Optimization of large-diameter deep-hole stope blasting technology based on numerical simulation: a case study of the Dongguashan copper mine by Jiang Guo, Shaowei Sun, Niming Jiang, Jiachuang Wang, Mingjian Huang, Xiaobing Yan, Wenjun Yang, Qinli Zhang

“…Abstract In large-diameter deep-hole blasting operations for mining stopes, optimizing blasting techniques can enhance ore recovery rates while minimizing damage to the surrounding rock mass. …”
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PROMETHEUS: Long-Term Exacerbation and Mortality Benefits of Implementing Single-Inhaler Triple Therapy in the US COPD Population by Gerard Criner, Fernando Martinez, Norbert Feigler, Hitesh Gandhi, Bruce Pyenson, Matthew Emery, Umang Gupta, Muthiah Vaduganathan

“…Agent annual characteristics reflected incident cases, changes in COPD severity, treatment, mortality, and exacerbations under status quo treatment patterns and scenarios for the adoption of SITT. The scenarios assumed the reduced exacerbation and mortality rates associated with SITT according to ETHOS trial outcomes mean values…”
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Effects of long-term maize/peanut intercropping and phosphorus application on soil surface electrochemical properties and crop yield by Rentian Ma, Ning Yu, Shiwei Zhao, Shiwei Zhao, Taiji Kou, Nianyuan Jiao

“…This study took the soil under the maize-peanut intercropping system which has been planted for 12 years as the research object, the physical, chemical, and electrochemical properties of soil, and crop yield under different planting patterns [sole-crop maize (SM), sole-crop peanut (SP), and maize-peanut intercropping (M/P)] and phosphorus application rates [P application (180 kg P2O5 ha−1) and no P application (0 kg P2O5 ha−1)] were studied. …”
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Analysis of Tumor and Tumor-Like Entities Tested on the Orthopaedic In-Training Examination From 2012 to 2023 by Sean Kelly, MD, Braden Goldberg, MD, Eli Bryk, MD, FAAOS, FAOA, FACS, Vincent Vigorita, MD

“…Emphasizing highyield topics and adapting to evolving question patterns can optimize educational outcomes and improve board pass rates.…”
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Epigenetic Regulation of Neutrophils in ARDS by Jordan E. Williams, Zannatul Mauya, Virginia Walkup, Shaquria Adderley, Colin Evans, Kiesha Wilson

“…Acute respiratory distress syndrome (ARDS) is an inflammatory pulmonary condition that remains at alarming rates of fatality, with neutrophils playing a vital role in its pathogenesis. …”
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Impact of the agri-geographical transformation of rural settlements on the geospatial dynamics of soil erosion intensity in municipalities of Central Serbia by Srejić Tanja, Manojlović Sanja, Sibinović Mikica, Lukić Tin, Kričković Emina, Durlević Uroš

“…Cluster analysis (CA) was used to differentiate rural areas of municipalities based on selected indicators. The highest rates of soil erosion intensity reduction were found in the regressive and dominantly regressive types (average specific gross erosion 1971: Ws1 = 980 m3/km2/year; 2011: Ws2 = 587 m3/km2/year). …”
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In silico and in vitro assessment of TP53, ATM, RAD51, and BAX genes in gastric cancer and their contribution to radiotherapy resistance by Junwei Zhang, Pengtao He

“…Mutational analysis showed that TP53 was altered in 88% of gastric cancer samples, while ATM, RAD51, and BAX exhibited lower mutation rates. Survival analysis suggested that elevated expression of TP53, RAD51, and BAX may be linked to poorer survival outcomes, while reduced ATM expression appeared to associate with decreased overall survival. …”
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Decoding stimulus-specific regulation of promoter activity of p53 target genes by Flavia Vigliotti, Nicolai Engelmann, Mark Sinzger-D’Angelo, Heinz Koeppl, Heinz Koeppl, Alexander Loewer, Alexander Loewer

“…Indeed, stimulus-specific stochastic gene expression is predominantly regulated by promoter activation and deactivation rates. Interestingly, we found that in many situations, transcriptional activity was uncoupled from the total amount of p53 and the fraction bound to DNA, highlighting that transcriptional regulation by p53 is a multi-dimensional process. …”
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Research on the microstructure influence mechanism of hydraulic asphalt concrete based on fuzzy sets by Fang Jianyin, Bian Junhua, Constantinos Soutis, Dang Faning, Qin Yuan, Ren Jie, Gao Jun

“…The findings demonstrate that the mesoscale numerical model effectively replicates the microstructural characteristics of hydraulic asphalt concrete, exhibiting interface thickness measurements up to 0.33 mm that show strong concordance with empirical data. Maximum interface rates occur near the convergence point of aggregate-to-binder ratio curves under both λ₁→0 and λ₂→1 boundary conditions. …”
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Is mechanism of injury associated with outcome in spinal trauma? An observational cohort study from Tanzania. by Chibuikem Anthony Ikwuegbuenyi, Julie Woodfield, François Waterkeyn, Scott L Zuckerman, Beverly Cheserem, Andreas Leidinger, Albert Lazaro, Hamisi K Shabani, Roger Härtl, Halinder S Mangat

“…Improved neurological outcomes were associated with incomplete injuries (AIS B-D), while higher mortality rates were linked to cervical injuries and complete (AIS A) injuries.…”
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Direct and Indirect Protection with Pediatric Quadrivalent Live-Attenuated Influenza Vaccination in Europe Estimated by a Dynamic Transmission Model by Laetitia Gerlier, Judith Hackett, Richard Lawson, Sofia Dos Santos Mendes, Catherine Weil-Olivier, Markus Schwehm, Martin Eichner

“… # Conclusions The model highlights direct and indirect protection benefits when vaccinating healthy children with QLAIV in Europe, across a range of demographic structures, contact patterns and vaccination coverage rates.…”
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Century-Long Cycles of Evolution of the Country’s Active Population by A. I. Latysheva

“…The collected factual material allows us to draw a conclusion about the general patterns of creative activity of the population both at the beginning of the last century and in our years. …”
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A Retrospective Analysis of CLL Patients in a Romanian Hematology Center by Ana-Maria IORDAN, Minodora Cezarina ONISAI, Anca RAITARU, Claudia DESPAN, Ionel GELATU, Silvia CIORTAN, Daniela GEORGESCU

“…Time to first treatment (TTFT), treatment patterns, and response rates were evaluated. Statistical tests included MannWhitney U and Fisher’s exact test, with p < 0.05 considered significant. …”
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Impact of COVID-19 on mucormycosis presentation and laboratory values: A comparative analysis. by Sepideh Hejazi, Ali Gholampour Kargar, Sahar Ravanshad, Arash Ziaee, Maryam Emadzadeh, Mona Kabiri, Reza Khoshbakht, Mohammad Hossein Ahmadi, Masoumeh Hosseinpoor, Hamed Khosravi, Imtiaz Ahmed, Mehdi Bakhshaee

“…The study compared patient laboratory studies and presentation symptoms between COVID-19 history-positive and COVID-19 history-negative groups, with a particular focus on mortality rates and associated comorbidities such as diabetes, cancer and immunosuppressive treatment.…”
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Integrative Approaches to Prostate Disease Management: Nutrition, Exercise, and Lifestyle Modifications by Patrick Maduabuchi Aja, Peter Chinedu Agu, Angela Mumbua Musyoka, Wisdom Ngwueche, Joseph Uche Odo, Esther Ugo Alum, Ilemobayo Victor Fasogbon, Mbyemeire Herbert, Ejike Daniel Eze

“…Physical activity emerged as a key component, enhancing hormonal balance, reducing inflammation, and improving survival rates in prostate cancer patients. Aerobic and resistance exercises were particularly effective in mitigating treatment side effects such as fatigue and muscle loss. …”
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Immunosenescence-Related Gene MAFF is Involved in Immune Regulation and Malignant Progression in Pancreatic Adenocarcinoma by Fenglin Zhang, Kexin Liu, Mengfan Ao, Jiangang Zhao, Xinghe Liao, Ping Li, Hao Chen

“…The elevated-risk cohort, as identified by the risk assessment metric, correlates with poorer survival rates. Additionally, we uncover an association between the risk indicator and the tumor milieu, encompassing immune cell infiltration patterns and drug sensitivity profiles. …”
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Burden and inequality of autism spectrum disorders in global, East asian, and Southeast Asian regions, 1990–2021: result from the global burden of disease study 2021 by Wen Liu, Xinhao Gong, Jinping Ou, Shoulin Chen

“…Abstract Introduction Autism Spectrum Disorders (ASD) represent a range of neurodevelopmental conditions characterized by abnormal behavioral patterns. ASD is frequently comorbid with other neurodevelopmental disorders. …”
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Appropriateness of the Empirical Antibiotics Prescribed and Their Concordance with National Guidelines for Three Selected Infections among Cancer Patients in a Tertiary Care Centre... by Gayashan Chathuranga, Thushari Dissanayake, Neluka Fernando, Chandanie Wanigatunge

“…Conclusion. High resistance rates were observed against the prescribed empirical antibiotics. …”
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Intramedullary nailing with and without cerclage in subtrochanteric fractures: an updated systematic review and meta-analysis by Ahmed Oun, Omar Abdelaziz, Islam Saeed Elhois, Mohamed Al-Badaineh, Karim Zinhom, George Jabrieh, Hamza S. Al-Himyari, Abdullah A. Nada

“…No significant differences were observed in non-union, infection, or mortality rates. Quality assessment using the Newcastle–Ottawa Scale indicated high quality studies. …”
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INFLUENCE OF THE EVAPORITE FORMATION STRUCTURE ON SALT TECTONICS AND HYDROCARBON TRAPS (BY THE RESULTS OF NUMERICAL SIMULATION OF HALOKINESIS IN THE PRE-CASPIAN) by B. V. Lunev, V. V. Lapkovsky, M. P. Antipov, Y. A. Volozh, I. S. Postnikova

“…Since halokinesis is the main factor controlling the migration and accumulation of hydrocarbons in the Preaspian region, background and aim of prospecting and exploration require identifying the specifics of the formation of various types of salt structures and the relationship between their location patterns and halokinesis process.Numerical simulation shows that, depending on the instable layer thickness and its relationship with the total thickness of the overlying layers, the instability development occurs at different rates, forming different types of structures. …”
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