Contingent Analysis of Open Flap Debridement, Leukocyte-Rich Platelet-Rich Fibrin and Titanium Platelet-Rich Fibrin in the Treatment of Three-Walled Intra-Bony Defects in Chronic P... by Gowri Pendyala, Ameet Mani, Vinay Vadvadgi, Esha Thakare, Bharti Gupta

“…Evaluation of change in probing pocket depth, Gain in clinical attachment level was done at 9 Months, and defect fill and alveolar crestal bone resorption were evaluated at 6 and 9 Months after surgery by Analysis of Variance (ANOVA) with Post hoc Tukey’s test. Probing Pocket depth was measured from the gingival margin to the base of the pocket, Clinical attachment Level was measured from the cementoenamel junction of each tooth to the soft tissue base of the pocket by using a stent. …”
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Self-directed and prosocial wound care, snare removal, and hygiene behaviors amongst the Budongo chimpanzees by Elodie Freymann, Elodie Freymann, Elodie Freymann, Elodie Freymann, Catherine Hobaiter, Catherine Hobaiter, Michael Alan Huffman, Michael Alan Huffman, Harmonie Klein, Geresomu Muhumuza, Vernon Reynolds, Vernon Reynolds, Nora E. Slania, Nora E. Slania, Adrian Soldati, Adrian Soldati, Eguma Robert Yikii, Klaus Zuberbühler, Klaus Zuberbühler, Susana Carvalho, Susana Carvalho

“…We also document self-directed hygiene behaviors including postcoital genital leaf wiping and post-defecation leaf wiping. For the first time in Budongo, we report the presence of prosocial wound care, adding to similar observations documented at other chimpanzee field sites. …”
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Hemodynamic correlates of fluctuations in neuronal excitability: A simultaneous Paired Associative Stimulation (PAS) and functional near infra-red spectroscopy (fNIRS) study by Zhengchen Cai, Giovanni Pellegrino, Amanda Spilkin, Edouard Delaire, Makoto Uji, Chifaou Abdallah, Jean-Marc Lina, Shirley Fecteau, Christophe Grova

“…The effect of PAS on excitability and hemodynamic activity showed a trend of positive correlation with MEP ratios (post-PAS/pre-PAS) linked to HbO and HbR ratios (r = 0.19, p = 0.29; r = 0.18, p = 0.30, respectively). …”
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Novel Adiposity Indices Are Associated With Poor Prognosis in Heart Failure With Preserved Ejection Fraction Without the Obesity Paradox by Shuai Zhang, Panpan Xu, Tianhao Wei, Changjiang Wei, Yanling Zhang, Huixia Lu, Cheng Zhang

“…Methods and Results This study is a post hoc analysis of data from the TOPCAT (Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist) trial. …”
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Perceived, objective, and applied numeracy among pregnant women engaged in home blood pressure monitoring in GhanaAJOG Global Reports at a Glance by Emma R. Lawrence, MD, Sanaya Irani, BS, Betty Nartey, MPH, Brittney Collins, BS, Elorm Segbedzi-Rich, MD, Andrea Pangori, MS, Titus K. Beyuo, MD, Cheryl A. Moyer, PhD, Jody R. Lori, PhD, Samuel A. Oppong, MD

“…After training, participants engaged in home blood pressure monitoring for 2 to 4 weeks. A post-monitoring survey evaluated confidence and experience interpreting blood pressure values, a validated numeracy scale, and interpretation of blood pressure monitor outputs—half with numbers only and half with both numbers and colors. …”
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Common Variant in Glycoprotein Ia Increases Long‐Term Adverse Events Risk After Coronary Artery Bypass Graft Surgery by Hanning Liu, Zhengxi Xu, Haiyong Gu, Wenke Li, Wen Chen, Cheng Sun, Kun Zhao, Xiao Teng, Heng Zhang, Lixin Jiang, Shengshou Hu, Zhou Zhou, Zhe Zheng

“…Patients who are GPIA rs1126643 T‐allele carriers have a higher major adverse cardiac or cerebrovascular events risk post‐CABG than those who are CC homozygotes (hazard ratio [HR]=1.29; P=0.022). …”
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Crocin promotes ferroptosis in gastric cancer via the Nrf2/GGTLC2 pathway by Nan Yan, Gaofu Li, Linglin Zhao, Qijing Guo, Jie Yang, Jianhong Liu, Wei Zhou, Yue Gao, Yue Gao, Yushuang Luo, Yushuang Luo

“…Pathway enrichment analysis was performed on differentially expressed genes post-crocin treatment. Lentiviral vectors were used to knockdown and overexpress GGTLC2, exploring its role in GC progression and crocin’s therapeutic effects. …”
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Neoadjuvant in situ vaccination with cowpea mosaic virus as a novel therapy against canine inflammatory mammary cancer by Daniel Alonso-Miguel, Guillermo Valdivia, Diego Guerrera, Maria Dolores Perez-Alenza, Stanislav Pantelyushin, Angela Alonso-Diez, Veronique Beiss, Steven Fiering, Nicole F Steinmetz, Maria Suarez-Redondo, Johannes vom Berg, Laura Peña, Hugo Arias-Pulido

“…In the TME, higher neutrophilic infiltration and MPO expression, lower tumor Ki-67 PI, increase in CD3+ lymphocytes, decrease in FoxP3+/CD3+ ratio (p<0.04 for all comparisons), and no changes in CC-3+ immunostainings were observed in post-treatment tumor tissues when compared with pretreatment tumor samples. eCPMV-treated IMC patients had a statistically significant (p=0.033) improved overall survival than patients treated with medical therapy.Conclusions Neoadjuvant in situ eCPMV immunotherapy demonstrated anti-tumor efficacy and improved survival in IMC patients without systemic adverse effects. eCPMV-induced changes in immune cells point to neutrophils as a driver of immune response. …”
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Machine learning suggests polygenic risk for cognitive dysfunction in amyotrophic lateral sclerosis by Katerina Placek, Michael Benatar, Joanne Wuu, Evadnie Rampersaud, Laura Hennessy, Vivianna M Van Deerlin, Murray Grossman, David J Irwin, Lauren Elman, Leo McCluskey, Colin Quinn, Volkan Granit, Jeffrey M Statland, Ted M Burns, John Ravits, Andrea Swenson, Jon Katz, Erik P Pioro, Carlayne Jackson, James Caress, Yuen So, Samuel Maiser, David Walk, Edward B Lee, John Q Trojanowski, Philip Cook, James Gee, Jin Sha, Adam C Naj, Rosa Rademakers, The CReATe Consortium, Wenan Chen, Gang Wu, J Paul Taylor, Corey T McMillan

“…We demonstrate that a polygenic risk score derived using sCCA relates to longitudinal cognitive decline in the same cohort and also to in vivo cortical thinning in the orbital frontal cortex, anterior cingulate cortex, lateral temporal cortex, premotor cortex, and hippocampus (N = 90) as well as post‐mortem motor cortical neuronal loss (N = 87) in independent ALS cohorts from the University of Pennsylvania Integrated Neurodegenerative Disease Biobank. …”
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Plasma microRNA signatures of aging and their links to health outcomes and mortality: findings from a population-based cohort study by Lieke M. Kuiper, Michelle M. J. Mens, Julia W. Wu, Jaap Goudsmit, Yuan Ma, Liming Liang, Albert Hofman, Trudy Voortman, M. Arfan Ikram, Jeroen G. J. van Rooij, Joyce B. J. van Meurs, Mohsen Ghanbari

“…Abstract Background MicroRNAs are small non-coding RNAs that regulate gene expression post-transcriptionally and show differential expression in various tissues with aging phenotypes. …”
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“HEAL together”: a randomized, hybrid type 1 effectiveness-implementation trial protocol of a peer-delivered behavioral activation intervention to improve methadone treatment reten... by Jessica F. Magidson, Jessica F. Magidson, Valerie D. Bradley, Jessica S. Anane, Mary B. Kleinman, Julia W. Felton, Abigail C. Hines, Rithika Baskar, Aaron D. Greenblatt, Dwayne Dean, Morgan S. Anvari, Heather Fitzsimons, Melanie E. Bennett, Annabelle M. Belcher

“…Assessments are administered at baseline, post-treatment (approximately 3 months), and 6 months. …”
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Modulation of TvRAD51 Recombinase in <i>Trichomonas vaginalis</i> by Zinc and Cadmium as a Potential Mechanism for Genotoxic Stress Response by Jonathan Puente-Rivera, José Jesús Flores-Vega, Marcos Morales-Reyna, Elisa Elvira Figueroa-Angulo, Yussel Pérez-Navarro, Alfonso Salgado-Aguayo, Ángeles Carlos-Reyes, Maria Elizbeth Alvarez-Sánchez

“…Notably, TvRAD51 showed nuclear localization at early time points post-exposure, suggesting active participation in DNA repair processes. …”
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Selection and validation of reference genes for quantitative real-time PCR during the developmental stages of seeds in Sophora davidii by Jingjing Li, Jingjing Li, Shanrong Han, Shanrong Han, Zongren Xu, Bin Deng, Na Zheng, Na Zheng, Yaqiong Su, Yaqiong Su, Ziyao Qiao, Ziyao Qiao, Yun Yang, Yun Yang, Hong Zhang, Zongsuo Liang, Jing Liu, Shuai Liu

“…Quantitative real-time PCR (qRT-PCR) serves as a highly sensitive method for gene expression analysis, yet selecting appropriate reference genes is crucial to ensure the accuracy and reliability of results.MethodsTen candidate reference genes (18S, ACT13, RL15B, RL74, RLA2, RL182, RL291, EF1-α, EF1G, and YLS8) were evaluated for their expression stability in Sophora davidii seeds collected at five distinct developmental stages post-flowering, characterized by significant morphological changes. …”
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Semi-elemental versus polymeric formula for enteral nutrition in critically ill patients: a secondary analysis of a multicenter cluster-randomized controlled trial by Wei Wei, Wen Lu, Guofeng Chen, Jindan Gao, Jun Zhang, Defeng Zhang, Ruiqin He, Jingjing Huang, Rong Cai, Rongrong Yuan, Xun Wang, Jinxia Yu, Zilong Li, Lu Ke, Lin Gao, Zhengquan Wang

“…This study aimed to assess whether the use of semi-elemental formula compared to polymeric formula may provide benefits in patients receiving gastric tube feeding.MethodsThis is a post-hoc analysis of data from a multicenter, cluster-randomized, controlled, investigator-initiated trial (NEED trial). …”
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First-in-man histotripsy of hepatic tumors: the THERESA trial, a feasibility study by Joan Vidal-Jove, Xavier Serres, Eli Vlaisavljevich, Jon Cannata, Alex Duryea, Ryan Miller, Xavier Merino, Manuela Velat, Yossi Kam, Ryan Bolduan, Joseph Amaral, Timothy Hall, Zhen Xu, Fred T. Lee, Timothy J. Ziemlewicz

“…The primary endpoint was acute technical success, defined as creating a zone of tissue destruction per planned volume assessed by MRI 1-day post-procedure. Safety (device-related adverse events) through 2 months was a secondary endpoint.Results The 8 patients had a median age of 60.4 years with an average targeted tumor diameter of 1.4 cm. …”
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Impact of various aligner auxiliaries on orthodontic activity: A systematic review and network meta-analysis by Mohammad Khursheed Alam, Mohammad Younis Hajeer, Abedalrahman Shqaidef, Haytham Jamil Alswairki, Ahmed Ali Alfawzan, Deepti Shrivastava, Kumar Chandan Srivastava, Marco Cicciù, Giuseppe Minervini

“…Through this investigation, we aimed to highlight the impact of various aligner auxiliaries on orthodontic activity in patients undergoing orthodontic treatment on a pre/post treatment protocol basis. Methods: After a thorough search of the online journals, a total of 482 documents were found using keywords such as “Orthodontic Treatment”, “Aligner Auxiliaries”, “Elastic Ligatures” and “Tooth Movement.” …”
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Linguistique Et Phonétique Arabes** (1) by Abderrahmane Hadj Saleh

“…Dans tous les cas, la validité s’obtient par le caractère vérifiable de ces données 2) Distinction entre la structure grammaticale et le code, d’une part, et l’usage qu’on en fait dans des actes d’énonciation, d’autre part. 3) La notion de structure dans cette théorie déborde celle du structura-lisme post-saussurien : la structure est ici le résultat de la synthèse de la classe et de l’ordre. 4) Les unités de la langue ne sont pas nécessairement des segments (ou marginalement des accents). …”
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Exogenous Mitochondrial Transplantation Facilitates the Recovery of Autologous Nerve Grafting in Repairing Nerve Defects by Dongdong Li, Haolin Liu, Chaochao Li, Yanjun Guan, Xing Xiong, Ruichao He, Zhibo Jia, Lijing Liang, Jinjuan Zhao, Xinyu Miao, Yu Wang, Jiang Peng

“…SD rats were used to prepare a model of a 10 mm sciatic nerve defect repaired by ANT (Auto group) and a model of ANT supplemented with EM (Mito group). At 12 weeks post-operation, functional, neurophysiological, and histological evaluations of the target organ revealed that the Mito group exhibited significantly better outcomes compared with the Auto group, with statistically significant differences ( P < 0.05). …”
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New Field OB and OBe Binaries of the SMC Wing: Observational Properties and Population Modeling by Irene Vargas-Salazar, M. S. Oey, Jan J. Eldridge, Drew Weisserman, Helen C. Januszewski, Juliette C. Becker, Stefano Zazzera, Norberto Castro, Yongjung Kim, Kaitlin M. Kratter, Mario Mateo, John I. Bailey III

“…The models are broadly consistent with the binary origin scenario for OBe stars, and predict an even larger number of post-supernova OB binaries. Comparison with the kinematics supports a significant contribution from dynamical ejections for both OB and OBe stars, although less so for binaries.…”
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Electron microscopic findings predict clinical outcomes in patients with non‐ischaemic cardiomyopathy by Rie Higuchi, Shozo Konishi, Tomohito Ohtani, Fusako Sera, Misato Chimura, Machiko Kanzaki, Themistoklis Katsimichas, Masahiro Seo, Tetsuya Watanabe, Takahiro Okumura, Toyoaki Murohara, Hiroyuki Takahama, Atsushi Okada, Chisato Izumi, Masaru Hatano, Issei Komuro, Yoshihiko Ikeda, Yoshihiro Asano, Hatsue Ishibashi‐Ueda, Yasushi Sakata

“…Data on cardiac events (cardiac death or left ventricular assist device implantation) and LVRR, defined as achieving an EF > 35% with a 10% unit absolute increase, were collected 1 year post‐biopsy. Results A total of 148 patients were finally analysed. …”
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