Effects of therapeutic interventions on long COVID: a meta-analysis of randomized controlled trialsResearch in context by Chang Tan, Jiahao Meng, Xingui Dai, Baimei He, Pan Liu, Yumei Wu, Yilin Xiong, Heng Yin, Shuhao Wang, Shuguang Gao

“…Summary: Background: Long COVID, characterized by persistent multi-organ symptoms post-SARS-CoV-2 infection, poses a substantial global health burden. …”
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Anti-RBD IgG antibodies from endemic coronaviruses do not protect against the acquisition of SARS-CoV-2 infection among exposed uninfected individuals by Flávia Lopes Adami, Mateus Vidigal de Castro, Mateus Vidigal de Castro, Bianca da Silva Almeida, Isabela Pazotti Daher, Isabela Pazotti Daher, Márcio Massao Yamamoto, Keity Souza Santos, Keity Souza Santos, Keity Souza Santos, Mayana Zatz, Mayana Zatz, Michel Satya Naslavsky, Michel Satya Naslavsky, Daniela Santoro Rosa, Daniela Santoro Rosa, Edecio Cunha-Neto, Edecio Cunha-Neto, Edecio Cunha-Neto, Vivian Leite de Oliveira, Jorge Kalil, Jorge Kalil, Jorge Kalil, Silvia Beatriz Boscardin, Silvia Beatriz Boscardin

“…Plasma samples, collected at least 30 days post-PCR reaction, were assessed using indirect ELISA and competition assays to measure specific antibodies against the receptor-binding domain (RBD) portion of the Spike (S) protein from SARS-CoV-2, HCoV-229E, HCoV-NL63, HCoV-OC43, and HCoV-HKU1.ResultsIgG antibody levels against the four endemic coronavirus RBD proteins were similar between the PCR-positive and PCR-negative individuals, suggesting that IgG against endemic coronavirus RBD regions was not associated with protection from infection. …”
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Preoperative Mechanical Ventilation Prior to Surgical Repair for Type A Aortic Dissection: Incidence, Risk, and Outcomes by Angelo M. Dell’Aquila, Konrad Wisniewski, Adrian-Iustin Georgevici, Gábor Szabó, Francesco Onorati, Till J. Demal, Andreas Rukosujew, Sven Peterss, Caroline Radner, Joscha Buech, Antonio Fiore, Andrea Perrotti, Angel G. Pinto, Javier Rodriguez Lega, Marek Pol, Petr Kacer, Enzo Mazzaro, Giuseppe Gatti, Igor Vendramin, Daniela Piani, Luisa Ferrante, Mauro Rinaldi, Eduard Quintana, Robert Pruna-Guillen, Dario Di Perna, Zein El-Dean, Hiwa Sherzad, Giovanni Mariscalco, Mark Field, Amer Harky, Manoj Kuduvalli, Matteo Pettinari, Stefano Rosato, Tatu Juvonen, Timo Mäkikallio, Lenard Conradi, Giorgio Mastroiacovo, Fausto Biancari

“…The in-hospital mortality rate among IMV patients was 38% vs. 15% in non-IMV patients (<i>p</i> < 0.001), without a difference in post-discharge survival (<i>p</i> = 0.84). At the MMLR, patients who required IMV had 135% higher odds of in-hospital death compared to the remaining patients. …”
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Enhancement of anti‐sarcoma immunity by NK cells engineered with mRNA for expression of a EphA2‐targeted CAR by Pui Yeng Lam, Natacha Omer, Josh K. M. Wong, Cui Tu, Louisa Alim, Gustavo R. Rossi, Maria Victorova, Hannah Tompkins, Cheng‐Yu Lin, Ahmed M. Mehdi, Amos Choo, Melissa R. Elliott, Elaina Coleborn, Jane Sun, Timothy Mercer, Orazio Vittorio, Lachlan J. Dobson, Alexander D. McLellan, Andrew Brooks, Zewen Kelvin Tuong, Seth W. Cheetham, Wayne Nicholls, Fernando Souza‐Fonseca‐Guimaraes

“…Results CAR expression was successfully detected on the surface of NK cells post‐electroporation, indicating successful transfection. …”
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Development of a lung perfusion automated quantitative model based on dual-energy CT pulmonary angiography in patients with chronic pulmonary thromboembolism by Linfeng Xi, Jianping Wang, Anqi Liu, Yifei Ni, Jie Du, Qiang Huang, Yishan Li, Jing Wen, Hongyi Wang, Shuai Zhang, Yunxia Zhang, Zhu Zhang, Dingyi Wang, Wanmu Xie, Qian Gao, Yong Cheng, Zhenguo Zhai, Min Liu

“…PerAIDE effectively differentiated CTEPH from CTEPD (AUC = 0.809, 95% CI: 0.745–0.863). At the 3-month post-BPA, a significant reduction in perfusion defects was observed (0.36 vs. 0.33, p < 0.01). …”
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Altered thermal preference by preoptic estrogen receptor alpha neurons in postpartum females by Nan Zhang, Meng Yu, Qianru Zhao, Bing Feng, Yue Deng, Jonathan C. Bean, Qingzhuo Liu, Benjamin P. Eappen, Yang He, Kristine M. Conde, Hailan Liu, Yongjie Yang, Longlong Tu, Mengjie Wang, Yongxiang Li, Na Yin, Hesong Liu, Junying Han, Darah Ave Threat, Nathan Xu, Taylor Smiley, Pingwen Xu, Lulu Chen, Tianshu Zeng, Yanlin He, Chunmei Wang

“…Female mice with RE (>4 weeks post-weaning) displayed lower body temperature and a lower thermal preferred temperature, and lost preference for warm environments (30 °C) but preserved avoidance of cold environments (15 °C). …”
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Indo-Pacific Role in Iran’s East Look Strategy by Mohammad Reza Mohammadi

“…Based on the hypothesis that this engagement is affected by the challenges imposed by Western sanctions against Iran, and given the special position that the Indo-Pacific strategic area has in the post-Cold War geopolitical equations, Iran’s diplomatic apparatus has strong incentives to be present in the Indo-Pacific within the framework of the East Look strategy, which is expected to play a significant role in the future. …”
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Nanoscale piezoelectric patches preserve electrical integrity of infarcted hearts by Luís M. Monteiro, Pedro J. Gouveia, Francisco Vasques-Nóvoa, Susana Rosa, Ifigeneia Bardi, Rita N. Gomes, Simão Correia-Santos, Leonardo Ricotti, Lorenzo Vannozzi, Daniele Guarnera, Liliana Costa, André M. Leite-Moreira, Pedro Mendes-Ferreira, Adelino F. Leite-Moreira, Filippo Perbellini, Cesare M. Terracciano, Perpétua Pinto-do-Ó, Lino Ferreira, Diana S. Nascimento

“…Overall, the results presented here endorse Piezo patches as a promising therapeutic strategy to improve post-myocardial infarction structural and electrical remodeling.…”
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Cannabis legalization and cannabis use disorder in United States Veterans Health Administration patients with and without psychiatric disorders, 2005–2022: a repeated cross-section... by Deborah S. Hasin, Carol Malte, Melanie M. Wall, Daniel Alschuler, Tracy L. Simpson, Mark Olfson, Ofir Livne, Zachary L. Mannes, David S. Fink, Katherine M. Keyes, Magdalena Cerdá, Charles C. Maynard, Salomeh Keyhani, Silvia S. Martins, Scott Sherman, Andrew J. Saxon

“…Results were similar for MCL-only and MCL/RCL effects among disorder-specific groups (depression, post-traumatic stress disorder [PTSD], anxiety or bipolar disorders) and for MCL/RCL effects among patients with psychotic-spectrum disorders. …”
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Response‐adapted zanubrutinib and tislelizumab as a potential strategy to enhance CD19 CAR T‐cell therapy in relapsed/refractory large B‐cell lymphoma: A retrospective observationa... by Rong Shen, Wei‐Guo Cao, Li Wang, Ling‐Shuang Sheng, Yi‐Lun Zhang, Wen Wu, Peng‐Peng Xu, Shu Cheng, Meng‐Ke Liu, Yan Dong, Yue Wang, Xiang‐Qin Weng, Xu‐Feng Jiang, Qi Song, Hong‐Mei Yi, Lei Li, Sheng Chen, Zi‐Xun Yan, Wei‐Li Zhao

“…Patients were treated with zanubrutinib daily from leukapheresis to day 28 post‐infusion; those achieving complete response continued zanubrutinib monotherapy for 3 months, while partial responders received combined zanubrutinib for 3 months and tislelizumab for up to 2 years. …”
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Treatment With Avacopan in ANCA–Associated Vasculitis With Kidney Involvement by Duvuru Geetha, Frank B. Cortazar, Annette Bruchfeld, Andreas Kronbichler, Alexandre Karras, Georges N. Nakhoul, Peter A. Merkel, Sarah Bray, Alana M. Bozeman, David R.W. Jayne, C. Au Peh, A. Chakera, B. Cooper, J. Kurtkoti, D. Langguth, V. Levidiotis, G. Luxton, P. Mount, D. Mudge, E. Noble, R. Phoon, D. Ranganathan, A. Ritchie, J. Ryan, M. Suranyi, A. Kronbichler, A. Rosenkranz, K. Lhotta, N. Demoulin, C. Bovy, R. Hellemans, J. Hougardy, B. Sprangers, K. Wissing, C. Pagnoux, S. Barbour, S. Brachemi, S. Cournoyer, L. Girard, L. Laurin, P. Liang, D. Philibert, M. Walsh, C. Rigothier, J. Augusto, A. Belot, D. Chauveau, D. Cornec, N. Jourde-Chiche, M. Ficheux, P. Zaoui. Paris, A. Karras, A. Klein, F. Maurier, R. Mesbah, O. Moranne, A. Neel, T. Quemeneur, D. Saadoun, B. Terrier, P. Zaoui, M. Schaier, U. Benck, R. Bergner, M. Busch, J. Floege, F. Grundmann, H. Haller, M. Haubitz, B. Hellmich, J. Henes, B. Hohenstein, C. Hugo, C. Iking-Konert, F. Arndt, T. Kubacki, I. Kotter, P. Lamprecht, T. Lindner, J. Halbritter, H. Mehling, U. Schönermarck, N. Venhoff, V. Vielhauer, O. Witzke, I. Szombati, G. Szucs, G. Garibotto, F. Alberici, E. Brunetta, L. Dagna, S. De Vita, G. Emmi, A. Gabrielli, L. Manenti, F. Pieruzzi, D. Roccatello, C. Salvarani, H. Dobashi, T. Atsumi, S. Fujimoto, N. Hagino, A. Ihata, S. Kaname, Y. Kaneko, A. Katagiri, M. Katayama, Y. Kirino, K. Kitagawa, A. Komatsuda, H. Kono, T. Kurasawa, R. Matsumura, T. Mimura, A. Morinobu, Y. Murakawa, T. Naniwa, T. Nanki, N. Ogawa, H. Oshima, K. Sada, E. Sugiyama, T. Takeuchi, H. Taki, N. Tamura, T. Tsukamoto, K. Yamagata, M. Yamamura, P. van Daele, J. de Zoysa, A. Rutgers, Y. Teng, R. Walker, I. Chua, M. Collins, K. Rabindranath, J. de Zoysa, M. Svensson, B. Grevbo, S. Kalstad, M. Little, M. Clarkson, E. Molloy, I. Agraz Pamplona, J. Anton, V. Barrio Lucia, S. Ciggaran, M. Cinta Cid, M. Diaz Encarnacion, X. Fulladosa Oliveras, M. Jose Soler, H. Marco Rusinol, M. Praga, L. Quintana Porras, A. Segarra, A. Bruchfeld, M. Segelmark, I. Soveri, E. Thomaidi, K. Westman, T. Neumann, M. Burnier, T. Daikeler, J. Dudler, T. Hauser, H. Seeger, B. Vogt, D. Jayne, J. Burton, R. Al Jayyousi, T. Amin, J. Andrews, L. Baines, P. Brogan, B. Dasgupta, T. Doulton, O. Flossmann, S. Griffin, J. Harper, L. Harper, D. Kidder, R. Klocke, P. Lanyon, R. Luqmani, J. McLaren, D. Makanjuola, L. McCann, A. Nandagudi, S. Selvan, E. O'Riordan, M. Patel, R. Patel, C. Pusey, R. Rajakariar, J. Robson, M. Robson, A. Salama, L. Smyth, J. Sznajd, J. Taylor, P. Merkel, A. Sreih, E. Belilos, A. Bomback, J. Carlin, Y. Chang Chen Lin, V. Derebail, S. Dragoi, A. Dua, L. Forbess, D. Geetha, P. Gipson, R. Gohh, G.T. Greenwood, S. Hugenberg, R. Jimenez, M. Kaskas, T. Kermani, A. Kivitz, C. Koening, C. Langford, G. Marder, A. Mohamed, P. Monach, N. Neyra, G. Niemer, J. Niles, R. Obi, C. Owens, D. Parks, A. Podoll, B. Rovin, R. Sam, W. Shergy, A. Silva, U. Specks, R. Spiera, J. Springer, C. Striebich, A. Swarup, S. Thakar, A. Tiliakos, Y. Tsai, D. Waguespack, M. Chester Wasko

“…Introduction: Kidney disease impacts long-term outcomes of patients with granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA). This post hoc analysis evaluated the effect of avacopan in a subgroup of patients with GPA or MPA and kidney involvement at baseline from the ADVOCATE trial. …”
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Permafrost–wildfire interactions: active layer thickness estimates for paired burned and unburned sites in northern high latitudes by A. C. Talucci, M. M. Loranty, J. E. Holloway, B. M. Rogers, H. D. Alexander, N. Baillargeon, J. L. Baltzer, L. T. Berner, A. Breen, L. Brodt, B. Buma, B. Buma, J. Dean, C. J. F. Delcourt, L. R. Diaz, C. M. Dieleman, T. A. Douglas, G. V. Frost, B. V. Gaglioti, R. E. Hewitt, T. Hollingsworth, T. Hollingsworth, M. T. Jorgenson, M. J. Lara, R. A. Loehman, M. C. Mack, K. L. Manies, C. Minions, S. M. Natali, J. A. O'Donnell, D. Olefeldt, A. K. Paulson, A. V. Rocha, L. B. Saperstein, T. A. Shestakova, T. A. Shestakova, T. A. Shestakova, S. Sistla, O. Sizov, A. Soromotin, M. R. Turetsky, S. Veraverbeke, M. A. Walvoord

“…Simultaneously, wildfire activity across northern boreal forest and Arctic/subarctic tundra regions impacts permafrost stability through the combustion of insulating organic matter, vegetation, and post-fire changes in albedo. Efforts to synthesis the impacts of wildfire on permafrost are limited and are typically reliant on antecedent pre-fire conditions. …”
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Multiple Symptoms Study 3 – An extended-role general practitioner clinic for patients with persistent physical symptoms: a Randomised Controlled Trial by Christopher Burton, Cara Mooney, Laura Sutton, David White, Jeremy Dawson, Kate Fryer, Monica Greco, Michelle Horspool, Aileen Neilson, Gillian Rowlands, Tom Sanders, Ruth Thomas, Steve Thomas, Cindy Cooper, Jonathan Woodward, Emily Turton, Waquas Waheed, Pavi Kumar, Katie Ridsdale, Ellen Mallender, Vincent Deary

“…Outcome: The primary outcome measure was the PHQ-15 at 52 weeks post randomisation. Randomisation: Participants were randomised 1 : 1 using a centralised web-based system, stratified by study centre with random permuted blocks of varying sizes. …”
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BioImpedance Spectroscopy to maintain Renal Output: the BISTRO randomised controlled trial by Simon J Davies, David Coyle, Elizabeth Lindley, David Keane, John Belcher, Fergus Caskey, Indranil Dasgupta, Andrew Davenport, Ken Farrington, Sandip Mitra, Paula Ormandy, Martin Wilkie, Jamie MacDonald, Mandana Zanganeh, Lazaros Andronis, Ivonne Solis-Trapala, Julius Sim

“…The intervention was associated with £382 (95% confidence interval −£3319 to £2556) lower average cost per patient (price year 2020) and 0.043 (95% confidence interval −0.019 to −0.105) more quality-adjusted life-years and no harm compared to control. A post hoc 5-year analysis found better survival with more residual kidney function at enrolment and at any time over the next 2 years. …”
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EIF4A3 Promotes Muscle Atrophy and Aging by Inhibiting the FAK Pathway Through NEDD9 mRNA Destabilization by Qian Li, Xiaohang Yin, Wensi Wan, Yi Zhou, Siqi Wang, Yuwei Yan, Jingying Chen, Xinyi Ren, Junli Gao, Yuying Chen, Yanan Zhang, Caiyue Cui, Emeli Chatterjee, Guoping Li, Ming Wu, Yan Zhang, Dongchao Lu, Tingting Yang, Yongjun Zheng, Jin Li

“…The exon junction complex (EJC), a protein complex assembly that binds to RNA, facilitates post‐transcriptional regulation by participating in mRNA splicing, mRNA export, translation and nonsense‐mediated mRNA decay. …”
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The kynurenine pathway as a potential link between ethanol-induced behavioral alterations and neuroinflammation by Leticia Gil de Biedma-Elduayen, Leticia Gil de Biedma-Elduayen, Leticia Gil de Biedma-Elduayen, Leticia Gil de Biedma-Elduayen, Pablo Giménez-Gómez, Pablo Giménez-Gómez, Pablo Giménez-Gómez, Pablo Giménez-Gómez, Pablo Giménez-Gómez, Nuria Morales-Puerto, Nuria Morales-Puerto, Nuria Morales-Puerto, Nuria Morales-Puerto, Rebeca Vidal, Rebeca Vidal, Rebeca Vidal, Rebeca Vidal, Álvaro Del Río-García, Álvaro Del Río-García, Álvaro Del Río-García, Álvaro Del Río-García, Carlos Núñez-de la Calle, Carlos Núñez-de la Calle, Carlos Núñez-de la Calle, Carlos Núñez-de la Calle, Lluna Careaga, Lluna Careaga, Lluna Careaga, Lluna Careaga, María Dolores Gutiérrez-López, María Dolores Gutiérrez-López, María Dolores Gutiérrez-López, María Dolores Gutiérrez-López, Esther O’Shea, Esther O’Shea, Esther O’Shea, Esther O’Shea, María Isabel Colado, María Isabel Colado, María Isabel Colado, María Isabel Colado

“…Here, we investigate the effect of EtOH dependence and withdrawal on behavioral and cognitive parameters, the nucleus accumbens (NAc) transcriptome, and KYN, TRP and serotonin (5-HT) levels and KYN/TRP and 5-HT/TRP ratios in mice.MethodsAdult male mice were subjected the Chronic Intermittent ethanol (CIE) paradigm, a model for dependence and withdrawal. Twenty-four hours post-EtOH exposure, we analyzed behavioral and cognitive parameters, sequenced the NAc transcriptome, and measured KYN, TRP and 5-HT levels as well as KYN/TRP and 5-HT/TRP ratios in plasma, limbic forebrain, cortex and cerebellum using HPLC.ResultsThe CIE model induced anxiety-like behavior and memory impairment. …”
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The Impact of Conservative Accounting on the Speed of Leverage Adjustment in Response to Stock Price Crash Risk by Abdullah Khaled Azeez, Akbar Zavari Rezaei, Mehdi Heidari

“…Materials & MethodsThis study employed both experimental and statistical methods to test the hypotheses. By utilizing post-event observations, the study minimized the potential for variable manipulation. …”
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Dose-escalation studies of mesenchymal stromal cell therapy for decompensated liver cirrhosis: phase Ia/Ib results and immune modulation insights by Lei Shi, Ziying Zhang, Song Mei, Zerui Wang, Zhe Xu, Weiqi Yao, Limin Liu, Mengqi Yuan, Yuefei Pan, Kaidi Zhu, Kai Liu, Fanglin Meng, Jiao Sun, Wenying Liu, Xiaohui Xie, Tengyun Dong, Lei Huang, Fanping Meng, Jun-Liang Fu, Yuanyuan Li, Chao Zhang, Xing Fan, Ming Shi, Yu Zhang, Yonggang Li, Wei-Fen Xie, Peng Zhang, Fu-Sheng Wang

“…These effects were sustained for up to seven days post-treatment but diminished by Day 14. Preliminary clinical signals included improvements in Child–Pugh scores, Model for End-Stage Liver Disease scores, liver function markers, and quality-of-life metrics, particularly in the higher-dose and multiple-dose groups. …”
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Comprehensive profiling of the catalytic conformations of human Guanylate kinase by Lei Wang, Zihuan Li, Yumi Xuan, Jingkun Qin, Shuju Li, Fumei Zhong, Yuexiao Song, Kanglong Yang, Mengqi Lv, Fudong Li, Zhang Jiahai, Yueyin Pan, Shouhong Guang, Yuzheng Zhao, Yunyu Shi, Xing Liu, Yingying Du, Jia Gao, Ke Ruan

“…Three key complexes, pre-reaction state (GMP/ATPγS), transition state (AlF4 - mimic), and post-reaction state (GDP/ADP), collectively delineate the reversible catalytic pathway. …”
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Long-term effectiveness, adherence and safety of twice-yearly paliperidone-palmitate long acting-injectable in patients with schizophrenia in Europe: 2-year mirror-image data from... by Sofía Manchado Perero, Ana Rodríguez Lorente, Alba García-Pérez, Guillermo Isidro García, Guillermo Isidro García, Luis Alberto Forcen-Muñoz, Santiago Ovejero García, Rocío Sáez Povedano, Ana Luisa González-Galdámez, Laura Mata Iturralde, Mariluz Ramirez Bonilla, Mariluz Ramirez Bonilla, Paloma Fuentes-Pérez, Claudia Ovejas-Catalán, Paula Suárez-Pinilla, Paula Suárez-Pinilla, Blanca Fernández Abascal, Blanca Fernández Abascal, Miguel Omaña Colmenares, María Pilar Campos-Navarro, Enrique Baca-García, Ana Lara Fernández, Sergio Benavente-López, Alberto Raya Platero, Miguel Barberán Navalón, Sergio Sánchez-Alonso, Javier Vázquez-Bourgon, Javier Vázquez-Bourgon, Javier Vázquez-Bourgon, Sofia Pappa, Sofia Pappa, Juan Antonio García-Carmona, Juan Antonio García-Carmona, Juan Antonio García-Carmona

“…In this 2-year mirror-image study we compare the number of hospital admissions 1 year pre- and post-PP6M initiation as well as the CGI scores at baseline and the point of each PP6M administration. …”
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