The effects of single and multiple BOPPPS-integrated model sessions on public health students' competences: a two-stage study combining quasi-experimental and cross-sectional analy... by Qiqi Liu, Jixuan Ma, Chuansha Wu, Yang Du, Ting Chen, Xiaojie Sun, Qin Zhao, Yunhao Liu, Yuqin Shi, Yingying Gu, Min Zhou, Ling Zhang, Ting Zhou

“…This study aimed to integrate the bridge-in, objective, pre-assessment, participatory learning, post-assessment, and summary (BOPPPS) framework with problem-based learning (PBL), team-based learning (TBL), and case-based learning (CBL) to develop a novel instructional model, termed the BOPPPS-integrated model (BIM), and to assess the influences of single and multiple BIM interventions on the competences of undergraduate public health students. …”
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Identification of a moxidectin dose for 4- to 11-year-old children to support registration and potential use for onchocerciasis elimination: results of an open-label pharmacokineti... by Nicholas O. Opoku, Felix Doe, Mannel E. Agbogah, Rukaya Laryea, Shelter K. Gordor, Bismark S. Donkor, Edwin Anyomitse, Dickson Kugali, Mariëlle van Zutphen-van Geffen, Danielle J. Navarro, Craig R. Rayner, Kashyap Patel, Annette C. Kuesel, Melinda Lowe, Sally Kinrade

“…Moxidectin plasma concentrations were measured at 1, 2, 4, 8, 24 and 72 h and at 1, 2, 4 and 12 weeks post-dose. The maximum concentration (Cmax; ng/ml) and area under the concentration–time curve from dosing to infinity (AUC0-∞; ng h/ml) were obtained through non-compartmental analysis. …”
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BRAF inhibitor resistance of melanoma cells triggers increased susceptibility to natural killer cell-mediated lysis by Antoine Toubert, Eric Pasmant, Alexandra Frazao, Louise Rethacker, Géraldine Jeudy, Marina Colombo, Marie-Françoise Avril, Helene Moins-Teisserenc, Marie Roelens, Sophie Dalac, Eve Maubec, Anne Caignard

“…We determined the levels of several soluble molecules including NK ligands in 61 melanoma patients at baseline and 6 months M post-treatment with targeted therapies or immunotherapies.Results Vemurafenib resistance involved activation of p-AKT in SK28R and of p-MEK/p-ERK in M14R cells and was accompanied by modulation of NK ligands. …”
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Pediatric autoimmune diseases in the light of COVID-19 pandemic, A retrospective observational big data study by Rim Kasem Ali Sliman, Hilla Cohen, Shereen Shehadeh, Reut Batcir, Yigal Elenberg Alter, Keren Cohen, Ilana Koren, Inbal Halabi, Hussein Sliman, Mohamad Hamad Saied

“…The study compared pre-pandemic (2019) with pandemic/post-pandemic periods (2020–2023), encompassing a cohort of over 1.5 million children. …”
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Key technologies of efficient extraction of coalbed methane (gas) in Guizhou coal mine area by Wang YI, Longjun LIANG, Lichong YAN, Zhihua YAN, Jie CHEN, Wei GAO, Yi LOU, Fuqin YANG, Haiyang HU, Jiawei ZHU

“…Especially in the goaf of coal mine, when the coal seam is goaf, five stress fields are formed in the tendency due to the post-mining release and redistribution of ground stress, resulting in different degrees of impact on the overlying strata in adjacent areas. …”
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Association between anion gap and postoperative delirium in patients undergoing open heart surgery by Jun Wang, Hui Zhong, Lu Chen, Hong-Chun Ding, Zhong-Jie Lu, Bin-Su Wang, Shun-Bi Liu, Jing Luo, Li-Wen Hou, Li-Wen Hou, Yuan-Zhang Liu, Sheng Ding, Feng Gao, Li Jiang

“…Patients aged 18 or older who underwent OHS, were admitted to the ICU post-surgery, and had an AG test within the first 24 h after surgery were included. …”
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Atividades de dissecção de cadáveres e residência médica: relato da experiência do Serviço de Cirurgia Plástica do Hospital Universitário Professor Edgard Santos da Universidade Fe... by Victor Diniz de Pochat, Rogério Rafael da Silva Mendes, Adson Andrade de Figuerêdo, Nivaldo Alonso, Marcelo Sacramento Cunha, José Valber Lima Meneses

“…Thus, the importance of using cadavers to teach anatomy and surgical skills in undergraduate and post-graduate courses is reinforced. This study aimed to report scientific outcomes related to cadaver dissection in the Plastic Surgery Service of Hospital Universitário Professor Edgard Santos (HUPES), Universidade Federal da Bahia, from 2009 to 2011, and the importance of this activity for plastic surgery resident training. …”
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Stage-dependent proteomic alterations in aqueous humor of diabetic retinopathy patients based on data-independent acquisition and parallel reaction monitoring by Yeanqi Jin, Junbin Liu, Xueli Zhang, Liang Zhang, Ying Cui, Xiaoyang Luo, Haoxian Zhu, Zhifan Chen, Mengya Liu, Xiyu Wu, Xinyu Chen, Shuoxin Liao, Guanrong Wu, Xiang Fang, Qianli Meng

“…C6, FAM3C, SPP1, and JCHAIN levels were altered post-anti-VEGF treatment. Pharmacological prediction identified potential therapeutic compounds, including perindopril, triciribine, and XAV-939 for NPDR, and topiramate, triciribine, and vecuronium for PDR. …”
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PSMB10 maintains the stemness of chemotherapeutic drug-resistant leukemia cells by inhibiting senescence and cytotoxic T lymphocyte-mediated killing in a ubiquitinated degradation... by Xiao Ma, Yingnan Li, Di Wang, Jialan Niu, Qian Li, Ying Chen, Mengyuan Wang, Jin Wen, Chenxi Liao, Nan Wang, Xiaolan Zhang, Jiwei Chang, Jiayi Yang, Lei Li, Jing Zou, Danyue Peng, Lingbo Liu

“…The specific high expression of PSMB10 in post-chemotherapy nonsenescent LSCs predicts a poor AML prognosis. …”
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Emergency department initiated resuscitative endovascular balloon occlusion of the aorta (REBOA) for out‐of‐hospital cardiac arrest is feasible and associated with improvements in... by James Daley, Ryan Buckley, Kathryn Cannon Kisken, Douglas Barber, Raj Ayyagari, Charles Wira, Ani Aydin, Igor Latich, Juan Carlos Perez Lozada, Daniel Joseph, Angelo Marino, Hamid Mojibian, Jeffrey Pollak, Cassius Ochoa Chaar, James Bonz, Justin Belsky, Ryan Coughlin, Rachel Liu, John Sather, Reinier Van Tonder, Rachel Beekman, Elyse Fults, Austin Johnson, Christopher Moore

“…Unfortunately, all patients re‐arrested soon after intra‐aortic balloon deflation and none survived to hospital admission. At 30 seconds post‐aortic occlusion, investigators noted a statistically significant increase in end tidal carbon dioxide of 26% (95% confidence interval, 10%, 44%). …”
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Systematic Sex-Based Inequity in the MELD Score-Based Allocation System for Liver Transplantation in Germany by Leke Wiering, Leke Wiering, Annette Aigner, Marieke van Rosmalen, Brigitta Globke, Brigitta Globke, Tomasz Dziodzio, Nathanael Raschzok, Nathanael Raschzok, Münevver Demir, Wenzel Schöning, Frank Tacke, Petra Reinke, Johann Pratschke, Robert Öllinger, Paul V. Ritschl, Paul V. Ritschl

“…We assessed the impact of sex on transplantation rates, waiting list mortality and post-transplant survival in 25,943 patients waitlisted for liver transplantation in Germany between 2003 and 2017 using competing risk analysis. …”
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<i>ZmNLR</i><i>-7</i>-Mediated Synergistic Regulation of ROS, Hormonal Signaling, and Defense Gene Networks Drives Maize Immunity to Southern Corn Leaf Blight by Bo Su, Xiaolan Yang, Rui Zhang, Shijie Dong, Ying Liu, Hubiao Jiang, Guichun Wu, Ting Ding

“…Analysis of tissue expression patterns revealed that <i>ZmNLR-7</i> was expressed in all maize tissues, with the highest expression level (5.11 times) exhibited in the leaves, and that its transcription level peaked at 11.92 times 48 h post <i>Bipolaris maydis</i> infection. Upon inoculating the <i>ZmNLR-7</i> EMS mutants with <i>Bipolaris maydis</i>, the disease index was increased to 33.89 and 43.33, respectively, and the lesion expansion rate was higher than that in the wild type, indicating enhanced susceptibility to southern corn leaf blight. …”
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Drainage system research and application of deep coalbed methane gas reservoirs in Daning-Jixian block by Ming CHEN, Dameng WANG, Lizhu YU, Junyi SUN, Xin FENG, Kang ZHANG, Xianfeng GU, Liwei WANG, Zesong YIN, Huan ZHANG

“…Furthermore, through the normalization of production time and horizontal segment length from 29 gas wells’ dynamic production data, the research preliminarily identifies that deep coalbed methane have gone through 4 production stages, with Stage I being post-fracture flowback, Stage II characterized by rapid initial production, Stage III focusing on exploring rational production allocation, and Stage IV indicating a decrease in gas production. …”
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Isolation of Murine Pancreatic Stellate Cells and the Establishment of a New ex-vivo Activation Model by Wang X, Li M, Liu X, Sun G, Zhang D, Sun L, Yin Y, Zhang W, Hao J

“…RT-PCR revealed progressive upregulation of acta2 (&amp;ast;&amp;ast;p&lt; 0.01, d4 compared to d2, &amp;num;&amp;num;p&lt; 0.01,d7 compared to d4,&amp;ast;&amp;ast;p&lt; 0.01,d7 compared to d2), col1a (&amp;ast;&amp;ast;p&lt; 0.01, d4 compared to d2,&amp;ast;&amp;ast;p&lt; 0.01,d7 compared to d2), and actg2 (&amp;ast;&amp;ast;p&lt; 0.01, d4 compared to d2, &amp;num;&amp;num;p&lt; 0.01,d7 compared to d4, &amp;ast;&amp;ast;p&lt; 0.01,d7 compared to d2) mRNA levels at 2, 4, and 7 days post-adhesion. Fibroblast markers were also upregulated, and KEGG and GO enrichment analyses identified key pathways involved in ECM-receptor interactions, cell cycle regulation, PI3K-Akt signaling, and extracellular matrix remodeling.Conclusion: The Nycodenz gradient efficiently isolates quiescent mPSCs, and short-term caerulein treatment effectively activates mPSCs ex vivo, providing a valuable model for studying mPSC activation and related signaling pathways.Keywords: pancreatic stellate cells, chronic pancreatitis, pancreatic fibrosis…”
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Overexpression of the ABA Synthesis Gene OsABA2 Enhances Seed Storability in Rice by Yongxiang Liao, Pengfei Jiang, Mingming Zhang, Fangli Jin, Mengyuan Li, Jiazhi Dong, Daiming Guo, Yingxiu Liao, Asif Ali, Saira Saleem, Xiangyang Zhang, Qinggui Jiang, Su Liu, Hongyu Zhang, Xiaoqiong Chen, Kangxi Du, Hao Zhou, Duo Xia, Peizhou Xu, Xianjun Wu

“…For practical application, Gang46B—a hybrid rice parental line with poor storability—significantly improved its post-aging germination rates. These findings demonstrate that the overexpression of OsABA2 enhances seed storability by regulating ABA biosynthesis pathway and associated oxidative response. …”
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Landscape analysis of m5C modification regulators unveils DNMT1-mediated dysregulated pyrimidine metabolism in hepatocellular carcinoma by Xuhui Zhao, Shengwei Mao, Yuan Fang, Jiafeng Chen, Lifu Bi, Jie Li, Jinglei Wu, Jun Gao, Shiguang Yang, Jialu Fu, Xiaoling Wu, Guiqi Zhu, Zheng Tang, Yinghong Shi, Jian Zhou, Jia Fan, Xingxing Zhang, Jinling Jiang, Weiren Liu

“…Abstract The 5-methylcytosine (m5C) post-transcriptional modification has been linked with the development and progression of a variety of cancers. …”
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Mechanistic Advances in the Therapeutic Application of Bixin for Lung Inflammation In Vitro and In Vivo by Alexsandro Tavares Figueiredo-Junior, Bruno Clemente Brandão Marques, Douglas Galdino dos Santos, Wesley Leandro Gouveia, Raysa Magali Pillpe Meza, Luzineide Wanderley Tinoco, Lídia Moreira Lima, Samuel Santos Valenca, Manuella Lanzetti

“…In the in vitro study, RAW 264.7 macrophages were exposed to CSE and post-treated with KBx to evaluate their ability to revert the redox imbalance caused by the stressor. …”
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A multivalent mRNA vaccine elicits robust immune responses and confers protection in a murine model of monkeypox virus infection by Yansheng Li, Lin Cheng, Lixu Jiang, Zhuohuan Li, Jing Rao, Tong Wu, Fangyan Zhang, Baocai Xie, Yu He, Lianrong Wang, Zheng Zhang, Shi Chen

“…Immune profiling reveals enhanced B- and T-cell receptor diversity and distinct CDR3 motifs post-vaccination. These findings demonstrate the potential of using mRNA-based multivalent vaccines as an effective strategy for preventing mpox and related Orthopoxvirus infections.…”
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Comparison of pathogen detection performance between metagenomic next-generation sequencing and conventional culture in organ preservation fluids and recipient wound drainage fluid... by Jiyuan Li, Wenjia Yuan, Chen Gao, Lei Liu, Lei Song, Wei Cao, Xuejing Zhu, Yachun Han, Ruobing Liang, Gongbin Lan, Shaojie Yu, Yu Wang, Liang Tan, Helong Dai, Xubiao Xie, Longkai Peng, Fenghua Peng

“…BackgroundPrompt identification and management of donor-derived infections post-kidney transplantation are critical. This study aims to assess the effectiveness of metagenomic next-generation sequencing (mNGS) in detecting pathogens within donor organ preservation fluids and recipient wound drainage fluids, with a comparison made against conventional culture methods.MethodsThis study involved 141 kidney transplant patients (May 1st, 2020 to Jan 31st, 2024). …”
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Echocardiographic evaluation of myocardial structural and functional changes in patients with stage 5 chronic kidney disease before and after kidney transplantation by M. Sh. Khubutiya, E. V. Shuvalova, O. N. Rzhevskaya, L. T. Khamidova, A. A. Ivannikov, Kh. G. Alidzhanova, A. G. Balkarov, I. V. Dmitriev

“…It was found that after 3 months post kidney transplantation, there was a decrease in the left atrium diameter, volume, and volume index. …”
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