Trends in prescription opioid use in Europe: A DARWIN EU® multinational cohort study including seven European countries by Junqing Xie, Mike Du, Yuchen Guo, Cesar Barboza, James T. Brash, Antonella Delmestri, Talita Duarte-Salles, Talita Duarte-Salles, Jasmine Gratton, Romain Griffier, Raivo Kolde, Wai Yi Man, Núria Mercadé-Besora, Marek Oja, Sarah Seager, Katia Verhamme, Dina Vojinovic, Edward Burn, Daniel Prieto-Alhambra, Daniel Prieto-Alhambra, Martí Català, Annika M. Jödicke

“…Annual period prevalence and incidence rates of opioid prescriptions were estimated, and long-term trends were quantified as the percent change from 2012 to 2019. …”
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Molecular Evolutionary Analyses of the RNA-Dependent RNA Polymerase (<i>RdRp</i>) Region and <i>VP1</i> Gene in Sapovirus GI.1 and GI.2 by Fuminori Mizukoshi, Ryusuke Kimura, Tatsuya Shirai, Asumi Hirata-Saito, Eri Hiraishi, Kosuke Murakami, Yen Hai Doan, Hiroyuki Tsukagoshi, Nobuhiro Saruki, Takeshi Tsugawa, Kana Kidera, Yoshiyuki Suzuki, Naomi Sakon, Kazuhiko Katayama, Tsutomu Kageyama, Akihide Ryo, Hirokazu Kimura

“…Further, the MRCAs of the <i>RdRp</i> region and <i>VP1</i> gene in HuSaV GI.2 diverged in 1960 and 1943, respectively. The evolutionary rates were higher for <i>VP1</i> gene in HuSaV GI.1 than that in HuSaV GI.2, furthermore, were higher in GI.1 Cluster B than GI.1 Cluster A. …”
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Barriers and facilitators to implementing a task-sharing mental health intervention for Sickle Cell Disease populations in low- and middle-income countries: a qualitative analysis... by John Patena, Leah Elster, Tania Hameed, Sumedha Kulkarni, Alden Yuanhong Lai, Annika C. Sweetland, Joyce Gyamfi, Temitope Ojo, Angela Odoms-Young, Charmaine Royal, Emmanuel Peprah

“…BackgroundPeople living with Sickle Cell Disease (SCD) experience higher rates of common mental disorders (CMD). There is an alarming treatment gap in the provision of adequate mental health services for CMDs in low- and middle-income countries (LMIC). …”
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Spatio-Temporal Characteristics and Driving Forces of Landscape Ecological Risks in Highly Urbanized Areas: A Case Study of Suzhou City by Lingyue LU, Dawei SHAO, Dianming WU

“…However, relatively little attention has been given to urbanized areas characterized by high rates of population growth and land development. …”
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A longitudinal qualitative study of clinical nurses caring for hospitalized adults during the first fifteen months of COVID-19: lessons in professional survival and leadership by Elizabeth M. Norman, Mildred Ortu Kowalski, Roxanne Sabatini, Carol S. Jones, Wendy Silverstein

“…At the time of this April surge, nurses were exposed to a virus with no standard treatments and high mortality rates. Using a longitudinal qualitative design, the team hoped to answer questions about what compelled these nurses to continue to come to work? …”
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Long-term outcomes of dupilumab therapy in severe asthma: A retrospective, multicenter, real-world study by Carlo Mümmler, MD, Alexandra Lenoir, MD, Jeremias Götschke, MD, Michael Gerckens, MD, Merle Kaiser, MD, Moritz Kayser, MD, Nora Drick, MD, Hendrik Suhling, MD, Leonie Biener, MD, Carmen Pizarro, MD, Dirk Skowasch, MD, Nikolaus Kneidinger, MD, PhD, Jürgen Behr, MD, Katrin Milger, MD

“…Real-world data on the continuation and cessation patterns of dupilumab and long-term treatment efficacy are scarce. …”
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Oncolytic Vaccinia Virus Armed with GM-CSF and IL-7 Enhances Antitumor Immunity in Pancreatic Cancer by Wenyi Yan, Yujing Xuan, Ruimin Wang, Ziyan Huan, Yu Guo, Huilin Dun, Lihua Xu, Ruxia Han, Xianlei Sun, Lingling Si, Nicholas Robert Lemoine, Yaohe Wang, Pengju Wang

“…The synergistic effects of VVL-GL7 and the PD-1 blockade further improved therapeutic outcomes, resulting in significantly higher tumor remission rates compared to monotherapy and achieving complete tumor regression in pancreatic cancer models. …”
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Risk of developing drug abuse in administration of a new hexaazaisowurtzitane derivative-based analgesic (experimental study) by S. G. Krylova, T. N. Pove’teva, K. A. Lopatina, Yu. V. Nesterova, E. P. Zueva, O. G. Afanas’eva, P. V. Kulpin, E. A. Kiseleva, N. I. Suslov, D. A. Kulagina, S. V. Sysolyatin, V. V. Zhdanov

“…Previous in vivo and in silico studies (docking, molecular modeling, molecular dynamics simulation) on the multi-target mechanism of thiowurtzine explain the absence of its morphine-like effect by the fact that the major targets of the analgesic are TRPA1 receptors and voltage-gated Ca 2+ channels. With a high degree of probability, the conclusions made herein predict no drug abuse development when thiowurtzine is used in the clinical setting. …”
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Toward improving retention in HIV care after pregnancy: lessons from a post-pandemic cohort in the United States by Alexandra H. Latham, Alexandra H. Latham, Alexandra H. Latham, Andrea Lugo Morales, Andrea Lugo Morales, Andrea Lugo Morales, Elizabeth Barba Gutierrez, Elizabeth Barba Gutierrez, Elizabeth Barba Gutierrez, Michael Jochum, Michael Jochum, Sarah Conrad, Sarah Conrad, Eva H. Clark, Kassandra Goytia, Megan Alam, Jessica Gerard, Jessica Gerard, Jennifer McKinney, Jennifer McKinney, Jennifer McKinney

“…IntroductionPeople living with HIV (PLWH) often experience low rates of retention in HIV care (RIC) and suboptimal viral suppression postpartum. …”
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Seasonal population dynamics and dietary switching of Vulpes spp. amplify Echinococcus spp. transmission in the Eastern Tibetan plateau: implications for wildlife-mediated zoonotic... by Xu Wang, Chuizhao Xue, Xueying Deng, Qilu Chen, Chunyang Li, Baixue Liu, Ying Wang, Yan Kui, Qingqiu Zuo, Jianhai Yin, Shuai Han, Yujuan Shen, Jianping Cao

“…This dietary diversification correlated with seasonal resource scarcity, driving foxes to exploit alternative prey. The infection rates of Echinococcus in V. ferrilata displayed the U-shaped seasonal patterns. …”
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Ten-year trends in opioid prescribing and vaso-occlusive crises in sickle cell disease: a population-based national cohort study (2011–2022)Research in context by Kevin Y. Xu, Terri V. Newman, Lakeya S. McGill, Enrico M. Novelli, Cheryl A. Hillery, Joanna L. Buss, Lisa Gong, Ruizhi Huang, Fanghong Dong, Dustin Stwalley, Joanne Salas, Shiyuan A. Liu, Jeffrey F. Scherrer, Tashalee R. Brown, Tae Woo Park, Marc R. LaRochelle, Richard A. Grucza, Charles R. Jonassaint

“…Primary outcomes were monthly rates of outpatient opioid prescriptions and VOC-related acute care encounters. …”
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Decentralized Immunization Monitoring: Lessons Learnt from a Pilot Implementation in Kumbotso LGA, Kano State, Nigeria by Adam Attahiru, Yahaya Mohammed, Fiyidi Mikailu, Hyelshilni Waziri, Ndadilnasiya Endie Waziri, Mustapha Tukur, Bashir Sunusi, Mohammed Nasir Mahmoud, Nancy Vollmer, William Vargas, Yusuf Yusufari, Gustavo Corrêa, Heidi W. Reynolds, Teemar Fisseha, Talatu Buba Bello, Moreen Kamateeka, Adefisoye Oluwaseun Adewole, Musa Bello, Imam Wada Bello, Sulaiman Etamesor, Joseph J. Valadez, Patrick Nguku

“…Univariate and bivariate analyses were performed to show patterns and relations across variables. Results: Out of 418 caregivers surveyed, 98.1% were female. …”
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Geographical variation of overweight, obesity and related risk factors: Findings from the European Health Examination Survey in Luxembourg, 2013-2015. by Hanen Samouda, Maria Ruiz-Castell, Valery Bocquet, Andrea Kuemmerle, Anna Chioti, Frédéric Dadoun, Ngianga-Bakwin Kandala, Saverio Stranges

“…Large disparities in the prevalence of overweight and obesity were found between municipalities, with the highest rates of obesity found in 3 municipalities located in the South-West of the country. …”
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Fertility intentions among Chinese adults: a cross-sectional study using a national survey by Mingyan Hao, Chenxiao Zhang, Haofeng Fu, Jingting Zhang, Ziyi Zhang, Baotong Ma, Ruitong Xia, Yuanwei Lu, Jingwen Liu, Hanjia Xin, Yumeng Cao, Saier Yang, Runqing Li, Ji Zhao, Jin Zhang, Zheng Gao, Yaxin Zeng, Yixiao Ding, Zhuolun Ren, Yan Guan, Na Zhang, Jia Li, Yan Ma, Pei Wei, Jingjing Dong, Chen Chen, Yajing Zhou, Jianzhong Zheng, Wei Liu, Lizheng Wang

“…To tackle the challenge of decreasing fertility rates effectively, it is essential that interventions focus on younger women and highlight the advantages of living with multiple generations. …”
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Preparation of land subsidence susceptibility map using machine learning methods based on decision tree (case study: Isfahan–Borkhar) by Negar Ghasemi, Iman Khosravi, Ali Bahrami

“…Studies estimate that approximately 3.5% of Iran's land area has been affected by subsidence, with some regions showing annual sinking rates of over 10 centimeters. Such rates are alarmingly high and have direct implications for urban development, agriculture, and even national heritage conservation. …”
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The Ethical Significance of Brain-Computer Interfaces as Enablers of Communication by Toma Gruica

“…Such moments fundamentally reconfigure the ethical relationship, shifting the patient from an object of interpretation to a subject capable of self-representation and autonomous expression.[8] These cases share the same ethical pattern: the BCI’s biggest impact is not the specific messages it transmits but its role as the enabler of transmission itself. …”
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Levels and types of physical activity in Russia according to the ESSE-RF study: is there a trace of the COVID-19 pandemic? by M. B. Kotova, S. A. Maksimov, S. A. Shalnova, A. V. Kontsevaya, Yu. A. Balanova, A. E. Imaeva, V. A. Kutsenko, G. A. Muromtseva, N. S. Karamnova, S. E. Evstifeeva, A. V. Kapustina, O. A. Litinskaya, M. S. Pokrovskaya, E. B. Yarovaya, T. V. Repkina, T. O. Gonoshilova, A. V. Kudryavtsev, N. I. Belova, L. L. Shagrov, M. A. Samotrueva, A. L. Yasenyavskaya, E. N. Chernysheva, S. V. Glukhovskaya, I. A. Levina, E. A. Shirshova, E. B. Dorzhieva, E. Z. Urbanova, N. Yu. Borovkova, V. K. Kurashin, A. D. Tokareva, Yu. I. Ragino, G. I. Simonova, A. D. Khudyakova, V. N. Nikulin, O. R. Aslyamov, G. V. Khokhlova, A. V. Solovyova, A. A. Rodionov, O. V. Kryachkova, Yu. Yu. Shamurova, I. V. Tantsyreva, I. N. Baryshnikova, M. G. Ataev, M. O. Radjabov, M. M. Isakhanova, M. A. Umetov, L. V. Elgarova, I. A. Khakuasheva, E. I. Yamashkina, M. V. Esina, T. A. Kunyaeva, A. M. Nikitina, N. V. Savvina, Yu. E. Spiridonova, E. A. Naumova, A. A. Keskinov, V. S. Yudin, S. M. Yudin, O. M. Drapkina

“…Compared to the urban population, rural residents have higher physical activity rates (23,9 vs 20,3%, p&lt;0,001). The proportion of people with high physical activity is also higher among people with higher income levels (p&lt;0,001). …”
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Numerical Simulation Study on the Dynamic Processes and Evolution Laws of Multiple Granular Flows in a Gully by LEI Ming, ZHANG Liang, YE Chen, WANG Xiekang

“…Compared with the first granular flow, subsequent ones feature shorter durations and higher energy dissipation rates. The velocity and displacement of base granules increase significantly as the friction coefficient decreases and the secondary slope increases. …”
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Investigation of methicillin, beta lactam, carbapenem, and multidrug resistant bacteria from blood cultures of septicemia suspected patients in Northwest Ethiopia by Abebe Birhanu, Getachew Gebre, Eden Getaneh, Hana Yohannes, Netsanet Baye, Gizeaddis Belay Mersha, Mitkie Tigabie, Mulat Dagnew, Getachew Ferede, Teshiwal Deress, Wondwossen Abebe

“…Gram-positive bacteria, particularly S. aureus, and gram-negative bacteria like K. pneumoniae and E. coli were predominant. High rates of methicillin, beta-lactam, and carbapenem resistance were observed, emphasizing the magnitude of antimicrobial resistance. …”
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Dependence of Indicators of Daily Blood Pressure Monitoring on Activity of Pathological Process in Patients with Systemic Lupus Erythematosus by Abrahamovych O., Abrahamovych U., Kushyna A., Guta S., Synenkyi O.

“…According to the first goal was rated the BP in the SLE patients during the period of 24 hours, for which: a) were examined the average daily, maximum and minimum levels of systolic blood pressure (SBP), diastolic blood pressure (DBP), the average blood pressure; b) was analysed the daily index (DI) of SBP, DBP and the average blood pressure; c) was examined the time index (TI) of SBP, DBP and the average blood pressure. …”
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