans, Li Zhang, Kelsy Robinson

“…This study investigates the dynamic immune responses to APEC infection in broiler chickens, with a focus on survival rates, airsac lesion scores, and cytokine gene expression patterns in lung tissue. …”
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