Successful multidisciplinary treatment including repeated metastasectomy for recurrent squamous cell esophageal carcinoma: a case report by Kosuke Hirose, Hiroshi Saeki, Yuichiro Nakashima, Tomohiro Kamori, Yoshiaki Fujimoto, Tetsuro Kawazoe, Hiroya Matsuoka, Yasuhiro Haruta, Shun Sasaki, Tomoko Jogo, Qingjiang Hu, Yasuo Tsuda, Koji Ando, Eiji Oki, Ryuzo Hiratsuka, Yoshinao Oda, Masaki Mori

“…Multiple mediastinal and abdominal lymph node (LN) metastases were detected in the right lung a year later, which necessitated chemoradiation to a dose of 50.4 Gy with concomitant CDDP and 5-FU. Post-treatment computed tomography (CT) showed a good response. …”
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Prescription of benzodiazepines, z-drugs, and gabapentinoids and mortality risk in people receiving opioid agonist treatment: Observational study based on the UK Clinical Practice... by John Macleod, Colin Steer, Kate Tilling, Rosie Cornish, John Marsden, Tim Millar, John Strang, Matthew Hickman

“…We identified episodes of prescription of benzodiazepines, z-drugs, and gabapentinoids and used linear regression and Cox proportional hazards models to assess the associations of co-prescription (prescribed during OAT and up to 12 months post-treatment) and concurrent prescription (prescribed during OAT) with treatment duration and mortality. …”
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Effect of Ticagrelor on Glycaemic Parameters and Inflammatory Mediators in High Fat Diet and Streptozotocin Induced Diabetic Rats: An Experimental Study by Sachin Patel, Nayana K Hashilkar, Vidya Mahalmani

“…One-way Analysis of Variance (ANOVA) followed by Bonferroni’s post hoc test was used for the analysis of study variables, and paired data were analysed using the paired t-test. …”
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Amorphous calcium zinc phosphate promotes macrophage-driven alveolar bone regeneration via modulation of energy metabolism and mitochondrial homeostasis by Shuze Wang, Lei Cao, Caihao Huang, Junyi Wang, Jialin Liu, Yeyuan Wang, Qiang Wang, Qing Zhou, Xing Zhang, Dan Zhang

“…Our results demonstrated that ACZP can inhibit the IP3R/MCU pathway in macrophages, restoring their anti-inflammatory capabilities and ultimately achieving significant effects in the alveolar bone defects of New Zealand white rabbits. Twelve weeks post-surgery, the defects in the ACZP group were filled with nearly 70 % newly formed bone tissue. …”
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Docosahexaenoic Acid and Nervonic Acid Synergically Enhance Cognitive Memory in Normal Mice via Brain Fatty Acids Remodeling by Hai‐Yan Ou, Lei Feng, Rui‐Ye Chen, Hui‐Yun Lu, Shuang Cai, Zhi‐You Yang

“…Lipidomic analyses suggest levels of NA, dihomo‐γ‐linolenic acid, EPA, DHA, and linoleic acid were increased in the white matter post low dose of DHA + NA treatment, as well as increased levels of dihomo‐γ‐linolenic acid, EPA, and DHA in the gray matter compared with control mice. …”
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Studies of the boron erosion and deposition in shadowed areas in EAST by Yuming Liu, Rong Yan, Lei Mu, Chuannan Xuan, Baoguo Wang, Yuqi Sheng, Zichao Lin, Ziqiang Zhou, Dahuan Zhu, Andrey Litnovsky, Junling Chen

“…Following a single boronization using 10 g of carborane, the B-based coating on C-QMB exhibited a lifetime of ∼10 ^4 s under plasma exposure. Post-mortem analyses revealed that about 30 nm of a boron-carbon film remained on the C-QMB, demonstrating strong oxygen gettering capability and minor iron and copper contamination. …”
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Opposing role of phagocytic receptors MERTK and AXL in Progranulin deficient FTD by Claire Dudley Clelland, Li Fan, Rowan Saloner, Jon Iker Etchegaray, Chad Richard Altobelli, Sally Salomonsson, Alisha M. Maltos, Aradhana Sachdev, Jingjie Zhu, Se-In Lee, Yaqiao Li, Yungui Zhou, David Le, Chao Wang, Gillian Carling, Lay Kodama, Faten Sayed, Jaun A. Perez-Bermejo, Ethan G. Geier, Jennifer S. Yokoyama, Howie Rosen, Alissa L. Nana, Salvatore Spina, Lea T. Grinberg, William W. Seeley, Fanny Elahi, Adam L. Boxer, Michelle R. Arkin, Li Gan

“…Using single-nuclei RNA sequencing of the post-mortem brain tissue from adult heterozygous pathogenic granulin variant (GRN+/−) carriers we find dysregulation of microglia, phagocytosis and the phagocytic receptors MERTK and AXL. …”
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Effects of Virtual Reality-based Interventions on Depression, Anxiety, and Abilities of Daily Living in Stroke Survivors: A Systematic Review and Meta-analysis by Huanhuan Li, Lu Zhou, Gao Liu, Lei Wang, Qingwei Zhao, Shaohong Xu, Enli Cai

“…Results: This review identified 16 studies out of the 4439 records retrieved, consisting of a total of 756 stroke patients. Post-intervention analysis provided low certainty evidence that VR training reduced depression (SMD = –0.47; 95% CI: –0.88, –0.05, p = 0.03), but there was no significant effect on anxiety (SMD = –0.25; 95% CI: –0.53, 0.03, p = 0.08) and activities of daily living (SMD = 0.34; 95% CI: –0.05, 0.73, p = 0.09). …”
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Expectations regarding regenerative medicine and attitudes toward invasive surgical therapies in patients with Parkinson’s disease: A cross-sectional survey by Mika Watabe, Atsushi Shima, Kiyoaki Takeda, Yuta Terada, Yusuke Sakato, Akira Nishida, Ikko Wada, Haruhi Sakamaki-Tsukita, Kenji Yoshimura, Daisuke Kambe, Koji Furukawa, Masanori Sawamura, Etsuro Nakanishi, Yosuke Taruno, Hodaka Yamakado, Ryosuke Takahashi, Nobukatsu Sawamoto

“…Allogeneic iPS cells are considerably more practical, despite potential concerns regarding tumor formation post-transplantation. The present study aimed to clarify the perceptions and acceptance of patients with PD regarding regenerative medicine, invasive surgical treatments (deep brain stimulation, levodopa-carbidopa intestinal gel), and cell transplantation (iPS cells, embryonic stem cells, fetal-derived cells). …”
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Role of long non-coding RNA in plant flowering regulation(长链非编码RNA在植物开花调控中的作用) by 郑羽琪(ZHENG Yuqi), 苏逸然(SU Yiran), 彭俊睿(PENG Junrui), 杜佳宏(DU Jiahong), 武亮(WU Liang)

“…Within these pathways, long non-coding RNA (lncRNA) works in conjunction with related proteins to regulate key factors at transcriptional, post-transcriptional and epigenetic levels. They achieve this by modifying histones, participating in alternative splicing, and producing or competitively binding to microRNA (miRNA) and small interfering RNA (siRNA), thereby either promoting or inhibiting flowering. …”
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Impact of transcranial magnetic stimulation therapy on the volumes of amygdala and hippocampal subfields in patients with major depressive disorder by WANG Sirui, KONG Gai, LI Hui, QIAN Zhenying, CUI Huiru, TANG Yingying

“…Clinical depressive and anxiety symptoms were assessed by using the Hamilton Depression Scale (HAMD), Montgomery-Asberg Depression Rating Scale (MADRS), and Hamilton Anxiety Scale (HAMA) at baseline and post-TMS treatment. Patients underwent a baseline magnetic resonance imaging (MRI) scan followed by TMS treatment targeting the left dorsolateral prefrontal cortex (DLPFC) at a frequency of 10 Hz, totaling 20 sessions. …”
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Visualization of the research landscape on the 20 m shuttle run test in the last 15 years: bibliometric analysis with VOSviewer of the most cited studies by Boryi A. Becerra-Patiño, Boryi A. Becerra-Patiño, Juan David Paucar Uribe, Rodrigo Yáñez-Sepúlveda, Tomas Reyes-Amigo, Júlio Brugnara Mello, João Martins, Anelise Reis Gaya, José Francisco López-Gil, José Francisco López-Gil, Jorge Olivares-Arancibia

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Sirtuin 1 expression in elderly patients with type 2 diabetes mellitus by Mohamed M. M. Hassaan, Imam M. Esmayel, Mayada M. Mousa, Samia Hussein, Ahmed K. Y. Alkolaly, Batoul A. Hegazy, Rodalia M. Makhlouf

“…SIRT4 is an ADP-ribosyltransferase that downregulates glutamate dehydrogenase in β cells, with a subsequent reduction in insulin secretion. SIRT5 regulates post-translational modifications. SIRT6 is a mono-ADP-ribosyl transferase. …”
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Impact of Endovascular Revascularization on Functional Connectivity and Cognition in Symptomatic Chronic Internal Carotid Artery Occlusion Patients: A Preliminary Exploratory Study by Renjie Ji, Shixin Zhang, Hanfeng Chen, Chunlan Deng, Ziqi Xu, Jie Zhang, Benyan Luo

“…Resting-state functional magnetic resonance imaging (rs-fMRI) and neuropsychological assessment were performed on all participants, before and after 6 months post-recanalization in the patient group. FC alterations in multiple brain networks and their correlations with cognitive scores were analyzed. …”
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Safety and efficacy of 3- and 5-day regimens of levamisole in loiasis: a randomized, placebo-controlled, double-blind clinical trial by Cédric B. Chesnais, Marlhand C. Hemilembolo, Bachiratou A. Sahm, Florentin Toutin, Ericson Djeutassong, Nadia Nga-Elomo, Benjamin Cuer, Mas A. Ntsiba-N’Goulou, Miveck Pakat, Sébastien D. S. Pion, François Missamou, Michel Boussinesq, Jérémy T. Campillo

“…By day 7, a higher proportion of participants achieved ≥40% MFD reduction in the LEV-5 group (44.4%) compared to LEV-3 (34.6%) and PLA (8.3%) (P = 0.051). Post hoc contrasts confirmed significantly greater MFD reduction with LEV-5 versus LEV-3. …”
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Is there an alternative to diclofenac i/m injections for rapid relief of severe pain? Results of randomized controlled and partially blind forsage study by A. E. Karateev, E. Yu. Pogozheva, E. S. Filatova, A. M. Lila, V. N. Amirdjanova, V. A. Nesterenko

“…Starting from the 3rd hour post-administration there was no statistically significant difference in pain intensity between the two groups. …”
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Early weaning-induced intestinal barrier dysfunction associates with Th17/Treg imbalance in squabs by Qianqian Xu, Zhiying Luo, Tianliang Ling, Wenyan Zhao, Xinyang Dong

“…A total of 160 hatched squabs were randomly assigned to two groups: one received artificial pigeon milk starting from day 7 post-hatching, while the other group continued to be nourished by their parent pigeons. …”
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Evaluating Quality of Care Indicators for Metastasis Development in Cutaneous Squamous Cell Carcinoma Among Mexican Renal Transplant Recipients by Andrea Malagon‐Liceaga, Jesus Alejandro Romero‐Aguila, Bonfilio Roberto Lazcano‐Prieto, Fanny Carolina Lopez‐Jimenez, Rebeca Palafox‐Romo, Samantha Paola Bermudez Rodriguez, Verónica Monserrat Díaz Sanchez, Judith Dominguez‐Cherit, Silvia Mendez‐Flores, Ana Lilia Ruelas‐Villavicencio

“…The AJCC 7 guidelines in 2015 improved reporting quality, with 30.5% of reports meeting comprehensive criteria post‐2015, compared to 9.4% before (p = 0.005). LASSO logistic regression identified predictors of metastasis: tumor differentiation (OR 3.0, 95%CI: 2–4.5), reporting tumor depth (OR 1.4, 95%CI: 1.2–1.7), and reporting perivascular invasion (OR 8.66, 95%CI: 4.8–15.6). …”
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Disagreement Persists on Optimal Rehabilitation Goals and Timelines for Weight-Bearing Restriction, Knee Brace Use, and Return to Sports After Posterolateral Corner Reconstruction by Ilan Y. Mitchnik, M.D., Tomer Mimouni, M.Sc., Loren S. Haichin, M.Sc., Suzana Bayyouk, B.P.T., Gilbert Moatshe, M.D., Dror Lindner, M.D., Jorge Chahla, M.D., Ph.D., Yiftah Beer, M.D., Ron Gilat, M.D.

“…Overall, 31% of rehabilitative goals and timelines had good-to-excellent agreement rates. Post-2019 consensus, adherence to a stepwise rehabilitative approach significantly improved, especially for initiating strength exercises after muscular endurance exercises (P = .009) and initiating power exercises after strength exercises (P = . 031). …”
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Bismuth sulfide-titania heterostructure used for photothermal amplified sonodynamic therapy against hypoxic tumor by Rui Chen, Zhiqi Yang, Yining Chen, Jinjie Wang, Yuhang Wang, Liqi Wei, Pengcheng Yu, Mengyuan Zhang, Yan Yan, Shuo Yang, Lili Wang, Yan Cheng

“…After being administrated into tumor, Bi2S3-TiO2 NPs can effectively improve oxygen content at 8 h post 808 nm laser irradiation. The tumor growth inhibition rate of Bi2S3-TiO2 NPs with 808 nm laser or ultrasound irradiation is 77.49 ± 3.96 % and 63.64 ± 2.2.7 %, respectively, while it reaches up 88.82 ± 3.98 % when 808 nm laser and ultrasound are applied in sequence, proving the photothermal amplified sonodynamic therapeutic efficacy against hypoxic tumor. …”
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