Pirfenidone Prevents Myocarditis by Restoring Metabolic Hormone Levels in a Mouse MASH Model and its Effect on H9c2 Myoblast Viability under Glucolipotoxicity by Daniel López-Cifuentes, Ana S. Sandoval-Rodríguez, Ángel O. Vázquez-Esqueda, Jonathan S. Rodríguez-Sanabria, Juan Armendáriz-Borunda, Jorge Gutiérrez-Cuevas

“…The data were analyzed using one-way ANOVA followed by Tukey's post-hoc test in Graphpad Prism v10.0. Results: HFHC mice developed MASH, myocarditis and fibrosis (P≤0.05). …”
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Characterization of Netrin-1 and Its Receptors UNC5B and Neogenin-1 in a Rat Rotator Cuff Tear Model: Associations with Inflammatory Mediators and Neurite Extension by Kosuke Inoue, Kentaro Uchida, Mitsuyoshi Matsumoto, Ryo Tazawa, Etsuro Ohta, Akito Hattori, Tomonori Kenmoku, Yuka Ito, Yui Uekusa, Gen Inoue, Masashi Takaso

“…A rat supraspinatus tear model was employed to assess, in vivo, the expression of genes encoding netrin-1 (<i>Ntn1</i>) and its receptors (<i>Unc5b</i> and <i>Neo1</i>) at 0, 7, 14, 28, and 56 days post-injury (n = 10 per time point). Primary rat tenocytes isolated from rotator cuff tissue were treated in vitro with recombinant netrin-1, and transcriptional changes in genes encoding TNF-α (<i>Tnfa</i>), IL-6 (<i>Il6</i>), MMP-1 (<i>Mmp1</i>), and MMP-3 (<i>Mmp3</i>) were quantified by qRT-PCR. …”
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C-reactive protein-to-prealbumin ratio as prognostic marker in hemodialysis patients with Omicron infection by Quanchao Zhang, Caibao Lu, Zhifen Wu, Shaofa Wu, Lili Jiang, Han Wang, Jin He, Bingshuang Tang, Bingfeng Yang, Shengli Liao, Liao Wang, Hongwei Chen, Moqi Li, Wenchang He, Yiqin Wang, Jie Li, Jinghong Zhao, Ling Nie

“…Survival rate differences between higher and lower CP ratio groups were analyzed using the Kaplan-Meier method.Results From the total, 98 patients (11.6%) succumbed, with a majority (80/98) within a month post-infection. C-reactive protein, prealbumin, and CP ratio were all associated with all-cause mortality in the crude model. …”
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Does mean arterial pressure augmentation improve neurological recovery of blunt spinal cord injuries: an EAST multicenter trial by Jeffry Nahmias, Ryan Peter Dumas, Brian Daley, Dalier R Mederos, Bradley M Dennis, Michael Steven Farrell, Stephanie Scott, Gregory Schaefer, Asanthi Ratnasekera, Alison Smith, Scott Armen, Joshua Hill, Carlos H Palacio, Caitlin Anne Fitzgerald, Stephanie Doris, Claudia Alvarez, John D Berne, Lindsey Perea, Aimee LaRiccia, James Bardes, Bhairav Shah, Tanisha Kashikar, Erik Teicher, Jennifer Huber, Malia Eischen, H Akin Erol, Lauren Colom, Melissa Moncrief, William DeVoe, William Brigode, Melissa Linskey Dougherty, Emily Alberto, Stephen Gadomski, Salina Wydo, Jennifer Schweinsburg, M Chance Spalding

“…Patients were divided into two groups: neurological improvement and no improvement, based on their change in ASIA score from arrival to hospital discharge.Results A total of 19 centers contributed 222 patients of those, 164 had pre-ASIA and post-ASIA scores. The ASIA improvement group had 36 patients (22%). …”
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Frailty, Pitavastatin, and Major Adverse Cardiovascular Events Among People With HIV by Kristine M. Erlandson, MD, MS, Ariela R. Orkaby, MD, Triin Umbleja, MSc, Heather J. Ribaudo, PhD, Todd T. Brown, MD, PhD, Markella V. Zanni, MD, Marissa R. Diggs, AB, Sarah M. Chu, MSN, Kathleen V. Fitch, MSN, Carl J. Fichtenbaum, MD, Carlos Malvestutto, MD, MPH, Judith A. Aberg, MD, Gerald S. Bloomfield, MD, MPH, Judith S. Currier, MD, Karen T. Tashima, MD, Marcus Vinícius Guimarães de Lacerda, MD, PhD, Sonya L. Heath, MD, Michael T. Lu, MD, MPH, Alan Landay, PhD, George A. Kuchel, MD, Pamela S. Douglas, MD, Steven K. Grinspoon, MD

“…Methods: We conducted a post hoc analysis of the REPRIEVE trial, a randomized, blinded trial of pitavastatin 4 mg vs placebo. …”
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Predictive Value of R₂CHA₂DS₂-VA Score for 90-Day Functional Outcomes After Endovascular Thrombectomy in Acute Ischemic Stroke by Faruk Boyacı, Cetin Kursad Akpınar, Mustafa Kursat Sahin, Murat Akcay, Hasan Dogan, Mustafa Yenercag, Guney Erdogan, Berkant Ozturk, Yankı Boyacı, Orhan Ince

“…Higher baseline NIHSS scores were associated with unfavorable outcomes (OR = 1.201, 95%, CI: 1.014–1.422, <i>p</i> = 0.034), and this association remained significant for NIHSS scores measured 24 h post-EVT (OR = 1.467, 95%, CI: 1.230–1.748, <i>p</i> < 0.001). …”
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Full lifecycle carbon emissions accounting and regional environmental impact assessment of typical open-pit coal mines by Mingqi LIU, Xiaoping ZHANG, Yu WANG, Zhipeng YANG, Xinhong YU, Agudamu HU, Guoqing YANG, Ying ZHU, Yingnan CAO, Wei LIU, Tianlong ZHENG, Yaoqiang HUO, Jianguo LIU

“…The results of the accounting process indicate that the annual carbon emission of open-pit coal mine is 1538178.60 tCO2e, and the carbon dioxide equivalent emission per 1 t of raw coal produced is 0.05 tCO2e, which mainly comes from methane fugitive emissions caused by coal mining and post-mine activities (accounting for 79.92%). In addition, carbon emissions from fossil fuel combustion account for 13.71% of the total carbon emissions; whereas emissions associated with electricity and water consumption represent the smallest proportion, at 6.37%. …”
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Impact of a specialized pediatric dysphagia rehabilitation program on caregiver quality of life and coping strategies by Pilar Ortiz Pérez, Inés Valero Arredondo, Encarnación Torcuato Rubio, Marta Herrador López, Andrés Rosa López, Pascual García-Herrera Taillefer, Víctor Manuel Navas-López

“…Caregivers of patients with greater neurological impairment, particularly those with GMFCS IV-V and using feeding tubes, were more likely to have higher post-intervention PedsQL-FIM scores. Conclusion: Our findings underscore the significant impact of dysphagia on caregiver QoL and the effectiveness of individualized rehabilitation programs in improving patient outcomes and mitigating caregiver burden. …”
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Ability and utility of the Physician Well-Being Index to identify distress among Chinese physicians by Zejun Li, Peng Pu, Min Wu, Xin Wang, Huixue Xu, Xiaoyu Zhang, Qijian Deng, Winson Fuzun Yang, Yueheng Liu, Qianjin Wang, Manyun Li, Yuzhu Hao, Li He, Yunfei Wang, Qiuxia Wu, Yi-Yuan Tang, Tieqiao Liu

“…Assuming a prevalence of 29.2% for low QOL, the PWBI could reduce the post-test probability to 6.9% or increase it to 70.8%. …”
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Inhibition of Farnesoid-x-receptor signaling during abdominal sepsis by dysbiosis exacerbates gut barrier dysfunction by Shuwen Qian, Zehua Su, Jiaqi Lin, Qianhao Hou, Xiaomei Wang, Yuling Li, Jieying Wang, Changchun Huang, Zetian Wang, Francisco Javier Cubero, Xiangrui Wang, Lijun Liao

“…Methods Expression levels of FXR and FGF15 in the liver and intestines, alongside assessments of gut barrier function, were evaluated in septic wild-type (WT) mice 24 h post-cecal ligation and puncture (CLP) surgery. Subsequently, the FXR agonist INT-747 was administered to explore the relationship between FXR activation and gut barrier function. …”
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Primary Carcinomas of the Episiotomy Scar Site: A Systematic Literature Review by Andrea Palicelli, Federica Torricelli, Gabriele Tonni, Alessandra Bisagni, Eleonora Zanetti, Magda Zanelli, Venus Damaris Medina-Illueca, Beatrice Melli, Maurizio Zizzo, Andrea Morini, Maria Paola Bonasoni, Giacomo Santandrea, Giuseppe Broggi, Rosario Caltabiano, Francesca Sanguedolce, Nektarios I. Koufopoulos, Ioannis Boutas, Aleksandra Asaturova, Lorenzo Aguzzoli, Vincenzo Dario Mandato

“…Patients were usually post-/peri-menopausal (eight cases, 61%) (age range: 31–70 years, mean 50). …”
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Effect of Erector Plane Muscle Block and Thoracic Paravertebral Block on Postoperative Analgesia in Patients with Breast Cancer: A Meta-analysis by CHEN Tianren, DU Zhongying, TANG Lu, CHEN Wenqiang, WANG Chun'ai

“…ObjectiveTo compare the efficacy and safety of erector spinae plane block (ESPB) and thoracic paravertebral block (TPVB) in preventing acute post-surgical pain syndrome (PSP) of breast cancer.MethodsThe following databases, both domestic and international, including Embase, Cochrane Library, Web of Science, PubMed, CNKI, VIP, Wanfang, and Sinomed, were searched via computer to gather clinical randomized controlled trials (RCTs) on ESPB and TPVB for breast cancer patients. …”
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SLOW READING AS A METHOD FOR REVEALING IMPLICIT MEANINGS IN THE LITERARY WORK by Hryhorii D. Klochek, Mariia V. Foka

“…He is one of those young people who, having survived the war, cannot find themselves in the post-war world. At the same time, the main artistic meaning of the story can also be interpreted as an expression of the idea of the global loneliness of people, the alienation of human existence, that is embodied in the images of the American couple, the hotel owner, and the writer himself as an “image of the author.” …”
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Tiller fertility is critical for improving grain yield, photosynthesis, and nitrogen efficiency in wheat by Yong-gang DING, Xin-bo ZHANG, Quan MA, Fu-jian LI, Rong-rong TAO, Min ZHU, Chun-yan LI, Xin-kai ZHU, Wen-shan GUO, Jin-feng DING

“…High grain yield was attributed to more effective ears by high tiller fertility and greater single-spike yield by increasing post-anthesis single-stem biomass. Compared to other groups, the HH group demonstrated a longer leaf stay-green ability and a greater flag leaf photosynthetic rate after anthesis. …”
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The toxicity of guaiacol on craniofacial cartilage development through ROS-induced oxidative stress in zebrafish embryos by Xianhua Zhang, Runfa Wu, Fasheng Liu, Min Huang, Xiaoyan Huang, Nannan Wang, Qianqian Huang, Minhong Zhang, Xinjun Liao, Huiqiang Lu, Lan Liao

“…Zebrafish embryos were exposed to 0.08–0.24 mM GUA from 12 to 120 h post-fertilization (hpf). GUA induced craniofacial malformations, behavioral abnormalities (reduced locomotion, impaired stimuli response), and oxidative stress via reactive oxygen species (ROS) accumulation. …”
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Sequential layer-by-layer deposition for high-performance fully thermal-evaporated red perovskite light-emitting diodes by Yajing Li, Na Meng, Yutian Xu, Bufan Yu, Junhao Liu, Yuanhao Cui, Ziqiang Wang, Xinwu Ke, Tengfei Pan, Xue Min, Jiangshan Chen, Dongge Ma, Lingfeng Chao, Zhelu Hu, Yingdong Xia, Qingxun Guo, Yonghua Chen, Wei Huang

“…Here, we demonstrate a facile layer-by-layer thermal-evaporation strategy to fabricate high-quality perovskite-emitting films with tunable emission wavelengths. 5-Aminovaleric acid is introduced to regulate interfacial reactions during deposition, slow down crystallization during post-annealing, and passivate defects through coordination interactions. …”
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How reliable is the labeling of a commercial phytosteroid product? A 12-week randomized double-blind training study by Joshua Dissemond, Tim Havers, Steffen Held, Stephan Geisler, Tihomir Kostov, Patrick Diel, Svea Türschmann, Maria K. Parr, Eduard Isenmann

“…Liver and kidney function, along with endocrine parameters, were measured via blood samples pre- and post-intervention. Additionally, the concentration of 20E and DSG in the product was measured by LC-MS/MS, and its biological activity was evaluated using C2C12 cells after the intervention. …”
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Left Atrial Remodeling Identification and Catheter Ablation Outcomes With 18F‐Fluorodeoxyglucose Positron Emission Tomography in Persistent Atrial Fibrillation by Tristan Raoult, Bernhard L. Gerber, Quentin Garnir, Christophe Scavée, Varnavas Varnavas, Aurélien Wauters, Damien Gruson, Eric Nellessen, Michel Hesse, Christophe Beauloye, Véronique Roelants, Sébastien Marchandise

“…Patients were followed for up to 24 months post CA to assess AF recurrence. Results Global LGU extent was 16.8% (7.6–42.6) and correlated with left atrial volume index (R2=0.20, P=0.039) and low voltage area during AF and right atrial pacing (R2=0.54 and R2=0.35 respectively, both P<0.001). …”
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Tratamento de sequelas de queimadura de face com laser de CO2 fracionado em pacientes com fototipos III a VI Treatment of facial burn sequelae using fractional CO2 lasers in patien... by Alessandra Grassi Salles, Adelina Fátima do Nascimento Remigio, Valéria Berton Liguori Zacchi, Marcus Castro Ferreira

“…<br>BACKGROUND: Reports on improvement in post-traumatic or pathological scars with the use of fractional CO2 laser (CO2F) conclude that it is a safe and effective technology, though used only in patients with phototypes II to III. …”
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COVID-19 and neuropathy in type 2 diabetes by Georgios Ponirakis, Ibrahim Al-Janahi, Einas Elgassim, Aisha Al Obaidan, Hoda Gad, Ioannis N. Petropoulos, Adnan Khan, Hadeel B. Zaghloul, Hamda Ali, Mashhood A. Siddique, Fatima F. S. Mohamed, Lina H. M. Ahmed, Youssra Dakroury, Abeer M. M. El Shewehy, Shaikha N. Al-Thani, Farheen Ahmed, Rawan Hussein, Salah Mahmoud, Iuliia Salivon, Moayad Homssi, Nebras H. Hadid, Ateeque Mohamed Ali, Safah Khan, Ziyad R. Mahfoud, Mahmoud A. Zirie, Gulfidan Bitirgen, Yousuf Al-Ansari, Mohammed I. Alhatou, Stephen L. Atkin, Rayaz A. Malik

“…Patients with T2D underwent assessments with the NICE post-COVID questionnaire, DN4 questionnaire, vibration perception threshold (VPT), and corneal confocal microscopy (CCM) before and 11.0 ± 8.9 months after developing COVID-19. …”
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