Remote multicomponent rehabilitation compared to standard care for survivors of critical illness after hospital discharge (iRehab): a protocol for a randomised controlled assessor-... by Julie Bruce, Jason Madan, Martin Underwood, Roger Kenyon, Miriam Ratna, Ranjit Lall, Gavin D Perkins, Ella Terblanche, Kerry Raynes, Brenda O'Neill, Mandana Zanganeh, Rowena Williams, Danny McAuley, Paul Dark, Bronwen Connolly, Chen Ji, Judy Martina Bradley, Rachel Clarke, Jill Costley, Nigel D Hart, Penelope Firshman, Katherine Jones, Annette Henderson

“…The primary outcome is Health-related quality of life (HRQoL) at eight weeks post-randomisation measured using the EQ-5D-5L. Secondary outcomes are: HRQoL (six months), physical function, fatigue, anxiety and depression, healthcare resource use at eight weeks and six months and intervention acceptability. …”
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Real-time vertical position estimation of the plasma column using fast imaging in the Aditya-U tokamak by S. Aich, S. Patel, L. Pradhan, A.K. Kumawat, B. Hegde, K. Galodiya, R.L. Tanna, K.A. Jadeja, M.B. Chowdhuri, N. Yadava, K. Patel, H. Raj, A.B. Patel, R. Kumar, K. Singh, S. Dolui, A. Kumar, J. Ghosh, K. Yadav, I. Haque, S. Banerjee, N. Ramaiya

“…First, the appropriate location for collecting visible radiation for accurate estimation of the horizontal and vertical plasma column positions is identified by post-processing the data from a fast imaging camera and benchmarking it with existing magnetic and spectroscopic measurements. …”
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Prediction of antipsychotic drug efficacy for schizophrenia treatment based on neural features of the resting-state functional connectome by Song Liu, Meng Wang, Weiyi Han, Anran Chen, Xuzhen Liu, Kang Liu, Xue Li, Yi Chen, Luwen Zhang, Qing Liu, Xiaoge Guo, Xiujuan Wang, Ning Kang, Yong Han, Yuanbo Li, Xi Su, Luxian Lv, Bing Liu, Wenqiang Li, Yongfeng Yang

“…Baseline clinical status and post-treatment outcome were assessed using the Positive and Negative Symptom Scale (PANSS), and clinical improvement was rated by the total score reduction. …”
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THE EXPERIENCE OF PEDIATRIC HEART TRANSPLANTATION ON NORTH-WEST OF RUSSIAN FEDERATION by M. A. Simonenko, T. M. Pervunina, P. A. Fedotov, Yu. V. Sazonova, E. S. Vasichkina, V. E. Rubinchik, A. V. Berezina, D. A. Zverev, A. E. Bautin, A. A. Kostareva, A. P. Polyakova, L. B. Mitrofanova, M. Yu. Sitnikova, G. V. Nikolaev, M. L. Gordeev, M. A. Karpenko

“…In long-term follow-up there was no signifi cant post transplant complications and comorbidities.Conclusion. …”
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Effects of Chestnut Tannin Extract on Enteric Methane Emissions, Blood Metabolites and Lactation Performance in Mid-Lactation Cows by Radiša Prodanović, Dušan Bošnjaković, Ana Djordjevic, Predrag Simeunović, Sveta Arsić, Aleksandra Mitrović, Ljubomir Jovanović, Ivan Vujanac, Danijela Kirovski, Sreten Nedić

“…Measurements of EME, dry matter intake (DMI), milk yield (MY), and blood and milk parameters were carried out pre- and post-21-day supplementation period. Compared with the no-additive group, the CNT extract reduced methane production, methane yield, and methane intensity in CNT₄₀ and CNT₈₀ (<i>p</i> < 0.001). …”
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Genome-Wide Identification of <i>G3BP</i> Family in U’s Triangle <i>Brassica</i> Species and Analysis of Its Expression in <i>B. napus</i> by Alain Tseke Inkabanga, Qiheng Zhang, Shanshan Wang, Yanni Li, Jingyi Chen, Li Huang, Xiang Li, Zihan Deng, Xiao Yang, Mengxin Luo, Lingxia Peng, Keran Ren, Yourong Chai, Yufei Xue

“…The RasGAP SH3 domain binding protein (G3BP) is a highly conserved family of proteins in eukaryotic organisms that coordinates signal transduction and post-transcriptional gene regulation and functions in the formation of stress granules. …”
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The effects of single and multiple BOPPPS-integrated model sessions on public health students' competences: a two-stage study combining quasi-experimental and cross-sectional analy... by Qiqi Liu, Jixuan Ma, Chuansha Wu, Yang Du, Ting Chen, Xiaojie Sun, Qin Zhao, Yunhao Liu, Yuqin Shi, Yingying Gu, Min Zhou, Ling Zhang, Ting Zhou

“…This study aimed to integrate the bridge-in, objective, pre-assessment, participatory learning, post-assessment, and summary (BOPPPS) framework with problem-based learning (PBL), team-based learning (TBL), and case-based learning (CBL) to develop a novel instructional model, termed the BOPPPS-integrated model (BIM), and to assess the influences of single and multiple BIM interventions on the competences of undergraduate public health students. …”
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Identification of a moxidectin dose for 4- to 11-year-old children to support registration and potential use for onchocerciasis elimination: results of an open-label pharmacokineti... by Nicholas O. Opoku, Felix Doe, Mannel E. Agbogah, Rukaya Laryea, Shelter K. Gordor, Bismark S. Donkor, Edwin Anyomitse, Dickson Kugali, Mariëlle van Zutphen-van Geffen, Danielle J. Navarro, Craig R. Rayner, Kashyap Patel, Annette C. Kuesel, Melinda Lowe, Sally Kinrade

“…Moxidectin plasma concentrations were measured at 1, 2, 4, 8, 24 and 72 h and at 1, 2, 4 and 12 weeks post-dose. The maximum concentration (Cmax; ng/ml) and area under the concentration–time curve from dosing to infinity (AUC0-∞; ng h/ml) were obtained through non-compartmental analysis. …”
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BRAF inhibitor resistance of melanoma cells triggers increased susceptibility to natural killer cell-mediated lysis by Antoine Toubert, Eric Pasmant, Alexandra Frazao, Louise Rethacker, Géraldine Jeudy, Marina Colombo, Marie-Françoise Avril, Helene Moins-Teisserenc, Marie Roelens, Sophie Dalac, Eve Maubec, Anne Caignard

“…We determined the levels of several soluble molecules including NK ligands in 61 melanoma patients at baseline and 6 months M post-treatment with targeted therapies or immunotherapies.Results Vemurafenib resistance involved activation of p-AKT in SK28R and of p-MEK/p-ERK in M14R cells and was accompanied by modulation of NK ligands. …”
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Key technologies of efficient extraction of coalbed methane (gas) in Guizhou coal mine area by Wang YI, Longjun LIANG, Lichong YAN, Zhihua YAN, Jie CHEN, Wei GAO, Yi LOU, Fuqin YANG, Haiyang HU, Jiawei ZHU

“…Especially in the goaf of coal mine, when the coal seam is goaf, five stress fields are formed in the tendency due to the post-mining release and redistribution of ground stress, resulting in different degrees of impact on the overlying strata in adjacent areas. …”
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Association between anion gap and postoperative delirium in patients undergoing open heart surgery by Jun Wang, Hui Zhong, Lu Chen, Hong-Chun Ding, Zhong-Jie Lu, Bin-Su Wang, Shun-Bi Liu, Jing Luo, Li-Wen Hou, Li-Wen Hou, Yuan-Zhang Liu, Sheng Ding, Feng Gao, Li Jiang

“…Patients aged 18 or older who underwent OHS, were admitted to the ICU post-surgery, and had an AG test within the first 24 h after surgery were included. …”
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Atividades de dissecção de cadáveres e residência médica: relato da experiência do Serviço de Cirurgia Plástica do Hospital Universitário Professor Edgard Santos da Universidade Fe... by Victor Diniz de Pochat, Rogério Rafael da Silva Mendes, Adson Andrade de Figuerêdo, Nivaldo Alonso, Marcelo Sacramento Cunha, José Valber Lima Meneses

“…Thus, the importance of using cadavers to teach anatomy and surgical skills in undergraduate and post-graduate courses is reinforced. This study aimed to report scientific outcomes related to cadaver dissection in the Plastic Surgery Service of Hospital Universitário Professor Edgard Santos (HUPES), Universidade Federal da Bahia, from 2009 to 2011, and the importance of this activity for plastic surgery resident training. …”
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Stage-dependent proteomic alterations in aqueous humor of diabetic retinopathy patients based on data-independent acquisition and parallel reaction monitoring by Yeanqi Jin, Junbin Liu, Xueli Zhang, Liang Zhang, Ying Cui, Xiaoyang Luo, Haoxian Zhu, Zhifan Chen, Mengya Liu, Xiyu Wu, Xinyu Chen, Shuoxin Liao, Guanrong Wu, Xiang Fang, Qianli Meng

“…C6, FAM3C, SPP1, and JCHAIN levels were altered post-anti-VEGF treatment. Pharmacological prediction identified potential therapeutic compounds, including perindopril, triciribine, and XAV-939 for NPDR, and topiramate, triciribine, and vecuronium for PDR. …”
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PSMB10 maintains the stemness of chemotherapeutic drug-resistant leukemia cells by inhibiting senescence and cytotoxic T lymphocyte-mediated killing in a ubiquitinated degradation... by Xiao Ma, Yingnan Li, Di Wang, Jialan Niu, Qian Li, Ying Chen, Mengyuan Wang, Jin Wen, Chenxi Liao, Nan Wang, Xiaolan Zhang, Jiwei Chang, Jiayi Yang, Lei Li, Jing Zou, Danyue Peng, Lingbo Liu

“…The specific high expression of PSMB10 in post-chemotherapy nonsenescent LSCs predicts a poor AML prognosis. …”
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Emergency department initiated resuscitative endovascular balloon occlusion of the aorta (REBOA) for out‐of‐hospital cardiac arrest is feasible and associated with improvements in... by James Daley, Ryan Buckley, Kathryn Cannon Kisken, Douglas Barber, Raj Ayyagari, Charles Wira, Ani Aydin, Igor Latich, Juan Carlos Perez Lozada, Daniel Joseph, Angelo Marino, Hamid Mojibian, Jeffrey Pollak, Cassius Ochoa Chaar, James Bonz, Justin Belsky, Ryan Coughlin, Rachel Liu, John Sather, Reinier Van Tonder, Rachel Beekman, Elyse Fults, Austin Johnson, Christopher Moore

“…Unfortunately, all patients re‐arrested soon after intra‐aortic balloon deflation and none survived to hospital admission. At 30 seconds post‐aortic occlusion, investigators noted a statistically significant increase in end tidal carbon dioxide of 26% (95% confidence interval, 10%, 44%). …”
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Systematic Sex-Based Inequity in the MELD Score-Based Allocation System for Liver Transplantation in Germany by Leke Wiering, Leke Wiering, Annette Aigner, Marieke van Rosmalen, Brigitta Globke, Brigitta Globke, Tomasz Dziodzio, Nathanael Raschzok, Nathanael Raschzok, Münevver Demir, Wenzel Schöning, Frank Tacke, Petra Reinke, Johann Pratschke, Robert Öllinger, Paul V. Ritschl, Paul V. Ritschl

“…We assessed the impact of sex on transplantation rates, waiting list mortality and post-transplant survival in 25,943 patients waitlisted for liver transplantation in Germany between 2003 and 2017 using competing risk analysis. …”
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<i>ZmNLR</i><i>-7</i>-Mediated Synergistic Regulation of ROS, Hormonal Signaling, and Defense Gene Networks Drives Maize Immunity to Southern Corn Leaf Blight by Bo Su, Xiaolan Yang, Rui Zhang, Shijie Dong, Ying Liu, Hubiao Jiang, Guichun Wu, Ting Ding

“…Analysis of tissue expression patterns revealed that <i>ZmNLR-7</i> was expressed in all maize tissues, with the highest expression level (5.11 times) exhibited in the leaves, and that its transcription level peaked at 11.92 times 48 h post <i>Bipolaris maydis</i> infection. Upon inoculating the <i>ZmNLR-7</i> EMS mutants with <i>Bipolaris maydis</i>, the disease index was increased to 33.89 and 43.33, respectively, and the lesion expansion rate was higher than that in the wild type, indicating enhanced susceptibility to southern corn leaf blight. …”
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Drainage system research and application of deep coalbed methane gas reservoirs in Daning-Jixian block by Ming CHEN, Dameng WANG, Lizhu YU, Junyi SUN, Xin FENG, Kang ZHANG, Xianfeng GU, Liwei WANG, Zesong YIN, Huan ZHANG

“…Furthermore, through the normalization of production time and horizontal segment length from 29 gas wells’ dynamic production data, the research preliminarily identifies that deep coalbed methane have gone through 4 production stages, with Stage I being post-fracture flowback, Stage II characterized by rapid initial production, Stage III focusing on exploring rational production allocation, and Stage IV indicating a decrease in gas production. …”
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Isolation of Murine Pancreatic Stellate Cells and the Establishment of a New ex-vivo Activation Model by Wang X, Li M, Liu X, Sun G, Zhang D, Sun L, Yin Y, Zhang W, Hao J

“…RT-PCR revealed progressive upregulation of acta2 (&amp;ast;&amp;ast;p&lt; 0.01, d4 compared to d2, &amp;num;&amp;num;p&lt; 0.01,d7 compared to d4,&amp;ast;&amp;ast;p&lt; 0.01,d7 compared to d2), col1a (&amp;ast;&amp;ast;p&lt; 0.01, d4 compared to d2,&amp;ast;&amp;ast;p&lt; 0.01,d7 compared to d2), and actg2 (&amp;ast;&amp;ast;p&lt; 0.01, d4 compared to d2, &amp;num;&amp;num;p&lt; 0.01,d7 compared to d4, &amp;ast;&amp;ast;p&lt; 0.01,d7 compared to d2) mRNA levels at 2, 4, and 7 days post-adhesion. Fibroblast markers were also upregulated, and KEGG and GO enrichment analyses identified key pathways involved in ECM-receptor interactions, cell cycle regulation, PI3K-Akt signaling, and extracellular matrix remodeling.Conclusion: The Nycodenz gradient efficiently isolates quiescent mPSCs, and short-term caerulein treatment effectively activates mPSCs ex vivo, providing a valuable model for studying mPSC activation and related signaling pathways.Keywords: pancreatic stellate cells, chronic pancreatitis, pancreatic fibrosis…”
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Overexpression of the ABA Synthesis Gene OsABA2 Enhances Seed Storability in Rice by Yongxiang Liao, Pengfei Jiang, Mingming Zhang, Fangli Jin, Mengyuan Li, Jiazhi Dong, Daiming Guo, Yingxiu Liao, Asif Ali, Saira Saleem, Xiangyang Zhang, Qinggui Jiang, Su Liu, Hongyu Zhang, Xiaoqiong Chen, Kangxi Du, Hao Zhou, Duo Xia, Peizhou Xu, Xianjun Wu

“…For practical application, Gang46B—a hybrid rice parental line with poor storability—significantly improved its post-aging germination rates. These findings demonstrate that the overexpression of OsABA2 enhances seed storability by regulating ABA biosynthesis pathway and associated oxidative response. …”
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