A Phase I Dose-Escalation Clinical Trial of Bronchoscopic Cryoimmunotherapy in Advanced-Stage NSCLC by Jun-Chieh J. Tsay, MD, MS, Antonio Velez, MD, Destiny Collazo, BS, Isaac Laniado, MD, Jamie Bessich, MD, Vivek Murthy, MD, Andrew DeMaio, MD, Samaan Rafeq, MD, Benjamin Kwok, MD, Fares Darawshy, MD, Ray Pillai, MD, Kendrew Wong, MD, Yonghua Li, MD, PhD, Rosemary Schluger, RN, Alena Lukovnikova, BS, Sofia Roldan, BS, Matt Blaisdell, BS, Fernanda Paz, Kelsey Krolikowski, BS, Katherine Gershner, MD, Yong Liu, PhD, Judy Gong, BA, Sara Borghi, PhD, Fang Zhou, MD, Aristotelis Tsirigos, PhD, Harvey Pass, MD, Leopoldo N. Segal, MD, MS, Daniel H. Sterman, MD

“…Safety was assessed by review of BCI-related complications, including grades 2 to 3 bleeding, pneumothorax requiring intervention, and National Cancer Institute Common Terminology Criteria for Adverse Events grade 3 to 5 adverse events. Pre- and post-BCI blood samples were collected to explore changes in the systemic immune profile. …”
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日本解決學力下降問題之政策分析： 以課綱修訂和全國學力測驗為主 The Policy Analysis to Solve Academic Decline in Japan– Course of Study and National Assessment of Academic Ability... by 李宜麟 Yi-Lin Lee, 楊思偉 Szu-Wei Yang

“…Japan’s education system thus faced a quality bottleneck, with a knowledge-heavy approach that struggled to meet the demands of a knowledge-based post-industrial economy. Mounting social issues, such as intense competition, school violence, absenteeism, student suicides, and juvenile crime, underscored the need for reform. …”
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應用智慧型家教系統於國小學童閱讀策略 教學之學習歷程研究 A Study on the Learning Process of Applying an Autotutoring System to Teach Reading Strategies to Elementary School Children... by 陳茹玲 Ju-Ling Chen, 曾厚強 Hou-Chiang Tseng, 連啟舜 Chi-Shun Lien, 蔡旻穎 Min-Ying Tsai, 宋曜廷 Yao-Ting Sung

“…The between-subject factor is reading ability (high vs. low), while the within-subject factor is test type (pre-test and post-test), with background knowledge as a covariate. …”
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Long-term efficacy and immunopersistence of an Escherichia coli-produced HPV-16/18 bivalent vaccine: an observational extension study following a randomised, double-blind Phase III... by Fanghui Zhao, Qi Chen, Chao Zhao, Lingling Nie, Shangying Hu, Jian Yin, Lingxian Qiu, Zhaofeng Bi, Jiali Quan, Yufei Li, Mingzhu Li, Xun Zhang, Qinjing Pan, Caihong Li, Lidong Ke, Xiaoli Liu, Fengxian Zheng, Cuihong Dai, Zhe Wang, Xuefeng Kuang, Xinhua Jia, Yingying Su, Shoujie Huang, Qiufen Zhang, Weijin Huang, Lihui Wei, Jun Zhang, Ting Wu, Youlin Qiao, Ningshao Xia

“…Here, we report data on the long-term efficacy and immunopersistence up to 10 years post-vaccination. Methods: In the Phase III clinical trial (NCT01735006), 7372 women were enrolled and randomly assigned to receive the HPV or control vaccine (hepatitis E vaccine). …”
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Invasive urodynamic investigations in the management of women with refractory overactive bladder symptoms: FUTURE, a superiority RCT and economic evaluation by Mohamed Abdel-Fattah, Christopher Chapple, Suzanne Breeman, David Cooper, Helen Bell-Gorrod, Preksha Kuppanda, Karen Guerrero, Simon Dixon, Nikki Cotterill, Karen Ward, Hashim Hashim, Ash Monga, Karen Brown, Marcus Drake, Andrew Gammie, Alyaa Mostafa, Rebecca Bruce, Victoria Bell, Christine Kennedy, Suzanne Evans, Graeme MacLennan, John Norrie

“…Data collection during follow-up Participant-reported outcomes were assessed by self-completed questionnaire at baseline and 3, 6 and 15 months post randomisation. An additional 24-month post-randomisation questionnaire was completed by participants whose treatment had been delayed by the COVID-19 pandemic. …”
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Clinical and cost-effectiveness of percutaneous nephrolithotomy, flexible ureterorenoscopy and extracorporeal shockwave lithotripsy for lower pole stones: the PUrE RCTs by Oliver Wiseman, Daron Smith, Kath Starr, Lorna Aucott, Rodolfo Hernández, Ruth Thomas, Steven MacLennan, Charles Terry Clark, Graeme MacLennan, Dawn McRae, Victoria Bell, Seonaidh Cotton, Zara Gall, Ben Turney, Samuel McClinton

“…Main outcome measures The primary outcome measure was health status ‘area under the curve’, measured weekly to 12 weeks post intervention with the EuroQol-5 Dimensions, five-level version. …”
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Serotonin 5-HT2A and 5-HT2C receptors differentially modulate the acquisition and expression of voluntary alcohol drinking in male mice by Sandy C. Simões, Livia N. Amorim, Yasmim A. Serra, Camila S. Abreu, Maria Clara E. Santana, João P. C. Leite, Carla M. Kaneto, Roberta C. A. Costa, Kaio R. Ferreira, Isabelle C. S. de Oliveira, Alexandre J. Oliveira-Lima, Agnieszka Sulima, Kenner C. Rice, Eduardo A. V. Marinho, Lais F. Berro, Lais F. Berro

“…On the other hand, while post-acquisition treatment with a 5-HT2A antagonist alone decreased alcohol intake and preference during re-exposure, co-administration of a 5-HT2C antagonist blocked these effects.DiscussionOur findings suggest that 5-HT2A and 5-HT2C receptors differentially modulate the acquisition and expression of voluntary alcohol drinking in mice.…”
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When gender matters: inequalities in health services utilization and risk factors monitoring after acute myocardial infarction by Irene López-Ferreruela, Irene López-Ferreruela, Antonio Gimeno-Miguel, Antonio Gimeno-Miguel, Clara Laguna-Berna, Clara Laguna-Berna, Sara Malo, Sara Malo, Sara Malo, Sara Castel-Feced, Sara Castel-Feced, María José Rabanaque, María José Rabanaque, María José Rabanaque, Isabel Aguilar-Palacio, Isabel Aguilar-Palacio, Isabel Aguilar-Palacio

“…In addition, socioeconomic status and place of residence played a role in health services utilization differences.ConclusionsGender inequalities are still present in post-AMI care and CVRF management, with women being more likely to receive less adequate treatment and management. …”
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Caregiver feeding practices for infants and toddlers and their eating behaviors in Singapore by Phaik Ling Quah, Phaik Ling Quah, Daniel Wei Keong Chan, Daniel Wei Keong Chan, Daniel Wei Keong Chan, See Ling Loy, See Ling Loy, Chengsi Ong, Chengsi Ong, Chai-Hoon Nowel Tan, Michael Yong Hwa Chia, Terence Buan Kiong Chua, Fabian Yap, Fabian Yap, Fabian Yap, Mei Chien Chua, Mei Chien Chua, Mei Chien Chua, Kok Hian Tan, Kok Hian Tan

“…Older children (13– < 36 months) also more frequently required special mealtime settings (36.6%), viewed screens during meals (29.9%), and were less likely to be offered post-midnight meals nightly (22.6% compared to infants; 70.3%; 0–< 13 months; p < 0.05).ConclusionThese findings underscore the need for culturally tailored educational interventions to improve suboptimal feeding practices in children under three in Singapore’s multiethnic population.…”
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The safety of combining Endostar with concurrent chemoradiotherapy for the treatment of locally advanced cervical cancer and the evaluation of its anti-angiogenic effects via trans... by Fang Wu, Fang Wu, Zhouxue Lu, Zhouxue Lu, Jinting Que, Shanshan Ma, Shanshan Ma, Li Jiang, Li Jiang, Xiaobi Tang, Xiaobi Tang, Chengshan Zheng, Chengshan Zheng, Li Zhou, Li Zhou, Qiufeng Huang, Qiufeng Huang, Yong Zhang, Yong Zhang

“…In the CRT+E group, VM rates, TTP, and MTT significantly differed at three time points (with P values of 0.003, 0.002, and P<0.001, respectively), whereas the CRT group showed no significant changes (all P>0.05). Post-radiotherapy, statistically significant differences emerged between the CRT+E and CRT groups for VM rates (P = 0.027), MTT (P = 0.027), and TTP (P < 0.001), while PI showed no significant difference (65.67 ± 36.53 vs. 74.69 ± 61.21, P = 0.598).ConclusionThe combination of Endostar with CCRT for locally advanced cervical cancer (LACC) demonstrated favorable safety and tolerability. …”
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Characterization of full-length long noncoding RNAs and identification of virus-responsive lncRNAs in Sogatella furcifera by Yawen Ban, Yawen Ban, Ting Cui, Ting Cui, Lifei Zhao, Lifei Zhao, Xue Li, Xue Li, Qing Bai, Qing Bai, Qingfa Wu, Qingfa Wu

“…., 93 transcripts between 0 and 72 h post-oviposition) and molting (e.g., 16 in pre-ecdysis), while sex-biased expression patterns emerged after 24 h. …”
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Ten-Year Evaluation of Ventilator-Associated Pneumonia (VAP) According to Initial Empiric Treatment: A Retrospective Analysis Using Real-World Data by Alejandro Rodríguez, Julen Berrueta, Carolina Páez, Ronny Huertas, Marco Marotta, Laura Claverias, Josep Gómez, Sandra Trefler, Frederic F. Gómez Bertomeu, María Dolores Guerrero-Torres, Sergio Pardo-Granell, Ester Picó-Plana, Alicia Selles-Sánchez, Francisco Javier Candel, Ignacio Martín-Loeches, María Bodí

“…The population was divided into three periods: (P1) from 2014 to 2018 (pre-COVID-19); (P2) from 2019 to 2021 (COVID-19); and (P3) from 2022 to 2024 (post-COVID-19). Binary logistic regression was used to identify which variables were independently associated with ICU mortality. …”
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Genetic variants in immune mediators as potential molecular biomarkers for oral cancer evaluation: Insights from a systematic revaluation by computational analyses and Bayesian app... by Juliana Campos Botelho, Samuel Arcebispo Brasileiro, André Victor Oliveira Monteiro, Alessandro Luiz Araújo Bentes Leal, Naum Neves da Costa dos Santos, Gabrielly Ribeiro Alves, Reyce Santos Koga, Haline Alves da Silva, José Rogério Souza Monteiro, Denis Vieira Gomes Ferreira, Adenilson Leão Pereira, Ana Carolina Alves de Oliveira, Márcia Socorro Silva Lima Duarte, Felipe Rodolfo Pereira da Silva

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Creatine monohydrate versus creatine hydrochloride on strength and body composition in elite team-sport athletes: A placebo-controlled randomized clinical trial comparing low dosag... by Daniel Londoño-Velásquez, Yuliana Zuluaga-Narváez, Luis Rojas-Posada, Maximiliano Kammerer-López, Óscar M. Cardona-Arenas, Olga L. Quiroz-Bastidas, Mario A. Quintero-Velásquez, Andrés Rojas-Jaramillo, Richard B. Kreider, Diego A. Bonilla

“…All groups followed an 8-week supplementation protocol with standardized body composition and performance tests assessed pre- and post-intervention. The isokinetic strengths and peak torque of the external and internal rotation muscle strengths of the bilateral shoulders were measured using a Humac Norm isokinetic dynamometer (Computer Sports Medicine Inc., Stoughton, MA, USA). …”
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Robot-assisted augmented reality navigation for osteotomy and personalized guide-plate in mandibular reconstruction: a preclinical study by Xing Li, Qing Sun, Long Shao, Zhihui Zhu, Ruiqi Zhao, Fanhao Meng, Zehua Zhao, Kedi Jihu, Xiting Xiang, Tianyu Fu, Danni Ai, Minghao Huo, Xiaojun Wang, Jian Yang, Tao Zhang

“…Abstract Background Oral and maxillofacial tumors, particularly those requiring mandibular reconstruction, present significant clinical challenges due to the complexities involved in achieving precise surgical outcomes and ensuring post-operative stability. Traditional methods for mandibular reconstruction, such as freehand bending of titanium plates, often result in errors in osteotomy and reconstruction, compromising both the precision and stability of the procedure. …”
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Assessment of regional variation in the management of heart failure with a preserved ejection fraction between the Russian Federation and the European Union: the results of the int... by Nathan Mewton, Clara Saldarriaga, Irina Dyachuk, Han Naung Tun, Ilya Giverts, Anastasia Shchendrygina, Natalia Cherkasova, Aleksandr Suvorov, Irina Komarova, Nadezhda Mukhina, Violetta Sitnikova, Elena Kuzheleva, Soloveva Anzhela, Nikolay Novitsky, Andrey Baglikov, Alina Bibarsova, Anastasia Rogova, Viktoria Lezhneva, Ekaterina Stepanenko, Sydney Goldfeder de Gracia, Vergun Marija, Yu V Mareev, Galib Imanov

“…We aimed to assess a physician-reported HFpEF management in the Russian Federation (RF) and a variation in the diagnosis and treatment of HFpEF between the RF and the European Union (EU).Design/settings It is a post hoc analysis of an academic web-based international HFpEF designed as a cross-sectional survey and conducted between May 2023 and July 2023.Participants Medical doctors who work in the fields of cardiology and general medicine.Results Among 1460 medical doctors who completed the study were 166 Russian and 646 European specialists. …”
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An Evaluation of the Safety, Immunogenicity, and Protective Efficacy of a Combined Diphtheria–Tetanus–Acellular Pertussis, <i>Haemophilus influenzae</i> Type b, and ACYW135 Meningo... by Xiuwen Sui, Zhujun Shao, Yuanyuan Ji, Hairui Wang, Qingfu Xu, Bochao Wei, Zhuojun Duan, Chang Wang, Ying Yang, Jiayu Zhao, Tao Zhu

“…Orbital blood was collected 14 days post-immunization to measure IgG titers against pertussis, diphtheria, tetanus, Hib, and meningococcal antigens. …”
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Timing of mechanical ventilation and its association with in-hospital outcomes in patients with cardiogenic shock following ST-elevation myocardial infarction: a multicentre observ... by Waleed AlHarbi, Mohammed Qutub, Prashanth Panduranga, Jassim Al Suwaidi, Wael Al Mahmeed, Hassan Khan, Sultan Alobaikan, Abdullah Alenezi, Mohammed AlShehri, Abdulrahman Arabi, Amin Daoulah, Awad Abdulrazaq AlQahtani, Zubair Shahid, Ahmed Jamjoom, Ahmed Elmahrouk, Abeer Said Mohamed Al Rawahi, Gladsy Selva Livingston, Ala’a Al-deen Tayseer Mousa, Hatem Aloui, Mubarak Aldossari, Nooraldaem Yousif, Husam Noor, Rajesh Rajan, Amr A Arafat, Omar Kanbr, Alsayed Almarghany, Mokhtar Kahin, Abdulwali Abohasan, Faisal Al Nasser, Badr Alzahrani, Alaa Aldossari, Taher Hassan, Mohammed Ali Balghith, Khalid Alshali, Amir Lotfi

“…Increased delay in MV was associated with a higher mortality risk during the first 60 min post-diagnosis, beyond which the risk plateaued. …”
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Placental epigenetic clocks derived from crowdsourcing: Implications for the study of accelerated aging in obstetrics by Gaurav Bhatti, Herdiantri Sufriyana, Roberto Romero, Tushar Patel, Fasil Tekola-Ayele, Ibrahim Alsaggaf, Nardhy Gomez-Lopez, Emily C.Y. Su, Bogdan Done, Steve Hoffmann, Alena van Bömmel, Cen Wan, Jake Albrecht, Charles Novak, Tinnakorn Chaiworapongsa, Marina Sirota, Nima Aghaeepour, Gustavo Stolovitzky, David R. Bryant, Adi L. Tarca

“…Models developed during and post-challenge compared favorably to existing models in terms of accuracy, yet they were better calibrated throughout gestation and indicated that reports of accelerated epigenetic aging in preterm preeclampsia were likely due to modeling artifacts. …”
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Intranasal Administration of Cold-Adapted Live-Attenuated Eurasian Avian-like H1N1 Vaccine Candidate Confers Protection Against Different-Lineage H1N1 Viruses in Mice by Qiu Zhong, Zuchen Song, Fei Meng, Yanwen Wang, Yijie Zhang, Zijian Feng, Yali Zhang, Yujia Zhai, Yan Chen, Chuanling Qiao, Hualan Chen, Huanliang Yang

“…In mice, it was attenuated, with viral titers in the nasal turbinates and lungs reduced 1000–10,000-fold compared to the wild-type strain, and it cleared by day 5 post infection. Intranasal immunization elicited strong cross-reactive immune responses. …”
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