POSSIBILITIES OF SURGICAL CORRECTION OF INTERNAL CAROTID ARTERY THROMBOSIS IN PATIENTS WITH ACUTE ISCHEMIC STROKE by V. A. Lukyanchikov, E. V. Udodov, N. A. Polunina, A. S. Tokarev, V. A. Dalibaldyan, O. Y. Nakhabin, E. V. Grigoryeva, Y. I. Shatokhina, N. Y. Kudryashova, G. K. Guseynova, E. A. Khodykin, V. G. Dashyan, V. L. Lemenyov, V. V. Krylov

“…The improvement of functional deficit in the early post-operative period was 4.85 scores according to NIHSS, 1.2 scores according to Rankin scale and 2.3 scores according to Rivermead mobility index. …”
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Ponatinib/blinatumomab for relapsed Philadelphia chromosome-positive leukemia as a bridge to allogeneic transplantation by Yasutaka Sadaga, Daisuke Watanabe, Yuho Najima, Daichi Sadato, Chizuko Hirama, Kana Kato, Kaori Kondo, Chika Kato, Satoshi Sakai, Yasuhiro Kambara, Masashi Shimabukuro, Atsushi Jinguji, Naoki Shingai, Kyoko Haraguchi, Takashi Toya, Hiroaki Shimizu, Takeshi Kobayashi, Yoshiki Okuyama, Yuka Harada, Daisuke Mizuchi, Noriko Doki

“…Case 2: A 39-year-old man with Ph + ALL achieved hematological CR (hCR) with one cycle of inotuzumab ozogamicin and mCR with Pona/BLIN after post-transplant relapse but developed extramedullary relapse with BCR::ABL-negative clone and underwent a second allo-HCT in non-remission. …”
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Long-Term Effect of Semaglutide on the Glomerular Filtration Rate Slope in High-Risk Patients with Diabetic Nephropathy: Analysis in Real-World Clinical Practice by Enrique Luna, Álvaro Álvarez, Jorge Rodriguez-Sabiñón, Juan Villa, Teresa Giraldo, Maria Victoria Martín, Eva Vázquez, Noemi Fernández, Belén Ruiz, Guadalupe Garcia-Pino, Coral Martínez, Lilia Azevedo, Rosa María Diaz, Nicolas Roberto Robles, Guillermo Gervasini

“…<b>Results:</b> In the whole study population, the median eGFR slope significantly improved from −3.29 (IQR 7.54) to −0.79 (IQR 6.01) mL/min/1.73 m²/year post-treatment (<i>p</i> < 0.001). Multiple linear regression showed a hazard ratio for the effect of semaglutide on the eGFR slope of 4.06 (2.43–5.68), <i>p</i> < 0.001. …”
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Effects of Xenon on Neuroinflammatory Markers: a Prospective Pilot Study by A. I. Shpichko, R. A. Cherpakov, A. K. Shabanov, A. K. Evseev, I. V. Goroncharovskaya, O. A. Grebenchikov

“…Using laboratory equipment, we evaluated the effect of half-hour daily inhalations of a 30% air mixture with 30% xenon for 7 days on the level of markers of neuronal damage and regeneration of nervous tissue.AIM To study the effect of inhalation of an air-xenon mixture on the dynamics of markers of neuroinflammation and restoration of nervous tissue in patients after traumatic brain injury (TBI).MATERIAL AND METHODS We conducted a prospective randomized clinical trial evaluating the effect of inhaled xenon for sedation on the level of consciousness and spasticity in patients with prolonged post-coma impairment of consciousness. Patients were randomized into 2 equal groups. …”
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Diagnostic accuracy of CADe-assisted reading versus clinician reading for polyp detection in colon capsule endoscopy: a multicentre prospective study by Ian Io Lei, Nicolas Parsons, Cristiana Huhulea, Hagen Wenzek, Elizabeth White, Pablo Laiz, Charlie Noble, Alexander Robertson, Anastasios Koulaouzidis, Ramesh Arasaradnam

“…Participants (prospectively and retrospectively enrolled) included those ≥18 years referred for CCE under the urgent cancer pathway or for post-polypectomy surveillance. CCEs were performed using PillCam™ COLON 2 and analysed using AiSPEED™. …”
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Neuroprotective Effect of Methylene Blue in a Rat Model of Traumatic Optic Neuropathy by Nicolás S. Ciranna, Ronan Nakamura, Rafael Peláez, Álvaro Pérez-Sala, Patricia Sarrión, Juan C. Fernández, Alejandra Paganelli, Agustín P. Aranalde, Ulises P. Ruiz, Juan J. López-Costa, César F. Loidl, Alfredo Martínez, Manuel Rey-Funes

“…Furthermore, the number of cell nuclei in the ganglion cell layer (GCL) was recorded in post mortem histological sections. <b>Results</b>: IONC induced very significant reductions in electrophysiological parameters including scotopic a- and b-wave, OPs, photopic b-wave, PhNR amplitude and N2 amplitude. …”
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Identification of <i>Peroxiredoxin</i> (<i>PRX</i>) Genes from Pepper Fruits: Involvement in Ripening and Modulation by Nitric Oxide (NO) by Fátima Ramírez-Mellado, Salvador González-Gordo, José M. Palma, Francisco J. Corpas

“…These findings indicate the diversification of <i>PRX</i> genes in pepper fruits and how some of them are regulated by NO, either at the level of gene expression or through protein <i>S</i>-nitrosation, a NO-promoting post-translational modification (PTM). Given that Prxs play a crucial role in stress tolerance, these data suggest that Prxs are vital components of the antioxidant system during pepper fruit ripening, an event that is accompanied by physiological nitro-oxidative stress.…”
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Applying neural network algorithms to ascertain reported experiences of violence in routine mental healthcare records and distributions of reports by diagnosis by Ava J. C. Mason, Vishal Bhavsar, Vishal Bhavsar, Riley Botelle, David Chandran, Lifang Li, Aurelie Mascio, Jyoti Sanyal, Giouliana Kadra-Scalzo, Angus Roberts, Marcus Williams, Marcus Williams, Robert Stewart, Robert Stewart

“…Descriptive and regression analyses were conducted to investigate variation by age, sex, ethnic group, and diagnostic category (ICD-10 F chapter sub-headings plus post-traumatic stress disorder (PTSD) as a specific condition).ResultsPatients with a mood disorder (adjusted odds ratio 1.63, 1.55-1.72), personality disorder (4.03, 3.65-4.45), schizophrenia spectrum disorder (1.84, 1.74-1.95) or PTSD (2.36, 2.08-2.69) had a significantly increased likelihood of victimisation compared to those with other mental health diagnoses. …”
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Transcatheter edge‐to‐edge repair of atrial secondary mitral regurgitation positively influences atrial remodelling by Aniela Petrescu, Martin Geyer, Julian Andres Gelves Meza, Omar Hahad, Tobias Ruf, Valeria Maria deLuca, Lukas Hobohm, Theresa Gößler, Felix Kreidel, Philipp Lurz, Ralph Stephan vonBardeleben

“…These patients were more likely to have lower post‐interventional mitral valve mean pressure gradients (2.2 ± 0.8 mmHg vs. 2.8 ± 1.1 mmHg, P = 0.02) and lower BNP at discharge and at 1 month follow‐up [319 (197.8 to 526) vs. 560 (279.3 to 929), P = 0.07, and 287.5 (191.3 to 386.3) vs. 506.5 (223.3 to 935.5), P = 0.06, respectively]. …”
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Decoding the immune microenvironment of secondary chronic myelomonocytic leukemia due to diffuse large B-cell lymphoma with CD19 CAR-T failure by single-cell RNA-sequencing by Xudong Li, Hong Huang, Fang Wang, Mengjia Li, Binglei Zhang, Jianxiang Shi, Yuke Liu, Mengya Gao, Mingxia Sun, Haixia Cao, Danfeng Zhang, Na Shen, Weijie Cao, Zhilei Bian, Haizhou Xing, Wei Li, Linping Xu, Shiyu Zuo, Yongping Song, Tingting Yang, Xiuyuan Hao

“…This study aims to characterize the immune microenvironment of a newly identified secondary tumor post-CAR-T therapy, to clarify its pathogenesis and potential therapeutic targets. …”
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Hair salons as a promising space to provide HIV and sexual and reproductive health services for young women in Lesotho: a citizen scientist mixed-methods study by Malena Chiaborelli, Mamaswatsi Kopeka, Pontšo Sekhesa, Madeleine Sehrt, Tsepang Mohloanyane, Tala Ballouz, Dominik Menges, Jennifer A. Brown, Jennifer M. Belus, Felix Gerber, Fabian Raeber, Andréa Williams, David Jackson-Perry, Meri Hyöky, Donaldson F. Conserve, Karen Hampanda, Alain Amstutz, and the Hair SALON Citizen Scientist Working Group

“…Among stylists, 93.6% were comfortable offering oral HIV self-testing (HIVST), 92.4% pre-exposure prophylaxis (PrEP), and 91.7% post-exposure prophylaxis (PEP). Among clients, 93.5%, 88.3%, and 86.4% felt comfortable receiving the above-mentioned services, respectively. …”
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Pre-Existing Anti-Inflammatory Immune Conditions Influence Early Antibody Avidity and Isotype Profile Following Comirnaty^® Vaccination in Mice by Mariangeles Castillo, María C. Miraglia, Florencia C. Mansilla, Cecilia P. Randazzo, Leticia V. Bentancor, Teresa Freire, Alejandra V. Capozzo

“…Cytokine production and antibody responses were assessed at 0, 14, and 21 days post-vaccination (dpv) through serum analysis and ex vivo splenocyte stimulation with the SARS-CoV-2 receptor-binding domain (RBD) or LPS. …”
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Subcutaneous checkpoint inhibition is equivalent to systemic delivery when combined with nelitolimod delivered via pressure-enabled drug delivery for depletion of intrahepatic myel... by Diwakar Davar, Yujia Liu, Jason Laporte, Prajna Guha, Steven C Katz, Chandra C Ghosh, Lauren Cournoyer, Alizee Ballarin, Ilan B Layman, Molly Morrissey, Kayla Fraser, Shriya Perati, Bryan F Cox, Evgeny Yakirevich, Diana O Treaba, Timothy D Murtha

“…Tissues were harvested on Day 3 (D3) or Day 10 (D10) post-PEDD to enrich CD45+ cells and were analyzed via NanoString targeted transcriptomics (D3) or flow cytometry (FC, D10) to interrogate immune cell populations (D10). …”
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Reviewer Acknowledgements: Bridging Science, Care, and Community – GHMJ (Global Health Management Journal), Volume 8, Number 2, 2025 by GHMJ (Global Health Management Journal)

“…., 2025), while orthopedic data from Indonesia compares healing outcomes in different types of tibial fractures post-ORIF (Sakinah et al., 2025), offering evidence to improve trauma recovery. …”
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Effect of conditioned stimuli-triggered memory retrieval-extinction in patients with methamphetamine use disorder by Jing-Li Yue, Ru-Jia Wang, Si-Jing Chen, Xiao Lin, Qing Fang, Xiao-Jie Guo, Ye-Kun Sun, Kai Yuan, Yan-Ping Bao, Jie Shi, Yan-Xue Xue, Ping Wu, Lin Lu

“…Self-report cue-induced craving for METH, salivary cortisol and sympathetic responses were measured at baseline (day 1), post intervention (day 4) and two follow-up timepoints (days 34 and 184), with cue-induced craving and salivary cortisol as primary outcomes. …”
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Features of short-term heart rate variability in internally displaced people with type 2 diabetes mellitus by V.A. Serhiyenko, V.B. Sehin, V.I. Pankiv, A.A. Serhiyenko

“…Anxiety and depression inherent in IDP predict slow recovery and increase the risk of post-traumatic stress disorder and mortality. Dysfunction of the autonomic nervous system is often combined with type 2 diabetes mellitus (T2DM) and cardiac autonomic neuropathy (CAN). …”
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Maternal hepatitis B e antigen can be an indicator for antiviral prophylaxis of perinatal transmission of hepatitis B virus by Ying Lu, Yarong Song, Xiangjun Zhai, Fengcai Zhu, Jianxun Liu, Zhanjun Chang, Yi Li, Yiwei Xiao, Lili Li, Minmin Liu, Jia Liu, Zhongping Duan, Huaibin Zou, Hui Zhuang, Jie Wang, Jie Li

“…All the newborns were given standard passive–active immunoprophylaxis within 12 h after birth, and post-vaccination serologic testing was performed at 7 (±7d) months of age. …”
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Prognostic value of non-reactive burst suppression EEG pattern associated to early neonatal seizures Valor prognóstico do EEG com padrão de surto-supressão não reativo associado a... by Magda Lahorgue Nunes, Maria Margarida Giraldes, Ana Paula Pinho, Jaderson Costa da Costa

“…It is clearly associated with elevated morbidity and mortality and to the development of post-neonatal epilepsy.<br>RESUMO Convulsões representam o evento neurológico mais freqüente no período neonatal e a etiologia das crises parece ser o aspecto clínico mais associado ao prognóstico a longo prazo. …”
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Integrated Analysis of Differential Expression Profiles of miRNA and mRNA in Gonads of <i>Scatophagus argus</i> Provides New Insights into Sexually Biased Gene Expression by Yaling Lei, Kaizhi Jiao, Yuanqing Huang, Yuwei Wu, Gang Shi, Hongjuan Shi, Huapu Chen, Siping Deng, Guangli Li, Wenjing Tao, Dongneng Jiang

“…MicroRNAs (miRNAs), key post-transcriptional regulators, are known to modulate critical pathways governing sex determination and differentiation across several vertebrates. …”
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Actividad inmunopotenciadora de proteoliposomas de muy pequeño tamaño como componente activo de una vacuna peptídica para la terapia del cáncer de próstata by Franklin Fuentes Aguilar, Jesús Junco Barranco, Lesvia Calzada Aguilera, Eddy Bover Fuentes, Roberto Basulto Baker, Eulogio Pimentel Vázquez, María Dolores Castro Santana, Yovisleidys Lopez Saes, Niurka Arteaga Moré

“…Resultados: el análisis de la seroconversión anti GnRH reveló que el grupo inmunizado con el péptido GnRHm1-TT + VSSP desarrolló una potente respuesta inmune anti GnRH, que resultó significativamente superior a la alcanzada con el péptido emulsificado solo en Montanide. El análisis post-mortem  de los órganos diana denotó una drástica disminución de su peso y tamaño respecto al grupo control. …”
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