Cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6i): Mechanisms of resistance and where to find them by L. Foffano, L. Cucciniello, E. Nicolò, I. Migliaccio, C. Noto, C. Reduzzi, L. Malorni, M. Cristofanilli, L. Gerratana, F. Puglisi

“…Additionally, the importance of dissecting CDK4/6i resistance from endocrine resistance for personalized treatment is increasingly recognized.Liquid biopsy has emerged as a minimally invasive tool for identifying circulating biomarkers of resistance through the integration of multiparametric and dynamic assessments that encompass ctDNA, CTCs, exosomes, and epigenetic ctDNA alterations, representing a promising perspective for the clinical characterization of treatment resistance and guiding post-progression strategies to improve patient outcomes.Aim of this review is summarize potential mechanisms of CDK4/6i resistance, along with the advantages of using liquid biopsy to identify resistance biomarkers in HR+/HER2- MBC patients treated with CDK 4/6 inhibitors.…”
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Associations between self-efficacy and health-related quality of life in haemorrhagic stroke survivors: a longitudinal study by Wei Zhu, Qiaoyu Yang, Baoyue Zhang, Cong Wang, Chaofeng Fan

“…The three-level EuroQol five-dimension questionnaire (EQ-5D-3 L) and Stoke Self-efficacy Questionnaire (SSEQ) were assessed at four post-discharge time points: 1 month (T1), 3 months (T2), 6 months (T3), and 12 months (T4). …”
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Significance of Omega-3 Fatty Acids in the Prophylaxis and Treatment after Spinal Cord Injury in Rodent Models by Piotr Wojdasiewicz, Łukasz A. Poniatowski, Paweł Turczyn, Justyna Frasuńska, Agnieszka Paradowska-Gorycka, Beata Tarnacka

“…On the other hand, the therapeutic properties (post-SCI) include the increased production of endogenous antioxidants such as carnosine and homocarnosine, the maintenance of elevated GSH concentrations at the site of injury, reduced concentrations of oxidative stress marker (MDA), autophagy improvement (via increasing the expression of LC3-II), and p38 MAPK expression reduction in the superficial dorsal horns (limiting the sensation of neuropathic pain). …”
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Analisis Proksimat dan Karakteristik Fisik Beras Analog Berbasis Tepung Sukun dengan Penambahan Ikan Teri Nasi by Veronica Ima Pujiastuti, Maria Amrijati Lubijarsih, Dita Hanna Febriani

“…Analisis data menggunakan Analysis of Varian (ANOVA), dan uji Post Hoc Duncan Multiple Range Test (DMRT). Hasil: Penambahan ikan teri nasi meningkatkan kadar abu, dan protein, menurunkan lemak dan tidak berpengaruh terhadap karbohidrat dan energi secara signifikan dibandingkan kontrol. …”
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Proton therapy for uveal melanoma (preliminary results) by I.E. Panova, N.A. Vorob’ov, E.V. Samkovich, A.A. Bykhovsky, N.I. Martynova, E.M. Svistunova

“…Results. In the early post-radiation period, a radiation reaction was observed in the form of skin erythema (2 patients), exudative retinal detachment (3 patients). …”
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Wave dynamics and potential longshore sediment transport at Shippagan, Gulf of St Lawrence: insight into seasonal variability and extreme weather events by Jubin Thomas, Jubin Thomas, Jesbin George, Danika Van Proosdij, Danika Van Proosdij, Enda Murphy

“…Seasonal analysis highlights winter season waves are the dominant contributor to sediment transport, followed by spring and fall. Although, post-tropical storms contributed 5% to the total gross potential LST rates. …”
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Dynamic change of direction, isometric strength, and psychological readiness in final phase ACLR athletes: an integrated approach by JPJ Stofberg, Mariaan van Aswegen, Mark Kramer

“…Conclusions Reactive agility and psychological confidence progressively improved post-ACLR, with decision-making speed recovering earlier than acceleration ability. …”
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Advance care planning (ACP) to promote receipt of value-concordant care: Results vary according to patient priorities. by Holly G Prigerson, Martin Viola, Paul K Maciejewski, Francesca Falzarano

“…Interviews regarding patient priorities occurred a median of 111 days prior to death; data regarding EoL medical care were collected post-mortem from caregiver interviews and medical record abstraction. …”
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Lyophilized hydroalcoholic extract of Passiflora edulis and Zea mays L, as potential arterial hypotension and hypocholesterolemia in hypertensive Mus musculus induced hypertension by Víctor Carhuapoma-Delacruz, Mery L. Capcha Huamani, Nicasio Valencia Mamani, Mario Esparza

“…Mice were fasted to assess systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), glucose and cholesterol at baseline and post induction with L-NAME by indirect method. At 4 weeks of study the animals of G1-passion fruit and G2-purple corn showed significant antihypertensive and hypocholesterolemia effect (p<0.05) resulting the concentration 200 mg as optimal reducer and stabilizer of SBP, DBP, MAP, glucose and cholesterol. …”
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Long-term risk of stroke after acute coronary syndrome: the ABC-10* study on heart disease by Heba T. Mahmoud, Rocco Cordiano, David Merotto, Mattia Ludovico Dario, Fiorella Cavuto, Giuseppe Berton

“…Conclusion This long-term cohort study reinforces the role of established clinical predictors (age, AF, renal function) in post-ACS stroke risk and highlights novel geographic disparities in fatal stroke outcomes. …”
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Evaluación de un curso en línea para docentes de Ciencias de la Salud by Gustavo Homero Orozco Cazco, María Eugenia Solís Mazón, Jorge Noé Silva Castillo, Manuel David Isin Vilema, Patricio Ricardo Humanante Ramos

“…Material y Método: en el período junio, 2023 - febrero, 2024 se desarrolló un estudio con enfoque cuantitativo y un diseño no experimental ex-post-facto. La estrategia de la investigación se dividió en 8 etapas: determinación de las necesidades de capacitación, selección de la metodología o modelo para el diseño instruccional, diseño del MOOC, gestión, revisión de infraestructura y análisis de la calidad de la propuesta, implementación del curso en la plataforma, evaluación del MOOC, procesamiento y análisis de la información y elaboración de informe de evaluación del curso. …”
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Prioritizing psychological relief: fast-absorbing collagen sutures improve parental well-being in pediatric facial trauma care by Peili Xie, Kaixi Tan, Jianfei Zhang

“…Scar formation was evaluated using the Scar Cosmesis Assessment and Rating (SCAR) scale at 1 month postoperatively.ResultsBaseline SAS/SDS scores and GQOLI-74 domain scores showed no intergroup differences (P &gt; 0.05). Post-intervention, both groups exhibited reduced anxiety (ΔSAS: −12.3 ± 2.1 vs. −8.7 ± 1.8) and depression (ΔSDS: −10.9 ± 1.9 vs. −6.4 ± 1.5), with superior reductions in the observation group (P &lt; 0.05). …”
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Indications and Limitations of Resection and Ligaments Repair for Os Subfibulare Based on the Hasegawa Classification by Naohiro Hio MD, PhD, Masanori Taki MD, PhD, Atsushi Hasegawa MD, PhD

“…Results: In a study applying the Hasegawa classification to 17 joints, significant post-surgical improvements were noted in pain (VAS improved from 38.5±26.2 to 6.7±16.4), function (JSSF scale increased from 75.6±9.4 to 94.8±8.4), and subjective instability (reduced from 58.8% to 17.6%). …”
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Clinical usefulness of inside stents in anastomotic biliary strictures after liver transplantation by Naotaka Kugiyama, Shunpei Hashigo, Katsuya Nagaoka, Takehisa Watanabe, Shinya Ushijima, Yukiko Uramoto, Motohiro Yoshinari, Jun Morinaga, Ryosuke Gushima, Masakuni Tateyama, Motohiko Tanaka, Hideaki Naoe, Yasuhiko Sugawara, Taizo Hibi, Yasuhito Tanaka

“…Methods We compared retrospectively the stent patency period and stent dysfunction rate between inside stents (IS) and conventional plastic stents (PS) in 48 patients with post‐transplant strictures, distinguishing endoscopic biliary stenting with and without stent dysfunction at stent replacement. …”
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Roles of the lipopolysaccharide biosynthesis-related gene HP0858 in the fitness of Helicobacter pylori and its virulence in Galleria mellonella by Tram Thi Hong Nguyen, Pei-Chun Chen, Po-Chuan Wang, Wen-Han Wang, Chung-Yu Lan, Steffen Backert, Mou-Chieh Kao

“…In an in vivo Galleria mellonella infection model, the HP0858 knockout mutant showed significantly attenuated virulence, as no bacterial load was detectable in the larvae’s hemolymph 48 h post-infection, unlike the wild-type strain. Finally, we provided evidence that the enzyme encoded by HP0858 is involved in a general protein glycosylation system linked to LPS biosynthesis, specifically glycosylating the adhesin AlpA. …”
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Effects of bio-insecticide formulated from M. charantia leaves extract in association with gum Arabic/kaolinite composite on mortality of Callosobruchus maculatus and nutritional c... by Wangmene Bagamla, Bayang Jean Paul, Djakba Raphael, Ali Mahamat, Koubala Bargui Benoit, Harouna Massai

“…The preservation of post-harvest losses of cowpeas constitutes a major challenge for producers worldwide. …”
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Evaluating the Effectiveness of Artificial Intelligence in Prostate Cancer Detection using Biparametric Magnetic Resonance Imaging: A Comparative Study by Rossy Vlăduţ TEICĂ, Ioana Andreea GHEONEA

“…The study included 181 bpMRI scans from patients who presented for diagnostic evaluation rather than post-treatment monitoring. The AI software Mediaire analyzed the scans, and its findings were compared to the independent assessments of two radiologists specializing in prostate imaging. …”
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Validation of a Real-Time PCR Assay for Fully Automated Detection of <i>Bacillus cereus</i> in Donor Human Milk by Gemma Aran, Vanessa Pleguezuelos, Margarita Blanco, Cristina Garcia, Mariama Jallow, Mar López, Sara Monge, Natalia Casamitjana, Eva Alonso-Nogués, Gloria Soria

“…Since no microbial growth is acceptable in post-pasteurized DHM, microbiological testing of pre-pasteurized DHM provides information about its contamination level to determine if it should be accepted for pasteurization. …”
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Managing cancer pain at the end of life with multiple strong opioids: a population-based retrospective cohort study in primary care. by Wei Gao, Martin Gulliford, Michael I Bennett, Fliss E M Murtagh, Irene J Higginson

“…The dip significantly affected the correlation of the complex cases with persistent increasing background opioid prescribing (weighted correlation coefficients pre-, post-Shipman periods: 0.98(95%CI: 0.67-1.00), p = 0.011; 0.14 (95%CI: -0.85 to 0.91), p = 0.85). …”
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Impact of impaired intrinsic capacity on postoperative frailty in elderly patients undergoing colorectal surgery: study protocol for a single-center, prospective, cohort study by Jirun Wang, Shaoqi Tian, Lei Zhang, Jia Liu, Yuefang Liu, Lei Zhu, Peipei Shan, Ping Zhao, Yang Zhao, Youzhuang Zhu, Youzhuang Zhu

“…All assessments will be conducted at predetermined intervals through face-to-face interviews during hospitalization and via telephone follow-up post-discharge.DiscussionThis study aims to clarify the risk of postoperative frailty in older patients with impaired intrinsic capacity. …”
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