Serotonin 5-HT2A receptor expression is chronically decreased in the anterior cerebral cortex of male rats following repetitive low-level blast exposure by Rita De Gasperi, Rita De Gasperi, Georgina Perez Garcia, Georgina Perez Garcia, Miguel A. Gama Sosa, Miguel A. Gama Sosa, Gissel M. Perez, Rania Abutarboush, Rania Abutarboush, Usmah Kawoos, Usmah Kawoos, Patrick R. Hof, Patrick R. Hof, Patrick R. Hof, Carolyn W. Zhu, Carolyn W. Zhu, Carolyn W. Zhu, Stephen T. Ahlers, Gregory A. Elder, Gregory A. Elder, Gregory A. Elder, Gregory A. Elder

“…IntroductionMany Veterans who experienced blast-related traumatic brain injuries (TBIs) in Iraq and Afghanistan currently suffer from chronic cognitive and mental health problems that include depression and post-traumatic stress disorder (PTSD). Male rats exposed to repetitive low-level blast develop chronic cognitive and PTSD-related behavioral traits that are present for more than 1 year after exposure. …”
Get full text

The effects of Astragalus, Epimedium, and Fructus Ligustri Lucidi extract on the antioxidant capacity, and immune status of goslings under stress conditions by Qing Qu, Qing Qu, Qing Qu, Yihong Sun, Yihong Sun, Yihong Sun, Yayan Liang, Yayan Liang, Yayan Liang, Yongsheng Nie, Yongsheng Nie, Yongsheng Nie, Yongsheng Nie, Ming Gao, Ming Gao, Ming Gao, Yaohui Yuan, Wei Wang, Wei Wang, Wei Wang, Shuo Zhou, Shuo Zhou, Shuo Zhou

“…Supplementing with AEF and LP post-stress alleviated stress-induced the expression of inflammatory factors (TGF-β, TNF-α, IL-1β, IL-6), and improve L*, a*, b*, Ph45 (min), Ph24 (h) and drip loss in pectoral (p < 0.05). …”
Get full text

Genetic characterization of influenza A viruses circulating in Hong Kong, China, 2023: the first influenza epidemic after the lifting of 2.5 years of COVID-19 non-pharmaceutical in... by Jingyuan Bian, Joshua Fung, Lam-Kwong Lee, Wing-Yin Tam, Leo Chun-Hei Wong, Cyrus Ka-Wo Wong, Maverick Yu-Xuan Lau, Bei Jiang, Nicky Ho-Laam Tang, Alex Yat-Man Ho, Miranda Chong-Yee Yau, Jason Chi-Ka Cheng, Kristine Shik Luk, May Kin-Ping Lee, Jimmy Yiu-Wing Lam, Sandy Ka-Yee Chau, Qing Xiong, Gilman Kit-Hang Siu, Franklin Wang-Ngai Chow

“…These findings underscore Hong Kong’s high post–COVID–19 influenza diversity and the need for ongoing molecular surveillance to monitor emerging viral variants.…”
Get full text

Вплив удобрення на формуванняпродуктивності ячменю ярого в короткоротаційних сівозмінах by Марія ЩЕРБА, Оксана КАЧМАР, Ангеліна ДУБИЦЬКА, Оксана ВАВРИНОВИЧ, Оксана ТАРАВСЬКА

“…The use of intensive (manure + mineral fertilizers) and alternative (green mass of post-harvest oil radish + precursor by-products + mineral fertilizers) fertilization systems restrained the compaction process and provided 4.46–2.65 % lower values of capacity after winter wheat and by 3.5– 1.72 % after potatoes compared to the control without fertilizer. …”
Get full text

Competition in the product market, CEO's power, and readability of financial reports by Shokrollah Khajavi, Soraya Weysihesar, Ali Asghar Dehghani Saadi

“…Regarding the time dimension of the data, it is retrospective and post-event. To achieve the objectives of the research, 105 companies listed on the Tehran Stock Exchange were examined for the period from 2016 to 2022. …”
Get full text

SCREEN FORMS AT BIENNIALS OF CONTEMPORARY ART / ЭКРАННЫЕ ФОРМЫ НА БИЕННАЛЕ СОВРЕМЕННОГО ИСКУССТВА by KARTSEVA EKATERINA A. / КАРЦЕВА Е.А.

“…Video today is a popular tool for artists of postmodern, poststructuralist, post-conceptual orientations. These practices have not yet developed their economic model and have spread mainly through biennials and festivals of contemporary art, as the main form of their comprehension and display. …”
Get full text

High anal swab viral load predisposes adverse clinical outcomes in severe COVID-19 patients by Haibo Li, Lili Ren, Lulu Zhang, Yeming Wang, Li Guo, Conghui Wang, Yan Xiao, Ying Wang, Jian Rao, Xinming Wang, Ying Liu, Chaolin Huang, Xiaoying Gu, Guohui Fan, Hui Li, Binghuai Lu, Bin Cao, Jianwei Wang

“…The positivity and viral load in AS were higher in non-survivors than that of survivors at week 2 post symptom onset (P = 0.006). A high initial viral load in AS was associated with death (OR 1.368, 95% CI 1.076–1.741, P = 0.011), admission to the intensive care unit (OR 1.237, 95% CI 1.001–1.528, P = 0.049) and need for invasive mechanical ventilation (OR 1.340, 95% CI 1.076–1.669, P = 0.009). …”
Get full text

Gestión de riesgos en la realización de pruebas de función pulmonar pospandemia by Luis Puente Maestu, Juana M. Martínez Llorens, José Luis Valera Felices, Yolanda Torralba García, Marian Gimeno Peribáñez, Eusebi Chiner, Roberto Cabestre, Juan Rodríguez Hermosa, Raúl Godoy Mayoral, Celeste Marcos, Ana Balaña Corberó, Carlos Almonacid

“…Abstract: This document is a detailed proposal addressing the management of spirometry and other pulmonary function tests in the post-COVID-19 pandemic context in Spain. The introduction discusses how the pandemic has affected the performance of these essential tests and underscores the need for a pragmatic assessment of risks and benefits, given that the absence of pulmonary function studies may lead to significant diagnostic and therapeutic errors.The section on the epidemiological situation in Spain highlights that the WHO no longer considers COVID-19 a public health emergency of international concern, reflecting the reduced severity of the disease due to high vaccination coverage and the characteristics of circulating variants.The regulatory framework states that the Health Institute Carlos III has defined a new epidemiological surveillance strategy aimed at restoring social and healthcare normality. …”
Get full text

Mesocorticolimbic dopaminergic innervation modulates Levodopa-related improvements in gait in older slow walking Adults: A [11C]PE2I PET study by N. Paalanen, S. Roytman, M. van Emde Boas, A. Biddix, A. Luker, F. Michalakis, G. Carli, P. Kanel, C. Pongmala, R. Koeppe, L.M. Chahine, C. Rosano, N.I. Bohnen

“…Spatiotemporal gait parameters were evaluated at pre-intervention, following carbidopa pre-treatment, and post-intervention. Results: Levodopa treatment resulted in improved gait speed (β = 0.69 [0.07, 1.30], p = 0.031), double-support time (β = -0.26 [-0.51, −0.01], p = 0.041), and cadence (β = 0.54 [0.18, 0.89], p = 0.005), but not in turn duration (β = 0.41 [-0.33, 1.14], p = 0.264). …”
Get full text

Community burden of acute respiratory infections in Shanghai, a longitudinal cohort study in respiratory pathogens, China, 2024–2027 by Ting Zhang, Yan Luo, Li Zhang, Xiao Wang, Yifeng Shen, Yu Li, Zhongjie Li, Bing Zhao, Benjamin J Cowling, Chuchu Ye, Jianxing Yu, Lance Rodewald, Weizhong Yang, Xinmei Zhou, Ling Xin, Xuya Yu, Yanxin Xie, Yilin Jia, Linghui Zhao, Yaoyao Wang, Hualei Xin, Lipeng Hao, Lili Ren

“…Illness courses and clinical recoveries of ARI cases are assessed through weekly contact with ARI cases for 28 days post ascertainment.Findings to date Between 14 October 2024 and 22 November 2024, we enrolled 5387 community residents into the cohort, including 233 children aged from 6 months to 2 years, 278 preschool children aged 3–6 years, 575 school-age children aged 7–18 years, 2150 adults aged 19–64 years and 2151 older adults aged 65+years. …”
Get full text

Optimising cardiac surgery outcomes in people with diabetes: the OCTOPuS pilot feasibility study by Richard IG Holt, Katharine Barnard-Kelly, Mayank Patel, Philip Newland-Jones, Suvitesh Luthra, Jo Picot, Helen Partridge, Andrew Cook

“…Two important uncertainties in the management of people with diabetes undergoing major surgery exist: (1) how to improve diabetes management prior to an elective procedure and (2) whether that improved management leads to better post-operative outcomes. Objective The Optimising Cardiac Surgery ouTcOmes in People with diabeteS project aimed to assess whether a pre-operative outpatient intervention delivered by a multidisciplinary specialist diabetes team could improve diabetes management and cardiac surgical outcomes for people with diabetes. …”
Get full text

Multicentre pragmatic embedded stepped wedge cluster randomised trial comparing glucose 5% with sodium chloride 0.9% as the default drug diluent in the ICU: the sweet-water trial p... by Alexander Zarbock, Kai-Uwe Eckardt, Claudia Spies, Felix Balzer, Martin Witzenrath, Philipp Enghard, Björn Tampe, Oliver Hunsicker, Steffen Weber-Carstens, Bjoern Weiss, Jens Nee, Christian Strauss, Heiko Schenk, Jan-Hendrik Bernhard Hardenberg, Ricarda Merle Hinz, Mareen Pigorsch, Alexander Uhrig, Holger Müller-Redetzky, Tim Schroeder, Ulrike Trost, Daniel Zickler, Rainer Borgstedt, Mariam Abu-Tair, Uta Hildebrand, Dario von Wedel

“…Hypernatraemia adversely affects various physiological functions and is associated with delirium, prolonged length of stay and increased ICU and post-discharge mortality. The sodium load from intravenous drug diluents significantly contributes to ICU-acquired hypernatraemia, with drug infusions comprising about 30% of the daily fluid volume of an average ICU patient. …”
Get full text

HIV self-testing alone or with additional interventions, including financial incentives, and linkage to care or prevention among male partners of antenatal care clinic attendees in... by Augustine T Choko, Elizabeth L Corbett, Nigel Stallard, Hendramoorthy Maheswaran, Aurelia Lepine, Cheryl C Johnson, Doreen Sakala, Thokozani Kalua, Moses Kumwenda, Richard Hayes, Katherine Fielding

“…Measurement of linkage to post-test services following HIVST remains the biggest challenge, yet is the biggest driver of cost-effectiveness. …”
Get full text

Target Trial Emulation of the Modified Vaccinia Ankara-Bavarian Nordic Vaccine for Pre-Exposure Mpox Prevention in At-Risk Populations by Clara Suñer, Roser Escrig-Sarreta, Cristina Galván-Casas, Eduardo Matos, Amanda Gabster, Marcelo Wolff, Dan Ouchi, Andrea Alemany, Hugo Sánchez, Sandra Huaman, Dixennia Bejarano, Lourdes Carrés-Esteve, Cristina Santiago-Fernández, Javier Corral-Rubio, Adrià Mendoza, Àngel Rivero, Vicente Descalzo, Eva Orviz, Héctor Martínez-Riveros, Leonardo Méndez-Boo, Carmen Cabezas, Araceli Arce-Arnáez, Michael Marks, Oriol Mitjà, REMAIN Study Group

“…The primary endpoint was symptomatic mpox occurrence ≥14 days post-vaccination. <b>Results</b>: The primary analysis included 1028 individuals (514 vaccinated, 514 unvaccinated) with a median follow-up time of 9.3 months (IQR 4.7–13.7). …”
Get full text

Impact of the COVID-19 pandemic on antidepressant prescribing with a focus on people with learning disability and autism: an interrupted time series analysis in England using OpenS... by Ben Goldacre, David Evans, Orla Macdonald, Richard Croker, Rebecca Smith, Christopher Wood, Andrea Schaffer, Andrew Brown, Brian MacKenna, William Hulme, Chris Bates, Amir Mehrkar, Peter Inglesby, John Parry, Amelia Green, Helen Curtis, Alex Walker, Rose Higgins, Sebastian Bacon, Simon Davy, Tom Ward, Louis Fisher, Iain Dillingham, Milan Wiedemann, Lucy Bridges, Ben Butler-Cole, Colm Andrews, Christine Cunningham, Victoria Speed, Liam C Hart, Thomas O’Dwyer, Steve Maude

“…We did not find evidence that the pandemic was associated with a change in antidepressant prescribing trend in the general population (relative risk (RR) 1.00 (95% CI 0.97 to 1.02)), in those with autism (RR 0.99 (95% CI 0.97 to 1.01)) or in those with learning disability (RR 0.98 (95% CI 0.96 to 1.00)).New prescribing post restrictions was 13% and 12% below expected had COVID-19 not happened in both the general population and those with autism (RR 0.87 (95% CI 0.83 to 0.93), RR 0.88 (95% CI 0.83 to 0.92)), but not learning disability (RR 0.96 (95% CI 0.87 to 1.05)).Conclusions and implications In this England study, we did not see an impact of COVID-19 on overall antidepressant prescribing, although unique trends were noted, such as trends in new antidepressant prescriptions which increased in care homes over the pandemic and decreased in the general population and those with autism since recovery.…”
Get full text

Long-term alteration of heart rate variability following childhood maltreatment: Results of a general population study by Marian Stürmer, Johanna Klinger-König, Marcus Vollmer, Antoine Weihs, Stefan Frenzel, Marcus Dörr, Lars Kaderali, Stephan B. Felix, Beate Stubbe, Ralf Ewert, Henry Völzke, Hans J. Grabe, Elischa Krause

“…HRV was derived from 10-second electrocardiograms and 5-minute pre-sleep polysomnographic recordings. Post hoc analyses examined abuse and neglect. Results CM was associated with reduced HRV (logRMSSD: β = −0.20 [95%-CI: −0.28, −0.12], p = 1.2e−06), driven by neglect (β = −0.27 [−0.35, −0.18], p = 1.9e−09) rather than abuse (β = 0.01 [−0.12, 0.14], p = 1). …”
Get full text

Late anastomotic complication after laparoscopic surgery for clinical stage I low rectal cancers located within 5 cm of the anal verge: Sub‐analysis of the ultimate trial by Manabu Shimomura, Masanori Yoshimitsu, Yuichiro Tsukada, Hideki Ohdan, Jun Watanabe, Yosuke Fukunaga, Yasumitsu Hirano, Kazuhiro Sakamoto, Hiroki Hamamoto, Hisanaga Horie, Nobuhisa Matsuhashi, Yoshiaki Kuriu, Shuntaro Nagai, Madoka Hamada, Shinichi Yoshioka, Shinobu Ohnuma, Tamuro Hayama, Koki Otsuka, Yusuke Inoue, Kazuki Ueda, Yuji Toiyama, Satoshi Maruyama, Shigeki Yamaguchi, Keitaro Tanaka, Motoko Suzuki, Toshihiro Misumi, Takeshi Naitoh, Masahiko Watanabe, Masaaki Ito, Ultimate Trial Group

“…Abstract Background Although extensive research has been conducted on early anastomotic leakage (AL) after sphincter‐sparing surgery, the status of late anastomotic complications (post‐30 days) has received limited attention. These late complications significantly affect a patient's quality of life and often lead to permanent stoma creation. …”
Get full text

Urban greening for climate resilient and sustainable cities: grand challenges and opportunities by Prashant Kumar, Prashant Kumar, Prashant Kumar, Jeetendra Sahani, Karina Corada Perez, Ajit Ahlawat, Ajit Ahlawat, Maria de Fatima Andrade, Maria Athanassiadou, Shi-Jie Cao, Shi-Jie Cao, Lisa Collins, Sagnik Dey, Sagnik Dey, Silvana Di Sabatino, Christos H. Halios, Felicity Harris, Colin Horton, Luis Inostroza, Luis Inostroza, Laurence Jones, Laurence Jones, Thomas Rodding Kjeldsen, Ben McCallan, Ben McCallan, Aonghus McNabola, Aonghus McNabola, Rajeev Kumar Mishra, Sumit Kumar Mishra, Sumit Kumar Mishra, Sumit Kumar Mishra, Erick G. Sperandio Nascimento, Erick G. Sperandio Nascimento, Erick G. Sperandio Nascimento, Gwilym Owen, Khaiwal Ravindra, Neyval C. Reis, Veronica Soebarto, Jannis Wenk, Jannis Wenk, Hannah Sloan Wood, Runming Yao, Runming Yao, Runming Yao

Get full text

Antibodies against integrin αvβ6 have high diagnostic accuracy for ulcerative colitis by Patrick Bez, Martina Scapolan, Davide Giuseppe Ribaldone, Gian Paolo Caviglia, Silvia Zago, Cristina Trucco, Simone Frara, Antonino Caruso, Marta Ascolani, Michele Campigotto, Stefano Benvenuti, Stefano Martelossi, Lara De Lucchi, Marta Favero, Francesco Cinetto, Francesco Cinetto, Elisabetta Faggin, Laura Ventura, Marcello Rattazzi, Marcello Rattazzi, Tilde Manetta, Giulio Mengozzi, Antonio Antico, Carla Felice, Carla Felice

“…The UC patients presented higher values of anti-integrin αvβ6 IgG compared to CD, IBS, and controls (Kruskal–Wallis test and post-hoc Holm’s correction: p &lt; 0.001). The ROC of anti-integrin αvβ6 IgG performed optimally with an area under the curve of 0.93. …”
Get full text

Hyperspectral abdominal laparoscopy with real-time quantitative tissue oxygenation imaging: a live porcine study by Oscar MacCormac, Oscar MacCormac, Conor C. Horgan, Conor C. Horgan, Dale Waterhouse, Dale Waterhouse, Philip Noonan, Philip Noonan, Mirek Janatka, Mirek Janatka, Richard Miles, Richard Miles, Jaco Jacobs, Cameron Dockerill, Cameron Dockerill, Théo Trotouin, Théo Trotouin, Alexis Schizas, Barbara Seeliger, Barbara Seeliger, Barbara Seeliger, Sebastien Ourselin, Sebastien Ourselin, Michael Ebner, Michael Ebner, Tom Vercauteren, Tom Vercauteren, Jonathan Shapey, Jonathan Shapey, Jonathan Shapey

“…While intra-operative overt ischaemia can be perceived with the naked eye, timely recognition of borderline perfusion can prevent post-operative ischaemic complications, which is particularly relevant for colorectal anastomoses. …”
Get full text