Restoration of NOX4 signalling reverses endothelial colony-forming cell angiogenic dysfunction associated with experimental and clinical diabetes by Karla M. O’Neill, Kevin S. Edgar, Shun Hay Pun, David C. Campbell, Tinrui Toh, Xin N. Wong, Bianca Botezatu, Jyoti Kandel, Una McCoy, Jennifer Nicell, Catherine McClintock, Kiran J. McLoughlin, Yuxin Wu, Vinuthna Vani Madishetti, Arya Moez, Mohammed Alsaggaf, Eleanor K. Gill, Rawan A. Abudalo, Christina L. O’Neill, Edoardo Pedrini, Jasenka Guduric-Fuchs, Coy Brunssen, Henning Morawietz, Philip D. Dunne, Chris J. Watson, Reinhold J. Medina, David J. Grieve

“…Statistical significance was determined using one-way ANOVA with Bonferroni post-host testing or paired/unpaired Student’s t-test, as appropriate. …”
Get full text

Études comportementales pour la conservation du singe laineux de Poeppig (Lagothrix l. poeppigii) by Justine Philippon

“…Le but sera ici de savoir si le traumatisme lié à la capture et à la séparation subite du groupe natal produit des effets comparables à ceux du choc post-traumatique observés chez l’homme et les chimpanzés. …”
Get full text

Soft Tissue Augmentation by Electrospun Membranes embedded With Nano-Hydroxyapatite: Histologic and Volumetric Analyses by Yu Zhu, Zuohui Xiao, Yingxin Gu, Qiang Zhi, Zhuoli Huang, Yijie Zhang, Chunan Zhang, Shichong Qiao

“…The animals were sacrificed at 12 weeks post-surgery and received volumetric analyses. Histological examinations at the meantime were carried out at five different depths below the crest (0, 1.5, 2.5, 3.5 and 5.5 mm). …”
Get full text

Assessment and Enhancement of Coastal Community Resilience Strategies: A Case Study of Wuyuan Bay in Xiamen by Xu Mengjie, Liu Xingzhao, Xie Huili, Zhang Yang, Dai Hongxia, Zhou Yanhai, Huang Faming

“…Compared with traditional disaster prevention models, the synergistic mechanism between resilience theory and community risk management not only provides a theoretical framework for urban complex risk prevention, but also demonstrates dynamic adaptive advantages in pre-disaster prevention, disaster response, and post-disaster recovery. Accordingly, this study integrated the resilience community theory with the sponge city concept, selecting 25 storm surge-prone bay communities in the Xiamen Wuyuan Bay Area as samples to establish a community resilience evaluation framework encompassing exposure, vulnerability, adaptability, and spatial connectivity. …”
Get full text

Short-Term Hormonal Changes Following Microdissection Testicular Sperm Extraction among Men with Non-Obstructive Azoospermia: Findings from a Large Longitudinal Prospective Multice... by Fausto Negri, Edoardo Pozzi, Christian Corsini, Massimiliano Raffo, Federico Belladelli, Alessandro Bertini, Francesco Cattafi, Eugenio Ventimiglia, Rayan Matloob, Antonino Saccà, Luca Boeri, Alessia d’Arma, Francesco Montorsi, Andrea Salonia

“…Preoperative serum hormone levels (total testosterone [tT], luteinizing hormone [LH], follicle-stimulating hormone [FSH], and 17β-estradiol) were collected, with repeat measurements at 3-month post-surgery. We divided the cohort into two groups using a tT cut-off value of 3 ng/mL: 1) men who kept eugonadal status; and, 2) men who were initially eugonadal but became testosterone deficient (TD) after surgery. …”

Hypoxia promotes pancreatic adenocarcinoma progression by stabilizing ID1 via TRIM21 suppression by Rui Cheng, Rui Cheng, Yuanjun Tang, Yuanjun Tang, Xuedi Cao, Xuedi Cao, Zhanya Huang, Zhanya Huang, Yunyun Guo, Yunyun Guo, Renjing Jin, Renjing Jin, Renjing Jin, Yan Wang, Yan Wang, Yang Liu, Yang Liu, Yang Liu, Lixiang Xue, Lixiang Xue, Lixiang Xue, Lixiang Xue, Yuqing Wang, Yuqing Wang

“…Hypoxia elevated ID1 protein levels without significantly affecting its mRNA, suggesting post-translational stabilization. Mechanistic studies revealed that hypoxia inhibits ubiquitin-proteasome-mediated degradation of ID1 by downregulating TRIM21, an E3 ubiquitin ligase responsible for ID1 ubiquitination. …”
Get full text

Nuclear Spectral Energy Distributions of Luminous Infrared Galaxies by Tianmu Gao, Vivian U, Connor W. Auge, Yiqing Song, Sean T. Linden, Kazushi Iwasawa, Alessandro Peca, George C. Privon, David B. Sanders, Núria Torres-Albà, Loreto Barcos-Muñoz, James Agostino, Anne M. Medling

“…Binning the merging systems by interaction class, we find that the active galactic nucleus (AGN) fraction (fraction of AGN infrared luminosity to total infrared luminosity) appears enhanced in the late- and post-merger stages compared to the early-merger stage. …”
Get full text

Название by IG Budaeva, EG Ovsyannikova, EN Goryunova, OV Kulemina, DV Zaitsev, DV Motorin, RSh Badaev, DB Zammoeva, VV Ivanov, KV Bogdanov, OS Pisotskaya, YuV Mirolyubova, TS Nikulina, YuA Alekseeva, AYu Zaritskey, LL Girshova

“…WT1 expression level in the early post-induction period is a sensitive DFS marker. …”
Get full text

In-depth characterization of vaccine-induced neoantigen-specific T cells in patients with IDH1-mutant glioma undergoing personalized peptide vaccination by Martin Glas, Florian Battke, Dirk Hadaschik, Martin Schulze, Saskia Biskup, David Reardon, Christina Kyzirakos, Simone Kayser, Oliver Bartsch, Armin Rabsteyn, Henning Zelba, Borong Shao, Annekathrin Reinhardt, Carsten Greve, Lisa Oenning, Pauline Latzer, Tabea Riedlinger, Julian Wünsche, Johannes Harter, Magdalena Feldhahn, Yannick Bantel, Janina Johänning, Jiri Ködding, Olga Maksimovic, Veit Scheble, Alexandra M Miller, Michael Castro, Deborah T Blumenthal

“…Each vaccine consisted of peptides derived from numerous somatic mutations, including at least one peptide targeting the mutIDH1.Vaccine immunogenicity was determined by intracellular cytokine staining and simultaneous measurement of four T-cell activation markers (Interferon-γ, Tumor Necrosis Factor, Interleukin-2, CD154) after 12-day in vitro expansion of pre and post vaccination peripheral blood mononuclear cells. …”
Get full text

Multi-omics insights into functional alterations of the liver in growth-retarded offspring: transcriptomic, epigenetic and metabolomic profiles by Qun Lan, Sui Liufu, Xin Xu, Bohe Chen, Wenwu Chen, Kaiming Wang, Caihong Liu, Lanlin Xiao, Xiaolin Liu, Lei Yi, Jingwen Liu, Qiuchun Deng, Haiming Ma, Meng Kang

“…Conclusions Taken together, the genes and metabolites identified in this study provide gene-targeted and nutrition-based therapeutic strategies for piglets with growth limitations during the lactation and even post-weaning stages. Our findings also provide epigenetic insights into the molecular mechanisms underlying liver-mediated modulation of growth and development in offspring.…”
Get full text

Artificial Intelligence-Based Large Language Models Can Facilitate Patient Education by Xochitl Bryson, BA, Marleni Albarran, BS, Nicole Pham, MPH, Arianne Salunga, DO, Taylor Johnson, MD, MPH, Grant D. Hogue, MD, Jaysson T. Brooks, MD, Kali R. Tileston, MD, Craig R. Louer, MD, Ron El-Hawary, MD, Meghan N. Imrie, MD, James F. Policy, MD, Daniel Bouton, MD, Arun R. Hariharan, MD, Sara Van Nortwick, MD, Vidyadhar V. Upasani, MD, Jennifer M. Bauer, MD, Andrew Tice, MD, John S. Vorhies, MD

“…Results: The panel members had a mean of 8.9 years of experience post-fellowship (range: 3-23 years). The panel reported nearly equivalent agreement between AI-generated and physician-generated answers. …”
Get full text

Safety and Immunogenicity of a rAd35-EnvA Prototype HIV-1 Vaccine in Combination with rAd5-EnvA in Healthy Adults (VRC 012). by Michelle C Crank, Eleanor M P Wilson, Laura Novik, Mary E Enama, Cynthia S Hendel, Wenjuan Gu, Martha C Nason, Robert T Bailer, Gary J Nabel, Adrian B McDermott, John R Mascola, Richard A Koup, Julie E Ledgerwood, Barney S Graham, VRC012 Study Team

“…EnvA-specific immunogenicity was assessed four weeks post-injection. Solicited reactogenicity and clinical safety were followed after each injection.…”
Get full text

Genomic interrogation of invasive group A Streptococcus (iGAS) epidemiology and COVID-19 impacts in Victoria, Australia: a 6-year retrospective studyResearch in context by Jacqueline M. Morris, Jake A. Lacey, Kerrie Stevens, Lamali Sadeesh Kumar, Mathilda Wilmot, Janet Strachan, Marion Easton, Daneeta Hennessy, Tony M. Korman, Andrew J. Daley, Katherine B. Gibney, Adam W.J. Jenney, Steven Y.C. Tong, Benjamin P. Howden, Norelle L. Sherry

“…Fewer iGAS cases were noted between 2020 and 2021 in addition to genetic bottlenecks, likely reflecting the implementation of strict public health measures during the COVID pandemic, followed by a resurgence in cases post-COVID. Low levels of antimicrobial resistance were observed, primarily to macrolides and tetracyclines. …”
Get full text

Effects of sedatives on diaphragm activity monitored by ultrasound: a systematic review and meta-analysis by Jiaren Luo, Luhao Wang, Bilin Wei, Zhikun Huang, Huifang Zheng, Bin Gu, Fei Pei, Zenan Chang, Yang Liu, Xiangdong Guan, Xuyu Zhang, Zimeng Liu

“…Conclusion This meta-analysis reveals that sedatives can inhibit diaphragm activity, with this negative impact persisting post-awakening. Propofol alone achieves a more pronounced reduction in diaphragm activity than when combined with other sedatives. …”
Get full text

Analysis of the relationship between bronchoalveolar lavage lymphocyte fraction and detailed autoimmune features in patients with idiopathic interstitial pneumonia by Noriyuki Enomoto, Masayuki Watanuki, Shogo Nakai, Shusuke Yazawa, Yasutaka Mochizuka, Atsuki Fukada, Yuko Tanaka, Hyogo Naoi, Yusuke Inoue, Hideki Yasui, Masato Karayama, Yuzo Suzuki, Hironao Hozumi, Kazuki Furuhashi, Mikio Toyoshima, Masato Kono, Shiro Imokawa, Masato Fujii, Taisuke Akamatsu, Naoki Koshimizu, Koshi Yokomura, Hiroyuki Matsuda, Yusuke Kaida, Yutaro Nakamura, Masahiro Shirai, Kazutaka Mori, Masafumi Masuda, Tomoyuki Fujisawa, Naoki Inui, Hiroaki Sugiura, Hiromitsu Sumikawa, Masashi Kitani, Kazuhiro Tabata, Noriyoshi Ogawa, Takafumi Suda

“…To identify CTD-associated features that affect BAL lymphocyte fraction in patients with idiopathic interstitial pneumonia (IIP). This post hoc analysis of a prospective, multicentre cohort study was conducted between 2015 and 2020. …”
Get full text

Cholangiocarcinoma PDHA1 succinylation suppresses macrophage antigen presentation via alpha-ketoglutaric acid accumulation by Ning Zhang, Linmao Sun, Shuo Zhou, Changyong Ji, Tianming Cui, Qi Chu, Jiareng Ye, Shuhang Liang, Kun Ma, Yufeng Liu, Xianying Li, Xinyu Guo, Weizhi Zhang, Xuetian Gu, Cheng Cheng, Qingrui Zha, Shengwei Tao, Yunguang Zhang, Junhui Chu, Chenghui Wu, Yuchen Zhang, Jiabei Wang, Yao Liu, Lianxin Liu

“…Here, we elucidate the possibility of chemotherapy regimens sensitized by inhibiting succinylation in patients with cholangiocarcinoma from the perspective of post-translational modification. Our omics analysis reveals that succinylation of PDHA1 lysine 83, a key enzyme in the tricarboxylic acid cycle, alters PDH enzyme activity, modulates metabolic flux, and leads to alpha-ketoglutaric acid accumulation in the tumor microenvironment. …”
Get full text

Undertriage in geriatric trauma: insights from a multicentre cohort study by Daniel Anthony Koch, Lars Becker, Uwe Schweigkofler, Paul Hagebusch, Philipp Faul, Christian Waydhas, Florian Pavlu, Markus Baacke, Caspers Michael, Valentin Clemens, Helena Duesing, Matthias Froehlich, Sebastian Imach, Kai-Oliver Jensen, Christian Kleber, Annette Keß, Gerrit Matthes, Andre Nohl, Orkun Oezkurtul, Thomas Paffrath, Vera Pedersen, Kai Sprengel, Philipp Stoermann, Heiko Trentzsch, Rolf Lefering, Dan Bieler, Lisa Hackenberg, The Committee on Emergency Medicine, Intensive Care and Trauma Management (Sektion NIS) of the German Trauma Society (DGU) Germany

“…Trauma team activation was significantly lower in the geriatric group (15.8%) compared to younger patients (31.8%), despite similar injury severity. Post-hoc analysis revealed that 53.8% of geriatric patients requiring trauma care were undertriaged. …”
Get full text

The Effect of Using VR Box in Learning Effective Shadow Boxing by Salah Sadoon Sarteep

“…The results showed the effectiveness of virtual reality in learning effective shadow boxing; which presence of statistically significant differences between the experimental and control groups in the post-test and in favor of the experimental group.   …”
Get full text

Doxycycline inhibits MMP-2 retinal activity and modulates the angiogenic process in vitro and in vivo by María Lina Formica, María Constanza Paz, María Constanza Paz, María Victoria Vaglienti, María Victoria Vaglienti, Paula Virginia Subirada, Paula Virginia Subirada, Yamila Fernández, Yamila Fernández, Mariana Belén Joray, José Domingo Luna, Pablo Federico Barcelona, Pablo Federico Barcelona, Santiago Daniel Palma, María Cecilia Sánchez, María Cecilia Sánchez

“…VEGF-induced angiogenesis was assessed by tube formation assay in BAEC incubated with DXC for 24 h C57BL/6 mice exposed to OIR model, were intravitreally injected with a single dose of DXC at post-natal day (P)12 and retinas evaluated at P17.ResultsDXC significantly decreased pro MMP-2 and MMP-2 activity in MIO-M1 supernatants and increased hypoxic-induced mRNA expression of pigmentary epithelium-derived factor (PEDF). …”
Get full text

Creep Behavior and Long-Term Deformation Prediction of Ground Reinforced by High-Permeability Grouting by Li Chenhui, Xu Zhipeng, Zhou Pengkun, Zhang Hongbo, Zheng Yantao, Li Runguo, Liu Changwu

“…Both the Burgers and nonlinear viscoelastic–plastic models provided accurate fits to the experimental creep data across all stress levels, with coefficients of determination (R²) exceeding 0.95. Post-grouting settlement curves demonstrated the effectiveness of grouting in mitigating short-term deformation. …”
Get full text