An Evaluation of the Safety, Immunogenicity, and Protective Efficacy of a Combined Diphtheria–Tetanus–Acellular Pertussis, <i>Haemophilus influenzae</i> Type b, and ACYW135 Meningo... by Xiuwen Sui, Zhujun Shao, Yuanyuan Ji, Hairui Wang, Qingfu Xu, Bochao Wei, Zhuojun Duan, Chang Wang, Ying Yang, Jiayu Zhao, Tao Zhu

“…Orbital blood was collected 14 days post-immunization to measure IgG titers against pertussis, diphtheria, tetanus, Hib, and meningococcal antigens. …”
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Timing of mechanical ventilation and its association with in-hospital outcomes in patients with cardiogenic shock following ST-elevation myocardial infarction: a multicentre observ... by Waleed AlHarbi, Mohammed Qutub, Prashanth Panduranga, Jassim Al Suwaidi, Wael Al Mahmeed, Hassan Khan, Sultan Alobaikan, Abdullah Alenezi, Mohammed AlShehri, Abdulrahman Arabi, Amin Daoulah, Awad Abdulrazaq AlQahtani, Zubair Shahid, Ahmed Jamjoom, Ahmed Elmahrouk, Abeer Said Mohamed Al Rawahi, Gladsy Selva Livingston, Ala’a Al-deen Tayseer Mousa, Hatem Aloui, Mubarak Aldossari, Nooraldaem Yousif, Husam Noor, Rajesh Rajan, Amr A Arafat, Omar Kanbr, Alsayed Almarghany, Mokhtar Kahin, Abdulwali Abohasan, Faisal Al Nasser, Badr Alzahrani, Alaa Aldossari, Taher Hassan, Mohammed Ali Balghith, Khalid Alshali, Amir Lotfi

“…Increased delay in MV was associated with a higher mortality risk during the first 60 min post-diagnosis, beyond which the risk plateaued. …”
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Placental epigenetic clocks derived from crowdsourcing: Implications for the study of accelerated aging in obstetrics by Gaurav Bhatti, Herdiantri Sufriyana, Roberto Romero, Tushar Patel, Fasil Tekola-Ayele, Ibrahim Alsaggaf, Nardhy Gomez-Lopez, Emily C.Y. Su, Bogdan Done, Steve Hoffmann, Alena van Bömmel, Cen Wan, Jake Albrecht, Charles Novak, Tinnakorn Chaiworapongsa, Marina Sirota, Nima Aghaeepour, Gustavo Stolovitzky, David R. Bryant, Adi L. Tarca

“…Models developed during and post-challenge compared favorably to existing models in terms of accuracy, yet they were better calibrated throughout gestation and indicated that reports of accelerated epigenetic aging in preterm preeclampsia were likely due to modeling artifacts. …”
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Intranasal Administration of Cold-Adapted Live-Attenuated Eurasian Avian-like H1N1 Vaccine Candidate Confers Protection Against Different-Lineage H1N1 Viruses in Mice by Qiu Zhong, Zuchen Song, Fei Meng, Yanwen Wang, Yijie Zhang, Zijian Feng, Yali Zhang, Yujia Zhai, Yan Chen, Chuanling Qiao, Hualan Chen, Huanliang Yang

“…In mice, it was attenuated, with viral titers in the nasal turbinates and lungs reduced 1000–10,000-fold compared to the wild-type strain, and it cleared by day 5 post infection. Intranasal immunization elicited strong cross-reactive immune responses. …”
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Suicídio decomposto by Vera Couto, Tatiana Gomes, Rui Almeida, Eduarda Duarte

“…Nos casos em que os cadáveres se apresentam em avançado estado de decomposição, esta classificação poderá ser mais difícil de estabelecer, tendo em conta que eventuais lesões traumáticas poderão estar dissimuladas por fenómenos post mortem. Apresentação do caso: Um cadáver em avançado estado de decomposição apareceu no areal de uma praia. …”
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Multi-omics and AI-driven advances in miRNA-mediated hair follicle regulation in cashmere goats by Zhang Chunhua, Zhang Chunhua, Zhang Chunhua, Fu Le, Fu Le, Fu Le, Li Shengli, Li Shengli, Li Shengli, Wu Sachula, Wu Sachula, Wu Sachula, Hua Bao, Hua Bao, Hua Bao, Mu Lan, Mu Lan, Mu Lan, Marco Antonini, Sun Haizhou, Sun Haizhou, Sun Haizhou

“…Hair follicle development and cycling are governed by intricate genetic and molecular networks, with microRNAs (miRNAs) playing essential roles as post-transcriptional regulators. In cashmere goats, valued for their fine fiber, miRNAs have emerged as key modulators influencing hair follicle morphogenesis, regeneration, and fiber traits such as fineness and pigmentation. …”
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Neutralization sites of human papillomavirus-6 relate to virus attachment and entry phase in viral infection by Xinlin Liu, Jie Chen, Zhiping Wang, Daning Wang, Maozhou He, Ciying Qian, Shuo Song, Xin Chi, Zhibo Kong, Qingbing Zheng, Yingbin Wang, Hai Yu, Qinjian Zhao, Jun Zhang, Shaowei Li, Ying Gu, Ningshao Xia

“…HighlightsMajor neutralization sites of HPV6 were mapped on the pseudovirus cryo-EM structuremAb 15F7 binds HPV6 capsid with a novel top-rim binding modality and confers a post-attachment neutralizationmAb 17D5 binds capsid in top-centre manner but unexpectedly prevents virus from attachment to cell surface…”
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Role of heavy sweating for ST-segment elevation myocardial infarction: analysis of the China Acute Myocardial Infarction registry by Chao Wu, Zilong Zhang, Shuhong Su, Haiyan Xu, Lei Song, Yongjian Wu, Shubin Qiao, Yang Wang, Wei Li, Yida Tang, Xiaojin Gao, Jingang Yang, Yuejin Yang, on behalf of the China Acute Myocardial Infarction Registry Study Group

“…Heavy sweating group was more likely to achieve primary PCI (44.7% vs 32.9%) but shown similar rates of post-PCI TIMI 3 flow (95.5% vs 94.1%) and STR ≥ 50% (79.8% vs 78.2%). …”
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High-throughput phenotyping discovers new stable loci controlling senescence rate in bread wheat by Lei Li, Jindong Liu, Muhammad Adeel Hassan, Duoxia Wang, Keyi Wang, Shuaipeng Fei, Jianqi Zeng, Awais Rasheed, Xianchun Xia, Zhonghu He, Yong He, Yong Zhang, Yonggui Xiao

“…A total of 262 recombinant inbred lines derived from the cross of Zhongmai 578/ Jimai 22 were evaluated for senescence-related traits across three environments, spanning from heading to 35 d post-anthesis. The manual senescence rate (MSR) was quantified using the FLC and the active accumulated temperature, and UAV derived vegetation index were utilized to assess the stay-green rate (USG) facilitating the identification of senescent and stay-green lines. …”
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Host-specific adaptation in Fusarium oxysporum correlates with distinct accessory chromosome content in human and plant pathogenic strains by Dilay Hazal Ayhan, Serena Abbondante, Domingo Martínez-Soto, Siyuan Wu, Ricardo Rodriguez-Vargas, Shira Milo, Katherine Rickelton, Vista Sohrab, Shunsuke Kotera, Tsutomu Arie, Michaela Ellen Marshall, Marina Campos Rocha, Sajeet Haridas, Igor V. Grigoriev, Neta Shlezinger, Eric Pearlman, Li-Jun Ma

“…Interestingly, ACs from both genomes also encode proteins with shared functions, such as chromatin remodeling and post-translational protein modifications. Our phenotypic assays and comparative genomics analyses lay the foundation for future studies correlating genotypes with phenotype and for developing targeted antifungals for agricultural and clinical uses.IMPORTANCEFusarium oxysporum is a cross-kingdom fungal pathogen that infects both plants and animals. …”
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Arachidonic Acid Metabolism Down-Regulation-Mediated Tumor Necrosis Factor Signaling Contributes to Cutaneous Fibrosis and Skull Hyperplasia in Goldfish Hoods by Liang-Liang Li, Qi-Lin Xu, Wen-Jing Yi, Di-Di Ma, Hui Jin, De-Zheng Fu, Xiao-Li Yang, Yang Wang, Zhi Li, Zhong-Wei Wang, Xi-Yin Li, Meng Lu, Xiao-Juan Zhang, Li Zhou, Jian-Fang Gui, Peng Yu

“…Furthermore, we found that the down-regulation of arachidonic acid metabolism triggers an inflammatory response, culminating in the dysregulation of the tumor necrosis factor (TNF) pathway, which in turn enhances collagen deposition and epithelial cell proliferation—central to hood morphogenesis. During post-formation process, the aberrant TNF pathway expression and collagen accumulation inhibit osteoclast differentiation, promoting the irregular proliferation of the skull and the formation of bony protrusions that support hood attachment. …”
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Assessment of effectiveness and safety of thrombolytic therapy to pulmonary emboli by endobronchial ultrasound-guided transbronchial needle injectionCentral MessagePerspective by Yuki Sata, MD, PhD, Masato Aragaki, MD, PhD, Terunaga Inage, MD, PhD, Nicholas Bernards, PhD, Alexander Gregor, MD, PhD, Shinsuke Kitazawa, MD, PhD, Fumi Yokote, MD, PhD, Takamasa Koga, MD, PhD, Hiroyuki Ogawa, MD, PhD, Yoshihisa Hiraishi, MD, PhD, Tsukasa Ishiwata, MD, PhD, Andrew Effat, MS, Kate Kazlovich, MS, Harley Chan, PhD, Ichiro Yoshino, MD, PhD, Kazuhiro Yasufuku, MD, PhD, FRCSC

“…Considering the elapsed time, the average decrease of clot volume per hour at pre-t-PA to post t-PA was significantly greater in the TBNI group than in the systemic group (mm3/hour: systemic 68.1 ± 68.1 vs TBNI 256.8 ± 148.1, P < .05). …”
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Challenges and prospects in mentoring medical scientists in Latin America: a narrative review and recommendations by Rodrigo C. Menezes, Rodrigo C. Menezes, Rodrigo C. Menezes, Caian L. Vinhaes, Caian L. Vinhaes, Caian L. Vinhaes, Caian L. Vinhaes, Felipe Ridolfi, Felipe Ridolfi, Isabella B. B. Ferreira, Isabella B. B. Ferreira, Isabella B. B. Ferreira, Isabella B. B. Ferreira, Moises A. Huaman, Cesar Ugarte-Gil, Bruno B. Andrade, Bruno B. Andrade, Bruno B. Andrade, Bruno B. Andrade

“…ObjectiveTo identify the challenges for the development and mentorship of physician-scientists in Latin America, outline the key barriers to integrating research training into medical education and post-graduate pathways, and propose recommendations to foster structured mentorship, improve institutional support, and strengthen the research ecosystem for future physician-scientists.Study designNarrative review.MethodsA narrative review of relevant literature, institutional reports, and existing educational models was undertaken. …”
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Fecal Metabolome and Bacterial Composition in Severe Obesity: Impact of Diet and Bariatric Surgery by Nuria Salazar, Manuel Ponce-Alonso, María Garriga, Sergio Sanchez-Carrillo, Ana María Hernández-Barranco, Begoña Redruello, María Fernández, José Ignacio Botella-Carretero, Belén Vega-Piñero, Javier Galeano, Javier Zamora, Manuel Ferrer, Clara G de Los Reyes-Gavilán, Rosa Del Campo

“…Each participant contributed 4 fecal samples (baseline, post-diet, 1 month after surgery and 3 months after surgery). …”
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In-vitro and bioinformatic studies of bioactive compounds from Oceanimonas sp. JM-AZM31 and Lysinibacillus fusiformis JM-AZM37 of sponge-associated marine bacteria from a mangrove... by Jendri Mamangkey, Corrina Lailatul Fadjri, Sunarto, Apon Zaenal Mustopa, Dwi Suryanto, Nabila Swarna Puspa Hermana, Nur Arfa Yanti, Kusmiati Kusmiati, Herman Irawan, Adrian Hartanto, La Ode Adi Parman Rudia, Rizna Akmaliyah, Lucas William Mendes, Ferdin

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Sex-related differences in postoperative patient-reported outcomes among lung cancer patients: a multicenter cohort study by Jia Liao, Xiaoqun Hu, Xing Wei, Wei Dai, Hongfan Yu, Xin Tian, Yaqin Wang, Qin Qin, Na Xu, Yuanyuan Li, Qiang Li, Qiuling Shi, Xiaoqin Liu

“…Abstract Background Studies on sex-related differences in post-lung cancer surgery symptoms are limited. Understanding these differences may provide insights into patient recovery. …”
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Neuropsychiatric symptoms cluster as primary drivers of Long COVID complexity: a South Texas retrospective cohort study by Anne Marie Wells, Anne Marie Wells, Summer Rolin, Summer Rolin, Barbara Robles-Ramamurthy, Gabriela Gibson-Lopez, Gabriela Gibson-Lopez, Martin Goros, Jonathan A. Gelfond, Stephen Gelfond, Philip Balfanz, Melissa Deuter, Donald McGeary, Donald McGeary, Monica Verduzco-Gutierrez, Monica Verduzco-Gutierrez

“…Long COVID, previously known as Post-Acute Sequelae of SARS-CoV-2 (PASC), refers to prolonged symptoms or diagnosable conditions following COVID-19 infection. …”
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The Effect of Cerebellar Vermal rTMS with TBS Paradigm on Negative Symptoms, Cognitive Function and Serum Inflammatory Factors in Elderly Patients with Chronic Schizophrenia: a Ran... by DONG Xiaomei, ZHAO Hongyan, GENG Zhongli, XU Tianchao, WANG Qi

“…Compared with the control group, the observation group had higher post-treatment information processing speed scores [ (39.78±2.45) scores vs (37.24±1.10) scores], attention alertness scores [ (47.07±4.27) scores vs (40.01±2.17) scores], working memory scores [ (45.12±3.20) scores vs (41.89±4.11) scores], and social cognitive scores [ (46.40±4.29) scores vs (41.42±7.45) scores] (P&lt;0.05) . …”
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What are the broader impacts and value from a randomised controlled trial conducted in six public hospital antenatal clinics in Australia? An impact assessment using the Framework... by Peter G Gibson, Kirsten McCaffery, John Attia, Joerg Mattes, Megan E Jensen, Andrew Searles, Paul B Colditz, Shanthi Ann Ramanathan, Vanessa E Murphy, Michael Hensley, Michael Peek, Andrew Bisits, Leonie Kaye Callaway, Helen Barrett, Sean Seeho, Melanie Rao, Elissa Elvidge, Karen McLaughlin, Annelies Robijn, Warwick Giles, Alistair Abbott

“…Of the 1200 mothers who were part of BLT, 508 now have written asthma plans, 268 had a clinically significant improvement in their asthma control score and the proportion who improved their asthma plan knowledge increased by 58 percentage points from 12 to 70%.Conclusion This case example in the developing field of impact assessment illustrates how researchers can use evidence to demonstrate and report more broadly on the impact of and returns on research investment in a clinical trial.Trial registration number ACTRN12613000202763; Post results.…”
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Engineering a 3D platform for testis bioengineering: generation and proteomic profiling of decellularized fish testicular scaffolds by Ivana Felipe Rosa, Ivana Felipe Rosa, Ivana Felipe Rosa, Beatriz Marques Souza, Lucas Benites Doretto, Lucas Benites Doretto, Maira da Silva Rodrigues, Caroline Nascimento Barquilha, Matheus Naia Fioretto, Luiz Marcos Frediani Portela, José Carlos Souza Vieira, Luis Antonio Justulin, Pedro de Magalhães Padilha, Changwei Shao, Changwei Shao, Rafael Henrique Nóbrega

“…Notably, critical ultrastructural features—such as the basal lamina, seminiferous tubules, and the D-periodic banding pattern of collagen fibrils—were retained post-decellularization. Proteomic analyses revealed enrichment of proteins associated with ECM organization, cell adhesion, and collagen biosynthesis, while proteins involved in glycolysis and metabolic pathways were downregulated. …”
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