ACE2 shedding exacerbates sepsis-induced gut leak via loss of microbial metabolite 5-methoxytryptophan by Jiacheng Gong, Haoyang Lu, Yuhan Li, Qihan Xu, Yuanyuan Ma, Anni Lou, Wanfu Cui, Weihua Song, Peng Qu, Zhuoer Chen, Linghao Quan, Xi Liu, Ying Meng, Xu Li

“…Mice deficient in ACE2 exhibited increased intestinal permeability and higher mortality rates post-operation compared to their wild-type counterparts. …”
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The effects of 12 weeks of high-intensity interval rope skipping training on speed and power indexes in male soccer players by Bo Wei, Bo Wei, Wenhu Cheng, Jiangang Qiu

“…Participants were randomly assigned to an, EG (n = 13) performing high-intensity intermittent rope skipping (75%–85% HRmax with active intervals at 40%–70% HRmax) and a CG (n = 12) maintaining conventional training (75%–85% HRmax), both monitored via heart rate bands. Pre and post-intervention assessments included: sprint speed (30-m sprint), reaction speed (Optojump 5-s rapid frequency test), visual reaction speed (Optojump visual test), change-of-direction speed (T-test), and explosive power (standing long jump). …”
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The effects of a home-based resistance training programme on body composition and muscle function during weight loss in people living with overweight or obesity: a randomised contr... by Ahmad Binmahfoz, Lynsey Johnston, Emma Dunning, Cindy M. Gray, Stuart R. Gray

“…Body composition, muscle strength, and physical function were assessed at baseline and post-intervention. Results There was no effect of the resistance exercise training programme (all p > 0.05) on body composition including body mass index, total body mass, fat mass, fat free mass or muscle thickness during weight loss. …”
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In vitro activity and in vivo efficacy of omadacycline against Plasmodium species by Michael S. Madejczyk, Susan E. Leed, Karl Kudyba, Alison Roth, Monica L. Martin, Patricia Lee, Diane Anastasiou, Jessica V. Pierce, Alisa W. Serio, Diana Caridha

“…Parasitaemia was monitored by flow cytometry for up to 30 days post-infection. Results Omadacycline demonstrated comparable in vitro activity to doxycycline against both drug-sensitive and drug-resistant P. falciparum clones, while doxycycline showed reduced activity against two drug-resistant clones. …”
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Synthetic heparan sulfate mimics based on chitosan derivatives show broad-spectrum antiviral activity by Julia Revuelta, Luciana Rusu, Clara Frances-Gomez, Elena Trapero, Susana Iglesias, Eva Calvo Pinilla, Ana-Belén Blázquez, Alfonso Gutiérrez-Adán, Acsah Konuparamban, Oscar Moreno, María Gómez Martínez, Alicia Forcada-Nadal, María Luisa López-Redondo, Ana Isabel Avilés-Alía, IBV-Covid19-Pipeline, José Luis Llácer, Jordi Llop, Miguel Ángel Martín Acebes, Ron Geller, Alfonso Fernández-Mayoralas

“…Importantly, the drug was non-toxic in vivo and showed potent post-exposure therapeutic activity against both SARS-CoV-2 and RSV. …”
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Classification of and detection techniques for RNAi-induced effects in GM plants by Cecilia Diaz, Steve U. Ayobahan, Samson Simon, Luise Zühl, Andreas Schiermeyer, Elke Eilebrecht, Sebastian Eilebrecht

“…However, further studies are needed to fully understand and mitigate potential risks, particularly those related to transcriptional gene silencing (TGS) mechanisms, which are less predictable than post-transcriptional gene silencing (PTGS). Particularly the application of untargeted approaches such as small RNA sequencing and transcriptomics is recommended for thorough and comprehensive risk assessments.…”
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Harmonizing musculoskeletal health: transformative effects of 8-week intervention program on posture in music students by Stanislav Azor, Michal Marko, Štefan Adamčák, Pavol Bartik

“…Significant differences (p ˂ 0.05, ˂ 0.01) between 25 music students (M); in particular experimental group (n = 15) and control group (n = 10), were in 4 (80%) segments of body in post-test: (i) Head and neck; (ii) Abdomen and pelvis; (iii) Curvature of spine; (iiii) Shoulders and scapulas. …”
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Effects of Fospropofol Disodium and Propofol on the Postoperative Recovery of Elderly Patients Who Underwent Total Hip Arthroplasty: A Retrospective Study by Ding S, Wang Z, Li C, Wang G, Li J, Zhu H, He K

“…The secondary outcomes included the time of extubation and the time of stay in post-anesthesia care unit (PACU), hospital length of stay, perioperative hemodynamic data and patients’ liver and renal functions.Results: PONV occurred to be lesser in group F than in group P (15.94% vs 33.33%, P < 0.05). …”
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Evaluating Neurotherapeutic Potential of Naringenin by True Experiments: Insights into In-Vivo Psychiatry Care Models by Abdul Ghafoor, Sana Kashif, Syed Muhammad Shahkar Ali, Samreen Memon, Shaheer Suhail Memon, Asim Mehmood, Pirya Nangdev

“…The ELISA testing system measured Nerve Growth Factor (NGF) serum concentrations, and the data were analyzed with one-way ANOVA followed by Tukey post hoc comparisons between all samples. Data analysis was conducted using SPSS Version 21. …”
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Repetitive Transcranial Magnetic Stimulation for Neuropathic Pain and Neuropsychiatric Symptoms in Traumatic Brain Injury: A Systematic Review and Meta-Analysis by Xin Li, Tijiang Lu, Hong Yu, Jie Shen, Zhengquan Chen, Xiaoyan Yang, Zefan Huang, Yuqi Yang, Yufei Feng, Xuan Zhou, Qing Du

“…A significant advantage of 1 Hz rTMS over the right dorsolateral prefrontal cortex (DLPFC) in improving depression (MD=−6.52, 95% CI -11.58 to -1.46, P=0.01) was shown, and a significant improvement was noted in the Rivermead Post-Concussion Symptoms Questionnaire-13 (RPQ-13) scores of mild TBI patients after rTMS (MD=−5.87, 95% CI -10.63 to -1.11, P=0.02). …”
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Efficacy and Clinical Applicability of Impar Ganglion Block in the Treatment of Pudendal Neuralgia: A Systematic Review by Joelington Dias Batista, Gabrielly Santos Pereira, Jobson Dias Batista, Ludimila Dias Silva, Josie Resende Torres da Silva, Marcelo Lourenço da Silva

“…Eligible studies included RCTs, observational studies, and case series assessing pain reduction and quality of life post-IGB. Non-neuropathic pelvic pain studies were excluded. …”
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Prostate-Specific Antigen Reduction After Androgen Receptor Pathway Inhibitor Initiation: Real-World Comparison of Disease Progression Among Patients With Metastatic Castration-Sen... by Shawn Du, Carmine Rossi, Ibrahim Khilfeh, Porpong Boonmak, Gordon Wong, Dominic Pilon, Lorie Ellis

“…Weighted Kaplan-Meier analysis was used to compare overall survival and castration-resistance–free survival by 36 months post-index between those with and without ≥90% PSA reduction…”
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CO₂ emissions in G20 economies: A dynamic panel analysis of economic and energy-sector drivers by Nuriddin Shanyazov, Alibek Rajabov, Manzura Masharipova, Sadokat Rakhimova, Dilshodbek Saidov, Javohir Babajanov

“…The effect is especially significant in lower-income G20 countries and during the post-2005 era. Economic growth indicates a strong positive correlation with CO₂ emissions, characterized by elasticity values ranging from 0.83 to 0.89, whereas energy intensity also displays positive effects with coefficients between 0.69 and 0.82. …”
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Autograft vs Allograft With Bone Marrow Aspirate Concentrate as an Osteotomy Gap Filler in Lateral Column Lengthening for Progressive Collapsing Flatfoot Deformity by Ramesh Radhakrishnan MBBS, MRCS(Eng), Don Thong Siang Koh MBBS, BSc(Hon), MRCS, MMED(Ortho), Eric Wei Liang Cher MD, MRCS, MMed(Ortho), FRCSEd(Ortho), Wenxian Png MBBS, MMed(Ortho), MRCSEd, FRCSEd(Ortho), Inderjeet Rikhraj Singh MBBS, FRCS, FAMS, MHPE (Maastricht)

“…Radiologic union was evaluated through serial weightbearing radiographs at regular interval post-surgery. Results: Both groups A and B achieved radiologic union at an average of 5.64 ± 1.80 and 5.15 ± 2.58 months, respectively. …”
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Effect of Diabetes Self-Management Education on Knowledge and HbA1c Levels among Patients with Type 2 Diabetes Mellitus in Occupational Health Care by Susan Margarita, Insi Farisa Desy Arya, Helni Mariani, Elsa Pudji Setiawati, Maya Kusumawati, Kuswandewi Mutyara

“…Interestingly, only the intervention group showed a notable reduction in HbA1c levels (−1.9%), from 8.5% to 6.6%. Post-intervention HbA1c levels differed significantly between groups (p<0.05), with the control group remaining at 8.2%. …”
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Real-World Clinical Outcomes and Treatment Patterns Among Black and Non-Black Patients With Prostate Cancer Initiated on Apalutamide in a Urology Setting by Benjamin H. Lowentritt, Carmine Rossi, Erik Muser, Frederic Kinkead, Bronwyn Moore, Patrick Lefebvre, Dominic Pilon, Shawn Du

“…Persistence with apalutamide was reported at 6-, 12-, and 18-months post treatment initiation. Clinical outcomes described up to 24 months after apalutamide initiation using Kaplan-Meier analyses included progression to castration resistance, castration resistance-free survival (CRFS), and metastasis-free survival (MFS). …”
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An Optical Fiber Twist Sensor With Temperature Compensation Mechanism Based on T-SMS Structure by Yujian Li, Ping Lu, Zhiyuan Qu, Wei Zhang, Wenjun Ni, Deming Liu, Jiangshan Zhang

“…In addition, the temperature&#x0027;s influence can be compensated with post-measurement calculation through the cross-matrix. …”
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Voiding urodynamics parameters for women with and without symptomatic pelvic organ prolapse by José Tadeu Carvalho Martins, Gisele Vissoci Marquini, Laura Aparecida Xavier de Abreu, Zsuzsanna Ilona Katalin de Jármy Di Bella, Marair Gracio Ferreira Sartori

“…When evaluating the differences between patients with and without POP, it was observed that those who presented some type of pPOP were mean age (y) older (67.6 × 58.9); had higher post-void residue volume (mL) (85.9 × 33.9); higher PdetQmax (cmH2O) values (41.3 × 28.5); lower Qmax (mL/s) values on uroflowmetry (8.5 × 20.4), lower maximum cystometric capacity (mL) (325.7 × 381.2), lower bladder compliance (mL/cmH2O) (39.8 × 46.1) and lower Qmax (mL/cmH2O) in the flow/pressure study (8.4 × 18.0) (p<0.001). …”
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Difference in nutritional status and food sources for hard- and soft-shell crabs (Portunus trituberculatus) using amino acids and isotopic tracers by Hyeong Kyu Kwon, Nahyeon Kwon, Yang-Ki Cho, Jeomshik Hwang, Yangho Choi, Weol Ae Lim, Soo Jeong Lee, Jae Bong Lee, Guebuem Kim

“…Thus, this difference in food sources may be influenced by post-molt hiding behavior in soft-shell crabs, which limits access to high-trophic prey, or alternatively, by competition for food in coastal waters.…”
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Voluntary exercise alleviates ischemic brain injury in mice by modulating mitochondrial dysfunction by Beibei Li, Ye Zhou, Guifen Yang, Bo Li, Mingjin Zhu, Dan Lu, Senge Dai, Guoyuan Pan

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