Cognitive training gain transfer in cognitively healthy aging: per protocol results of the German AgeGain study by Florian U. Fischer, Florian U. Fischer, Bianca Kollmann, Bianca Kollmann, Dominik Wolf, Alexandra Sebastian, Alexandra Sebastian, Kristel Knaepen, David Riedel, Andreas Mierau, Andreas Mierau, Nicolas Ruffini, Nicolas Ruffini, Kristina Endres, Kristina Endres, Jennifer Winter, Heiko K. Strüder, Gerard N. Bischof, Gerard N. Bischof, Sofia Faraza, Sofia Faraza, Bernhard Baier, Harald Binder, Alexander Drzezga, Alexander Drzezga, Alexander Drzezga, Stefan Teipel, Stefan Teipel, Andreas Fellgiebel, Andreas Fellgiebel, Oliver Tüscher, Oliver Tüscher, Oliver Tüscher, Oliver Tüscher, Oliver Tüscher

“…Therefore, the present multicentric study used a cognitive training intervention to demonstrate training transfer and identify neurobiological modulators of successful transfer.MethodsIn total 235 subjects were enrolled in AgeGain; 180 underwent a broad 4-week cognitive training intervention at three study sites. Pre- and post-training neuropsychological testing was conducted and successful transferers were identified according to preregistered definitions. …”
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Tocilizumab-Based Treatment of Microvascular Inflammation in Kidney Transplant Recipients: A Retrospective Study by Johan Noble, Johan Noble, Johan Noble, Giorgia Comai, Giorgia Comai, Valeria Corredetti, Reda Laamech, Celine Dard, Thomas Jouve, Thomas Jouve, Diane Giovannini, Audrey Le Gouellec, Shivani Wadnerkar, Paolo Cravedi, Della Apuzzo, Della Apuzzo, Daniele Vetrano, Daniele Vetrano, Marco Busutti, Chiara Abenavoli, Chiara Abenavoli, Paolo Malvezzi, Lionel PE Rostaing, Lionel PE Rostaing, Gaetano Lamanna, Gaetano Lamanna

“…The eGFR trajectory significantly decreased after TCZ treatment (−1.2 ± 0.2 vs. 0.03 ± 0.2 mL/min/1.73 m2/month pre- vs. post-TCZ, respectively; p = 0.001). The percentage of patients with DSA decreased from 63.9% to 38.9% (p < 0.001), and the average MFI decreased from 9,537 to 7,250 (p = 0.001). …”
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Loomeprotsessi semiootilisest uurimisest helilooja käsikirjade näitel. Arvo Pärdi „Sieben Magnificat-Antiphonen“ lähivaates / Composer Manuscripts and the Semiotic Study of the Cre... by Kristina Kõrver

“…From a textological standpoint, the article considers the full lifespan of a work, from the earliest notation of an idea to the final manuscript, including post-publication revisions and arrangements for new ensembles. …”
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Genetic Interplay Between Attention-Deficit/Hyperactivity Disorder and Pain Suggests Neurodevelopmental Pathways and Comorbidity Risk by Nicolas P. Ciochetti, Victor F. de Oliveira, Iago Junger-Santos, Cibele E. Bandeira, Maria E. Tavares, Eduardo S. Vitola, Luis A. Rohde, Gustavo Melo de Andrade, Bruna S. da Silva, Eugenio H. Grevet, Claiton H. Dotto Bau, Diego L. Rovaris

“…Methods: We utilized various post–genome-wide association study analyses on summary data from samples ranging between 225,534 and 766,345 individuals. …”
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Expanded analysis of vertebral endplate disruption and its impact on vertebral compression fracture risk by Khaled Dibs, Prasath Mageswaran, Raju Raval, Evan Thomas, Emile Gogineni, Jeff Pan, Brett Klamer, Ahmet Ayan, Eric Bourekas, Daniel Boulter, Nicholas Fetko, Eric Cochran, Vikram Chakravarthy, John McGregor, Esmerina Tili, Joshua Palmer, Natalie Peters, Russell Lonser, Ahmed Elguindy, Eugene Yap, Soheil Soghrati, William Marras, John Grecula, Arnab Chakravarti, James Elder, Dukagjin Blakaj

“…The 1-year cumulative incidence of VCF was evaluated by follow-up MRI and CT scans at 3-month intervals post-treatment. Based on multivariate analysis, a nomogram was created using four independent predictors: EP disruption, steroid use, SINS ≥ 7, and adverse histology. …”
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A proteogenomic analysis of cervical cancer reveals therapeutic and biological insights by Jing Yu, Xiuqi Gui, Yunhao Zou, Qian Liu, Zhicheng Yang, Jusheng An, Xuan Guo, Kaihua Wang, Jiaming Guo, Manni Huang, Shuhan Zhou, Jing Zuo, Yimin Chen, Lu Deng, Guangwen Yuan, Ning Li, Yan Song, Jia Jia, Jia Zeng, Yuxi Zhao, Xianming Liu, Xiaoxian Du, Yansheng Liu, Pei Wang, Bing Zhang, Li Ding, Ana I. Robles, Henry Rodriguez, Hu Zhou, Zhen Shao, Lingying Wu, Daming Gao

“…Proteomic stratification identifies three patient subgroups with distinct features in prognosis, genetic alterations, immune infiltration, and post-translational modification regulations. PRKCB is further identified as a potential radioresponse-related biomarker of CC patients. …”
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Machine learning-based prediction model for lung ischemia-reperfusion injury: insights from disulfidptosis-related genes by Yanpeng Zhang, Yanpeng Zhang, Yanpeng Zhang, Jingyang Sun, Jingyang Sun, Jingyang Sun, Yihan Lin, Yihan Lin, Yihan Lin, Rongxuan Jiang, Rongxuan Jiang, Rongxuan Jiang, Niuniu Dong, Niuniu Dong, Niuniu Dong, Huanhuan Dong, Huanhuan Dong, Huanhuan Dong, Peng Li, Peng Li, Peng Li, Jinteng Feng, Jinteng Feng, Jinteng Feng, Zijiang Zhu, Guangjian Zhang, Guangjian Zhang, Guangjian Zhang

“…The CIBERSORT method was used to assess the infiltration levels of immune cells in lung tissue samples post-transplant. Finally, cell line and animal experiments were carried out to validate the effectiveness and applicability of the model.ResultsA total of 14,592 hub differential-expressed genes were identified, showing significant changes in cold ischemia and reperfusion samples. …”
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Basic therapeutic approaches to the management of hematology/oncology patients with new coronavirus infection (COVID-19) by E. N. Misyurina, E. A. Baryakh, N. F. Frolova, O. N. Kotenko, Z. Yu. Mutovina, S. S. Andreev, T. N. Tolstykh, K. V. Yatskov, E. A. Karimova, A. B. Makeshova, O. A. Rukavitsyn, A. V. Misyurin, Yu. Yu. Polyakov, M. A. Mingalimov, T. S. Chudnova, D. E. Gagloeva, D. D. Ivanova, A. I. Koneva, O. L. Kochneva, E. N. Zotina, E. Yu. Grishina, L. T. Shimanovskaya, V. N. Yakimets, E. I. Zhelnova

“…Recently, antiviral drugs and monoclonal antibodies have become available for pre- or post-exposure prophylaxis, as well as for early treatment of COVID-19. …”
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DFO-loaded PDA nanoparticles facilitated 3D stem cell spheroids for diabetic wound repair by normalizing the pathological microenvironment by Tong Luo, Peijun Zhu, Shuai Li, Maolin Qin, Zeyu Fang, Fangfang Wu, Qian Wu, Suhong Lu, Yinhe Zhang, Yuli Chen, Junhua Zhou, Daqing Chen, Liangliang Yang, Hongyu Zhang

“…Despite the high therapeutic potential of 3D stem cell spheroids, owing to their structural and functional advantages, the complex microenvironment encountered post-transplantation significantly diminishes their survival and efficacy. …”
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Clinical Outcomes and Health Care Utilization in Patients with Advanced Chronic Kidney Disease not on Dialysis After the Onset of the COVID-19 Pandemic in Ontario, Canada by Carol Wang, Yuguang Kang, Stephanie N. Dixon, Nivethika Jeyakumar, K. Scott Brimble, Amit X. Garg, Peter G. Blake, Therese A. Stukel, Matthew J. Oliver, Ahmed Al-Jaishi, Kristin K. Clemens, Longdi Fu, Jane Ip, Susan McKenzie, Louise Moist, Amber O. Molnar, Flory Muanda-Tsobo, Marian Reich, Pavel Roshanov, Samuel A. Silver, Ronald Wald, Matthew A. Weir, Kevin Yau, Ann Young, Kyla L. Naylor

“…Poisson generalized estimating equations were used to predict post-COVID-19 patient outcomes and health utilization based on pre-COVID trends, estimating relative changes between the observed and expected outcomes. …”
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Global Feature Focusing and Information Enhancement Network for Occluded Pedestrian Detection by ZHENG Kaikui, JI Kangyou, LI Jun, LI Qiming

“…Existing methods, including post-processing optimization, specific model based improvements, and body part feature based methods, have limitations such as inaccurate handling of heavily occluded positive samples, high computational complexity, and susceptible to background noise. …”
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Comparison of cerebrospinal fluid biomarkers in patients with severe COVID-19 neurological outcomes and Alzheimer’s disease by Fernanda G.Q. Barros-Aragão, Thaís L. Pinheiro, Talita P. Pinto, Bart Vanderborgh, Nathane B.S. Rezende, Guilherme B. de Freitas, Gabriel R. de Freitas, Fernando A. Bozza, Andrea S. Souza, Erika C. Rodrigues, Carlos O. Brandão, Paulo Mattos, Felipe K. Sudo, Fernanda F. Tovar-Moll, Fernanda G. De Felice

“…Considering that inflammation may persist post-COVID, our findings urge the assessment of possible AD-related biomarker changes in COVID-19 survivors with lingering symptoms.…”
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Fusion of SARS-CoV-2 neutralizing LCB1 peptide with Bacillus amyloliquefaciens RNase improves antiviral efficacy by Nikita N. Kostin, Tatyana V. Bobik, Elena V. Konovalova, Milita V. Kocharovskaya, Maria A. Simonova, Natalia Yu Rushkevich, Yuliana A. Mokrushina, George A. Skryabin, Roman S. Kalinin, Sergey I. Kovalchuk, Rustam H. Ziganshin, Leonid A. Kaluzhskiy, Oksana V. Gnedenko, Evgeniy O. Yablokov, Alexis S. Ivanov, Aleksandr S. Chernov, Vitaly A. Kazakov, Oksana N. Khokhlova, Arkady N. Murashev, Senlian Hong, Elena I. Shramova, Alexey A. Schulga, Ekaterina N. Lyukmanova, Mikhail P. Kirpichnikov, Ivan V. Smirnov, Alexey A. Belogurov, Yuri P. Rubtsov, Alexey V. Stepanov, Hongkai Zhang, Alexander G. Gabibov, Sergey M. Deyev

“…LCB1-ABD-Bn exhibits good tolerability at doses below 10 mg/kg and provides protection of SARS-CoV-2-infected CAG-hACE2 animals in 24-hour post-infection intraperitoneal treatment. Cryo-EM reveals the LCB1-ABD-Bn’s tight interaction with S protein RBD domains, highlighting its potential as a promising drug candidate against SARS-CoV-2.…”
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Evolution of antibiotic prescription in Primary Health Care according to the indicators of the Spanish Action Plan on Antibiotic Resistance (PRAN) by Carlos Marcilla Vázquez, Juan Ríos Laorden, Ángeles Lloret Callejo, Francisco Tejada Cifuentes, María José Tirado Peláez, Ignacio Párraga-Martínez

“…Pre-pandemic data (2014-2019) was 19.32 DID and 13.92 DOT, being reduced during the two years of the pandemic (2020-2021) to 8.30 DID and 6.05 DOT and subsequently increased to 18.05 DID and 12.40 DOT in post-pandemic years (2022-2023). An improvement in the adequacy of antibiotic prescription was observed after the COVID-19 pandemic, with a reduction of the consumption of amoxicillin-clavulanate and a greater consumption of penicillin and amoxicillin during pre-pandemic and pandemic years (p < 0.05). …”
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Mechanistic insights into JSS1_004-mediated antagonism of the DndBCDE-FGH restriction system and engineering applications by Yu He, Susu Jiang, Fang Wang, Junwu Bi, Siting Li, Fuliang Yin, Shi Chen, Chao Chen, Lianrong Wang

“…Upon host invasion, the early gene transcriptional fragment of JSS1 facilitated the rapid expression of JSS1_004, with a N-terminal kinase domain that mediated phosphorylation of serine, threonine, and tyrosine residues within the DndFGH defense complex. This post-translational modification induced conformational changes in the complex, effectively neutralizing its restriction activity against phage propagation. …”
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Transcription factor ELF4 in physiology and diseases: Molecular roles and clinical implications by Dian Hu, Zerui Zhang, Yijun Wang, Siwen Li, Jiaqian Zhang, Zhangfan Wu, Mengyu Sun, Junqing Jiang, Danfei Liu, Xiaoyu Ji, Shuai Wang, Yufei Wang, Xiangyuan Luo, Wenjie Huang, Limin Xia

“…This review provides an in-depth overview of the molecular structure and post-translational modifications of ELF4. It also summarizes the hallmarks of ELF4 in physiology and diseases, with a particular focus on its significance in oncology. …”
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The myeloid cell-driven transdifferentiation of endothelial cells into pericytes promotes the restoration of BBB function and brain self-repair after stroke by Tingbo Li, Ling Yang, Jiaqi Tu, Yufan Hao, Zhu Zhu, Yingjie Xiong, Qingzhu Gao, Lili Zhou, Guanglei Xie, Dongdong Zhang, Xuzhao Li, Yuxiao Jin, Yiyi Zhang, Bingrui Zhao, Nan Li, Xi Wang, Jie-Min Jia

“…Deciphering the mechanism by which E-pericytes coordinate post-stroke recovery may reveal a novel therapeutic opportunity.…”
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How well do coverage surveys and programmatically reported mass drug administration coverage match? Results from 214 mass drug administration campaigns in 15 countries, 2008–2017 by Karsor Kollie, Nebiyu Negussu, Scott D Nash, Donal Bisanzio, Fiona M Fleming, Pamela S Mbabazi, Richard Reithinger, Kathryn L Zoerhoff, Katherine Gass, John Kraemer, Brian B Fuller, Lynsey Blair, Roland Bougma, Aboulaye Meite, Bizuayehu Gashaw, Nana-Kwadwo Biritwum, Jean Frantz Lemoine, Helena Ullyartha Pangaribuan, Eksi Wijayanti, Clara Fabienne Rasoamanamihaja, Lazarus Juziwelo, Square Mkwanda, Pradip Rimal, Issa Gnandou, Bocar Diop, Ameyo Monique Dorkenoo, Rachel Bronzan, Edridah Muheki Tukahebwa, Fatima Kabole, Violetta Yevstigneyeva, Lauren Courtney, Joseph Koroma, Egide Endayishimye, Margaret C Baker

“…Surveyed treatment coverage came from post-MDA community-based coverage evaluation surveys, which were conducted as per standardised WHO recommended methodology.Results Coverage estimates using routine reporting and surveys gave the same result in terms of whether the minimum coverage threshold was reached in 72% of the MDAs surveyed in the Africa region and in 52% in the Asia region. …”
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Integrated Multiomics Analyses of the Molecular Landscape of Sarcopenia in Alcohol‐Related Liver Disease by Nicole Welch, Pugazhendhi Kannan, Saurabh Mishra, Annette Bellar, Vandana Agrawal, Grahame Kidd, Emily Benson, Ryan Musich, Raya Tabbalat, Ling Li, J. Mark Brown, Belinda Willard, Karyn A. Esser, Laura E. Nagy, Srinivasan Dasarathy

“…Conclusions An integrated multiomics approach, combined with experimental validation, identifies HIF1α stabilization and accelerated post‐mitotic senescence as novel mechanisms of sarcopenia in ALD. …”
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The geoarchaeology, chronology and environment of Lusakert-1, a Late Middle Palaeolithic rockshelter (Kotayk Province, Armenia) by Keith N. Wilkinson, Ethel Allué, Simon J. Armitage, Adam van Arsdale, Guy Bar-Oz, Alex Brittingham, Boris Gasparyan, Jayson Gill, Philip Glauberman, Thomas F.G. Higham, Ellery Frahm, Tanner Kovach, Vasilija Lukich, Carolina Mallol, Yannick Raczynski-Henk, Iván Rey Rodríguez, Jennifer E. Sherriff, Aayush Srivastava, Lior Weissbrod, Reuven Yeshurun, Daniel S. Adler

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