Extracorporeal carbon dioxide removal compared to ventilation alone in patients with acute hypoxaemic respiratory failure: cost-utility analysis of the REST RCT by Ashley Agus, James J. McNamee, Colette Jackson, Danny F. McAuley

“…The cost per quality-adjusted life-year was estimated at 12 months post randomisation. Results Mean EuroQol-5 Dimensions, five-level version utility scores were low and similar for each group. …”
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Freehand ventricular catheter placement in ventriculoperitoneal shunt surgery is associated with higher rates of proximal catheter failure compared to image guidance by Nikhil Sharma, Jeffery R. Head, Regan M. Shanahan, Shovan Bhatia, Michael R. Kann, Sydney Scanlon, Amogh Vellore, Michael Raver, Hussam Abou-Al-Shaar, Nicolas M. Kass, Fritz Steuer, Lucille Cheng, Stephen P. Canton, Arka N. Mallela, Peter C. Gerszten, Edward G. Andrews

“…VC revision is associated with inaccurate placement and highly inaccurate VCs (>2 cm TTF) are more likely to require revision in the immediate post-operative period.…”
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Influence of body mass index on cardiovascular risk in rheumatoid arthritis varies across anti-citrullinated protein antibody status and biologic use by George Athanasios Karpouzas, Anne Grete Semb, Ellen-Margrethe Hauge, Dionicio Angel Galarza-Delgado, Miguel A González-Gay, Solbritt Rantapää-Dahlqvist, Petros P Sfikakis, Virginia Pascual-Ramos, Irazú Contreras-Yáñez, Carol Hitchon, Elena Myasoedova, Durga Prasanna Misra, Iris J Colunga-Pedraza, Alfonso Corrales, George Kitas, José Ramón Azpiri-lópez, Sarah R Ormseth, Patrick Dessein, Piet Leonardus Cornelis Maria van Riel, Durez Patrick, Brian Bridal Logstrup

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Transcatheter Aortic Valve Replacement in Patients With Small Aortic Annulus: An Observational Study by Hanad Bashir, MD, Christian W. Schmidt, MS, Kofi Ansah, MD, Gustavo Mendez-Hirata, MD, Geoffrey A. Answini, MD, J. Michael Smith, MD, Saad Hasan, MD, Jeffrey Griffin, MD, Robert Dowling, MD, Dean J. Kereiakes, MD, Puvi Seshiah, MD, Joseph Choo, MD, Zaid Alirhayim, MD, Santiago Garcia, MD

“…Comorbidities and risk profiles were well balanced between groups. At 30 days post-transcatheter aortic valve replacement, SEV had lower aortic valve mean gradients (8 mmHg [6, 11] vs. …”
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Hepatic resection for recurrent hepatocellular carcinoma during pregnancy: a case report by Takashi Maeda, Daisuke Imai, Huanlin Wang, Kyohei Yugawa, Nao Kinjo, Koto Kawata, Shinichiro Ikeda, Keitaro Edahiro, Kazuki Takeishi, Tomohiro Iguchi, Hiroto Kayashima, Noboru Harada, Mizuki Ninomiya, Shohei Yamaguchi, Kozo Konishi, Shinichi Tsutsui, Hiroyuki Matsuda

“…Case presentation A 36-year-old woman underwent laparoscopic partial hepatectomy for HCC (20 mm in diameter) in segment 5 of the liver during follow-up after being determined as a hepatitis B virus carrier two and a half years ago. Post-surgery follow-up abdominal ultrasonography revealed a 36-mm tumor in segment 7 of the liver. …”
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Efficacy and mechanism of action of cipargamin as an antibabesial drug candidate by Hang Li, Shengwei Ji, Nanang R Ariefta, Eloiza May S Galon, Shimaa AES El-Sayed, Thom Do, Lijun Jia, Miako Sakaguchi, Masahito Asada, Yoshifumi Nishikawa, Xin Qin, Mingming Liu, Xuenan Xuan

“…Combining CIP with TQ effectively eliminated B. microti infection in SCID mice with no relapse, and parasite DNA was not detected by qPCR within 90 days post-infection. Our findings reveal the efficacy of CIP as an antibabesial agent, its limitations as a monotherapy due to resistance development, and the potential of combination therapy with TQ to overcome said resistance and achieve complete parasite clearance.…”
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Induction of reproduction of fish Anasa Nomorhampus sp. endemic Palu, Central Sulawesi orally through hormon bioencapsulation use Chironomus sp. by Dinda Wahyu Rezki, Agus Oman Sudrajat, Dinar Tri Soelistyowati, Odang Carman

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Staphylococcus epidermidis uses the SrrAB regulatory system to modulate oxidative stress and intracellular survival in mouse macrophage cell line Ana-1 by Chunjing Zhao, Zongkai Bai, Xiaoting Chen, Shuangjie Shang, Baitong Shen, Li Bai, Di Qu, Yang Wu, Youcong Wu

“…Compared to SE1457, the viable cell counts of the ∆srrAB mutant significantly decreased in the post-stationary phase culture, coinciding with a sharp increase in reactive oxidative species (ROS) accumulation. …”
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Effects of Dietary Supplementation with Extruded Linseed on Growth Performance and Meat Quality of Young Holstein Bulls by Stella Dokou, Maria Eleni Filippitzi, Anestis Tsitsos, Vasiliki Papanikolopoulou, Stergios Priskas, Vangelis Economou, Eleftherios Bonos, Ilias Giannenas, Georgios Arsenos

“…Adding extruded linseed did not result in differences in meat quality traits (<i>p</i> > 0.05), except for meat pH, which was significantly decreased in the LS group (<i>p</i> < 0.05), indicating more efficient post-mortem glycolysis. Finally, the inclusion of extruded linseed resulted in higher levels of α-linolenic acid in the meat (<i>p</i> < 0.05). …”
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Epigenomic preconditioning of peripheral monocytes determines their transcriptional response to the tumor microenvironment by Máté Kiss, Laszlo Halasz, Eva Hadadi, Wilhelm K. Berger, Petros Tzerpos, Szilard Poliska, Daliya Kancheva, Aurélie Gabriel, Romina Mora Barthelmess, Ayla Debraekeleer, Jan Brughmans, Yvon Elkrim, Liesbet Martens, Yvan Saeys, Bence Daniel, Zsolt Czimmerer, Damya Laoui, Laszlo Nagy, Jo A. Van Ginderachter

“…Epigenomic features, such as post-translational modification of histones and chromatin accessibility, are key determinants of transcription factor binding and thereby play an important role in controlling transcriptional responses to the tissue environment. …”
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Use of mulberry leaf meal in fattening diets for rabbits: a comprehensive approach from animals to consumers by I. Biasato, M. Renna, G.L. Cerutti, F. Maccagno, C. Lussiana, I. Ferrocino, S. Bellezza Oddon, C. Caimi, G. Xiccato, A. Trocino, A. Pauciullo, A. Brugiapaglia, L. Gasco

“…A total of 480 crossbred rabbits weaned at 45 days of age were allotted to two dietary treatments (30 replicate cages/treatment, 8 rabbits/cage). During the post-weaning phase (45–63 days of age), both groups were fed the same commercial feed; during the fattening phase (64–88 days of age), two isonitrogenous, isolipidic and isoenergetic diets were fed: (1) control diet (C) and (2) MLM diet (10% MLM). …”
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A dual-drug strategy to enhance the function of cryopreserved ovaries by promoting revascularization and inhibiting follicle over-activation by Lingyu Li, Jian Yang, Longzhong Jia, Jing Liang, Kaixin Cheng, Xuebing Yang, Lu Mu, Ge Wang, Kaiying Geng, Qiuxian Hu, Xueqiang Xu, Zhen Li, Guoliang Xia, Ting Guo, Jiawei Zhang, Yan Zhang, Hua Zhang

“…Grafts were collected at 3, 7, 14, and 120 days post-transplantation, with measurements of vascular density, tip cell density, follicle activation, and remaining follicles. …”
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<i>Plasmodium falciparum</i> Subtilisin-like Domain-Containing Protein (PfSDP), a Cross-Stage Antigen, Elicits Short-Lived Antibody Response Following Natural Infection with <i>Pla... by Jonas A. Kengne-Ouafo, Collins M. Morang’a, Nancy K. Nyakoe, Daniel Dosoo, Richmond Tackie, Joe K. Mutungi, Saikou Y. Bah, Lucas N. Amenga-Etego, Britta Urban, Gordon A. Awandare, Bismarck Dinko, Yaw Aniweh

“…We also discovered that PfSDP protein is immunogenic in children from different endemic areas with antibody levels increasing from acute infection to day 7 post-treatment, followed by a gradual decay. The limited effect of antibodies on erythrocyte invasion could imply that it might be more involved in other processes in the development of the parasite.…”
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The impact of early vs. delayed surgery on outcomes in cervical spinal cord injury without fracture or dislocation by Sirui Xiao, Hui Yan, Beixi Bao, Yuxuan Wu, Xiaokang Cheng, Chunyang Xu, Jiaguang Tang

“…Intergroup comparisons were also made regarding hospitalization duration, time to return to work post-discharge, in-hospital treatment costs, and patient satisfaction 2 years after treatment.ResultsMSCC showed a significant positive correlation with postoperative neurological recovery metrics including RR, JOA, AMS, and AMSRR, while its correlation with ASSRR was weaker. …”
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The impact of opioid analgesics with concomitant antipsychotic use on pain modulation and management in internal medicine: a cross-sequential study protocol by Nicola Grignoli, Nicola Grignoli, Nicola Grignoli, Simone Livoti, Simone Livoti, Angela Greco, Angela Greco, Michela Pironi, Roberta Noseda, Alessandro Ceschi, Alessandro Ceschi, Alessandro Ceschi, Alessandro Ceschi, Maria Luisa Garo, Luca Gabutti, Luca Gabutti

“…This integration allows for a comprehensive examination of pain modulation and management among internal medicine recipients of concomitant opioids and antipsychotic treatment, spanning both hospitalization and post-discharge periods. By leveraging EHR data, the study protocol ensures reliability and standardization while minimizing missing information. …”
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Impact of CYP3A5 1* and 3* single nucleotide variants on tacrolimus pharmacokinetics and graft rejection risk in pediatric kidney transplant patients by Lesly Yanira Xajil-Ramos, Lesly Yanira Xajil-Ramos, Lesly Yanira Xajil-Ramos, Lesly Yanira Xajil-Ramos, Jesús Alonso Gándara-Mireles, Jesús Alonso Gándara-Mireles, Rodrigo José Vargas Rosales, Rodrigo José Vargas Rosales, Rodrigo José Vargas Rosales, Oscar Kevin Sánchez García, Andrea Mariela Ruano Toledo, Amy Kateleen Aldana de la Cruz, Ismael Lares-Asseff, Ismael Lares-Asseff, Leslie Patrón-Romero, Horacio Almanza-Reyes, Randall Lou-Meda

“…The CYP3A5 *3/*3 genotype was most prevalent (66.7%), followed by *1/*3 (26.7%) and *1/*1 (6.7%). During the 6-month post-transplant period, CYP3A5 expressers required significantly higher tacrolimus doses to achieve target trough levels. …”
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Abstract 067: Outcomes for large vessel occlusion patients with severe baseline disability with and without endovascular thrombectomy by Amine J. Awad, Michael J. Young, Alexander Andreev, Adam A. Dmytriw, Justin E. Vranic, James D. Rabinov, Christopher J. Stapleton, Alvin S. Das, Anna K. Bonkhoff, Lara Carvalho de Oliveira, Markus D. Schirmer, Thabele M. Leslie‐Mazwi, Aneesh B. Singhal, Aman B. Patel, Natalia S. Rost, Robert R. Regenhardt

“…Conclusion Among patients with severe baseline disability, EVT is associated with less post‐stroke accumulated disability without limiting transitions to comfort care. …”
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Effects of Wolbachia removal on microbial composition and diversity in Aedes albopictus: implication of using wAlbB for discriminating irradiation-based sterile and wild males by Paerhande Dilinuer, Ming Li, Datao Lin, Yu Wu, Zhongdao Wu, Xiaoying Zheng, Dongjing Zhang

“…Although Wolbachia removal minimally affect host fitness, its impact on microbiota remains unclear. Characterizing post-elimination microbial communities is the first step to identify novel endogenous biomarkers for SIT monitoring. …”
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Servizi Sociali Territoriali e Università: Esempi di Sinergie Possibili per un Percorso di Qualità by Laura Bini

“…This development does not do justice to the actual requirements of Italian society faced with ever increasing post-modern complexity which is reflected also in the nature of social problems because it implies a continuation of a faith in modernity with its idea of technical, clear-cut solutions while social relations have decidedly moved beyond that belief. …”
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Integrating secondary prevention of rheumatic heart disease into the primary healthcare system in Northern Uganda by Emmy Okello, Craig Sable, David A Watkins, Andrea Z Beaton, Chris T Longenecker, Nicholas J Ollberding, Joselyn Rwebembera, Jenifer Atala, Jafesi Pulle, Rachel Sarnacki, Ndate Fall, Linda Oyella, Neema W Minja, Sarah R de Loizaga, Jenipher Kamarembo, Francis Odong, Doreen Nakagaayi, Judith W Dexheimer, Kristen M Danforth

“…This study evaluated the feasibility and effectiveness of integrating secondary antibiotic prophylaxis into primary health centres to improve access and adherence to RHD care.Methods We conducted a hybrid type III study using a mixed-method, pre–post design to evaluate a package of implementation strategies centred on decentralised RHD care and use of an electronic medical record in Gulu and Lira, Uganda. …”
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