Predictors of recurrence after conversion therapy in unresectable hepatocellular carcinoma treated with HAIC, bevacizumab, and sintilimab by Chang-Fu Liu, Xiao-Hui Zhao, Shi-Bo Zhu, Hai-Peng Yu, Wen-Ge Xing, Hui-Kai Li

“…In multivariate analysis, tumor size decline ratio (OR=0.002; 95% CI: 0.000–0.117; p=0.002) and AFP decline ratio (OR=0.240; 95% CI: 0.067–0.862; p=0.029) during conversion therapy independently predicted a lower recurrence risk. Elevated post-therapy bilirubin level remained an adverse predictor (OR=1.020; 95%CI: 1.000–1.030; p=0.039). …”
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Acupuncture Modulates Spatiotemporal Neuronal Dynamics in Mild Cognitive Impairment: A Protocol for Simultaneous EEG-fMRI Study by Li YQ, Chen ZW, He H, Liu YW, Ye F, Yang ZQ, Li DH, Bao QN, Zhang XY, Zhong WQ, Wu KX, Yao J, Xu P, Yang SQ, Wang ZW, Yin ZH, Liang FR

“…The primary outcome measure will be the improvement in the Alzheimer’s Disease Assessment Scale-Cognitive subscale (ADAS-Cog) score from baseline to post-treatment. Secondary outcomes will include improvements in specific cognitive domains such as memory, executive function, language, and attention. …”
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Comprehensive assessment and progression of health status during neurorehabilitation in survivors of critical illness: a prospective cohort study by Marion Egger, Melanie Finsterhölzl, Daria Farabegoli, Franziska Wippenbeck, Maria Schlutt, Friedemann Müller, Volker Huge, Klaus Jahn, Jeannine Bergmann

“…Abstract Background Critical illness survivors frequently suffer from long-term impairments, often described as post-intensive care syndrome (PICS). PICS encompasses physical, cognitive, and mental impairments. …”
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Effects of dietary formic acid polymer supplementation on growth performance, blood parameters, and intestinal health in lipopolysaccharide-challenged broilers by Guohui Zhou, Yilin Ge, Yuemeng Fu, Changfei An, Changjin Li, Yang Li, Weiren Yang, Ning Jiao, Jiali Chen

“…Samples were collected on day 21, 3 h post-challenge. The experiment lasted 21 days. LPS treatment reduced growth performance, immune function, and caused systemic inflammation, intestinal barrier damage, and microbiota dysbiosis in broilers. …”
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Durability of Antibody Responses to SARS-CoV-2 Vaccination over 12 Months in Pediatric Inflammatory Bowel Disease by Sally J. Lawrence, Marina Viñeta Paramo, Frederic Reicherz, Jeffrey N. Bone, Zahra Jama Hussein Shire, Loujain Bilal, Gabriella Guerra, Liam Golding, Pascal M. Lavoie, Kevan Jacobson

“…This study aimed to quantify SARS-CoV-2 antibody responses post vaccination in these immunosuppressed patients over 12 months. …”
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Short Sleep Duration is Inversely Associated with the Prevalence of Underweight in a Young Japanese Population by Ishikawa S, Furukawa S, Miyake T, Yoshida O, Murakami Y, Kanamoto A, Miyazaki M, Shiomi A, Nakaguchi H, Saneto H, Marui K, Kokubu M, Numata Y, Koizumi M, Kato A, Kusumoto K, Kumagi T, Matsuura B, Hiasa Y

“…Sho Ishikawa,1 Shinya Furukawa,2 Teruki Miyake,1 Osamu Yoshida,1 Yoshimasa Murakami,1 Ayumi Kanamoto,1 Masumi Miyazaki,1 Akihito Shiomi,1 Hironobu Nakaguchi,3 Hironobu Saneto,1 Kaori Marui,1 Masahito Kokubu,1 Yuki Numata,1 Mitsuhito Koizumi,1 Aki Kato,2 Katsunori Kusumoto,2 Teru Kumagi,4 Bunzo Matsuura,3 Yoichi Hiasa1 1Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon, Ehime, Japan; 2Health Services Center, Ehime University, Matsuyama, Ehime, Japan; 3Department of Lifestyle-related Medicine and Endocrinology, Ehime University Graduate School of Medicine, Toon, Ehime, Japan; 4Post Graduate Medical Education Center, Ehime University Hospital, Toon, Ehime, JapanCorrespondence: Shinya Furukawa, Health Services Center, Ehime University, Bunkyo, Matsuyama, Ehime, 790-8577, Japan, Tel +81-89-927-9198, Fax +81-89-927-9196, Email furukawa.shinya.mf@ehime-u.ac.jpStudy Objectives: Many studies have shown that sleep disorders including short sleep duration are associated with obesity. …”
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Risk Factors and Postoperative Outcomes in Pouchitis Following Restorative Proctocolectomy: An 18-Year Single-Center Study by Luisa Bertin, Mohamad Nasrallah, Carlo Redavid, Erica Bonazzi, Daria Maniero, Greta Lorenzon, Caterina De Barba, Sonia Facchin, Marco Scarpa, Cesare Ruffolo, Imerio Angriman, Andrea Buda, Matteo Fassan, Carmelo Lacognata, Brigida Barberio, Fabiana Zingone, Edoardo Vincenzo Savarino

“…Pouch failure was significantly associated with a previous diagnosis of Crohn’s disease (OR 9.500, 95% CI 1.821–49.571) and post-surgical fistulas (OR 41.597, 95% CI 4.022–430.172). …”
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Acrylamide induces spatiotemporal metabolic profiling disturbance via targeting taurine and hypotaurine metabolism during early zebrafish development by Anli Wang, Jia Zeng, Xiaoran Song, Yingyu Huang, Jianxin Yao, Li Zhu, Yuchen Gao, Binjie Wang, Yuanzhao Wu, Zhongshi Xu, Ruonan Zheng, Yazhou Qin, Jiye Wang, Weixuan Yao, Xuzhi Wan, Haoyu Li, Pan Zhuang, Jingjing Jiao, Shulin Zhuang, Yu Zhang

“…A comprehensive metabolites analysis of four different acrylamide exposures (0, 0.5, 1.0, and 2.0 mM) at different zebrafish developmental stages (6, 24, 48, 72, 96, and 120 h post fertilization, hpf) was performed. Metabolite changes throughout the zebrafish development (6–120 hpf) were closely associated with taurine and hypotaurine metabolism. …”
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Smallholder Cattle Farmers’ Knowledge, Attitudes, and Practices Toward Rabies: A Regional Survey in Kazakhstan by Nurbek Ginayatov, Zukhra Aitpayeva, Izimgali Zhubantayev, Leila Kassymbekova, Assylbek Zhanabayev, Gulmira Abulgazimova, Raikhan Arynova, Alim Bizhanov, Assiya Mussayeva, Maxat Berdikulov, Marat Aisin, Zaure Sayakova, Spandiyar Tursunkulov, Nurkuisa Rametov, Ainur Akhmadiyeva, Aigul Bulasheva, Nurgul Jussupbekova, Olzhas Yeskhojayev, Gulnara Baikadamova, Kaissar Kushaliyev, Nadezhda Burambayeva, Arman Issimov

“…While 87% recognized the importance of rabies vaccination in dogs, 81% were unaware of pre-exposure prophylaxis (PrEP) for cattle, and 72% lacked knowledge of PrEP for humans. Awareness of the post-exposure prophylaxis (PEP) regimen was significantly higher in the Aktobe region (<i>p</i> < 0.002). …”
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Genetic Parameters, Linear Associations, and Genome-Wide Association Study for Endotoxin-Induced Cortisol Response in <i>Holstein heifers</i> by Bruno A. Galindo, Umesh K. Shandilya, Ankita Sharma, Flavio S. Schenkel, Angela Canovas, Bonnie A. Mallard, Niel A. Karrow

“…Research indicates that LPS administration leads to a significant rise in cortisol post-challenge. Building on this understanding, the present study aimed to estimate genetic parameters for serum cortisol response to LPS challenge in <i>Holstein heifers</i> and its linear associations with production, health, reproduction, and conformation traits. …”
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Analysis of the safety and efficacy of microwave ablation of several foci of multiple lung metastases from colorectal cancer by Bohan Song, Jinfeng Bai, Jinmei Zhou, Yinshan Yang, Qijie Wu, Ming Huang, Hongjie Fan, Xianshuo Cheng, Ping Liu, Yu-Dong Xiao, Xin Zhao, Chongying Deng, Shuai Luo, Rong Ding

“…Chest-enhanced CT scans were performed at 1, 3, 6, and 12 months post-MWA to assess ablation outcomes. The primary focus was the median overall survival (mOS), while secondary endpoints encompassed median progression-free survival (mPFS), technical success rates, and safety. …”
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Efek Lama Penyimpanan Asi Terhadap Kadar Protein dan Lemak yang Terkandung Didalam ASI by Indri Putri Sari, Ariadi ., Ety Yerizel

“…Ini merupakan <em>true experiment</em> dengan pendekatan <em>pretest-post test control group design</em>. Pemeriksaan kadar protein dan lemak dilakukan di Laboratorium Teknologi Hasil Ternak Fakultas Peternakan Universitas Andalas padang, pada bulan November 2014 dengan total 32 sampel. …”
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Bariatric surgery for patients with type 2 diabetes mellitus requiring insulin: Clinical outcome and cost-effectiveness analyses. by Emma Rose McGlone, Iain Carey, Vladica Veličković, Prem Chana, Kamal Mahawar, Rachel L Batterham, James Hopkins, Peter Walton, Robin Kinsman, James Byrne, Shaw Somers, David Kerrigan, Vinod Menon, Cynthia Borg, Ahmed Ahmed, Bruno Sgromo, Chandra Cheruvu, Gul Bano, Catherine Leonard, Howard Thom, Carel W le Roux, Marcus Reddy, Richard Welbourn, Peter Small, Omar A Khan

“…The main outcome measure for the clinical study was insulin cessation at 1-year post-surgery: relative risks (RR) summarising predictive factors were determined, unadjusted, and after adjusting for variables including age, initial body mass index (BMI), duration of T2DM, and weight loss. …”
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Evaluación del efecto de un programa de ejercicio físico sobre la capacidad cardiorrespiratoria en académicos de la Universidad de Sonora con síndrome metabólico: un estudio piloto... by María Elena Chávez Valenzuela, Melanie Valdez García, Alejandrina Bautista Jacobo, Graciela Hoyos Ruiz, Nidia Carolina Barahona Herrejón, Carlos Ernesto Ogarrio Perkins

“…A pre-experimental study with a pre and post test design was carried out in a single group of 10 individuals who participated voluntarily (47.10 ± 11.10 years). …”
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Artificial intelligence-assisted diagnosis and prognostication in low ejection fraction using electrocardiograms in inpatient department: a pragmatic randomized controlled trial by Dung-Jang Tsai, Chin Lin, Wei-Ting Liu, Chiao-Chin Lee, Chiao-Hsiang Chang, Wen-Yu Lin, Yu-Lan Liu, Da-Wei Chang, Ping-Hsuan Hsieh, Chien-Sung Tsai, Yuan-Hao Chen, Yi-Jen Hung, Chin-Sheng Lin

“…While overall echocardiogram utilization remained similar between groups (17.1% vs. 17.3%, HR 1.00, 95% CI: 0.92–1.09), the intervention group demonstrated higher positive predictive value for identifying low EF among patients receiving echocardiogram (34.2% vs. 20.2%, p < 0.001). Post-hoc analysis revealed increased cardiology consultation rates among high-risk patients in the intervention group (29.3% vs. 23.5%, p = 0.027). …”
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In Vitro Study Comparing SARS-CoV-2 Ancestral and Omicron Lineages Sequence &amp; Neutralization Differences by Ms Ashley Burroughs, Dr Clinton Paden, Neha Mittal, Juan Castro, Peter Cook, Sandra Lester, Heather Hicks, Dr. Azaibi Tamin, Fatimah Dawood, Jennifer DeCuir, Diya Surie, Dr. Melissa M Coughlin, Dr. Jennifer L. Harcourt, Dr. Natalie J. Thornburg, Dr. Lydia J. Atherton

“…In vitro neutralization activity of paired pre- and post- SARS-CoV-2 vaccination sera pools were tested using a focus reduction neutralization test (FRNT) against ancestral strain USA-WA1/2020, and Omicron variants XBB.1.5, JD.1.1.1, BA.2.86 and JN.1. …”
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Topical TLR7 agonist and radiotherapy in patients with metastatic breast cancer by Ping Jin, Xiaochun Li, Francesco Marincola, Ena Wang, Sandra Demaria, Davide Bedognetti, Darawan Rinchai, Sylvia Adams, Yelena Novik, Ruth Oratz, David Stroncek, Judith Goldberg, Silvia Chiara Formenti, Maria Fenton-Kerimian, Pascale G Levine

“…These revealed that the presence of a T-helper 1 functional orientation of the tumor microenvironment paralleled by the downregulation of DNA-repair genes was associated with CR after IMQ+RT, but not after IMQ alone. No post-treatment activation of immune-effector functions was observed in stable and progressing lesions.Conclusions Our findings support the safety and clinical efficacy of combining topical IMQ with local RT for recurrent breast cancer, with evidence of local and occasional systemic antitumor activity.Trial registration number NCT01421017.…”
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Effects of Feed Additives (<i>Nannochloropsis gaditana</i> and <i>Hermetia illucens</i>) on Growth and Expression of Antioxidant and Cytokine Genes in Nile Tilapia (<i>Oreochromis... by László Ardó, Zsuzsanna J. Sándor, Márton Orbán, János Szakáli, Janka Biró, Anita Annamária Szűcs, Gyula Kovács, Michelle Lévai, Balázs Gregosits, Zsuzsanna Brlás-Molnár, Emese Békefi

“…Subsequently, <i>gpx</i> upregulation was observed in the EXP-S group in the post-stress stage compared to pre-stress. Based on our results, we recommend the inclusion of any of the tested additives at the evaluated doses to enhance the non-specific immune response of Nile tilapia. …”
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COMPARATIVE CHARACTERISTICS OF MULTIMORBIDITY, DRUG TREATMENT AND OUTCOMES IN POSTSTROKE PATIENTS WITH ATRIAL FIBRILLATION AND WITH OR WITHOUT HISTORY OF MYOCARDIAL INFARCTION (REG... by E. Yu. Okshina, M. M. Loukianov, S. Yu. Martsevich, S. S. Yakushin, N. P. Kutishenko, I. S. Yavelov, A. N. Vorobyev, K. G. Pereverzeva, A. V. Zagrebelnyy, N. A. Dmitrieva, E. V. Kudryashov, S. A. Boytsov, O. M. Drapkina, K. A. Moseichuk

“…During the four-year period of observation, in comparison with post-stroke patients without a history of MI, the mortality rate for all causes was 1.5 times higher (56.6% and 37.6%, p = 0.0001), the incidence of non-fatal MI was higher (2.0% and 0.3%,p = 0.04). …”
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High-power short-duration vs conventional radiofrequency ablation for atrial fibrillation in patients over 80 years of age: A propensity-score matched cohort analysis by Alex Tunsch Martinez, MD, Raphael Spittler, MD, Nico Erhard, MD, Florian Englert, MD, Jan Syväri, MD, Hannah Krafft, MD, Miruna Popa, MD, Theresa Reiter, MD, Dominic Dischl, MD, Eva Koops, MD, Marta Telishevska, MD, Sarah Lengauer, MD, Gabriele Hessling, MD, Isabel Deisenhofer, MD, FHRS, Fabian Bahlke, MD

“…Propensity score matching revealed 102 pairs for maximizing comparability. A post-ablation 42-day blanking period was applied. …”
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