Clinical Evidence of Acupoint Stimulation for Primary Dysmenorrhea: A Systematic Review and Updated Meta-Analysis by Wang Y, Liu L, Wu X, Wu Y, Qin R, Wang M, Zhou B, Sun J, Song Y, Zhang M, Li M, Yu L

“…Compared with non-steroidal anti-inflammatory drugs (NSAIDs), acupoint stimulation showed both immediate effects (post-first-treatment SMD − 2.85, 95% CI − 4.06 to − 1.64) and sustained benefits (3 cycles SMD − 1.58, 95% CI − 2.43 to − 0.73; following 3 cycles SMD − 3.74, 95% CI − 5.57 to − 1.90), particularly with invasive techniques. …”
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Cardiovascular risks associated with adjuvant endocrine therapy in women with breast cancer: a population-based cohort study by Iokfai Cheang, Ying Gue, Mei-Zhen Wu, Jia-Yi Huang, Qing-Wen Ren, Ziqi Chen, Yi-Kei Tse, Hang-Long Li, Yap-Hang Chan, Hung-Fat Tse, Xinli Li, Gregory Y. H. Lip, Kai-Hang Yiu

“…Conclusion The study indicates that AIs are linked to a higher risk of cardiovascular events in post-menopausal patients compared to TMX. In younger patients, TMX’s protective effect on cardiovascular outcomes may be less pronounced. …”
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Sex differences in discontinuations due to side effects of second-generation integrase strand transfer inhibitors: a systematic review and meta-analysisResearch in context by Zhou Fang, Tetiana Povshedna, Rowan Patterson, Erin Ready, Helene C.F. Cote, Melanie C.M. Murray, Elizabeth M. King

“…Studies in pregnancy, post-partum, pediatrics, co-infections (e.g., TB), and monotherapy were excluded. …”
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Un broche de cinturón tardoantiguo de la cueva de Lazaldai (Zuia, Álava/Araba) by José Ángel Hierro Gárate, Enrique Gutiérrez Cuenca, Leticia Tobalina Pulido, Diego Garate Maidagan, Iñaki Intxaurbe Alberdi, Antonio Torres Riesgo, Sergio Salazar Cañarte

“…This f ind contributes to our understanding of regional identity construction and the circulation of objects and ideas in post-Roman western Europe.…”
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Breaking prolonged sitting with high-intensity interval training to improve cognitive and brain health in middle-aged and older adults: a protocol for the pilot feasibility HIIT2SI... by Charles Hillman, Talha Syed, Dominika M Pindus, Tomasz S Ligeza, Jin Kuang, Scott Paluska, Joseph So, Miroslaw Wyczesany, Jesus Sarol, Flor B Quiroz, Ramiya Shanmugam, Maciej Kos, Naiman Khan, Art Kramer

“…The primary outcomes include the feasibility (recruitment and retention rates, percentage of valid electroencephalogram data), acceptability of time commitment, HIIT bouts and neurocognitive assessments, fidelity (the intensity of HIIT breaks, percentage of time spent sitting) and the amplitude and the latency of the P3b component of event-related brain potentials measured during the modified Eriksen flanker task at pretests, after the first and the third PA bout and at post-test. General linear mixed-effects models will be used to test the effects of the intervention on the P3b component.Ethics and dissemination The Institutional Review Board at the University of Illinois Urbana-Champaign provided the ethical approval for the study. …”
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Glucose metabolism in heterozygous familial hypercholesterolemia with a founder effect and a high diabetes prevalence: a cross-sectional study by Ana María González-Lleó, Yeray Brito-Casillas, Virginia Martín-Santana, Yaiza Gil-Quintana, Antonio Tugores, Roberto Scicali, Marta Riaño, Luisa Hernández-Baraza, Roberto Jiménez-Monzón, Josefa Girona, Francesco Di Giacomo Barbagallo, Luis Masana, Mauro Boronat, Ana M. Wägner, Rosa M. Sánchez-Hernández

“…Compared with HeFH-It patients, HeFH-GC individuals had higher fasting glucose levels (99 vs. 92.5 mg/dL; p = 0.004) and lower 120-min post-OGTT glucose levels (115 vs. 136.5 mg/dL; p = 0.001). …”
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Histone deacetylases facilitate Th17-cell differentiation and pathogenicity in autoimmune uveitis via CDK6/ID2 axis by Chun Zhang, Xiuxing Liu, Chenyang Gu, Yuhan Su, Jianjie Lv, Yidan Liu, Yuehan Gao, Hui Chen, Nanwei Xu, Jing Xiao, Zhuping Xu, Wenru Su

“…Our further studies showed that targeted inhibition of HDACs effectively alleviated EAU, restored its Th17/Treg balance, and reduced inflammatory gene expression, especially in CD4+ T cells. Post-HDACs inhibition, Treg proportions increased with enhanced immunomodulatory effects. …”
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Comprehensive genomic and transcriptomic analyses reveal prognostic stratification for esophageal squamous cell carcinoma by Jian Gao, Qiming Wang, Fangqiu Fu, Yue Zhao, Teng Yang, Xiangze Li, Yihua Sun, Hong Hu, Longfei Ma, Longsheng Miao, Xiaoyang Luo, Ting Ye, Yiliang Zhang, Yang Zhang, Ziling Huang, Hang Li, Longlong Shao, Midie Xu, Kuaile Zhao, Shiyue Zhang, Mou Zhang, Jun Wang, Chong Dai, Xiaoxiao Shang, Tingyi An, Yawei Zhang, Jiaqing Xiang, Zhiwei Cao, Bin Li, Haiquan Chen

“…In contrast, activation of the epithelial-keratinization (EpK) pathway was strongly linked to favorable prognosis and lower post-chemotherapy recurrence rates. Independent validation supported S100A8 + S100A9 complex as a key marker of EpK pathway. …”
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Remote Ischemic Preconditioning Prevents Acute Kidney Injury Following Coronary Angiography by Oladipupo Olafiranye, MD, MS, Adam C. Straub, PhD, Yingze Zhang, PhD, Rahul Chaudhary, MD, MBA, Megan P. Miller, BS, Kathan Trivedi, MD, Lawrence Hoang, MD, Oussama Khalifa, MD, Adetola Ladejobi, MD, MPH, Floyd W. Thoma, BS, Ning Feng, MD, PhD, Aref Rahman, MD, John A. Kellum, MD

“…The product of urinary tissue inhibitor of metalloproteinase-2 and insulin-like growth factor-binding protein-7, 2 markers of AKI, significantly increased at 48 hours post-angiography compared to pre-angiography level (0.51 vs 0.89; P = 0.004) in the sham-RIPC but not in the RIPC group (0.39 vs 0.68; P = 0.091). …”
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Myostatin Levels in SMA Following Disease‐Modifying Treatments: A Multi‐Center Study by Fiorella Piemonte, Sara Petrillo, Anna Capasso, Giorgia Coratti, Adele D'Amico, Michela Catteruccia, Maria Carmela Pera, Concetta Palermo, Marika Pane, Emanuela Abiusi, Gianpaolo Cicala, Marianna Villa, Chiara Bravetti, Chiara Arpaia, Agnese Novelli, Salvatore Falqui, Stefania Fiori, Giulia Napoli, Silvia Baroni, Francesco Danilo Tiziano, Enrico Bertini, Giacomo Comi, Stefania Corti, Eugenio Mercuri

“…The longitudinal cohort included 46 treatment‐naive patients assessed at baseline and 12 months post‐treatment. Myostatin levels were measured using ELISA. …”
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Construction and Evaluation of a Rat Model of Abnormal Uterine Bleeding by LIAN Hui, JIANG Yanling, LIU Jia, ZHANG Yuli, XIE Wei, XUE Xiaoou, LI Jian

“…Uterine bleeding was recorded during the 48-hour observation period post-modeling. Serum and uterine tissue samples were collected from the model group at 0, 12, 24, 36, and 48 h after mifepristone administration, while the normal control group was sampled at 36 h. …”
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Adjuvant melatonin therapy during exercise prescription in breast cancer survivors on physical and anthropometric parameters, quality of life, and hormonal response. A randomized c... by Ana M. Celorrio San Miguel, Luis M. Cacharro, Gema Santamaría, Manuel Garrosa, Manuel Garrosa, Marta Celorrio San Miguel, Enrique Roche, Enrique Roche, Enrique Roche, Enrique Roche, Evelina Garrosa, Diego Fernández-Lázaro, Diego Fernández-Lázaro, Diego Fernández-Lázaro

“…Our findings suggest no clear effect of melatonin in post-treatment for BCS in the mentioned parameters. …”
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The Impact of Whole Body Vibration on Muscle Tone, and Sensory Motor Function in Children with Spastic Diplegic Cerebral Palsy by Hussein HM, Dakheel N, Alshammari HZM, Alshammari AA, Gabr AM, El-Shamy SM, SD S, A RH, Dewir IM, Mohamed AR, Ibrahim AA

“…However, there were limited studies involving the effect of WBV on the tone and function of diplegic CP; we aimed to investigate the effect of WBV on muscle tone, function, and sensorimotor function in children with CP.Patients and Methods: This is a single-blind randomized controlled clinical trial involving 54 spastic diplegic CP child recruited from local rehabilitation centers in the Ha’il region of Saudi Arabia, they were randomly divided into the WBV group (n = 28 with mean age of 9.47± 1.92), which received standard physical therapy and WBV therapy, and the control group (n = 26 with mean age of 9.73± 1.62) they received standard physical therapy three time per week for four weeks; Muscle tone, function, strength and Sensory motor integration were evaluated pre and post interventions.Results: At baseline, the two groups had no significant differences. …”
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Efficacy and safety of flupentixol-melitracen in patients with refractory chronic cough: a randomised, double-blinded, placebo-controlled clinical trialResearch in context by Qiang Chen, Mengru Zhang, Li Zhang, Alimire Aierken, Ran Dong, Xianghuai Xu, Li Yu, Kefang Lai, Zhongmin Qiu

“…The safety set (SS) was used for safety analysis and included all patients who took at least one dose of treatment and had post-dose safety records. The FAS and SS were equivalent in this study. …”
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<i>Cenostigma bracteosum</i> Hydroethanolic Extract: Chemical Profile, Antibacterial Activity, Cytotoxicity, and Gel Formulation Development by Addison R. Almeida, Francisco A. S. D. Pinheiro, Marília G. M. Fideles, Roberto B. L. Cunha, Vitor P. P. Confessor, Kátia N. Matsui, Weslley S. Paiva, Hugo A. O. Rocha, Gislene Ganade, Laila S. Espindola, Waldenice A. Morais, Leandro S. Ferreira

“…The prepared gels remained stable over the 30-day post-production analysis period. <b>Conclusions</b>: These findings provide a better understanding of the chemical diversity of the secondary metabolites of a common Caatinga biome species—<i>C. bracteosum</i>—specifically present in leaves hydroethanolic extract and gel formulation adapted for skin application with activity against <i>S. aureus.…”
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Digital education and exercise therapy versus minimal intervention for young people at high risk of early onset knee osteoarthritis after ACL reconstruction: a study protocol for t... by Jackie L. Whittaker, Amanda Cammalleri, Candice Archibald, Alexandra Brooks-Hill, Patrick Chin, Sarah Clark, Jennifer C. Davis, Alison M. Hoens, Michael A. Hunt, Karin Kausky, Angelina Ko, Lise Leveille, Linda C. Li, Parth Lodhia, Justin M. Losciale, Maxi Miciak, Amber D. Mosewich, Adnan Sheikh, Trish Silvester-Lee, Linda K. Truong, Dominic Wade, David R. Wilson, Hui Xie, Xian He Yan, Ewa M. Roos

“…Consensus recommendations to prevent post-traumatic knee osteoarthritis include person-centered education and exercise-based treatments. …”
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Role of Frailty Index-Laboratory to predict COVID-19 mortality: a prospective study by Elda De Vita, Nicola Veronese, Giacomo Guido, Luisa Frallonardo, Sergio Cotugno, Giorgia Manco Cesari, Marinella Cibelli, Alessandra Vigna, Davide Capruzzi, Monica Fiorella, Carmen Rita Santoro, Gaetano Brindicci, Francesco Di Gennaro, Annalisa Saracino

“…Mortality data were collected up to 90 days post-admission. Cox regression analysis, adjusting for demographics, comorbidities, COVID-19 symptoms, and vaccination status, was employed to examine the relationship between FI-LAB scores and mortality.ResultsOne thousand, four hundred ninety-two patients were included in the study population, the mean age was 57.2 years (SD = 15.9), with 56.6% being male. …”
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Predictors of response and enteral autonomy in children with short bowel syndrome treated with teduglutide: a real-life multicentre cohort studyResearch in context by Lorenzo Norsa, Arianna Ghirardi, Esther Ramos Boluda, Anat Guz-Mark, Iva Hojsak, Johannes Hilberath, Ilse Juia Broekaert, Rocío González Sacristán, Antonella Lezo, Paula Guerra, Pierre Poinsot, Cecile Lambe, Lorenzo D'Antiga

“…Information on patients’ post-surgical anatomy, amount of PN calories and volume required at baseline and at 3, 6 and 12 months after TED start, along with biochemical markers of PN tolerance and complications, were recorded. …”
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Hydration assessment and physical performance of mountain bike cyclists in competition in a hot environment by Rayane Carvalho de Moura, Crislane de Moura Costa, Cirley Pinheiro Ferreira, Valmir Oliveira Silvino, Bruna Lorena Soares Cavalcante Sousa, Esmeralda Maria Lustosa Barros, Leandra Caline dos Santos, Karoline de Macêdo Gonçalves Frota, Sandro Soares Almeida, Sérgio Luís Galan Ribeiro, Acácio Salvador Veras e Silva, Michelly da Silva Pinheiro, João Victor Neves Veras, Paulo Henrique Carvalho de Sousa, Guilherme de Azambuja Pussieldi, Glêbia Alexa Cardoso, Marcos Antonio Pereira dos Santos

“…There was a significant decrease in body mass between the pre- and post-competition moments (79.15 ± 14.65 kg; 76.15 ± 14.36 kg) (p = 0.000). …”
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THE AESTHETICS OF RUINS IN VERNACULAR PHOTOGRAPHY IN RUSSIAN SOCIAL MEDIA: STATING THE RESEARCH PROBLEM / ЭСТЕТИКА РУИН В ВЕРНАКУЛЯРНОЙ ФОТОГРАФИИ РУССКОЯЗЫЧНЫХ СОЦИАЛЬНЫХ МЕДИА: П... by CHUMAKOVA VARVARA PAVLOVNA / ЧУМАКОВА ВАРВАРА ПАВЛОВНА

“…As our research has demonstrated, the popularity of the aesthetization of ruins in the modern network culture may be associated with the crisis of identity and the reevaluation of relations with the past in the post-Soviet space. Статья посвящена феномену вернакулярной фотографии руин и связанных с ней изображений в современных русскоязычных социальных медиа. …”
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