Supported implementation of tailored multicomponent fall prevention interventions in hospital: a feasibility study by Bethan Richards, Vasi Naganathan, Catherine Sherrington, Leanne Hassett, Matthew Jennings, Andrew Hallahan, Abby Haynes, Charlotte McLennan, Wendy Tilden, Tamsin McVeigh, Veethika Nayak

“…Reach: 28/38 (74%) survey respondents were aware of the multicomponent fall prevention interventions on their ward, with 24 (86%) reporting a positive impact on clinical practice post implementation. Adoption: delivery of multicomponent hospital fall prevention interventions increased 1.1/10 points between preimplementation (n=61) postimplementation (n=38) surveys. …”
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A universal testing and treatment intervention to improve HIV control: One-year results from intervention communities in Zambia in the HPTN 071 (PopART) cluster-randomised trial. by Richard Hayes, Sian Floyd, Ab Schaap, Kwame Shanaube, Peter Bock, Kalpana Sabapathy, Sam Griffith, Deborah Donnell, Estelle Piwowar-Manning, Wafaa El-Sadr, Nulda Beyers, Helen Ayles, Sarah Fidler, HPTN 071 (PopART) Study Team

“…Data from four communities in Zambia receiving the full intervention (including immediate ART for all individuals with HIV) were used to determine proportions of participants who knew their HIV status after the CHiP visit; proportions linking to care and initiating ART following referral; and overall proportions of HIV-infected individuals who knew their status (first 90 target) and the proportion of these on ART (second 90 target), pre- and post-intervention. We are not able to assess progress towards the third 90 target at this stage of the study. …”
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Application of the Fitness and Nutrition Program for Seniors (FANS) to improve Physical Activity and Kinanthropometric Measures among Community-Dwelling Older Adults living with Fr... by Pei-Shan Li, Chia-Jung Hsieh, Nae-Fang Miao, Chuan-Hsiu Tsai, Chieh-Yu Liu, Hung-Ru Lin, Shu-Fang Vivienne Wu, Jordan Koh

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Optimizing High-Power Performance of [001]-Oriented Pb(Mg_1/3Nb_2/3)-PbTiO₃ Through Combined DC and AC Polarization Above Curie Temperature by Yuliang Zhu, Xiaobo Wang, Wenchao Xue, Xinran Wen, Chengtao Luo

“…Pb(Mg_1/3Nb_2/3)O₃-PbTiO₃ single crystals (PMN-PT SCs) are widely utilized in high-performance piezoelectric devices due to their exceptional piezoelectric properties. Among the various post-processing techniques for domain engineering in PMN-PT SCs, alternating current polarization (ACP) has become a widely adopted method for enhancing piezoelectric performance. …”
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Safety and effectiveness of multimodal opioid-free anaesthesia for pain and recovery after laparoscopic surgery: a systematic review and meta-analysis by Jiang Liu, Li Jing, Lin Cheng, Sifan Qin, Xinyan Geng, Shirong Fang

“…The secondary outcomes included the incidence of postoperative nausea and vomiting (PONV), antiemetic use, extubation time (measured in minutes), post-anaesthesia care unit discharge time (measured in minutes), shivering, bradycardia, hypotension and pruritus.Data extraction and synthesis Meta-analyses were performed using Stata16 software, using the DerSimonian and Laird’s method and inverse variance to summarise effect sizes for each outcome under a random effects model for all outcomes. …”
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Comparative adherence and persistence of single-inhaler and multiple-inhaler triple therapies among patients with chronic obstructive pulmonary disease in Japan: a retrospective co... by Olivia Massey, Robert Wood, Kieran J Rothnie, TAKEO ISHII, Alexandrosz Czira, Chris Compton, Afisi Ismaila, Sandra Jokšaitė, Lucinda Camidge, Akiko Mizukami, Masao Yarita, Rad Siddiqui, Thomas Jennison, Kenichi Hashimoto

“…The proportion of adherent patients was significantly greater for SITT versus MITT users at 6 months (19.7% vs 10.2%, p<0.0001), 12 months (6.0% vs 3.8%, p=0.0009) and 18 months (3.8% vs 1.4%, p<0.0001) post-index. Median persistence was also significantly higher for SITT versus MITT users (2.0 vs 1.0 months, p<0.001). …”
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Stationary Cycling Exercise With Virtual Reality to Reduce Depressive Symptoms Among People With Mild to Moderate Depression: Randomized Controlled Trial by Na Zhang, Chenlu Hong, Yuejia Wang, Haiqin Chen, Yueli Zhu, Miao Da, Zhongxia Shen, Xudong Zhao, Jiali Xu, Jiaxiu Sheng, Yanan Luo, Meiying Xu

“…Response rate, remission rate, satisfaction, compliance, and adverse events were assessed post intervention. Outcomes were analyzed using an ITT approach. …”
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Effect of rapamycin-eluting stents on in-stent restenosis and early inflammatory response in coronary artery narrowing animal models by Jianbing Zhang, Jingyi Zhu, Baiping Sui, Ying Wang, Bingxue Zhang

“…The cardiovascular injury scores (P = 0.072) and endothelialization scores (P = 0.085) differed slightly among the four groups (P > 0.05). Post-operative liver function indicators (alanine transaminase, aspartate transaminase), kidney function indicators (blood urea nitrogen, serum creatinine), and myocardial injury markers (creatine kinase, creatine kinase-MB) also showed neglectable differences among the four groups (P > 0.05). …”
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Enhanced T-cell immunity and lower humoral responses following 5-dose SARS-CoV-2 vaccination in patients with inborn errors of immunity compared with healthy controls by Vitor Gabriel Lopes da Silva, Gabriela Justamante Händel Schmitz, Kathleen E. Sullivan, Júlia Barbate, Maria Izabel de Haro Azinar, Carolina Sanchez Aranda, Maria Isabel de Moraes-Pinto

“…T-cell responses to Spike were stronger in patients with IEI post-booster (405 vs. 149 spot-forming cells/million PBMC; p = 0.002). …”
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Evaluation and improvement of crop root-water-uptake and transpiration in AquaCrop by Ting Zhang, Qiang Zuo, Jianchu Shi, Yuchuan Fan, Sumei Zhang, Xun Wu, Alon Ben-Gal

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Polymorphisms in the GNAS Gene as Predictors of Ventricular Tachyarrhythmias and Sudden Cardiac Death: Results From the DISCOVERY Trial and Oregon Sudden Unexpected Death Study by Heinrich Wieneke, Jesper Hastrup Svendsen, Jeffrey Lande, Sebastian Spencker, Juan Gabriel Martinez, Bernhard Strohmer, Lauri Toivonen, Hervé Le Marec, F. Javier Garcia‐Fernandez, Domenico Corrado, Adriana Huertas‐Vazquez, Audrey Uy‐Evanado, Carmen Rusinaru, Kyndaron Reinier, Csaba Foldesi, Wieslaw Hulak, Sumeet S. Chugh, Winfried Siffert

“…In the DISCOVERY trial, genotypes of 2 SNPs in the GNAS gene were nominally significant in the prospective screening and significantly associated with VT when viewed as recessive traits in post hoc analyses (TT vs CC/CT in c.393C>T: HR 1.42 [CI 1.11‐1.80], P=0.005; TT vs CC/CT in c.2273C>T: HR 1.57 [CI 1.18‐2.09], P=0.002). …”
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Theory-screened Prussian blue analogues-based nanozymes for promoting diabetic wound healing via ferroptosis inhibition by Qingrong Dong, Xiaomei Shen, Ge Fang, Jia Shi, Xiafeng Zhu, Jiangfeng Du, Hui Zhang, Cuicui Ge

“…Through computational and experimental methods, the optimized Prussian blue analogues (MPBs) with highest iron chelating efficiency and efficacy (CuPBs) are screened out and both the CuPBs and the post-chelated products have been demonstrated to exhibit reactive oxygen species (ROS)-scavenging activities. …”
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Fe2O3-type iron oxide nanoparticles from Aerva lanata leaf extract exhibit antibiofilm, discriminatory toxicity in cancer cells, and theranostic against oxidative stress in zebrafi... by Anusuya Nagaraj, Oriparambil Sivaraman Nirmal Ghosh, Hazem K Ghneim, Yazeed A AlSheikh, Kaleemuddin Mohammed, Sudhakar Poda, Naveen Kumar Kalagatur

“…Fe NPs were found biocompatible up to 50 µg/mL in zebrafish embryos at 24, 48, 72, and 96 h post fertilization (hpf). Moreover, Fe NPs showed amelioration potential against hydrogen peroxide-induced oxidative stress at 30 µg/mL. …”
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Prediction of Pathologic Response in Unresectable Hepatocellular Carcinoma After Downstaging with Locoregional and Systemic Combination Therapy by Yang C, Chen Y, Sheng L, Wang Y, Zhang X, Yang Y, Ronot M, Jiang H, Song B

“…Performance of the response criteria in predicting pathologic response was assessed with the area under the receiver operator characteristic curve (AUC).Results: Among all radiologic and pathologic response criteria, MPR was the only independent predictor of post-resection recurrence-free survival (RFS) (adjusted hazard ratio 0.34, 95% CI 0.16– 0.72, p=0.004). …”
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Diagnostic value of microRNA-27 and -339 in heart transplant recipients with myocardial fibrosis by O. P. Shevchenko, D. A. Velikiy, S. O. Sharapchenko, O. E. Gichkun, A. V. Marchenko, A. A. Ulybysheva, V. S. Pavlov, N. P. Моzheikо, N. N. Кoloskovа, A. O. Shevchenko

“…The combination of molecular-genetic and proteomic biomarkers in one test improves the diagnostic characteristics of these expressions with respect to post-transplant complications in heart recipients.…”
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Regulation of retinoic acid inducible gene I signal transduction by bluetongue virus through the ubiquitin-proteasome system by Danfeng LU, Zhenxing ZHANG, Zhanhong LI, Pei ZHU, Zhuoran LI

“…Treatment with the proteasome inhibitor MG-132 significantly suppressed RIG-I degradation induced by BTV infection; The nuclear translocation ratio of IRF3 in MG-132 treated SPAE cells increased by 9.67 and 8.66 percentage points compared with their untreated counterparts at 24 hours post-infection (24 hpi) and 48 hpi; The expression level of IFN-α increased by 2.18-fold comparing with that of the corresponding untreated group at 48 hpi; The genomic copy numbers of BTV decreased to 74% and 85% of those of the untreated counterparts at 24 and 48 hpi, respectively. …”
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Biochemical investigation of association of arsenic exposed polymorphic variants and disease susceptibility by Syed Muhammad Shoaib, Samina Afzal, Muhammad Sajid Hamid Akash, Kanwal Rehman, Amjad Hussain, Ahmed Nadeem, Asif Shahzad, Sabry M. Attia

“…The groundwater exhibited significantly elevated arsenic concentrations (68.18 ± 21.28 μg/L) in comparison to both water and sanitation agency Faisalabad (WASA)-supplied water (9.81 ± 1.2 μg/L) and locally filtered water (8.12 ± 1.42 μg/L), as determined by one-way ANOVA followed by Bonferroni's post-test at P < 0.05. An association was established between arsenic concentration and the incidence of disease, such as diabetes mellitus. …”
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The role of ubiquitination and deubiquitination in urological tumours by Lifeng Gan, Lifeng Gan, Lifeng Gan, Peiyue Luo, Peiyue Luo, Peiyue Luo, Junrong Zou, Junrong Zou, Wei Li, Wei Li, Wei Li, Qi Chen, Qi Chen, Qi Chen, Le Cheng, Le Cheng, Le Cheng, Fangtao Zhang, Fangtao Zhang, Fangtao Zhang, Haidong Zhong, Haidong Zhong, Haidong Zhong, Liying Zheng, Biao Qian, Biao Qian

“…Ubiquitination, a form of post-translational modification, occurs in eukaryotic cells and involves several key components, such as Ub-activating enzymes, Ub-binding enzymes, and Ub-protein ligases. …”
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The ASSIST Trial: Acute Effects of Manipulating Strength Exercise Volume on Insulin Sensitivity in Adults Living With Obesity: A Randomized Controlled, Crossover, Clinical Trial by Luis Filipe Rocha Silva, Paulo H. Evangelista Silva, Jordan Ottoni do Carmo, Bruna Caroline Chaves Garcia, Elizabethe Adriana Esteves, Zachary Aaron Mang, Fabiano Trigueiro Amorim, Marco Fabrício Dias‐Peixoto, Fernando Gripp, Valmor Tricoli, Flavio de Castro Magalhaes

“…Results One‐way repeated measure analysis of variance followed by Tukey as post hoc showed that indexes of insulin sensitivity improved after the high‐volume session (p < 0.05) but not after the low‐volume session (p > 0.05) (effect size [EF] for high and low volume, respectively): insulin area under the curve (AUC) [−0.53 and −0.05], C‐peptide AUC [0.58 and 0.18], Cederholm index [0.59 and 0.11], skeletal muscle index [0.89 and 0.60], Gutt index [0.78 and 0.20], Stumvoll index [0.81 and 0.18], and the simple index [0.52 and 0.16]). β‐cell function showed a strong tendency to improve (p < 0.06) after the high‐volume session (EF for high and low volume, respectively): C‐peptidogenic index [0.58 and −0.20], C‐peptide oral disposition index [0.72, −0.33]. …”
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Newborn Screening for Gaucher Disease: The New Jersey Experience by Caitlin Menello, Shaney Pressley, Madeline Steffensen, Sarah Schmidt, Helio Pedro, Reena Jethva, Karen Valdez-Gonzalez, Darius J. Adams, Punita Gupta, Lorien Tambini King, Milen Velinov, Sharon Anderson, Peyman Bizargity, Beth Pletcher, Allysa Tuite, Christina Kresge, Debra Lynn Day-Salvatore, Ryan Kuehl, Can Ficicioglu

“…Three type I GD patients started enzyme replacement therapy, with the youngest starting at 28 months of age. Post-treatment data are available for these individuals. …”
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