Findings from a cluster randomised feasibility study of a school-based physical activity role model intervention (CHARMING) for 9–10-year-old girls by Kelly Morgan, Jordan Van Godwin, Rebecca Cannings‑John, Rhiannon Tudor Edwards, Rachel Granger, Britt Hallingberg, Graham Moore, Bethan Pell, Esther van Sluijs, Holly Whiteley, Jemma Hawkins

“…Following baseline, six primary schools were randomly allocated to intervention or control (usual practice) on a 2:1 basis. Post-intervention delivery, observations (n = 30), focus groups (n = 13) and interviews (n = 22) were conducted to explore study and intervention acceptability, feasibility and fidelity. …”
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Ambulatory care management of 69 patients with acute severe ulcerative colitis in comparison to 695 inpatients: insights from a multicentre UK cohort study by Shaji Sebastian, Neeraj Bhala, Nicholas A Kennedy, Sreedhar Subramanian, Shameer Mehta, Matthew J Brookes, Alexandra J Kent, Jonathan P Segal, Christopher A Lamb, Gareth J Walker, Aamir Saifuddin, Thomas Edward Conley, Lucy Hicks, Kamal V Patel, Haidee Aleman Gonzalez

“…Forty per cent of patients treated as ambulatory from diagnosis required subsequent hospital admission.Conclusions In a post hoc analysis of one of the largest ASUC cohorts collected to date, we report an emerging UK ambulatory practice which challenges treatment paradigms. …”
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The influence of dental occlusion on hamstring muscle isokinetic parameters in active competitive soccer athletes: a randomized controlled trial by Stine Hecht, Yoon Jeong Choi, Andrea Stroux, Florian Beuer, Manja von Stein-Lausnitz, Till E. Bechtold

“…Statistical analysis was performed with one-factorial analysis of variance (ANOVA) followed by post hoc pairwise comparison.ResultsThere was a significant decrease in maximum torque (Nm) and muscle work (J) during extension movement with the simulated MO is compared to HO and to HS. …”
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Validation of a biomarker‐based mortality score for cardiogenic shock patients: Comparison with a clinical risk score by Elina Hynninen, Heli Tolppanen, Mercedes Rivas‐Lasarte, Tuukka Tarvasmäki, Veli‐Pekka Harjola, Benjamin Deniau, Mari Hongisto, Ewa A. Jankowska, Raija Jurkko, Toni Jäntti, Anu Kataja, Alexandre Mebazaa, Tuija Sabell, Alessandro Sionis, Johan Lassus

“…Methods and results The study is a post hoc analysis of the CardShock Study, a prospective, observational European multicentre study on CS. …”
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SREBF1-mediated SND1 transcriptional activation promotes prostate cancer progression via MTDH interaction through the SESN2/AMPK/mTOR axis by Yijie Tang, Yufan Ying, Xueyou Ma, Jiahe Yi, Zixiang Liu, Yuqing Wu, Shen Lin, Xuan Shu, Zhixiang Qi, Jindan Luo, Xiangyi Zheng, Jiangfeng Li, Liping Xie, Ben Liu

“…Growing evidence indicates that Staphylococcal nuclease and Tudor domain containing 1 (SND1) is a multifunctional protein extensively involved in transcriptional regulation, RNA maturation, post-transcriptional modifications, and other processes. …”
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Scaling a parenting program to reduce child maltreatment in Tanzania: The role of facilitator fidelity in adolescent and parent outcomes by Mackenzie Martin, Jamie M. Lachman, Francisco Calderon, Qing Han, Yulia Shenderovich, Esther Nydetabura, Nyasha Manjengenja, Joyce Wamoyi, Frances Gardner

“…A total of 24 facilitator assessments could be linked with pre-post surveys from 3057 families. Findings: Analyses found mixed results, with fidelity having positive, negative, and insignificant associations with participant outcomes. …”
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The promoting effects of digital targeted cognitive training in medication treatment for children with ADHD: a randomized controlled trial by Chen Dang, Yu Zhu, Xiangsheng Luo, Lu Liu, Yuan Feng, Guisen Wu, Shaogen Zhong, Xin Wang, Jianzhao Zhang, Yike Zhu, Siqi Liu, Ziqi Liu, Li Qin, Xiaohui Ma, Yufeng Wang, Xiaoyi Wang, Jian Yang, Changming Wang, Li Sun

“…Results Main results: When compared with M treatment, the TCT + M treatment did not show significant greater improvements in ADHD core symptoms, ecological executive functions, social functions, or laboratory cognitive functions. Post-hoc exploratory analysis results: (1) In patients who received ATX treatment, TCT + ATX led to greater improvement in ADHD-RS total, inattention, and hyperactivity/impulsivity symptoms. …”
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Snake Venom Peptide Fractions from <i>Bothrops jararaca</i> and <i>Daboia siamensis</i> Exhibit Differential Neuroprotective Effects in Oxidative Stress-Induced Zebrafish Models by Felipe Assumpção da Cunha e Silva, Brenda Rufino da Silva, Leticia Ribeiro de Barros, Emidio Beraldo-Neto, Adolfo Luis Almeida Maleski, Carlos Alberto-Silva

“…In vivo, neither pf-<i>Ds</i> nor pf-<i>Bj</i> (1–20 µg mL⁻¹) induced significant developmental toxicity in zebrafish larvae up to 120 h post-fertilization (hpf). The neuroprotective effects of both pf were evaluated using two experimental models: (I) Larvae at 96 hpf were exposed to either pf-<i>Ds</i> or pf-<i>Bj</i> (10 µg mL⁻¹) for 4 h, followed by co-exposure to H₂O₂ (0.2 mmol L⁻¹) for an additional 10 h to induce oxidative stress (4–20 h model); (II) Embryos at 4 hpf were treated with pf-<i>D</i>s or pf-<i>Bj</i> (10 µg mL⁻¹) continuously until 96 hpf, after which they were exposed to H₂O₂ (0.2 mmol L⁻¹) for another 24 h (96–120 h model). …”
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Evaluation of a fermented palm kernel meal as a prebiotic for enhancing immune response in Indonesian red claw crayfish (Cherax quadricarinatus) by Diki Danar Tri Winanti, Hilma Nahwa Firdausi, Maulid Wahid Yusup, Putu Cinthia Delis, Agus Setyawan, Yeni Elisdiana, Hilma Putri Fidyandini, Muhammad Kholiqul Amiin, Ari Widodo

“…Hemolymph samples were collected at baseline (day 0) and on days 3, 5, 7, and 14 post-treatment. Non-specific immune responses evaluated included total hemocyte count (THC), differential hemocyte count (DHC), phagocytosis activity (PA), phagocytosis index (PI), phenol oxidase (PO) activity, superoxide dismutase (SOD) activity, total plasma protein (TPP), and immune gene expression (lipopolysaccharide and β-1,3-glucan-binding protein [LGBP], lectin). …”
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At-home Breast Oncology care Delivered with EHealth solutions (ABODE) study protocol: a randomised controlled trial by Wei Xu, Eitan Amir, Madeline Li, Gary Rodin, Toni Zhong, Raymond H Kim, Allan Okrainec, Michael Reedijk, David McCready, Emily Thain, Kelly Metcalfe, Siba Haykal, Jeanna Mccuaig, Robin Forbes, Jaime Escallon, Janet Papadakos, Erin Kennedy, Amanda Mac, Dalia Schaffer, Mohini Kalia, Emma Reel, Adina Isenberg, C Anne Koch, Sarah Rotstein, Tulin D Cil, Jordan Cleland, Alexandra Easson, Sheila Jarvis, Wey Leong, Daniel Santa Mina, Larissa Peck, Sharmy Sarvanantham, Fahreen Walimohamed

“…Patients will complete questionnaires at enrolment, 6 and 12 months post-diagnosis to measure patient activation (Patient Activation Measure-13 score), distress, anxiety, quality of life and experiences with their care and information received. …”
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Uncovering the link between incidental physical activity and inhibition of automatic responses in aging. An ERP study by Javier Sanchez-Lopez, Juan Silva-Pereyra, Sergio Manuel Sánchez-Moguel, Graciela Catalina Alatorre-Cruz, Graciela Catalina Alatorre-Cruz, Mauricio González-López, Mauricio González-López, Mauricio González-López, Jorge A Sigg-Alonso, Mariana Pérez-Figueroa, Thalía Fernández

“…ERP analyses revealed greater late negativity as a result of the differences between conditions (1,050–1,200 ms) during the counting-Stroop task in the high-IPA group, suggesting more effective late-stage inhibitory processing post-execution likely related to re-evaluation and resolution of the conflict, while the low-IPA group lacked this effect. …”
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COVID-19 incidence after vaccination with different types of vaccines against SARS-CoV-2 by O. M. Drapkina, S. A. Berns, M. G. Chashсhin, A. Yu. Gorshkov, O. V. Zhdanova, L. N. Ryzhakova, O. A. Litinskaya, M. S. Pokrovskaya

“…Until now, there remains a certain interest in studying the role of booster vaccination  in  the  formation  of  post-vaccination  immunity  against  the Severe  acute  respiratory  syndrome  coronavirus  2  (SARS-CoV-2).  …”
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Supplement-driven iron overload accelerates phenotypic aging via inflammatory biomarkers: Potential counteraction through anti-inflammatory or antioxidant diets by Bin Li, Zhu Ming, Yina Wang, Yingfeng Zhang, Runyi Zhou, Can Zhang, Yue Wu, Guoliang Wang, Hongquan Xie, Ying Li, Ran Li

“…The results stayed robust even after adjusting for variables related to anemia and post-menstrual status. This study suggests that excessive use of supplements, resulting in iron overload, may accelerate individual aging through inflammation-related pathways. …”
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Single-cell transcriptome sequencing reveals the sphingolipid metabolism pathway plays an important role in leaf senescence in tobacco by Quan Sun, Bing Hou, Xinghui Liu, Langlang Zhang, Pingan Chang, Huimin Pang, Xiaohong He, Zexiang Huang, Jili Zhang, Guoxia Liu, Daping Gong, Mingli Chen

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Analysis of content, credibility, and reliability of information on chronic obstructive pulmonary disease treatment in YouTube™ videos: a cross-sectional observational study by Ana Luíza da Silva Nunes Teixeira Rodrigues, Vanessa Kelly da Silva Lage, Redha Taiar, Joyce Noelly Vitor Santos, Laisa Braga Maia, Jousielle Márcia dos Santos, Vinícius Cunha Oliveira, Ana Cristina Rodrigues Lacerda, Vanessa Amaral Mendonça

“…This study evaluates the reliability and credibility of information concerning COPD treatment disseminated on YouTube, the most popular social media platform, and assess its alignment with the GOLD guideline. …”
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Self-reported health and depression among EIRA cohort: a moderated mediation model of sex and perceived social support by Raquel Sánchez-Recio, Raquel Sánchez-Recio, Bárbara Oliván-Blázquez, Bárbara Oliván-Blázquez, Bárbara Oliván-Blázquez, Fátima Méndez-López, Fátima Méndez-López, Fátima Méndez-López, Santiago Gascón-Santos, Santiago Gascón-Santos, Ruth Martí-Lluch, Ruth Martí-Lluch, Ruth Martí-Lluch, Ruth Martí-Lluch, Edurne Zabaleta-Del-Olmo, Edurne Zabaleta-Del-Olmo, Edurne Zabaleta-Del-Olmo, Olaya Tamayo-Morales, Olaya Tamayo-Morales, José A. Maderuelo-Fernández, José A. Maderuelo-Fernández, José A. Maderuelo-Fernández, Marc Casajuana, Tomas López-Jiménez, Emma Motrico, Emma Motrico, Irene Gómez-Gómez, Irene Gómez-Gómez, Álvaro Sánchez-Pérez, Álvaro Sánchez-Pérez, Álvaro Sánchez-Pérez, María Luisa Rodero-Cosano, Joan Llobera, Joan Llobera, Joan Llobera, Juan A. Bellón, Juan A. Bellón, Juan A. Bellón, Juan A. Bellón, Patricia Moreno-Peral, Patricia Moreno-Peral, Bonaventura Bolíbar, Bonaventura Bolíbar, José I. Recio-Rodríguez, José I. Recio-Rodríguez, Rafel Ramos, Rafel Ramos, Rafel Ramos, Rafel Ramos, Ana Clavería, Ana Clavería

“…Men reported experiencing more social support and self-perceived health (p &lt; 0.001) than women at the beginning of the study, but women reported higher social support at post-intervention. Moderation analyses showed that, post-intervention, those women (bsimple = −2.9867, p &lt; 0.001) and males (bsimple = −1.4337, p &lt; 0.001) who scored lower in depression reported higher social support.ConclusionIn primary care, it is necessary to encourage intervention strategies that promote social networks as a key element of positive action aimed at maintaining and improving the population’s health, especially in adults and more specifically in women.Clinical trial registrationClinicalTrials.gov, identifier NCT03136211.…”
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A Phase I Dose-Escalation Clinical Trial of Bronchoscopic Cryoimmunotherapy in Advanced-Stage NSCLC by Jun-Chieh J. Tsay, MD, MS, Antonio Velez, MD, Destiny Collazo, BS, Isaac Laniado, MD, Jamie Bessich, MD, Vivek Murthy, MD, Andrew DeMaio, MD, Samaan Rafeq, MD, Benjamin Kwok, MD, Fares Darawshy, MD, Ray Pillai, MD, Kendrew Wong, MD, Yonghua Li, MD, PhD, Rosemary Schluger, RN, Alena Lukovnikova, BS, Sofia Roldan, BS, Matt Blaisdell, BS, Fernanda Paz, Kelsey Krolikowski, BS, Katherine Gershner, MD, Yong Liu, PhD, Judy Gong, BA, Sara Borghi, PhD, Fang Zhou, MD, Aristotelis Tsirigos, PhD, Harvey Pass, MD, Leopoldo N. Segal, MD, MS, Daniel H. Sterman, MD

“…Safety was assessed by review of BCI-related complications, including grades 2 to 3 bleeding, pneumothorax requiring intervention, and National Cancer Institute Common Terminology Criteria for Adverse Events grade 3 to 5 adverse events. Pre- and post-BCI blood samples were collected to explore changes in the systemic immune profile. …”
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日本解決學力下降問題之政策分析： 以課綱修訂和全國學力測驗為主 The Policy Analysis to Solve Academic Decline in Japan– Course of Study and National Assessment of Academic Ability... by 李宜麟 Yi-Lin Lee, 楊思偉 Szu-Wei Yang

“…Japan’s education system thus faced a quality bottleneck, with a knowledge-heavy approach that struggled to meet the demands of a knowledge-based post-industrial economy. Mounting social issues, such as intense competition, school violence, absenteeism, student suicides, and juvenile crime, underscored the need for reform. …”
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Long-term efficacy and immunopersistence of an Escherichia coli-produced HPV-16/18 bivalent vaccine: an observational extension study following a randomised, double-blind Phase III... by Fanghui Zhao, Qi Chen, Chao Zhao, Lingling Nie, Shangying Hu, Jian Yin, Lingxian Qiu, Zhaofeng Bi, Jiali Quan, Yufei Li, Mingzhu Li, Xun Zhang, Qinjing Pan, Caihong Li, Lidong Ke, Xiaoli Liu, Fengxian Zheng, Cuihong Dai, Zhe Wang, Xuefeng Kuang, Xinhua Jia, Yingying Su, Shoujie Huang, Qiufen Zhang, Weijin Huang, Lihui Wei, Jun Zhang, Ting Wu, Youlin Qiao, Ningshao Xia

“…Here, we report data on the long-term efficacy and immunopersistence up to 10 years post-vaccination. Methods: In the Phase III clinical trial (NCT01735006), 7372 women were enrolled and randomly assigned to receive the HPV or control vaccine (hepatitis E vaccine). …”
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Perspectives of Chinese Adult Patients with Alopecia Areata on Janus Kinase Inhibitors Therapy: A Qualitative Analysis Based on Social Media Platforms by Song H, Xiao Y, Wang D

“…This study aimed to investigate the perspectives of Chinese adult AA patients on JAK inhibitor therapy through a qualitative analysis of social media discussions.Methods: Keyword searches were conducted on two major Chinese social media platforms, Bidu and Sina Weibo, to retrieve AA-related discussion posts within China. A total of 300 posts met the inclusion criteria and were analyzed using natural language processing techniques. …”
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