Time dependency of thrombectomy for large artery atherosclerosis versus cardioembolic stroke subtypes: evidence from the ANGEL-ACT registry by Yue Yin, Hanlin Chen, Anxin Wang, Anxin Wang, Anxin Wang, Xiaoli Zhang, Xiaoli Zhang, Xiaoli Zhang, Miao Li, Ligang Song, Ligang Song, Ligang Song, Baixue Jia, Baixue Jia, Baixue Jia, Ning Ma, Ning Ma, Ning Ma, Dapeng Mo, Dapeng Mo, Dapeng Mo, Xuan Sun, Xuan Sun, Xuan Sun, Feng Gao, Feng Gao, Feng Gao, Yiming Deng, Yiming Deng, Yiming Deng, Zhongrong Miao, Zhongrong Miao, Zhongrong Miao

“…Methods: Study participants were selected from the Endovascular Treatment Key Technique and Emergency Workflow Improvement of Acute Ischemic Stroke Registry to conduct a post-hoc analysis of a prospective, observational study. …”
Get full text

Multiomics analysis unveils key biomarkers during dynamic progress of IAV infection in mice by Huan Lei, Huan Lei, Huan Lei, Yixi Xu, Yixi Xu, Yixi Xu, Hao Zhang, Hao Zhang, Hao Zhang, Bin Zhang, Wenjun Luo, Wenjun Luo, Wenjun Luo, Xiao Liu, Xiao Liu, Xiao Liu, Haijun Zhang, Haijun Zhang, Haijun Zhang, Jinming Yang, Jinming Yang, Jinming Yang, Wen Wen, Wen Wen, Wen Wen, Ping Wang, Ping Wang, Ping Wang, Shijun Xu, Shijun Xu, Shijun Xu

“…We employed the DIABLO multi-omics integration method to analyze dynamic changes in the lung transcriptome, metabolome, and serum metabolome from mild to severe stages of infection.ResultsOur analysis highlighted the critical importance of intervention within the first 6 days post-infection to prevent severe disease. We identified several novel biomarkers associated with disease progression, including Ccl8, Pdcd1, Gzmk, kynurenine, L-glutamine, and adipoyl-carnitine. …”
Get full text

Assessing environmental change and population declines of large wading birds in southwestern India by K.M. Aarif, Aymen Nefla, K.A. Rubeena, Yanjie Xu, Zakher Bouragaoui, M. Nasser, C.T. Shifa, T.R. Athira, K. Jishnu, Jasmine Anand, Seerangan Manokaran, P.P. Moosa, Anu Gopinath, Omer R. Reshi, K.M. Rajaneesh, H. Byju, Thadickal V. Joydas, Karuppasamy P. Manikandan, Mohd Irfan Naikoo, Christian Sonne, Sabir Bin Muzaffar

“…Densities of all the studied wader species decreased significantly from 2010 to 2019, with highest densities in agroecosystems or estuarine habitats and in post-monsoon seasons but lowest in mudflats and in monsoon seasons. …”
Get full text

Study on the risk factors for colorectal polyp recurrence: a cross-sectional retrospective cohort study by Fang Li, Fang Li, Mengge Lu, Mengge Lu, Bo Xu, Zheng Xiang, Zheng Xiang, Yuan Zhang, Yuan Zhang, Boran Cao, Xuewei Li, Xuewei Li, Yanan Wu, Yanan Wu, Rongrong Zheng, Rongrong Zheng, Qin Cai, Qin Cai, Jun Shen, Pengfei Xin, Pengfei Xin, Lianbo Xiao, Lianbo Xiao, Yanqin Bian, Yanqin Bian

“…The risk prediction model can be used to predict post-surgical recurrence of colorectal polyps with a sensitivity of 0.88 and specificity of 0.56. …”
Get full text

Overdose education and naloxone distribution in jails: Examining the impact of the Communities That HEAL intervention in 4 states by Timothy Hunt, Carrie B. Oser, Peter D. Friedmann, Nicole Mack, Peter Balvanz, Bridget Freisthler, Redonna K Chandler, Karli Hochstatter, Daniel R. Harris, LaShawn Glasgow, Lauren D’Costa, Mary R. Russo, Barry Eggleston, Arnie Aldridge, Paul Bellair, Allyson G. Cogan, James L. David, Nabila El-Bassel, Dawn Goddard-Eckrich, Steve Gomori, Holly Hagan, Steve Hanson, JaNae Holloway, Elizabeth N. Kinnard, Charlie Knott, Michael W. Konstan, Sharon L. Walsh, Patricia A. LeBaron, Michael S. Lyons, Margaret McGladrey, Joan Papp, Sean M. Murphy, Sandra Springer, Emmanuel Oga, Michele Staton, Elizabeth Schady, Fernando Montero, Hilary L. Surratt, Danelle Stevens-Watkins, John Winhusen, Gary A. Zarkin, Greer A. Hamilton, Joel G. Sprunger

“…Conclusions The CTH intervention engaging community coalitions to deploy evidence-based practices was effective in increasing OEND implementation in jails, helping address elevated overdose risks for individuals during and post-release from incarceration. Partnerships between state, community, and jail-based stakeholders are needed to assure expanded access to this lifesaving, evidence-based approach.…”
Get full text

Early introduction of IL-10 weakens BCG revaccination’s protection by suppressing CD4+Th1 cell responses by Qing Lei, Hui Fu, Zongjie Yao, Zijie Zhou, Yueqing Wang, Xiaosong Lin, Yin Yuan, Qi Ouyang, Xinyue Xu, Jinge Cao, Mengze Gan, Xionglin Fan

“…IL-10 expression peaked in the lungs 3–6 weeks post-revaccination and was also detected in lymph nodes and spleen as early as 2 weeks following the booster dose, regardless of the intervals between the prime and booster vaccinations. …”
Get full text

基于患者指南的健康教育对缺血性卒中患者二级预防用药依从性的影响(Effects of Health Education Based on the Patient Version of Guidelines on Medication Compliance in Secondary Prevention among Patients with Ischemic... by 王瑞香1，朱思静1，梁嘉贵2，晏利姣3，蓝远霞1 (WANG Ruixiang1, ZHU Sijing1, LIANG Jiagui2, YAN Lijiao3, LAN Yuanxia1 )

“…The scores of disease knowledge and post-intervention nursing satisfaction of the two groups were collected before and after intervention. …”
Get full text

Influence of Movement Restriction During the COVID-19 Pandemic on Uptake of DMPA-SC and Other Injectable Contraceptive Methods in Nigeria by Adefalu AA, Bankole OA, Olabode F, Afolabi MB, Buba MA, Dafe V, Kalu MN, Watkins E

“…This increase persisted post-restriction, with mean consumption reaching 124,561 units. …”
Get full text

Inhibition of interferon regulatory factor 4 orchestrates T cell dysfunction, extending mouse cardiac allograft survival by Wenjia Yuan, Hedong Zhang, Longkai Peng, Chao Chen, Chen Feng, Zhouqi Tang, Pengcheng Cui, Yaguang Li, Tengfang Li, Xia Qiu, Yan Cui, Yinqi Zeng, Jiadi Luo, Xubiao Xie, Yong Guo, Xin Jiang, Helong Dai, Sihan Zhou, Xiuyuan Hao

“…Combining ultra-low-dose Trametinib (0.1 mg·kg−1·day−1) and Rapamycin (0.1 mg·kg−1·day−1) demonstrably extended graft survival, with 4 out of 5 mice exceeding 100 days post-transplantation. Moreover, analysis of grafts at day 7 confirmed sustained IFN regulatory factor 4 (IRF4) inhibition, enhanced PD-1 expression, and suppressed IFN-γ secretion, reinforcing the in vivo efficacy of this IRF4-targeting approach. …”
Get full text

Genome-wide identification of sugarcane HAT gene family and functional analysis of ScHAT1 in stress response by Shijiang Cui, Shiwei Yang, Ping Zhao, Shoujian Zang, Zhenxiang Li, Peixia Lin, Wanying Zhao, Yuanyuan Zhang, Dongjiao Wang, Youxiong Que, Qibin Wu

“…Its expression was significantly upregulated in the smut-susceptible ROC22 variety post smut pathogen infection. Additionally, ScHAT1 gene conferred enhanced tolerance to salt and drought stress. …”
Get full text

First result of boronization assisted by the ICWC on EAST with full metal wall by Y.H. Guan, G.Z. Zuo, W. Xu, Y.W. Yu, Z. Sun, Z. Wang, R. Ding, L. Zhang, T. Zhang, Z.W. Wu, S.T. Mao, H.L. Zhao, T.Q. Jia, S.A. Puyang, L. Wang, T. Wauters, X.Z. Gong, J.S. Hu

“…After one time 12 g boronization, it was found the thickness of B film was approximately 120 nm. Post-boronization observations indicated that substantial hydrogen (H) release during initial plasma discharges compared with the consumed W/B wall, attributed to H co-deposition during the ICWC-boronization processing, which led to uncontrollable divertor neutral pressure and plasma density. …”
Get full text

A standards-based application for improving platelet transfusion workflow by William Gordon, Maria Aguad, Layne Ainsworth, Samuel Aronson, Jane Baronas, Edward Comeau, Rory De La Paz, Justin B.L. Halls, Vincent T. Ho, Michael Oates, Adam Landman, Wen Lu, Shawn N. Murphy, Fei Wang, Indira Guleria, Sean R. Stowell, Melissa Y. Yeung, Edgar L. Milford, Richard M. Kaufman, William J. Lane

“…We looked at application usage over time and developed a multivariable logistic regression model to compute odds ratios that a patient undergoing HSCT would have a complicated thrombocytopenia course, with several model covariates including pre-/post-application deployment. Results: Usage of the application has been consistent since launch, with a slight dip during the first COVID wave. …”
Get full text

Anesthesia of Baryancistrus xanthellus (Siluriformes: Loricariidae): Bioassays with exposure and re-exposure cause reverse tolerance to eugenol by T.P. Nascimento, F.J.T. Barros, O.L.P. Couto, M.D.R. Paz, S.V.N. Junior, L.M. Sousa, T.S. Pereira

“…No mortality occurred within 72 hours post-anesthesia in any group, indicating low short-term toxicity. …”
Get full text

Preparation and Adsorption Performance of Polyacrylamide/<italic>Nicandra Physalodes </italic>(L.) <italic>Gaertn</italic> Composite Material for Congo Red Removal by GUO Wanjin, SUN Hao, CAO Chuqing, ZHAO Lijun

“…Therefore, it is imperative to explore the development of an efficient, non-polluting, and convenient post-treatment adsorbent for Congo red in wastewater.MethodsA composite adsorbent was created using <italic>Nicandra physalodes </italic>(L.) …”
Get full text

Global diversity of soil-transmitted helminths reveals population-biased genetic variation that impacts diagnostic targets by Marina Papaiakovou, Andrea Waeschenbach, Olumide Ajibola, Sitara SR Ajjampur, Roy M. Anderson, Robin Bailey, Jade Benjamin-Chung, Maria Cambra-Pellejà, Nicolas R. Caro, David Chaima, Rubén O. Cimino, Piet Cools, Anélsio Cossa, Julia Dunn, Sean Galagan, Javier Gandasegui, Berta Grau-Pujol, Emma L. Houlder, Moudachirou Ibikounlé, Timothy P. Jenkins, Khumbo Kalua, Eyrun F. Kjetland, Alejandro J. Krolewiecki, Bruno Levecke, Adrian JF Luty, Andrew S. MacDonald, Inácio Mandomando, Malathi Manuel, Maria Martínez-Valladares, Rojelio Mejia, Zeleke Mekonnen, Augusto Messa, Harriet Mpairwe, Osvaldo Muchisse, Jose Muñoz, Pauline Mwinzi, Valdemiro Novela, Maurice R. Odiere, Charfudin Sacoor, Judd L. Walson, Steven A. Williams, Stefan Witek-McManus, D. Timothy J. Littlewood, Cinzia Cantacessi, Stephen R. Doyle

“…STH control relies on microscopy-based diagnostics to monitor parasite prevalence and enable post-treatment surveillance; however, molecular diagnostics are rapidly being developed due to increased sensitivity, particularly in low-STH-prevalence settings. …”
Get full text

Surgical field contamination analysis in various artificial joint arthroplasties by Akihito Oya, Noboru Matsumura, Atsuhiro Fujie, Shu Kobayashi, Kengo Harato, Kazuya Kaneda, Tatsuaki Matsumoto, Mitsuru Yagi, Taku Suzuki, Robert Nakayama, Morio Matsumoto, Masaya Nakamura

“…Results: No early PJIs or bacterial growth was observed post-surgery. However, bacterial contamination was detected in 7 cases (4.7%), primarily in surgical trays. …”
Get full text

MiR‐146a engineered extracellular vesicles derived from mesenchymal stromal cells more potently attenuate ischaemia–reperfusion injury in lung transplantation by Xiucheng Yang, Shanchao Hong, Tao Yan, Mingzhao Liu, Mingyao Liu, Jin Zhao, Bingqing Yue, Di Wu, Jingbo Shao, Man Huang, Jingyu Chen

“…This innovative approach presents a promising strategy for enhancing donor lung preservation and improving post‐transplant outcomes in LTx. Highlights Nebulized Delivery of miR‐146a Engineered hucMSC‐EVs Mitigates Ischemia‐Reperfusion Injury (IRI) in Lung Transplantation. …”
Get full text

Longitudinal Tracking of ALK-Rearranged NSCLC From Plasma Using Circulating Tumor RNA and Circulating Tumor DNA by Simon Heeke, PhD, Saumil Gandhi, MD, PhD, Hai T. Tran, PharmD, Vincent K. Lam, MD, Lauren A. Byers, MD, Don L. Gibbons, MD, PhD, Carl M. Gay, MD, PhD, Mehmet Altan, MD, Mara B. Antonoff, MD, FACS, Xiuning Le, MD, PhD, Janet Tu, MD, Maliazurina B. Saad, PhD, Michelle Pek, PhD, Jonathan Poh, PhD, Kao Chin Ngeow, DPhil, Anne Tsao, MD, MBA, FACHE, Tina Cascone, MD, PhD, Marcelo V. Negrao, MD, Jia Wu, PhD, George R. Blumenschein, Jr., MD, John V. Heymach, MD, PhD, Yasir Y. Elamin, MD

“…ALK rearrangements were detected in two patients pre-LCT, exclusively in ctRNA, but cleared completely post-LCT. The detection of ALK fusion at baseline was associated with significantly worse progression-free survival (p = 0.033). …”
Get full text

Níveis de ruído em Unidade Terapia Intensiva Neonatal antes e após intervenção educativa [Noise levels in a Neonatal Intensive Care Unit before and after an educational interventio... by Vitória Eugenia Martins, Maria Paula Custódio Silva, Camila dos Santos Machado, Cinthia Lorena Silva Barbosa Teixeira, Divanice Contim, Jesislei Bonolo do Amaral Rocha

“…Data were collected in three stages – pre-intervention noise measurement, educational intervention, and post-intervention noise measurement – and were examined by descriptive analysis. …”
Get full text

In-depth assessment of BRAF, NRAS, KRAS, EGFR, and PIK3CA mutations on cell-free DNA in the blood of melanoma patients receiving immune checkpoint inhibition by Isabel Heidrich, Charlotte Rautmann, Cedric Ly, Robin Khatri, Julian Kött, Glenn Geidel, Alessandra Rünger, Antje Andreas, Inga Hansen-Abeck, Finn Abeck, Anne Menz, Stefan Bonn, Stefan W. Schneider, Daniel J. Smit, Christoffer Gebhardt, Klaus Pantel

“…Persistent or re-emerging ctDNA positivity post-therapy correlated with shorter progression-free survival (PFS, p = 0.003), while ctDNA-negative patients showed significantly improved outcomes. …”
Get full text