Identification and Characterization of Antiviral Activity of Synthetic Compounds Against Mayaro Virus by Ana Paula Andreolla, Andrea Cristine Koishi, Alessandra Abel Borges, Larissa Albuquerque de Oliveira, Viviane Guedes de Oliveira, Nerilson Marques Lima, Eloah Pereira Ávila, Pedro Pôssa de Castro, Giovanni Wilson Amarante, Mauro Vieira de Almeida, Juliano Bordignon, Claudia Nunes Duarte dos Santos

“…<b>Results:</b> Seven compounds showed anti-MAYV activity and were non-toxic for the following cell lines: Naringenin, LLA9A, chrysin, and its ester C6. Post-infection treatments with these selected compounds significantly decreased the percentage of infected cells and the release of infectious viral particles in the supernatant. …”
Get full text

A pragmatic randomized trial to compare strategies for implementing primary HPV testing for routine cervical cancer screening in a large healthcare system by Chun R. Chao, Nancy Cannizzaro, Erin E. Hahn, Ernest Shen, Chunyi Hsu, Quyen Ngo-Metzger, Michael K. Gould, Corrine E. Munoz-Plaza, Michael H. Kanter, Patricia Wride, Lena H. Ajamian, Melissa Hodeib, Benjamin I. Broder, Ivette T. Curiel, Alicia Castaneda, Stephanie K. Ong, Krishnansu Tewari, Ramez N. Eskander, Devansu Tewari, Brian S. Mittman

“…., use of primary HPV screening) during the post-intervention period was high, with no observed difference between study arms: 98.4% (95% confidence interval [CI] 96.3%-100%) for the locally-tailored arm and 99.1% (95% CI: 97.8%-100%) for the centrally-administered arm (p = 0.34). …”
Get full text

Bismuth ferrite reinforced porous bioactive glass scaffolds: In vitro and antibacterial properties by S. Amitha Banu, Sk Hasanur Rahaman, Khan Sharun, Merlin Mamachan, Swapan Kumar Maiti, Amarpal, Subhadip Bodhak, Vamsi Krishna Balla, Abhijit M. Pawde

“…The BAG and BAG-BF porous scaffolds exhibited porosities of ∼74 % (BAG), ∼65 % (0.5 BAG-BF), and ∼64 % (1.5 BAG-BF), with post-sintering weight losses of 5 %, 2.5 %, and 5 %, respectively. …”
Get full text

S-nitros(yl)ation of CaMKIIα and its precision redox regulation by SNOTAC plays a critical role in learning and memory by Boyu Chu, Xinhua Qiao, Hui Ye, Xiaoli Cui, Shuli Zhang, Wenting Su, Yuying Zhang, Chuanxin Sun, Xuanhao Wu, Tiepeng Wang, Hua Li, Jianbing Wu, Zhangjian Huang, Chang Chen

“…To address this question, our study surprisingly observed that during learning and memory tasks, S-nitrosation of CaMKIIα, a key redox-based post-translational modification, significantly increased in mouse hippocampus. …”
Get full text

Integrated omics identifies molecular networks of brain-body interactions of brain injury by Yuan-Hong Deng, Hong Wang, Jia-Hang Zhang, Yu-Fei Wang, Meng-Yao Wang, Xin-Ru Pan, Yao-Dan Zhang, Yuan-Hui Gan, Yi He, Fang Xie, Xiao-Shuang Feng, Jia-Xin Xie, Bai-Tong Liu, Jiang-Tao Wang, Xin-Xiao Zhang, Peng-Fei Wang, Jie Li, Shu-Guang Yu, Qing-Wu Yang, Ming-Ze Bai, Yong Tang, Xiao-Yi Xiong

“…Ten DEPs were shared among three organs post-stroke, with eight in heart, six in spleen, and five in intestine. …”
Get full text

Effects of aerobic or resistance exercise during neoadjuvant chemotherapy on tumor response and therapy completion in women with breast cancer: The randomized controlled BENEFIT tr... by Martina E. Schmidt, Siri Goldschmidt, Charlotte Kreutz, Jana Müller, Andreas Schneeweiss, Anne M. May, Friederike Rosenberger, Joachim Wiskemann, Karen Steindorf

“…Results: Overall, there was no significant difference in post-intervention tumor size between RT or AT and WCG. …”
Get full text

Antimicrobial efficacy of methylene blue-functionalized graphene oxide-mediated photodynamic therapy against Enterococcus faecalis in root canal disinfection by Rizwan Jouhar, FCPS, Mohamad S. Halim, M.Res.Dent, Sayed A. Quadri, MD, Muhammad A. Ahmed, PhD, Faheem Shah, PhD

“…Sonic activation (groups 2, 4, and 6) was performed at 6000 cpm for 2 min, whereas laser activation (groups 3–6) was performed with a 650 nm, 200 mW laser for 2 min. Post-treatment CFU/mL counts and bacterial load decreases were recorded. …”
Get full text

The role of deubiquitinases in cardiovascular diseases: mechanisms and therapeutic implications by Xiangyu Fei, Xiangyu Fei, Xiangyu Fei, Xiangyu Fei, Xiangyu Fei, Chao Song, Chao Song, Chao Song, Chao Song, Jian Cui, Jian Cui, Jian Cui, Jian Cui, Yuqing Li, Yuqing Li, Yuqing Li, Yuqing Li, Yuqing Li, Xiaoyong Lei, Huifang Tang, Huifang Tang, Huifang Tang, Huifang Tang, Huifang Tang

“…The ubiquitination system is a vast and complex. It is an important post-translational modification that plays a crucial role in various cellular processes. …”
Get full text

Applications of Human‐Centered Design to Food Is Medicine Interventions: The THRIVE Pilot Trial by Khadijat Adeleye, Kennedy McDaniel, Irma Iribe, Adeline Assani‐Uva, Janice Dugbartey, Aminata Sinyan, Bijaya Bhattarai, Samantha DeMarco, Tosin Tomiwa, Mojisola Olusola‐Bello, Chelsea Akubo, Faith E. Metlock, D’Janee Kyeremeh, Adrián McMahon, Maya Kramer‐Johansen, India Washington, Peiyu Chen, Christy Rodriguez, Mia Johnson, William Xiao, Samuel Gledhill, Samuel Yeboah‐Manson, Natania Kurien, Lydia Vassiliadi, Jennifer Freeman, Anna Maria Izquierdo‐Porrera, Lessly Palencia, Valerie K. Sullivan, Yvonne Commodore‐Mensah, Oluwabunmi Ogungbe

“…Data collection included detailed session notes, post‐session surveys, prototypes, and documentation of visual outputs. …”
Get full text

Impacto de los cuidados domiciliarios en la calidad de vida. Análisis de la experiencia piloto “A Gusto en Mi Casa” by Javier García García, Álvaro Elices Acero, Juan María Prieto Lobato, Pablo De la Rosa Gimeno

“…Se recogieron datos a través de entrevistas semiestructuradas con las personas usuarias (Escala GENCAT pre-post), cuestionarios telefónicos de satisfacción y valoración de las atenciones y entrevistas con las profesionales orientadas a recoger su valoración experta sobre la implementación y los resultados del proyecto. …”
Get full text

International society of liquid biopsy (ISLB) perspective on minimal requirements for ctDNA testing in solid tumors by Nicola Fusco, Konstantinos Venetis, Francesco Pepe, Omshree Shetty, Silvia Calabuig Farinas, Simon Heeke, Julia V. Burnier, Simon J. Patton, Ellen Heitzer, Giovanni Nigita, Paul Hofman, Maria Jose Serrano, Massimo Cristofanilli, Eloisa Jantus-Lewintre, David R. Gandara, Christian Rolfo, Umberto Malapelle

“…Ensuring reliable and reproducible ctDNA testing necessitates standardization across the pre-analytical, analytical, and post-analytical phases. Key considerations include appropriate blood collection, efficient cfDNA isolation and purification, thorough assay validation, and precise data interpretation. …”
Get full text

Multi‐omics analysis revealed biomarkers for coronary atherosclerosis: Occurrence and development by Mengxue He, Dongxue Wang, Yong‐Jiang Xu, Jiachen Shi, Aiyang Liu, Xiaoxi Zhao, Yunlai Gao, Yuan He, Yu Zhang, Ru‐Xing Wang, Yuanfa Liu

“…Results Multi‐omics analysis revealed that plasma metabolites exhibited the strongest correlation with CA severity, effectively distinguished different CA stages from healthy controls. Post hoc analysis confirmed the diagnostic model's robustness, with an AUC value higher than .933 (95% CI: .828–.984, sensitivity 93.75%, and specificity 80%). …”
Get full text

Factors Influencing Nerinetide Effect on Clinical Outcome in Patients Without Alteplase Treatment in the ESCAPE-NA1 Trial by Mayank Goyal, Bijoy K. Menon, Johanna Ospel, Mohammed Almekhlafi, Charlotte Zerna, Raul Nogueira, Ryan McTaggart, Andrew M. Demchuk, Alexandre Y. Poppe, Brian Buck, Kathy Heard, Manish Joshi, Diogo Haussen, Shawna Cutting, Shelagh B. Coutts, Daniel Roy, Jeremy L. Rempel, Thalia S. Field, Dar Dowlatshahi, Brian van Adel, Richard Swartz, Ruchir Shah, Eric Sauvageau, Volker Puetz, Frank L. Silver, Bruce Campbell, René Chapot, Michael Tymianski, Michael D. Hill, on Behalf of the ESCAPE-NA1 Investigators

“…We constructed two multivariable models using variables known prior to randomization and variables known immediately post-EVT procedure to provide adjusted estimates of effect. …”
Get full text

Risk of neuropsychiatric and related conditions associated with SARS-CoV-2 infection: a difference-in-differences analysis by Yiwen Lu, Jiayi Tong, Dazheng Zhang, Jiajie Chen, Lu Li, Yuqing Lei, Ting Zhou, Leyna V. Aragon, Michael J. Becich, Saul Blecker, Nathan J. Blum, Dimitri A. Christakis, Mady Hornig, Maxwell M. Hornig-Rohan, Ravi Jhaveri, W. Schuyler Jones, Amber Brown Keebler, Kelly Kelleher, Susan Kim, Abu Saleh Mohammad Mosa, Kathleen Pajer, Jonathan Platt, Hayden T. Schwenk, Bradley W. Taylor, Levon H. Utidjian, David A. Williams, Raghuram Prasad, Josephine Elia, Christopher B. Forrest, Yong Chen

“…Neuropsychiatric outcomes are examined 28 to 179 days post-infection or negative test between March 2020 and December 2022. …”
Get full text

Complicaciones de la administración intraósea de vancomicina en artroplastia total de cadera by W.F. Martínez, L. Camacho Terceros, F. Garbini, E.J. Bochatey, F.A. Lopreite

“…Detailed records and documentation of complications during hospitalization and the first three months post-surgery were maintained. As a secondary outcome measure, the incidence of PJI was explored. …”
Get full text

Development and validation of an LDH-focused nomogram for the early prediction of heart failure in patients with acute ST-elevation myocardial infarction after percutaneous coronar... by Panting Wei, Jingjin Hou, Ruijiao Yu, Kun Na, Jiaqi He, Xiaojie Zhao, Ziqi Liu, Yan Xu, Yi Li, Chenghui Yan, Haibo Yu, Yaling Han

“…Results Patients with STEMI who developed HF within one year exhibited higher LDH levels within 24 hours post-PCI. A nomogram model was constructed that included alcohol drinking, left anterior descending artery involvement, and creatine kinase-MB, log N-terminal pro b-type natriuretic peptide, and LDH levels. …”
Get full text

Robust in vitro assay for analyzing the neutralization activity of serum specimens against hepatitis B virus by Ya-Li Zhang, Ying Gao, Jia-Li Cao, Jing-Hua Zhao, Tian-Ying Zhang, Chuan-Lai Yang, Hua-Long Xiong, Ying-Bin Wang, Shan-Hai Ou, Tong Cheng, Chang-Rong Chen, Quan Yuan, Ning-Shao Xia

“…In summary, the new cell-based assay provides a robust tool to analyse the anti-HBV NAT.Abbreviations: HBV: Hepatitis B virus; HBsAg: Hepatitis B surface antigen; Anti-HBs: Hepatitis B surface antibody; HBeAg: Hepatitis B e antigen; Anti-HBc: Hepatitis B core antibody; qAnti-HBs: quantitative hepatitis B surface antibody; qAnti-HBc: quantitative hepatitis B core antibody; qHBeAg: quantitative hepatitis B e antigen; NAT: neutralization activity; HBIG: hepatitis B immune globulin; NTCP: Na+-taurocholate cotransporting polypeptide; IRES: internal ribosome entry site; ccHBV: cell culture derived hepatitis B virus; GE/cell: genome equivalent per cell; MOI: multiplicity of infection; Dpi: day post infection; HepG2-TetOn: a HepG2-derived cell line that expresses the doxycycline-regulated transactivator; ROC: receiver operating characteristic curve; AUROC: area under receiver operating characteristic curve; LLOQ: the lower limits of quantification; MDF50: the maximum fold dilution required to produce ≥50% inhibition; IC50: half maximal inhibitory concentration…”
Get full text

Recanalization and reperfusion in clinically-relevant porcine model of stroke by Błażej Nowak, Piotr Holak, Izabela Małysz-Cymborska, Alexandra Chovsepian, Yanina Dening, Jarosław Olszewski, Aleksandra Piecuch, Maria Jasieniak, Jakub Jasieniak, Arkadiusz Szterk, Maria Sady, Karolina Ferenc, Daniel Berchtold, Artur Jabłoński, Romuald Zabielski, Zdzisław Gajewski, Tim Magnus, Mirosław Janowski, Piotr Walczak, Andreas Meisel, Francisco Pan-Montojo, Francisco Pan-Montojo, Francisco Pan-Montojo, Dominika Gołubczyk

“…One month later the stroke was confirmed through follow-up MRI scans and post-mortem histological and immunohistochemical analyses.ResultsWe successfully induced stroke with an average lesion size based on ADC at 8.18 ± 4.98 cm3, ranging from 3.27 to 17.33 cm3. …”
Get full text

Alpha‐Ketoisocaproate Attenuates Muscle Atrophy in Cancer Cachexia Models by Pooreum Lim, Sang Woo Woo, Jihye Han, Young Lim Lee, Jin Ju Lim, Yeong Hoon Kang, Ji Wook Moon, Jeong Min Nam, Jeong Hyeon Kim, Donghun Kim, Jae Ho Shim, Hyeon Soo Kim

“…Grip strength was measured weekly, and mice were sacrificed 4 weeks post‐injection for muscle collection. C2C12 myotubes were treated with conditioned media (CM) derived from C26 or 4T1 cells. …”
Get full text

Early and Extensive Ultraviolet through Near Infrared Observations of the Intermediate-luminosity Type Iax Supernovae 2024pxl by W. B. Hoogendam, C. Ashall, D. O. Jones, B. J. Shappee, M. A. Tucker, M. E. Huber, K. Auchettl, D. D. Desai, A. Do, J. T. Hinkle, M. Y. Kong, S. Romagnoli, J. Shi, A. Syncatto, C. D. Kilpatrick

“…We find a tentative correlation between the H -band break Co ii velocity ∼20 days post-peak and absolute magnitude, with more luminous SNe Iax showing faster Co ii velocities. …”
Get full text