Design and Characterization of Inhibitors of Cell-Mediated Degradation of APOBEC3G That Decrease HIV-1 Infectivity by Aubrey M. Sawyer, Cristina C. Vaca, Neha Malik, Isabelle Clerc, Joshua Craft, Hannah Hudson, Gaël K. Scholtés, Gary E. Schiltz, Meejeon Roh, Chisu Song, Richard T. D’Aquila

“…The modified analogs designed, synthesized, and evaluated here inhibit cell-mediated post-translational degradation of A3G/F, whether Vif is present or not. …”
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“We have our reasons”: Exploring the acceptability of pre-exposure prophylaxis among gay, bisexual, and other men who have sex with men in Ghana by Gloria Aidoo-Frimpong, Gamji Rabiu Abu-Ba’are, Amos Apreku, Richard Panix Amoh-Otu, Edem Zigah, Prince Amu-Adu, Samuel Amuah, Laura Nyblade, Kwasi Torpey, LaRon E. Nelson

“…Under theme one, which indicated almost universal awareness of PrEP but inaccuracies about PrEP were common, these were the categories: (1) Awareness of PrEP and antiretroviral therapy [ART], (2) confusion between pre-exposure prophylaxis (PrEP) and post-exposure prophylaxis, (3) event-driven perceptions of PrEP usage, (4) Mixed understanding of PrEP: distinguishing PrEP from ART, and (5) advocacy for a comprehensive educational approach. …”
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Exposure-response analyses of venetoclax combined with hypomethylating agents in myelodysplastic syndromes: a retrospective study by Ji-Xin Tian, Ping Zhang, Xiao-Xu Wang, Jin-Wen Li, Dong-Xue Liu, Yi-Ying Liu, Zhi-Jian Xiao, Wen-Juan Miao

“…However, research regarding the VEN exposure in Chinese patients with MDS remains notably sparse.MethodsThis study retrospectively collected the predose (C0) and 6 h post-oral dosing plasma concentration (C6) of VEN for exposure-response analyses, using graphical analysis, receiver operator characteristic (ROC) curves, and logistic regression. …”
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Personal and existential-psychological resources of form tutors working with gifted children by N. V. Markina, E. L. Soldatova, I. L. Kachuro, A. Gavriliuc

“…This problem is considered in the context of the methodological shift from the classical to the post-non-classical scientific paradigm, from the “deficit model” to the model of “success and resilience” (S. …”
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Staged CBI for Reducing Anxiety and Depression in Lung Cancer Patients Undergoing Chemotherapy: A Retrospective Cohort Analysis by Chen L, Sun Y, Yu H, Sun M

“…The follow-up data were collected 6– 8 weeks after the Staged CBI sessions.Results: The SF-36 showed that effect size was large for most of the domains (Cohen’s d > 1.2) and post CBI intervention was not significant except physical function. …”
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Ketoprofen Lysine Salt Versus Corticosteroids in Early Outpatient Management of Mild and Moderate COVID-19: A Retrospective Study by Domenica Francesca Mariniello, Raffaella Pagliaro, Vito D’Agnano, Angela Schiattarella, Fabio Perrotta, Andrea Bianco

“…A final multivariate analysis suggests that KLS might reduce hospitalization risk, the need for oxygen supplementation, and the persistence of post-COVID-19 symptoms when compared to an oral corticosteroid after adjusting for significant co-variables. …”
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Tuberculosis in children in Russia by O. B. Nechaeva

“…From 2005 to 2019 among children of 0-14 years old, the proportion of lung damage increased from 18.0 to 32.1%, and among children 15-17 years old – from 80.8 to 89.1%.From 2005 to 2019, among children and adolescents aged 0-17 years notified with tuberculosis at the end of the year, the proportion of those HIV infected increased up to 3.4%, while the absolute number of children decreased down to 108.The proportion of children with MDR TB among those with a positive result of sputum test increases (2005 – 10.0%; 2019 – 45.8%).From 2005 to 2019, the rate of those died of tuberculosis decreased among children of 0-14 years old from 0.17 to 0.02 per 100,000 children (8.5 times), at the age of 15-17 years – from 0.22 to 0.07 per 100,000 children (3.1 times).The number of children aged 0-14 years, registered with post-vaccination complications decreased by 6.2 times (2005 – 947 children, 2019 – 153 children).…”
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Novel melasma therapy using combined low fluence and microsecond pulse Q switched 1064 nm neodymium doped yttrium aluminium garnet laser by Xianglei Wu, Qingqing Cen, Xiaoxi Lin, Ying Shang, Xue Wang, Zhen Zhang

“…Follow-ups were conducted at 1, 3, 6, and 12 months post-treatment. Of the 28 patients, 21 completed all treatments and follow-ups (5–10 sessions in total). …”
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Evaluation of a pharmacist-led actionable audit and feedback intervention for improving medication safety in UK primary care: An interrupted time series analysis. by Niels Peek, Wouter T Gude, Richard N Keers, Richard Williams, Evangelos Kontopantelis, Mark Jeffries, Denham L Phipps, Benjamin Brown, Anthony J Avery, Darren M Ashcroft

“…We used an interrupted time series analysis of rates (prevalence) of potentially hazardous prescribing and inadequate blood-test monitoring, comparing observed rates post-intervention to extrapolations from a 24-month pre-intervention trend. …”
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Concentrated growth factors promote epithelization in the mastoid obliteration after canal wall down mastoidectomy by Mengyi Liu, Lue Zhang, Quanming Zhang, Nan Zeng, Shuo Li, Shuyue Guo, Yaqin Zhao, Mingxing Tang, Qiong Yang

“…The proportion of patients group that achieved complete epithelialization within 60 days post operation was significantly higher in the CGF/HA group than the HA group. …”
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Exploration of beta diversity across altitude gradients in an Alpine region in Trentino using FOSS4G and a historical floristic archive by F. Geri, F. Zottele, N. La Porta, C. Tattoni, P. Zatelli, M. Ciolli, M. Ciolli

“…This study wants to demonstrate the FOSS4G capabilities presenting a preliminary exploration of species turnover across environmental gradients in the Province of Trento, a highly biodiverse region in the northeastern Italian Alps, using a large database of vegetation surveys from the 1970s that was digitized and organized into a geodatabase using FOSS4G in the FORCING project. GRASS, QGIS, PostGIS, and R were used to process data from 517 linear transects, encompassing 190,761 species records. …”
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Evaluating the inclusion of lesbian, gay, bisexual, transgender, and queer-related content in graduate medical education: a national survey of program directors by Andrew M. Pregnall, Joshua A. Pesantes, Gennady Vulakh, Youvin Chung, Setareh Gooshvar, C. Jessica Dine

“…The most covered clinical topics were Pre-Exposure Prophylaxis/Post-Exposure Prophylaxis (77.0%) and facial masculinization/feminization surgery (68.4%). …”
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The Contemporary Critical Reception of Walter Pater: Retrospective and Proleptical Views by Geoffrey Sadock

“…As Pater’s response to the beautiful, in art and life, becomes better understood, it will be seen that he is at once the culmination of a long line of theoretical rebels and the beginning of a post-modern, existential methodology that values art after the debacle of the 20th century and the collapse of ideologies that once sought to discredit him. …”
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3-D fracture network reconstruction and quantitative fractal analysis of subsurface rock fractures via integrated CT scanning and box-counting dimension methodology by Hongjian Wu, Xiangwei Kong, Xing Chen, Dianwei Guan

“…Unlike previous studies focusing on static fracture characterization, our framework uniquely captures hydraulic fracturing-induced dynamic transformations, revealing a 35–40 % decrease in fracture network concentration post-stimulation despite local expansion. Furthermore, the establishment of a morphology-driven natural fracture development index provides the first quantitative link between wall roughness coefficient (JRC) distributions and reservoir fracturability indices, offering actionable insights for stimulation design. …”
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Integration of the national HIV curriculum in medicine, nursing, and pharmacy programs in the United States by Cornelia Wagner, Kalob Gossett, Memoona Hasnain, Nathan Linsk, Ricardo Rivero

“…Methods HPPs completed faculty pre- and post-integration surveys for each course in which they integrated content from the NHC. …”
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A Method for Assessing the Severity of Obstructive Jaundice of Non-Neoplastic Origin by A. P. Vlasov, N. S. Sheyranov, O. V. Markin, T. I. Vlasova, T. A. Muratova, V. E. Ryazantsev, D. E. Timoshkin, K. M. Sinyavina, A. V. Kolesov

“…The method increases the objectivity of determining the severity of non-neoplastic origin by establishing the severity of liver damage and the processes underlying it.CONClUSiON The suggested clinical and laboratory index allows the severity of obstructive jaundice to be objectively and quickly determined upon admission of a patient to the hospital and also adequate therapy to be initiated in case of severe degree for anticipation of possible post-operative complications, so the treatment should be focused on managing triggers of hepatodepression. …”
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Combination Therapy for Cryptosporidiosis in Immunocompromised Patients by Wiwien Sugih Utami, M.S. Irham Rozaq, Laksmi Indreswari, Cholis Abrori, Bagus Hermansyah

“…The studies comprised 54 samples from post-kidney transplantation patients and one sample from an acute lymphoblastic leukemia (ALL) patient. …”
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CLINICAL EVALUATION OF THE RESULTS OF DELAYED STENTING OF THE OCCLUDED CORONARY ARTERY by E. Т. Аzoev, A. A. Inozemtsev, I. G. Ryadovoy, B. L. Mironkov

“…The method of delayed stenting for complicated forms of chronic occlusions when determining post-recanalization obliteration of the distal coronary bed is safe and acceptable since it allows obtaining an optimal clinical outcome.…”
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The Effects of Self-Efficacy-Based Fall Prevention Program among Elderly in Phibunmangsahan Town Municipality, Ubon Ratchathani Province, Thailand by Warunee Sukaree, Phandita Sukhumal, Pawena Limpiteeprakan

“…Data collection was conducted using pre- and post-intervention questionnaires, physical assessments of muscle strength, mobility, and postural control, and statistical analysis was performed using paired t-tests and independent t-tests to evaluate the effectiveness of the intervention. …”
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COVID-19 Early Detection in Doctors and Healthcare Workers (CEDiD) study: a cohort study on the feasibility of wearable devices by Anne Greenough, Abdel Douiri, Gaia Nebbia, Kariem El-Boghdadly, Rayka Malek, Alexander Zargaran, Sara Sousi, Gary Colville, Gill Radcliffe, Rocio T Martinez Nunez

“…No significant differences were found in the pre-infection and post-infection variations in the heart rate (p=0.31) or skin temperature (p=0.44). …”
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