An artificial intelligence-based platform for personalized predictions of Metacognitive Training effectiveness by Caroline König, Pedro Copado, Alfredo Vellido, Àngela Nebot, Cecilio Angulo, Maria Lamarca, Vanessa Acuña, Fabrice Berna, Steffen Moritz, Łukasz Gawęda, Susana Ochoa

“…Furthermore, the transparency requirements for artificial intelligence (AI) systems, as outlined in the AI Act regulation of the European Union, are addressed through the implementation of explainable AI models, using post-hoc explanations based on SHAP analysis for each predictive model. …”
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Analysis of the impact of caregiver training program intervention on frailty in colon cancer patients undergoing postoperative chemotherapy by Nie Tingting, Zhang Wei, Li Yuanyuan, Zhao Tianxue

“…The frailty status of the patients was assessed using the Fried frailty phenotype scale and the Comprehensive Frailty Assessment Instrument (including physical frailty, psychological frailty, social frailty, and environmental frailty dimensions) before the first chemotherapy session (pre-intervention) and after the total chemotherapy course (post-intervention). The frailty scores before and after the intervention were compared. …”
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Effect of telemedicine-supported structured exercise program in patients with chronic low back pain: a randomized controlled trial. by Yuan Feng, Chuanmei Zhu, Huizhen Liu, Tianjie Bao, Chongyang Wang, Zezhang Wang, Xiaoyi Wang, Ruishi Zhang, Yujia Zhang, Shaojun Zhang, Lin Yang, Siyi Zhu, Chengqi He

“…Linear mixed-effects model analysis was conducted at baseline, after 4 weeks (during treatment), and after 8 weeks (post-treatment), adhering to the principles of intention-to-treat (ITT) analysis.…”
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Efficacy of psychosocial interventions on social functioning in individuals with childhood maltreatment experiences: a protocol for a systematic review and network meta-analysis by Natalia E. Fares-Otero, Silvia Amoretti, Brisa Solé, Sarah L. Halligan, Eduard Vieta, Stefan Leucht, Soraya Seedat, Mathias Harrer

“…Other candidate moderators/mediators (personality, post-traumatic symptoms, brain structure/function, cognitive reserve) will also be explored and narratively summarised. …”
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Assessment of the effectiveness and safety of fixed-dose combination of alogliptin and pioglitazone in real clinical practice: results of the PROsperity study by M. V. Shestakova, M. I. Kharakhulakh, Y. A. Belolipetsky

“…Study design: Initially, after 3 and 6 months of incresync therapy, researchers recorded the target and current levels of HbA1c, fasting and post-prandial glycemic indices, as well as a wide range of cardiorenal-metabolic markers, including assessments of lipid profile, renal function, blood pressure, cardiovascular risk factors, concurrent medication, insulin resistance (HOMA-IR), and anthropometric measurements such as body weight and waist circumference, on the background of treatment. …”
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Differences in Plasma Extracellular Vesicles of Different Origin in On-Pump Versus Off-Pump Cardiac Surgery by Arthur Aquino, Napisat Abutalimova, Yi Ma, Imran Ismail-zade, Vadim Grebennik, Artem Rubinstein, Igor Kudryavtsev, Ekatherina Zaikova, Darina Sambur, Alexander Marichev, Olga Kalinina, Andrey Bautin, Anna Kostareva, Jarle Vaage, Alexey Golovkin

“…EV changes were significantly greater after on-pump surgery, highlighting a more pronounced response to this type of surgery and emphasizing the role of EVs as regulators of post-surgical inflammation.…”
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Efficacy of irreversible electroporation combined with immunotherapy versus irreversible electroporation alone in locally advanced pancreatic cancer: a propensity score-matched ret... by Pu Xi, Peng Sun, Miao Chen, Zehui Yao, Qi Zhu, Shengping Li, Chaobin He

“…This study aimed to evaluate the efficacy and safety of IRE combined with anti-PD-1 immunotherapy versus IRE alone in patients with LAPC.MethodsIn this retrospective study, LAPC patients treated either with IRE plus toripalimab (240 mg administered 7 days post-IRE) or with IRE alone were included. Propensity score matching (PSM) analyses were employed for analysis. …”
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One health surveillance: linking human and animal rabies surveillance data in Kenya by Samuel Kahariri, Samuel Kahariri, Samuel Kahariri, Samuel Kahariri, Lian F. Thomas, Lian F. Thomas, Bernard Bett, Marianne Mureithi, Brian Njuguna, Nyamai Mutono, Nyamai Mutono, Nyamai Mutono, Thumbi Mwangi, Thumbi Mwangi, Thumbi Mwangi, Thumbi Mwangi

“…The weak relationship between rabies cases and dog bites in humans and the negative correlation between rabies cases in dogs and humans point to potential underreporting of human cases, that could be possibly driven by misdiagnosis or limited access to healthcare, or effective post-exposure treatment.ConclusionUnderstanding these relationships is critical for improving the surveillance systems that can effectively support the rabies elimination program.…”
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The effect of acute beetroot juice consumption prior to climbing on lower-body isokinetic and isometric strength, aerobic power, and muscle soreness among mountain climbers by Alireza Daneshparvar, Mohammad Hemmatinafar, Mohsen Salesi, Rasoul Rezaei, Babak Imanian, Sepideh Pirmohammadi

“…The posttest session, held 72 hours after descending, repeated all baseline assessments.Results The results revealed a statistically significant decrease in DOMS in the gastrocnemius muscles 24 hours post-descending in the BRJ group compared to the control group (p = 0.003, pEta2 = 0.204). …”
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Integrated analysis of molecular and clinical features associated with overall survival in melanoma patients with brain metastasis by Swaminathan Kumar, Meredith S. Pelster, Merve Hasanov, Renato A. Guerrieri, Courtney W. Hudgens, Debora A. Ledesma, Fuchenchu Wang, Grant M. Fischer, Julie M. Simon, Lauren E. Haydu, Kalman V. Katlowitz, Y. N. Vashisht Gopal, Jennifer L. McQuade, Lawrence N. Kwong, Jason T. Huse, Alexander J. Lazar, Michael T. Tetzlaff, Jeffrey E. Gershenwald, Aron Y. Joon, Ken Chen, Ziyi Li, Prahlad T. Ram, Sherise D. Ferguson, Michael A. Davies

“…Thus, we analyzed clinical features and outcomes of 74 melanoma patients who underwent surgical resection (via craniotomy) between 1991 and 2015 at our institution with RNA-seq data generated from their MBMs. The median post-operative OS was 8.6 months (range 0.6–146.9). …”
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A structured lifestyle intervention to reduce cardiometabolic risk factors in individuals with obsessive–compulsive disorder: feasibility trial by Anna Holmberg, Matthias Lidin, Dante Lenninger, Sofia Asplund, Catharina Lavebratt, Christian Rück, Lina Martinsson, David Mataix-Cols, Lorena Fernández de la Cruz

“…We collected baseline, post-intervention and 3-month follow-up measures. …”
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Cortisol awakening response in pregnant women with depressive disorders: a potential marker of recovery status from pregnancy to postpartum by Carlinde W. Broeks, Babette Bais, Rien Van, Hilmar H. Bijma, Elisabeth F.C. van Rossum, Witte J.G. Hoogendijk, Mijke P. Lambregtse-Van den Berg, Astrid M. Kamperman

“…At baseline (12–32 weeks of pregnancy), participants provided saliva samples at awakening, +30, and +60 min post-awakening. The CAR was assessed using three measures: area under the curve relative to ground (AUCg), area under the curve relative to increase (AUCi), and peak reactivity (difference between awakening and +30 min cortisol levels). …”
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Alteration of the gut microbiota’s composition and metabolic output correlates with COVID-19-like severity in obese NASH hamsters by Valentin Sencio, Nicolas Benech, Cyril Robil, Lucie Deruyter, Séverine Heumel, Arnaud Machelart, Thierry Sulpice, Antonin Lamazière, Corinne Grangette, François Briand, Harry Sokol, François Trottein

“…Changes were more prominent and transient at day 4 post-infection in lean animals, alterations still persisted at day 10 in obese NASH animals. …”
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Rapid isolation and characterization of Wharton's jelly-derived mesenchymal stem cells maintained in fresh-prepared human AB-serum by Yudy Tjahjono, Sianty Dewi, Bernadette Dian Novita, Hendy Wijaya, Brilliant Dwi Putra, Suryo Kuncorojakti, Lucia Hendriati, FX Himawan Haryanto Jong, Teguh Widodo, Franklin Vincentius Malonda

“…Methods Human umbilical cords from three healthy donors were collected post-cesarean under strict inclusion criteria. WJ-MSCs were isolated using the explant culture method, with cells adhering to T75 flasks pre-coated with 2% gelatin. …”
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Molecular Cloning and Characterization of an Allene Oxide Cyclase Gene Associated with Fiber Strength in Cotton by Li-man WANG, You-min ZHU, Xiang-chao TONG, Wen-jing HU, Cai-ping CAI, Wang-zhen GUO

“…Hai7124, and one copy in the diploid cotton species G. herbaceum and G. raimondii. qRT-PCR showed that the GhAOC transcript was abundant in cotton fiber tissues from 8 to 23 days post anthesis (DPA), and the expression profiles were similar in the two cultivated tetraploid cotton species G. hirsutum acc. …”
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A short peptide for efficient cellular mRNA delivery: A potential application for inducing an immune response by Clémentine Ayélé Teko-Agbo, Emilie Josse, Karidia Konate, Sébastien Deshayes, Pascal de Santa Barbara, Sandrine Faure, Prisca Boisguérin, Eric Vivès

“…These peptide-based nanoparticles, which also have diameters ranging from 60 to 80 nm, showed remarkable stability over time when simply stored at 4°C and fully retained their transfection properties in vitro for up to several months post-formulation. Interestingly, we demonstrated in vivo that these nanoparticles were able to induce an immune response against the protein synthesized from the vectorized mRNA.…”
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Mitigating Response of <i>SlCSE06</i> Induced by 2-Ethylfuran to <i>Botrytis cinerea</i> Infection by Huilan Ye, Hongdou Gao, Jinnian Li, Linye Lu, Shilan Zheng, Chengxin Wu, Youliang Jin, Chengjuan Cao, Haisheng Zhu, Shuang Liu, Fenglin Zhong

“…Furthermore, the lignin content in OE6 was significantly higher than in WT, suggesting that the overexpression of <i>SlCSE06</i> enhanced lignin formation in tomato plants. At 5 days post-inoculation with <i>Botrytis cinerea</i>, the lesion diameter in OE6 decreased by 31.88% relative to the WT, whereas the lignin content increased by 370.90%. …”
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Application of continuous renal replacement therapy (CRRT) in patients with severe acute pancreatitis: an analytical study by Yiru Weng, Zhouzhou Dong, Gongjie Ye, Linhui Shi, Panpan Liu, Tingting Zhou, Honghua Ye

“…Conclusions CRRT serves as an independent protective factor against poor outcomes (discharge against medical advice (death within 24 h post-discharge (against medical advice)) /death) in SAP patients, while simultaneously reducing hospitalization duration and vasopressor requirements without increasing financial burden. …”
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The CXCL16/CXCR6 axis is linked to immune effector cell-associated neurotoxicity in chimeric antigen receptor (CAR) T cell therapy by I-Na Lu, Louisa Müller-Miny, Carolin Krekeler, Phyllis Fung-Yi Cheung, Georgia Antonopoulou, Astrid Jeibmann, Andreas Schulte-Mecklenbeck, Kornelius Kerl, Simon Call, Christian Reicherts, Annalen Bleckmann, Matthias Stelljes, Georg Lenz, Heinz Wiendl, Gerd Meyer zu Hörste, Oliver M. Grauer

“…Methods We analyzed paired peripheral blood and cerebrospinal fluid (CSF) samples from CAR T cell–treated patients who developed ICANS (n = 11) within 5–21 days post-infusion. ICANS severity was graded as follows: grade 1 (n = 3), grade 2 (n = 4), grade 3 (n = 1), and grade 4 (n = 3). …”
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Comparative Analysis of Differentially Expressed Genes and Metabolites in Waxy Maize Inbred Lines with Distinct Twin-Shoot Phenotypes by Mengfan Qin, Guangyu Li, Kun Li, Jing Gao, Meng Li, Hao Liu, Yifeng Wang, Keke Kang, Da Zhang, Wu Li

“…<i>sinensis</i> Kulesh) inbred lines, D35 (a polyembryonic line with twin shoots) and N6110 (single-shoot), exhibited similar relative growth rates during 1 to 5 days post-germination. UPLC-MS/MS profiling of 3- to 5-day-old seedling roots and shoots revealed that H2JA, MeSAG, and IAA-Val-Me were the common differentially accumulated metabolites (DAMs) of the 3-day-old vs. 5-day-old seedlings of D35 and N6110 in the same tissues, and MeSAG, tZ9G, cZROG, and DHZROG were identified in D35 vs. …”
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