Oligomeric alpha-synuclein causes early synaptic dysfunction of the corticostriatal pathway associated with non-motor symptoms by Laura Bellingacci, Miriam Sciaccaluga, Alfredo Megaro, Antonella Cardinale, Jacopo Canonichesi, Maria De Carluccio, Roberta Mastrantonio, Cinzia Costa, Massimiliano Di Filippo, Alessandro Usiello, Maria Teresa Viscomi, Paolo Calabresi, Alessandro Tozzi

“…Electrophysiological assessments and behavioral assays revealed several early alterations in OSyn rats, evident as early as 12 weeks post-OSyn injection. These included mild and variable reduction of motor activity, anxiety-like behavior, impaired bidirectional striatal long-term synaptic plasticity, and diminished spontaneous excitatory neurotransmission in the striatum. …”
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Impact of remdesivir on liver function: A comparative study of diabetic and non-diabetic COVID-19 patients by Zahra Zarei, Elham Nejadsadeghi, Seyedeh Leila Dehghani, Fateme Dadgar

“…The impact of remdesivir treatment on liver function revealed significant increases in liver enzyme levels among patients with diabetes post-treatment, contrasting with stable liver function in non-diabetic patients. …”
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Optimization of the surgical arteriovenous fistula for end-stage renal disease by David B. Kingsmore, MD, FRCS, Mb ChB, BMEdBiol, Ben Edgar, FRCS, Mb ChB, Karen Stevenson, PhD, FRCS, Mb ChB, BSc (MedSci)

“…All other reports of pre- or post-creation intervention/revisions/medication and not in English were excluded. …”
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Identification and characterization of the tumor necrosis factor receptor superfamily in the Chinese tree shrew (Tupaia belangeri chinensis) by Zongjian Huang, Nan Shi, Zhenqiu Luo, Fangfang Chen, Xunwei Feng, Yongjing Lai, Jian Li, Xiang Yi, Wei Xia, Anzhou Tang

“…Evaluation of transcriptome data from 70 samples infected with six types of viruses showed that most TNFRSF genes were upregulated in tree shrew post-viral infection. TNFRSF exerts antiviral function most probably through the activation of the NF-κB pathway, subsequently causing apoptosis of infected cells. …”
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Les approches plurielles des langues et des cultures

“…Pichler analyse les difficultés liées à l’écriture académique universitaire et propose des stratégies pour accompagner la transition post-scolaire. S. Melo explore l’écriture collaborative et l’intercompréhension, montrant comment le travail de groupe favorise l’apprentissage des langues. …”
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Heat stress in social housing districts: tree cover–built form interaction by Carlos Lopez-Ordoñez, Elena Garcia-Nevado, Helena Coch, Michele Morganti

“…Urban fabrics with high open space ratios, typical of the European post-war modernist social housing boom, are especially vulnerable to this issue, underscoring the importance of integrating vegetation as a key component of green infrastructure and a critical microclimatic resource. …”
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An analysis of the real world performance of an artificial intelligence based autism diagnostic by Carmela Salomon, Kelianne Heinz, Judith Aronson-Ramos, Dennis P. Wall

“…To gain insight into real-world device performance, a de-identified aggregate data analysis of the initial 254 Canvas Dx prescriptions fulfilled post-market authorization was conducted to determine: accuracy of autism predictions compared to clinical reference standard diagnosis and prior clinical trial data, key real-world prescriber and patient characteristics, proportion of determinate device outputs (positive or negative for autism) and impact of decision threshold settings on device performance. …”
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Acute administration of lovastatin had no pronounced effect on motor abilities, motor coordination, gait nor simple cognition in a mouse model of Angelman syndrome by Timothy A. Fenton, Stela P. Petkova, Anna Adhikari, Jill L. Silverman

“…Unexpectedly, deleterious effects of sedation were observed in wildtype (WT), age matched littermate control mice and despite a baseline hypolocomotive phenotype in AS mice, even further reductions in exploratory activity, were observed post-acute lovastatin treatment. Limitations of this work include that chronic lower dose regimens, more akin to drug administration in humans were beyond the scope of this work, and may have produced a more favorable impact of lovastatin administration over single acute high doses. …”
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Optimization design of nickel-titanium shape memory alloy anti-loose gaskets based on ABAQUS numerical simulation by Tianxiang Xue, Xinmei Li, Shuai Suo, Wen Li, Yanjiang Bu, Dongting Wu

“…Conversely, the residual stress and deformation predominantly resided on the gasket’s shoulder and were relatively minimal post-unloading, confirming its super-elasticity. …”
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Church Leaders’ Health Behaviors and Program Implementation in the Faith, Activity, and Nutrition Program in the United States by Kelsey R. Day, Sara Wilcox, Lindsay Decker, John Bernhart, Meghan Baruth, Andrew T. Kaczynski, Christine A. Pellegrini

“…Methods Pastors (n=93) and church coordinators (n=92) reported body mass index (BMI), self-rated health, fruit and vegetable consumption (F&V), and physical activity (PA) at baseline and 12 months post-training in the intervention. Church coordinators reported program implementation for their church. …”
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Clinical Trial: Effects of Autologous Dendritic Cell Administration on Renal Hemodynamics and Inflammatory Biomarkers in Diabetic Kidney Disease by Endang Drajat, Aziza Ghanie Icksan, Jonny Jonny, Aditya Pratama Lokeswara, Bhimo Aji Hernowo, Elvita Rahmi Daulay, Terawan Agus Putranto

“…Methods: A quasi-experimental pretest–post-test design was conducted involving 29 DKD patients. …”
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Anomaly Detection Using Machine Learning in Hydrochemical Data From Hot Springs: Implications for Earthquake Prediction by Ruijie Zhu, Fengtian Yang, Xiaocheng Zhou, Jiao Tian, Yongxian Zhang, Miao He, Jingchao Li, Jinyuan Dong, Ying Li

“…Despite limitations such as the inability to differentiate pre‐earthquake anomalies from post‐earthquake anomalies and pinpoint the precise location of earthquakes, this study successfully showcases the potential of machine learning algorithms in earthquake prediction, paving the way for further research and improved prediction methods.…”
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Patient satisfaction and quality of vision after bilateral implantation of enhanced monofocal IOL and mini-monovision: a prospective study by Andrea Llovet-Rausell, Jorge Navalón-Tortosa, Vasyl Druchkiv, Javier Coloma-Bockos, Jaime Moya-Roca, Fernando Llovet-Osuna

“…Abstract Background Patient expectations for post-cataract surgery outcomes have risen. This study aims to evaluate patient satisfaction after bilateral implantation of enhanced monofocal IOL (RayOne EMV RAO200E) designed with positive spherical aberration, used for monovision with a 1.00 D offset. …”
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Randomised active controlled trial examining effects of aerobic exercise, cognitive and music interventions on depression, balance and mobility in schizophrenia by Razieh Khanmohammadi, Hasan Mirali, Hasan Mohammadzadeh, Safiye Ebrahimi, Ina Shaw, Brandon S. Shaw

“…Statistical analyses were conducted using paired t-tests for within-group comparisons and ANCOVA with Bonferroni post hoc tests for between-group differences, with significance set at p ≤ 0.05. …”
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Dynamics of Suspended Particulate Matter in an Impounded River Under Dry and Wet Weather Conditions by T. T. Huynh, J. Kim, W. Kim, J. Hur, Q. N. Ho, Q. Bi, T. V. Bui, J. J. Kim, S. D. Lee, Y. Y. Choi, B. J. Lee

“…However, the highly turbulent flow conditions during the post‐flood period disturbed the tails of high turbidity and homogenized the vertical profiles of turbidity, temperature, and dissolved oxygen. …”
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Association of accelerometer-derived sleep measures with lifetime psychiatric diagnoses: A cross-sectional study of 89,205 participants from the UK Biobank. by Michael Wainberg, Samuel E Jones, Lindsay Melhuish Beaupre, Sean L Hill, Daniel Felsky, Manuel A Rivas, Andrew S P Lim, Hanna M Ollila, Shreejoy J Tripathy

“…<h4>Methods and findings</h4>In this post hoc cross-sectional analysis of the UK Biobank cohort, 10 interpretable sleep measures-bedtime, wake-up time, sleep duration, wake after sleep onset, sleep efficiency, number of awakenings, duration of longest sleep bout, number of naps, and variability in bedtime and sleep duration-were derived from 7-day accelerometry recordings across 89,205 participants (aged 43 to 79, 56% female, 97% self-reported white) taken between 2013 and 2015. …”
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The Efficiency of <i>Chlorella vulgaris</i> in Heavy Metal Removal: A Comparative Study of Mono- and Multi-Component Metal Systems by Eleni Kyratzopoulou, Nikoletta Kyzaki, Lamprini Malletzidou, Evangelos Nerantzis, Nikolaos A. Kazakis

“…The research illustrates the potential for <i>C. vulgaris</i> as a promising biosorbent for heavy metal remediation along with its post-treatment use in applications supporting the green circular economy.…”
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Implementación de microservicios en proyectos de IoT con Arduino by Marco Antonio Celis Crisostomo, Francisco Miguel Hernández López, Jorge Alberto Cárdenas Magaña, Emmnuel Vega Negrete

“…El objetivo principal es describir detalladamente los componentes y configuraciones necesarias para establecer esta comunicación, proporcionando ejemplos prácticos de los servicios HTTP más comunes: GET, POST, PUT y DELETE. Para la creación de los microservicios, se utiliza un servidor MAMP y se programa en PHP empleando el framework Slim. …”
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Effects of Sex and Age on Quadriceps and Hamstring Strength and Flexibility in High School Basketball Athletes by Takashi Nagai, Nathaniel Bates, April McPherson, Rena Hale, Timothy Hewett, Nathan D. Schilaty

“…Effects of sex and age were analyzed using t-tests and analysis of variance, respectively with Bonferroni corrected post hoc tests (*p*≤0.01). # Results A total of 172 high school basketball athletes (64 males/108 females; mean age (range): 15.7 (14-18) years old) participated in the study. …”
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Unstable maternal environment, separation anxiety, and heightened CO2 sensitivity induced by gene-by-environment interplay. by Francesca R D'Amato, Claudio Zanettini, Valentina Lampis, Roberto Coccurello, Tiziana Pascucci, Rossella Ventura, Stefano Puglisi-Allegra, Chiara A M Spatola, Paola Pesenti-Gritti, Diego Oddi, Anna Moles, Marco Battaglia

“…<h4>Methodology</h4>Having spent the first 24 hours after birth with their biological mother, outbred NMRI mice were cross-fostered to adoptive mothers for the following 4 post-natal days. They were successively compared to normally-reared individuals for: number of ultrasonic vocalizations during isolation, respiratory physiology responses to normal air (20%O(2)), CO(2)-enriched air (6% CO(2)), hypoxic air (10%O(2)), and avoidance of CO(2)-enriched environments.…”
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