Miotonia congênita: relato de sete pacientes Congenital myotonia: report of seven patients by Helga C. A. Azevedo, Lúcia I. Z. Mendonça, Paulo N. B. Salum, Mary S. Carvalho, Sueli K. Nagahashi-Marie, Alzira A. Siqueira-Carvalho, Maria A. Cerqueira, Umbertina C. Reed, José A. Levy

“…<br>Myotonia is the phenomenon of decrease of muscular relaxation rate, after either a contraction or a mechanical or electrical stimulus. …”
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Partisipasi Ibu Rumah Tangga Dalam Pengelolaan Sampah di Kelurahan Sungai Jawi Luar, Kecamatan Pontianak Barat, Kota Pontianak by Nurul Fadilah, Aji Ali Akbar, Hendri Sutrisno, Isna Apriani

“…In addition, it also analyzes the rate of waste generation and waste composition using the SNI-19-3964-1994 method for 8 days. …”
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Assessment of the Impacts of Different Carbon Sources and Sinks on Atmospheric CO₂ Concentrations Based on GEOS-Chem by Ge Qu, Jia Zhou, Yusheng Shi, Yongliang Yang, Mengqian Su, Wen Wu, Zhitao Zhou

“…The global average CO₂ concentration increased by 1.8 ppm year⁻¹ from 2006 to 2010, with China’s eastern region experiencing the highest growth rate of 3.0 ppm year⁻¹. Fossil fuel combustion is identified as the largest CO₂ emission source, followed by biomass burning, while oceans and land serve as significant CO₂ sinks. …”
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Optimized Water Management Strategies: Evaluating Limited-Irrigation Effects on Spring Wheat Productivity and Grain Nutritional Composition in Arid Agroecosystems by Zhiwei Zhao, Qi Li, Fan Xia, Peng Zhang, Shuiyuan Hao, Shijun Sun, Chao Cui, Yongping Zhang

“…A comprehensive analysis revealed that an incremental irrigation frequency progressively enhanced plant morphological traits (height, upper three-leaf area), population dynamics (leaf area index, dry matter accumulation), and physiological performance (flag leaf SPAD, net photosynthetic rate), all peaking under the W2 and W3 treatments. …”
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Anticancer properties of copolymer nanoparticles loaded with Foeniculum vulgare derivatives in Hs578T and SUM159 cancer cell lines by Shima Bourang, Sodabeh Jahanbakhsh Godehkahriz, Mehran Noruzpour, Rasool Asghari Zakaria, Sergio Granados-Principal

“…Moreover, the drug release pattern illustrated a higher release rate from synthesized nanoparticles under acidic conditions (pH = 5). …”
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High-fat diet mouse model receiving L-glucose supplementations propagates liver injury by Johnny Amer, Athar Amleh, Ahmad Salhab, Yuval Kolodny, Shira Yochelis, Baker Saffouri, Yossi Paltiel, Rifaat Safadi

“…D- and L-Glu supplementations showed significant decrease of Glycogenesis (low GYS2/PYGL ratio) and unchanged p-AKT pattern compared to their RD counterparts.ConclusionOur data indicate an increase in rate of de-novo lipogenesis (DNL) in RD-fed mice (High carbohydrate diet) and liver fibrosis following additional sugar supplementations. …”
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Night surveys reveal abundant populations of sea urchins with high erosive potential in Cayo Arenas, Banco de Campeche by Elizabeth Cabrera Rivera, Ana Molina-Hernández, Francisco Medellín-Maldonado, Sergio Guendulain-García, Esmeralda Pérez-Cervantes, Rodolfo Rioja-Nieto, Alexis E Medina-Valmaseda, Lorenzo Alvarez-Filip

“…At night, the abundance (14.5 ± 3.8 ind) and bioerosion rate (1.55 ± 0.53 kg CaCO3·m–2·y–1) were higher than during the day (2.6 ± 0.8 ind and 0.2 ± 0.06 kg CaCO3·m–2·y–1). …”
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l-[5-11C]Glutamine PET imaging noninvasively tracks dynamic responses of glutaminolysis in non-alcoholic steatohepatitis by Yiding Zhang, Lin Xie, Masayuki Fujinaga, Yusuke Kurihara, Masanao Ogawa, Katsushi Kumata, Wakana Mori, Tomomi Kokufuta, Nobuki Nengaki, Hidekatsu Wakizaka, Rui Luo, Feng Wang, Kuan Hu, Ming-Rong Zhang

“…Here, we developed a positron emission tomography (PET) imaging platform using l-[5-11C]glutamine ([11C]Gln) and evaluated its efficacy in NASH mice undergoing metabolic therapy with bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl)ethyl sulfide (BPTES), a glutaminase 1 (GLS1) inhibitor that intervenes in the first and rate-limiting step of glutaminolysis. PET imaging with [11C]Gln effectively delineated the pharmacokinetics of l-glutamine, capturing its temporal-spatial pattern of action within the body. …”
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Association of cancer and outcomes of patients hospitalized for COVID-19 between 2020 and 2023 [version 2; peer review: 1 approved, 2 approved with reservations, 1 not approved] by Robert F Terry, Rugiatu Z Kamara, Robert J Samuels, Donald S Grant, Sulaiman Lakoh, Mustapha Kabba, Innocent Nuwagira, Yusuf Sheku Tejan, Sia Morenike Tengbe, Ibrahim Franklyn Kamara, Shermarke Hassan, Abdulai Tejan Jalloh, Divya Nair, Laura Merson

“…Conclusions This study's findings underscore the heightened vulnerability of hospitalized COVID-19 patients with cancer, revealing a higher mortality rate, longer hospital stays, and an unstructured pattern of care that reflects the complexity of managing severely ill patients during a public health crisis like the COVID-19 pandemic.…”
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Expression of Carnitine Palmitoyltransferase I Isotypes in Gingival Tissues of Human Periodontitis by Yue Shen, Lu Lin, Weijun Yu, Zhurong Cui, Tingting Lin, Shucheng Hu, Yuanjie Shi, Yuting Gu, Min Jin, Eryi Lu

“…Introduction and aims: Carnitine palmitoyltransferase I (CPT1), the rate-limiting enzyme of fatty acid oxidation, plays a crucial role in inflammation. …”
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Intersecting factors of disadvantage and discrimination and their effect on daily life during the coronavirus pandemic: the CICADA-ME mixed-methods study by Carol Rivas, Amanda P Moore, Alison Thomson, Kusha Anand, Zainab Zuzer Lal, Alison Fang-Wei Wu, Ozan Aksoy

“…Limitations We could not explore area-level social distancing and infection rates. Data collection was largely online, possibly excluding some older, digitally deprived or more disabled participants. …”
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The antiprotease Spink7 promotes inflammation resolution by modulating multiple proteases activities during wound healing by Na Zhao, Guojian Wang, Shuang Long, Xiaofan Lv, Xinze Ran, Junping Wang, Yongping Su, Tao Wang

“…In both Spink7 knockdown and knockout models, quantitative comparisons were made between the healing rate of wounds and histopathological morphometric analysis. …”
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Habit-learning and decision-making circuits are susceptible to glycemic variability in type 2 diabetes: a longitudinal study by Carolina Moreno, Carolina Moreno, Carolina Moreno, Otília C. d’Almeida, Otília C. d’Almeida, Joana Crisóstomo, Nádia Canário, Leonor Gomes, Leonor Gomes, Leonor Gomes, Miguel Castelo-Branco, Miguel Castelo-Branco

“…Linear regression analysis showed that, for each increase of 1 mmol/L in MAGE value, the SPC of the temporal lobe decreases on average by 1.2% (higher atrophy rate).ConclusionThe relationship between longitudinal GM atrophy and GV has a regionally specific pattern, suggesting localized brain susceptibility to intra-daily glucose fluctuations. …”
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Analysis of the molecular nature associated with microsatellite status in colon cancer identifies clinical implications for immunotherapy by Wei Wu, Qihan Fu, Lulu Liu, Yi Zheng, Hangyu Zhang, Peng Zhao, Weijia Fang, Xuanwen Bao, Shaobing Cheng, Xiaomeng Dai, Xudong Zhu, Zhou Tong, Fanglong Liu

“…A receiver operating characteristic curve was used to evaluate the accuracy rate of neural network, reaching 100%.Conclusion Our analysis unraveled the difference in the molecular nature and genomic variance in MSI and MSS colon cancer. …”
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Seroprevalence and risk factors of bluetongue virus infection in sheep and goats in West Gondar zone, Northwest Ethiopia by Adem Beyan, Wassie Molla, Adugna Berju Molla, Mastewal Birhan, Saddam Mohammed Ibrahim, Bereket Dessalegn, Ambaye Kenubih, Abebe Tesfaye Gessese, Mebrie Zemene Kinde, Gashaw Getaneh Dagnaw, Melkie Dagnaw Fenta, Hana Tesfaye, Takele Tesgera, Liyuwork Tesfaw, Habtamu Abesha, Zewdu Seyoum Tarekegn, Haileyesus Dejene, Molalegne Bitew

“…A mixed-effects logistic regression was employed to evaluate the relationship between Bluetongue virus seropositivity and potential risk factors.ResultsThe overall seroprevalence rate at the individual animal level was 84.5% (95% CI: 81.09–87.82). …”
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Prevalence of Genetic Mutations in Patients with Metastatic Prostate Cancer in a Cohort of Mexican Patients by Orión Erenhú Rodríguez González, Edgar Iván Bravo Castro, Jesus Eduardo Osorio, Habiram Pacheco Guerrero, Brenda Suaste Carmona, Luis David Arreola Peralta, Noe Esaul Martinez Juárez, Juan Samuel Izquierdo Luna, José de Jesús Oswaldo Islas García, Omar Dimas Victorio Vargas, Rafael Alberto Valdez Flores, Jesús Javier Torres Gómez, José Gadú Campos Salcedo

“…<b>Conclusions:</b> Our study unveiled a mutation rate of 21.73%, marked by a significant prevalence of ATM, FANCA, FANCM, and Variants of Uncertain Significance (VUS). …”
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Association of depression in multiple sclerosis with fatigue, sleep disturbances, disability, and health-related quality of life: Outcomes of a cross-sectional study by E. Aparicio-Castro, A. Candeliere-Merlicco, C.M. Santa, R. Villaverde-González

“…The study was conducted through clinical evaluations and questionnaires related to depression: Beck Depression Inventory (BDI) and Hamilton Depression Rating Scale (HDRS); fatigue: Modified Fatigue Impact Scale; sleep quality: Pittsburgh Sleep Quality Index and Epworth Sleepiness Scale; and QoL: Multiple Sclerosis Quality of Life-54 (MSQOL-54). …”
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Focal liver lesions: multiparametric microvasculature characterization via super-resolution ultrasound imaging by Qian-Qian Zeng, Shi-Zhe An, Chao-Nan Chen, Zhen Wang, Jia-Cheng Liu, Ming-Xi Wan, Yu-Jin Zong, Xiao-Hua Jian, Jie Yu, Ping Liang

“…Following bolus injection of microbubbles at clinical concentration, SR-US was performed using a high frame rate (350–500 Hz) modified ultrasound scanner and a convex array transducer with a central frequency of 3.1 MHz. …”
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Variant pubertal development in Prader-Willi syndrome: early and slow progression of pubarche with normal age at gonadarche by Aneta Kodytková, Petra Dušátková, Shenali Anne Amaratunga, Stanislava Koloušková, Barbora Obermannová, Renata Pomahačová, Štěpánka Průhová, Marta Šnajderová, Zdeněk Šumník, Jiřina Zapletalová, Valerij Semjonov, Jan Lebl

“…The age at gonadarche was adequate – 10.0 years in girls (8.8–11.2), and 11.0 in boys (9.8–12.1). Progression rate of breast development from B2 to B4 was 3.9 (0.2–7.5) years in girls and of testicular volume from 4 ml to 15ml was 3.8 (0.0–8.1) years in boys. …”
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Viral characterization of the reassortants between canine influenza H3N2 and human pandemic (2009) H1N1 and avian H9N2 viruses in canine ex vivo tracheal explants by Tonia T. Kam, Christine H. T. Bui, Hin-Wo Yeung, Peter C. H. Wong, Alex W. H. Chin, John M. Nicholls, Malik Peiris, Kenrie P. Y. Hui, Leo L. M. Poon, Michael C. W. Chan

“…Results Co-passaging H3N2-CIV with human/avian influenza A viruses in canine tracheal explants resulted in a high rate of reassortment. Plaque-purified reassortants were all viable and able to propagate in mammalian alveolar epithelial cells. …”
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