Disrupted synaptic gene expression in Fabry disease: Findings from RNA sequencing by Laura López-Valverde, María E. Vázquez-Mosquera, Cristóbal Colón-Mejeras, J. Víctor Álvarez, Beatriz Martín López-Pardo, Lluis Lis López, Rosario Sánchez-Martínez, Manuel López-Mendoza, Mónica López-Rodríguez, Eduardo Villacorta-Argüelles, María A. Goicoechea-Diezhandino, Francisco J. Guerrero-Márquez, Saida Ortolano, Elisa Leao-Teles, Álvaro Hermida-Ameijeiras, María L. Couce

“…The objective was to identify gene expression patterns and investigate secondary cellular pathways affected by lysosomal dysfunction. …”
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Determinants of SARS-CoV-2 outcomes in patients with cancer vs controls without cancer: a multivariable meta-analysis with genomic imputationResearch in context by Mark T.K. Cheng, James S. Morris, Syed F.H. Shah, Abraham Tolley, José Chen-Xu, Nihal Sogandji, Long H. Fong, Anushka Irodi, Justine T.N. Chan, Kimia Kamelian, Benjamin L. Sievers, Shazia Sarela, Margaret K. Ho, Abigail Burn, Anita Patel, Ghislaine D. Mbolo, Muhammad Hasan, Abdulbasit O. Fehintola, Chan C. Yin, Enti Spata, Ravindra K. Gupta, David M. Favara

“…Using the Agency for Healthcare Research and Quality (AHRQ) risk of bias standards, 21 studies were rated good, one study rated was fair, and eight studies were rated poor. …”
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Posterior hippocampal sparing in Lewy body disorders with Alzheimer’s copathology: An in vivo MRI study by Jesse S. Cohen, Jeffrey Phillips, Sandhitsu R. Das, Christopher A. Olm, Hamsanandini Radhakrishnan, Emma Rhodes, Katheryn A.Q. Cousins, Sharon X. Xie, Ilya M. Nasrallah, Paul A. Yushkevich, David A. Wolk, Edward B. Lee, Daniel Weintraub, David J. Irwin, Corey T. McMillan

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Dependence of Indicators of Daily Blood Pressure Monitoring on Activity of Pathological Process in Patients with Systemic Lupus Erythematosus by Abrahamovych O., Abrahamovych U., Kushyna A., Guta S., Synenkyi O.

“…According to the first goal was rated the BP in the SLE patients during the period of 24 hours, for which: a) were examined the average daily, maximum and minimum levels of systolic blood pressure (SBP), diastolic blood pressure (DBP), the average blood pressure; b) was analysed the daily index (DI) of SBP, DBP and the average blood pressure; c) was examined the time index (TI) of SBP, DBP and the average blood pressure. …”
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Study on macroscopic anatomy and developmental model of pterygopalatine suture by ZHANG Wenyi, CHUNG Miri, XIE Yufan, JIANG Lingyong

“…Objective·To analyze the anatomical and macroscopic characteristics of the pterygopalatine suture (PPS) in Chinese population using cone-beam computed tomography (CBCT) technology, and to preliminarily investigate its developmental pattern and its association with the correction of maxillary underdevelopment. …”
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Sewage sludge from Taxco de Alarcón wastewater treatment plant as substrate to cultivate Panicum maximum by Erik Yoel Carreto-Morales, Jazmin Alaide López-Díaz, Mariana Martínez-Castrejón, Oscar Talavera-Mendoza, Roberto Carlos Almazán-Núñez, Giovanni Hernández-Flores

“…The response variables analyzed for MG were germination time (one month after plant emergence), height (HMG), growth rate GrMG, and yield (YMG), whereas in the SS and PS the content of organic matter was analyzed. …”
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Análise de interações solo-planta-clima em zonas diferenciadas de área de cultivo de milho Site-specific analysis of soil-plant-climate interactions on maize by Antonio O. Santos, Hélio do Prado

“…This caused the simulated rate of nitrogen for the maximum economic return, to be moderately different. …”
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The clinical utility and cost impact of cystatin C measurement in the diagnosis and management of chronic kidney disease: A primary care cohort study. by Adam Shardlow, Natasha J McIntyre, Simon D S Fraser, Paul Roderick, James Raftery, Richard J Fluck, Christopher W McIntyre, Maarten W Taal

“…<h4>Background</h4>To reduce over-diagnosis of chronic kidney disease (CKD) resulting from the inaccuracy of creatinine-based estimates of glomerular filtration rate (GFR), UK and international guidelines recommend that cystatin-C-based estimates of GFR be used to confirm or exclude the diagnosis in people with GFR 45-59 ml/min/1.73 m2 and no albuminuria (CKD G3aA1). …”
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Markers of vascular damage depending on the blood pressure level: data of the population study ESSE-RF by A. M. Erina, M. A. Boyarinova, E. V. Moguchaya, E. P. Kolesova, A. S. Aliyeva, O. P. Rotar, E. I. Baranova, S. A. Shalnova, A. D. Deev, Z. T. Astakhova, L. Z. Bolieva, G. V. Tolparov, V. S. Kaveshnikov, V. N. Serebryakova, I. A. Trubacheva, R. S. Karpov, A. Yu. Efanov, M. A. Storozhok, I. V. Medvedeva, S. V. Shalaev, A. N. Rogoza, A. O. Konradi, S. A. Boytsov, E. V. Shlyakhto

“…Glomerular filtration rate (GFR) was calculated using the CKD-EPI equation. …”
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The Anisotropic Time-Dependent Properties and Constitutive Model Analysis of Carbonaceous Slate with Different Foliation Angles by Yuanguang Zhu, Xuanyao Wang, Bin Liu, Haoyuan Xue

“…The results show that the instantaneous axial strain, <i>ε_i</i>, the axial creep strain, <i>ε_c</i>, the duration time of decelerating creep stage, <i>t_d</i>, and the steady creep strain rate, <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mrow><mover accent="true"><mrow><mi>ε</mi></mrow><mo>˙</mo></mover></mrow><mrow><mi>s</mi></mrow></msub></mrow></semantics></math></inline-formula>, increased with the rise in the loading ratio, <i>k</i>. …”
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Spatial heterogeneity of influential factors of urban housing prices based on multiscale geographically weighted regression models: A case study of the main urban area of Guilin ci... by 李杰杰(LI Jiejie), 孙昌盛(SUN Changsheng), 张春英(ZHANG Chunying), 胡欣琪(HU Xinqi)

“…The results indicate that: (1) Significant spatial autocorrelation is observed in housing prices in Guilin City, and the local spatial autocorrelation reveals a distinct clustering pattern characterized by predominant "high-high" and "low-low" clusters, with smaller occurrences of "high-low" and "low-high" clusters. (2) Compared to ordinary least squares (OLS) model and geographically weighted regression (GWR) model, MGWR model demonstrates higher coefficients of determination, enabling more accurate measurement of the scale and spatial variability of variable effects on housing prices. (3) The age of housing, education/medical and business facilities serve as global variables; greening rate, public transportation infrastructure, railway facilities, living amenities, and tourist attractions exhibit moderate levels of spatial heterogeneity; external transportation facilities display greater spatial heterogeneity, exerting significant and distinctly varied effects on housing prices within local areas. (4) The age of housing, living amenities, and tourist attractions negatively influence housing prices negatively; education/medical, and business facilities positively influence housing prices; while other variables exhibit varying inhibitory or appreciative effects on housing prices across different spatial locations.…”
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Paucity of viral infection symptoms in patients with immune-mediated inflammatory diseases by Carola Berking, Georg Schett, Andreas Ramming, Raja Atreya, Markus F Neurath, Bernhard Manger, Filippo Fagni, Arnd Kleyer, Milena L Pachowsky, Axel J Hueber, Stefan Kleinert, Karin Manger, Florian Schuch, Monika Ronneberger, David Simon, Michael Sticherling, Koray Tascilar, Christine Meder, Moritz Leppkes, Peter Dietrich, Verena Schoenau, Daniela Bohr, Fabian Hartmann, Selahattin Alp Temiz, Ioanna Minopoulou, Louis Schuster, Melek Yalcin Mutlu, Gerhard Kroenke, Till Orlemann, Johanna Mößner

“…Overall, patients with rheumatoid arthritis patients reported fewer symptoms (rate ratio=0.68, 95% CI, 0.59 to 0.80) than non-IMID controls.Conclusion Patients with IMID are over-represented in low-frequency subclusters, even among individuals who have reported a broad range of viral infection symptoms. …”
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Spatial transcriptomics reveal PI3K-AKT and metabolic alterations in aggressive, treatment-resistant lactotroph pituitary neuroendocrine tumors by Florencia Martinez-Mendoza, Sergio Andonegui-Elguera, Ernesto Sosa-Eroza, Erick Gomez-Apo, Aurea Escobar-España, Carolina Gonzalez-Torres, Javier Gaytan-Cervantes, Alam Palma-Guzman, Hugo Torres-Flores, Alberto Moscona-Nissan, Silvia Hinojosa-Alvarez, Jesús Hernandez-Perez, Roció A. Chavez-Santoscoy, Gerardo Guinto, Gerardo Y. Guinto-Nishimura, Blas E. Lopez-Felix, Erick U. Zepeda-Fernandez, Erick M. Estrada-Estrada, Victor Correa-Correa, Pedro A. Gonzalez-Zavala, Marco A. Asenscio-Montiel, Miguel A. Garcia-Vargas, Emmanuel Cantu-Chavez, Rocio L. Arreola-Rosales, Keiko Taniguchi-Ponciano, Daniel Marrero-Rodriguez, Moisés Mercado

“…Abstract Clinically aggressive lactotroph pituitary neuroendocrine tumors (PitNET) are invasive tumors with an unusually rapid growth rate despite maximally tolerated doses of dopamine agonist (DA). …”
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Diffusion and Risks of House Prices in the Netherlands by Alfred Larm Teye

“… The rate of home-ownership has increased significantly in many countries over the past decades. …”
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Correlation of excess salt intake identified by the survey with urine sodium level and blood pressure: data of ESSE-RF study by Yu. A. Balanova, V. A. Kutsenko, S. A. Shalnova, A. E. Imaev, A. V. Kapustina, G. A. Muromtseva, S. E. Evstifeeva, N. S. Karamnova, S. A. Maksimov, E. B. Yarovaya, O. M. Drapkina, A. N. Redko, S. N. Alekseenko, S. V. Gubarev, I. A. Viktorova, M. A. Livzan, I. A. Grishechkina, M. Yu. Rozhkova, N. N. Prishchepa, N. N. Vezikova, I. S. Skopets, S. S. Yakushin, E. V. Filippov, N. V. Dobrynina, N. N. Nikulina, K. G. Pereverzeva, K. A. Moseichuk

“…At the first phase in 2012-2014, 21,888 people (men — 38,2%) were included, and at the second phase in 2017 — 6,714 people (men — 44,7%). The response rate was 80%. We used standard questionnaire. Adding more salt and the consumption of salted foods (sausages, deli meats, and pickled foods) in the criteria “daily or almost daily” was considered excess salt intake (ESI). …”
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Regional lymph node invasion in pediatric non-rhabdomyosarcoma soft tissue sarcoma: an international cohort study from the International Soft Tissue Sarcoma ConsortiumResearch in c... by Daniel Orbach, Matthieu Carton, Amadeus T. Heinz, Lise Borgwardt, J Herve Brisse, Carlo Morosi, Erin R. Rudzinski, Akmal Safwat, Monika Sparber-Sauer, Stephanie Terezakis, Andrea Ferrari, Aaron R. Weiss, William H. Meyer, David O. Walterhouse, Timothy B. Lautz

“…We therefore to analyze the rate of N1 at diagnosis, the pattern of nodal relapse, and the prognostic impact of N1 in pediatric patients with NRSTS. …”
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Risk of developing drug abuse in administration of a new hexaazaisowurtzitane derivative-based analgesic (experimental study) by S. G. Krylova, T. N. Pove’teva, K. A. Lopatina, Yu. V. Nesterova, E. P. Zueva, O. G. Afanas’eva, P. V. Kulpin, E. A. Kiseleva, N. I. Suslov, D. A. Kulagina, S. V. Sysolyatin, V. V. Zhdanov

“…Previous in vivo and in silico studies (docking, molecular modeling, molecular dynamics simulation) on the multi-target mechanism of thiowurtzine explain the absence of its morphine-like effect by the fact that the major targets of the analgesic are TRPA1 receptors and voltage-gated Ca 2+ channels. With a high degree of probability, the conclusions made herein predict no drug abuse development when thiowurtzine is used in the clinical setting. …”
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Breeding of a new mid-to-late ripening apple cultivar Wangyuebingcui by XU Haihong, YANG Kai, LI Guangjin, ZHANG Guoqiang, TIAN Ge, AI Bohao, LI Xuqiang, WANG Junya

“…The cultivar combines high budbreak rate with moderate branching capacity, exhibiting spur-type growth pattern, sustained cluster-base productivity, and axillary flowering propensity. …”
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Effect of Chemical Processed Barley Grain (Hordeum vulgare) Through Steam Infrared Flaking on Productive and Parameters of Ruminal Fermentation in Holstein Lactating Cows by Amir Honarmand, Seyed Alireza Vakili, Mohsen Danesh Mesgarani, Abdolmansour Tahmasebi

“…Steam-infrared heated-flaking is a physical-specific process and it impresses on starch gelatinization and protein denaturation which may modify both site and rate of digestion. Treating barley grain with lactic acid have been shown to alter the chemical composition and the nutritional value of treated grains. …”
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Low-level atmospheric turbulence dataset in China generated by combining radar wind profiler and radiosonde observations by D. Meng, D. Meng, J. Guo, J. Guo, J. Chen, X. Guo, N. Li, Y. Sun, Z. Zhang, Z. Zhang, N. Tang, H. Xu, T. Chen, R. Yang, J. Hua

“…This dataset includes squared Brunt–Väisälä frequency (<span class="inline-formula"><i>N</i>²</span>), turbulent dissipation rate (<span class="inline-formula"><i>ε</i></span>), vertical eddy diffusivity (<span class="inline-formula"><i>K</i></span>), inner scale (<span class="inline-formula"><i>l</i>₀</span>), and buoyancy length scale (<span class="inline-formula"><i>L</i>_B</span>), which are provided twice daily at 00:00 and 12:00 UTC with a vertical resolution of 120 m, covering altitudes from 0.12 to 3.0 km above ground level (a.g.l.). …”
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