<i>Cenostigma bracteosum</i> Hydroethanolic Extract: Chemical Profile, Antibacterial Activity, Cytotoxicity, and Gel Formulation Development by Addison R. Almeida, Francisco A. S. D. Pinheiro, Marília G. M. Fideles, Roberto B. L. Cunha, Vitor P. P. Confessor, Kátia N. Matsui, Weslley S. Paiva, Hugo A. O. Rocha, Gislene Ganade, Laila S. Espindola, Waldenice A. Morais, Leandro S. Ferreira

“…The prepared gels remained stable over the 30-day post-production analysis period. <b>Conclusions</b>: These findings provide a better understanding of the chemical diversity of the secondary metabolites of a common Caatinga biome species—<i>C. bracteosum</i>—specifically present in leaves hydroethanolic extract and gel formulation adapted for skin application with activity against <i>S. aureus.…”
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Trends in prescription opioid use in Europe: A DARWIN EU® multinational cohort study including seven European countries by Junqing Xie, Mike Du, Yuchen Guo, Cesar Barboza, James T. Brash, Antonella Delmestri, Talita Duarte-Salles, Talita Duarte-Salles, Jasmine Gratton, Romain Griffier, Raivo Kolde, Wai Yi Man, Núria Mercadé-Besora, Marek Oja, Sarah Seager, Katia Verhamme, Dina Vojinovic, Edward Burn, Daniel Prieto-Alhambra, Daniel Prieto-Alhambra, Martí Català, Annika M. Jödicke

“…More data are needed to monitor evolving opioid prescription patterns in Europe, particularly in the post-pandemic era.…”
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Effect of Platelet-rich Fibrin on Soft-tissue and Hard-tissue Healing following Surgical Extraction of Mandibular Third Molar: A Prospective Interventional Study by Sudip Chakraborty, Chayan Kundu, Samiran Ghosh, Richi Burman, Avishek De Sarkar, Gourab Mandal, Somak Saha

“…Soft-tissue healing evaluation was performed using the parameters of the healing index on the 3rd, 7th, 14th, and 28th post-extraction days by two blind observers. Hard-tissue healing was evaluated using the Cone Beam Computed Tomography (CBCT) findings on the 1st month and 3rd month postoperatively. …”
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Digital education and exercise therapy versus minimal intervention for young people at high risk of early onset knee osteoarthritis after ACL reconstruction: a study protocol for t... by Jackie L. Whittaker, Amanda Cammalleri, Candice Archibald, Alexandra Brooks-Hill, Patrick Chin, Sarah Clark, Jennifer C. Davis, Alison M. Hoens, Michael A. Hunt, Karin Kausky, Angelina Ko, Lise Leveille, Linda C. Li, Parth Lodhia, Justin M. Losciale, Maxi Miciak, Amber D. Mosewich, Adnan Sheikh, Trish Silvester-Lee, Linda K. Truong, Dominic Wade, David R. Wilson, Hui Xie, Xian He Yan, Ewa M. Roos

“…Consensus recommendations to prevent post-traumatic knee osteoarthritis include person-centered education and exercise-based treatments. …”
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Role of Frailty Index-Laboratory to predict COVID-19 mortality: a prospective study by Elda De Vita, Nicola Veronese, Giacomo Guido, Luisa Frallonardo, Sergio Cotugno, Giorgia Manco Cesari, Marinella Cibelli, Alessandra Vigna, Davide Capruzzi, Monica Fiorella, Carmen Rita Santoro, Gaetano Brindicci, Francesco Di Gennaro, Annalisa Saracino

“…Mortality data were collected up to 90 days post-admission. Cox regression analysis, adjusting for demographics, comorbidities, COVID-19 symptoms, and vaccination status, was employed to examine the relationship between FI-LAB scores and mortality.ResultsOne thousand, four hundred ninety-two patients were included in the study population, the mean age was 57.2 years (SD = 15.9), with 56.6% being male. …”
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Suppressing lipid biosynthesis in Mycobacterium tuberculosis through polyketide synthase 13 thioesterase inhibition: Insights from computational analysis by Maha M. Alawi, Hattan S. Gattan, Azzah S. Alharbi, Mohammed H. Alruhaili, Ibrahim A. Al-Zahrani, Saad B.AL Masaud, Vivek Dhar Dwivedi, Esam I. Azhar

“…The molecular dynamics simulation was applied to analyze the structural properties in terms of stability, compactness, and flexibility of the post-validation of the docking result. The MMGBSA method was used to calculate the binding-free energy. …”
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Predictors of response and enteral autonomy in children with short bowel syndrome treated with teduglutide: a real-life multicentre cohort studyResearch in context by Lorenzo Norsa, Arianna Ghirardi, Esther Ramos Boluda, Anat Guz-Mark, Iva Hojsak, Johannes Hilberath, Ilse Juia Broekaert, Rocío González Sacristán, Antonella Lezo, Paula Guerra, Pierre Poinsot, Cecile Lambe, Lorenzo D'Antiga

“…Information on patients’ post-surgical anatomy, amount of PN calories and volume required at baseline and at 3, 6 and 12 months after TED start, along with biochemical markers of PN tolerance and complications, were recorded. …”
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Hydration assessment and physical performance of mountain bike cyclists in competition in a hot environment by Rayane Carvalho de Moura, Crislane de Moura Costa, Cirley Pinheiro Ferreira, Valmir Oliveira Silvino, Bruna Lorena Soares Cavalcante Sousa, Esmeralda Maria Lustosa Barros, Leandra Caline dos Santos, Karoline de Macêdo Gonçalves Frota, Sandro Soares Almeida, Sérgio Luís Galan Ribeiro, Acácio Salvador Veras e Silva, Michelly da Silva Pinheiro, João Victor Neves Veras, Paulo Henrique Carvalho de Sousa, Guilherme de Azambuja Pussieldi, Glêbia Alexa Cardoso, Marcos Antonio Pereira dos Santos

“…There was a significant decrease in body mass between the pre- and post-competition moments (79.15 ± 14.65 kg; 76.15 ± 14.36 kg) (p = 0.000). …”
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THE AESTHETICS OF RUINS IN VERNACULAR PHOTOGRAPHY IN RUSSIAN SOCIAL MEDIA: STATING THE RESEARCH PROBLEM / ЭСТЕТИКА РУИН В ВЕРНАКУЛЯРНОЙ ФОТОГРАФИИ РУССКОЯЗЫЧНЫХ СОЦИАЛЬНЫХ МЕДИА: П... by CHUMAKOVA VARVARA PAVLOVNA / ЧУМАКОВА ВАРВАРА ПАВЛОВНА

“…As our research has demonstrated, the popularity of the aesthetization of ruins in the modern network culture may be associated with the crisis of identity and the reevaluation of relations with the past in the post-Soviet space. Статья посвящена феномену вернакулярной фотографии руин и связанных с ней изображений в современных русскоязычных социальных медиа. …”
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Pirfenidone Prevents Myocarditis by Restoring Metabolic Hormone Levels in a Mouse MASH Model and its Effect on H9c2 Myoblast Viability under Glucolipotoxicity by Daniel López-Cifuentes, Ana S. Sandoval-Rodríguez, Ángel O. Vázquez-Esqueda, Jonathan S. Rodríguez-Sanabria, Juan Armendáriz-Borunda, Jorge Gutiérrez-Cuevas

“…The data were analyzed using one-way ANOVA followed by Tukey's post-hoc test in Graphpad Prism v10.0. Results: HFHC mice developed MASH, myocarditis and fibrosis (P≤0.05). …”
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Characterization of Netrin-1 and Its Receptors UNC5B and Neogenin-1 in a Rat Rotator Cuff Tear Model: Associations with Inflammatory Mediators and Neurite Extension by Kosuke Inoue, Kentaro Uchida, Mitsuyoshi Matsumoto, Ryo Tazawa, Etsuro Ohta, Akito Hattori, Tomonori Kenmoku, Yuka Ito, Yui Uekusa, Gen Inoue, Masashi Takaso

“…A rat supraspinatus tear model was employed to assess, in vivo, the expression of genes encoding netrin-1 (<i>Ntn1</i>) and its receptors (<i>Unc5b</i> and <i>Neo1</i>) at 0, 7, 14, 28, and 56 days post-injury (n = 10 per time point). Primary rat tenocytes isolated from rotator cuff tissue were treated in vitro with recombinant netrin-1, and transcriptional changes in genes encoding TNF-α (<i>Tnfa</i>), IL-6 (<i>Il6</i>), MMP-1 (<i>Mmp1</i>), and MMP-3 (<i>Mmp3</i>) were quantified by qRT-PCR. …”
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C-reactive protein-to-prealbumin ratio as prognostic marker in hemodialysis patients with Omicron infection by Quanchao Zhang, Caibao Lu, Zhifen Wu, Shaofa Wu, Lili Jiang, Han Wang, Jin He, Bingshuang Tang, Bingfeng Yang, Shengli Liao, Liao Wang, Hongwei Chen, Moqi Li, Wenchang He, Yiqin Wang, Jie Li, Jinghong Zhao, Ling Nie

“…Survival rate differences between higher and lower CP ratio groups were analyzed using the Kaplan-Meier method.Results From the total, 98 patients (11.6%) succumbed, with a majority (80/98) within a month post-infection. C-reactive protein, prealbumin, and CP ratio were all associated with all-cause mortality in the crude model. …”
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Does mean arterial pressure augmentation improve neurological recovery of blunt spinal cord injuries: an EAST multicenter trial by Jeffry Nahmias, Ryan Peter Dumas, Brian Daley, Dalier R Mederos, Bradley M Dennis, Michael Steven Farrell, Stephanie Scott, Gregory Schaefer, Asanthi Ratnasekera, Alison Smith, Scott Armen, Joshua Hill, Carlos H Palacio, Caitlin Anne Fitzgerald, Stephanie Doris, Claudia Alvarez, John D Berne, Lindsey Perea, Aimee LaRiccia, James Bardes, Bhairav Shah, Tanisha Kashikar, Erik Teicher, Jennifer Huber, Malia Eischen, H Akin Erol, Lauren Colom, Melissa Moncrief, William DeVoe, William Brigode, Melissa Linskey Dougherty, Emily Alberto, Stephen Gadomski, Salina Wydo, Jennifer Schweinsburg, M Chance Spalding

“…Patients were divided into two groups: neurological improvement and no improvement, based on their change in ASIA score from arrival to hospital discharge.Results A total of 19 centers contributed 222 patients of those, 164 had pre-ASIA and post-ASIA scores. The ASIA improvement group had 36 patients (22%). …”
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Frailty, Pitavastatin, and Major Adverse Cardiovascular Events Among People With HIV by Kristine M. Erlandson, MD, MS, Ariela R. Orkaby, MD, Triin Umbleja, MSc, Heather J. Ribaudo, PhD, Todd T. Brown, MD, PhD, Markella V. Zanni, MD, Marissa R. Diggs, AB, Sarah M. Chu, MSN, Kathleen V. Fitch, MSN, Carl J. Fichtenbaum, MD, Carlos Malvestutto, MD, MPH, Judith A. Aberg, MD, Gerald S. Bloomfield, MD, MPH, Judith S. Currier, MD, Karen T. Tashima, MD, Marcus Vinícius Guimarães de Lacerda, MD, PhD, Sonya L. Heath, MD, Michael T. Lu, MD, MPH, Alan Landay, PhD, George A. Kuchel, MD, Pamela S. Douglas, MD, Steven K. Grinspoon, MD

“…Methods: We conducted a post hoc analysis of the REPRIEVE trial, a randomized, blinded trial of pitavastatin 4 mg vs placebo. …”
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Predictive Value of R₂CHA₂DS₂-VA Score for 90-Day Functional Outcomes After Endovascular Thrombectomy in Acute Ischemic Stroke by Faruk Boyacı, Cetin Kursad Akpınar, Mustafa Kursat Sahin, Murat Akcay, Hasan Dogan, Mustafa Yenercag, Guney Erdogan, Berkant Ozturk, Yankı Boyacı, Orhan Ince

“…Higher baseline NIHSS scores were associated with unfavorable outcomes (OR = 1.201, 95%, CI: 1.014–1.422, <i>p</i> = 0.034), and this association remained significant for NIHSS scores measured 24 h post-EVT (OR = 1.467, 95%, CI: 1.230–1.748, <i>p</i> < 0.001). …”
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A first-in-human, prospective pilot trial of umbilical cord-derived mesenchymal stem cell eye drops therapy for patients with refractory non-Sjögren's and Sjögren's syndrome dry ey... by Di Zhang, Taige Chen, Qi Liang, Xuebing Feng, Jiaxuan Jiang, Zeying Chen, Yun Tang, Yiran Chu, Bin Wang, Kai Hu

“…No serious AEs were reported during the treatment and follow-up period. Post-treatment reductions in tear levels of IL-6 and IL-17A, along with an increase in MUC5AC, further confirmed the efficacy. …”
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Full lifecycle carbon emissions accounting and regional environmental impact assessment of typical open-pit coal mines by Mingqi LIU, Xiaoping ZHANG, Yu WANG, Zhipeng YANG, Xinhong YU, Agudamu HU, Guoqing YANG, Ying ZHU, Yingnan CAO, Wei LIU, Tianlong ZHENG, Yaoqiang HUO, Jianguo LIU

“…The results of the accounting process indicate that the annual carbon emission of open-pit coal mine is 1538178.60 tCO2e, and the carbon dioxide equivalent emission per 1 t of raw coal produced is 0.05 tCO2e, which mainly comes from methane fugitive emissions caused by coal mining and post-mine activities (accounting for 79.92%). In addition, carbon emissions from fossil fuel combustion account for 13.71% of the total carbon emissions; whereas emissions associated with electricity and water consumption represent the smallest proportion, at 6.37%. …”
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Impact of a specialized pediatric dysphagia rehabilitation program on caregiver quality of life and coping strategies by Pilar Ortiz Pérez, Inés Valero Arredondo, Encarnación Torcuato Rubio, Marta Herrador López, Andrés Rosa López, Pascual García-Herrera Taillefer, Víctor Manuel Navas-López

“…Caregivers of patients with greater neurological impairment, particularly those with GMFCS IV-V and using feeding tubes, were more likely to have higher post-intervention PedsQL-FIM scores. Conclusion: Our findings underscore the significant impact of dysphagia on caregiver QoL and the effectiveness of individualized rehabilitation programs in improving patient outcomes and mitigating caregiver burden. …”
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Ability and utility of the Physician Well-Being Index to identify distress among Chinese physicians by Zejun Li, Peng Pu, Min Wu, Xin Wang, Huixue Xu, Xiaoyu Zhang, Qijian Deng, Winson Fuzun Yang, Yueheng Liu, Qianjin Wang, Manyun Li, Yuzhu Hao, Li He, Yunfei Wang, Qiuxia Wu, Yi-Yuan Tang, Tieqiao Liu

“…Assuming a prevalence of 29.2% for low QOL, the PWBI could reduce the post-test probability to 6.9% or increase it to 70.8%. …”
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Inhibition of Farnesoid-x-receptor signaling during abdominal sepsis by dysbiosis exacerbates gut barrier dysfunction by Shuwen Qian, Zehua Su, Jiaqi Lin, Qianhao Hou, Xiaomei Wang, Yuling Li, Jieying Wang, Changchun Huang, Zetian Wang, Francisco Javier Cubero, Xiangrui Wang, Lijun Liao

“…Methods Expression levels of FXR and FGF15 in the liver and intestines, alongside assessments of gut barrier function, were evaluated in septic wild-type (WT) mice 24 h post-cecal ligation and puncture (CLP) surgery. Subsequently, the FXR agonist INT-747 was administered to explore the relationship between FXR activation and gut barrier function. …”
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