Identifying bellwether sewershed sites for sustainable disease surveillance in Bengaluru, India: a longitudinal studyResearch in context by Rebecca Fern Daniel, Subash K. Kannan, Namrta Daroch, Sutharsan Ganesan, Farhina Mozaffer, Vishwanath Srikantaiah, Lingadahalli Subrahmanya Shashidhara, Rakesh Mishra, Farah Ishtiaq

“…Interpretation: Using wastewater metrics helps in selecting permanent sewershed sites and identifying sub-sites that can be scaled up during peak outbreak periods to detect disease hotspots, or scaled down during lean periods, especially when clinical data are unavailable. In a post-pandemic world, particularly in low-resource settings, focusing on the best-performing sewershed sites will ensure high-quality data that captures valid signals amid the noise from wastewater, conserves resources, and optimises public health actions beyond SARS-CoV-2. …”
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Effects of neoadjuvant immunotherapy on hearing in patients with head and neck squamous cell carcinoma by Bryce Hambach, Anhelina Bilokon, John Lee, L. Noelle Allemang, Jennifer Chisholm, Chris K. Zalewski, Julie Christensen, Carmen C. Brewer, James L. Gulley, Clint T. Allen, Lisa L. Cunningham, Katharine A. Fernandez

“…Speech audiometry and tympanometry identified no differences in speech understanding or middle ear function pre-and post-treatment. Variations in DPOAE amplitudes were noted, potentially indicating early outer hair cell damage despite stable audiometric thresholds. …”
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Sirtuin-3 activation by honokiol attenuated anesthesia/surgery-induced cognitive impairment and neuronal ferroptosis via inhibiting mitochondrial GPX4 acetylation by Lian Zeng, Pengchao Hu, Xuan Wang, Xudong Ding, Qingsong Wang, Li Luo, Yu Zhang, Mingyue Li, Yilin Zhao, Shiyong Li, Ailin Luo

“…Results SIRT3 expression was found to be reduced in the hippocampal CA1 and CA3 regions post-surgery. HKL alleviated cognitive decline by inhibiting ferroptosis, evidenced by suppression of iron accumulation, oxidative stress, and mitochondrial dysfunction. …”
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Meta‐analysis of cardiac magnetic resonance in prognosticating left ventricular function in peripartum cardiomyopathy by Hawani Sasmaya Prameswari, William Kamarullah, Raymond Pranata, Iwan Cahyo Santosa Putra, Alberta Claudia Undarsa, Mohammad Iqbal, Triwedya Indra Dewi, Nuraini Yasmin Kusumawardhani, Mohammad Rizki Akbar, Astri Astuti

“…Conclusions Contrast‐enhanced CMR can be utilized as an adjunct examination in post‐partum PPCM patients to stratify the risk of poor LV function recovery while conducted at a suitable point in time.…”
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Precise stratification of prognosis in pancreatic ductal adenocarcinoma patients based on pre- and postoperative genomic information by Kokichi Miyamoto, Ryuichi Yoshida, Kazuya Yasui, Kunitoshi Shigeyasu, Kazuhiro Yoshida, Tomokazu Fuji, Kosei Takagi, Yuzo Umeda, Kazuyuki Matsumoto, Yuki Fujii, Toshiaki Takahashi, Kazuya Moriwake, Masashi Kayano, Takeyoshi Nishiyama, Yasuo Nagai, Hideki Yamamoto, Hironari Kato, Hiroshi Tazawa, Mizuki Morita, Motoyuki Otsuka, Toshiyoshi Fujiwara

“…Conclusion A risk stratification system based on liquid biopsy, specialised for each phase (pre- and post-surgery), has been proven to be a useful, simple, and practical prognostic prediction clinical tool to determine the optimal multidisciplinary treatment protocol for PDAC.…”
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A randomized phase II/III trial of rosuvastatin with neoadjuvant chemo-radiation in patients with locally advanced rectal cancer by Prachi S. Patil, Avanish Saklani, Naveena A. N. Kumar, Ashwin De’Souza, Rahul Krishnatry, Snehal Khanvilkar, Mufaddal Kazi, Reena Engineer, Vikas Ostwal, Anant Ramaswamy, Munita Bal, Priya Ranganathan, Ekta Gupta, Ekta Gupta, Sanjeev Galande, Sanjeev Galande

“…The pathological response rate, tumor regression grade (TRG), and post-surgical complications will be recorded.ConclusionThe addition of rosuvastatin to NACTRT may improve the oncological outcomes by increasing the likelihood of pCR in patients with locally advanced rectal cancer undergoing NACTRT. …”
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Long-term follow-up of modified shunt-restricted instep arterialized venous flap for reconstruction of hand defects by Wei Chen, Yang Jian, Maolin Cheng, Runxue Guan, Wenyu An, Chenglan Yang, Jian Zhou, Shujun Li, Shusen Chang, Chengliang Deng, Chengliang Deng, Kaiyu Nie, Kaiyu Nie, Zairong Wei, Zairong Wei, Zairong Wei, Zairong Wei

“…The flap color was pale in 11 cases and transitioned to a ruddy color within 2–5 h post-operatively, with an average of 3.3 h. Moreover, 12 cases developed mild swelling within 2 weeks postoperatively, whilst 4 cases presented with sporadic blisters. …”
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Delayed Viral Clearance Accompanied by Early Impaired Humoral and Virus-Specific T-Cell Response in Patients with Coronavirus Disease 2019 and Interstitial Lung Disease by Jiaying Zhong, Juan Li, Rui Wei, Bingpeng Guo, Tingting Cui, Peiyu Huang, Zhongfang Wang, Qun Luo, Qian Han

“…Similarly, a lower virus-specific T-cell (VST) immune response was observed 14 days post-symptom onset in the ILD group (CD4⁺ VSTs: 0.018 vs. 0.082, <i>p</i> = 0.005; CD8⁺ VSTs: 0.0008 vs. 0.047, <i>p</i> = 0.004). …”
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Impulsivity and aggression in suicide across age and sex: case–control study by Sergio Sanz-Gómez, Constanza Vera-Varela, Diego de-la-Vega-Sánchez, María Luisa Barrigón, Adrián Alacreu-Crespo, Julio A. Guija, Ana Sánchez, Santiago de León, Enrique Baca-García, Lucas Giner

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A custom-made mouthguard reduces head acceleration during soccer heading and prevents acute electrophysiological and cognitive changes in amateur male playersResearch in context by Claire Pitteu, Philippine Lepère, Philippe Poisson, Etienne Guillaud, Emilie Doat, Bertrand Glize, Patrick Dehail, Hélène Cassoudesalle

“…The difference in mean cSP between pre- and post-heading decreased statistically significantly with the CM-MG (−9·17 ms) compared to without (20·03 ms; p = 0·0016), with a median difference of −22·87 ms (95% CI [−45·85; −4·02]). …”
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Cryopreservable, scalable and ready-to-use cell-laden patches for diabetic ulcer treatment by Bangrui Yu, Lanlan Peng, Wenjun Dang, Ying Fu, Zhijie Li, Jinteng Feng, Heng Zhao, Tian Wang, Feng Xu, Martin L. Yarmush, Haishui Huang

“…This cell-hydrogel patch not only maintains cell viability and structure integrity during cryopreservation, but also can be directly utilized without centrifugation or incubation post cryopreservation. In addition, this tissue-adhesive hydrogel patch enables close wound contact and fast cellular response, and its scalable and flexible structure enables assembly for large or irregularly shaped ulcers. …”
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Activation of the Wnt signaling pathway and its role in epithelial-mesenchymal transition and hepatic fibrosis in alveolar echinococcosis by Binjie Wu, Binjie Wu, Yuxuan Yang, Yuxuan Yang, Shilei Cheng, Shilei Cheng, Zhixin Wang, Zhixin Wang, Haining Fan, Haining Fan

“…The mice were divided into control, Wnt pathway enhancement (Wnt3a), and Wnt pathway inhibition (DKK1) groups. Four weeks post-infection, AAV-EGFP, AAV-Wnt3a-EGFP, or AAV-DKK1-EGFP vectors were administered, followed by tissue collection four weeks later. …”
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Transcatheter aortic valve implantation for aortic stenosis in high surgical risk patients: A systematic review and meta-analysis. by Zulian Liu, Elaine Kidney, Danai Bem, George Bramley, Susan Bayliss, Mark A de Belder, Carole Cummins, Rui Duarte

“…This systematic review compares mortality and other important clinical outcomes up to 5 years post treatment following TAVI or other treatment in these risk groups.…”
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PATIENTS WITH COMBINATION OF CHRONIC HEART FAILURE, HYPERTENSION AND HISTORY OF MYOCARDIAL INFARCTION: CLINICAL AND ANAMNESTIC CHARACTERISTICS, ADMINISTRATION OF ACE INHIBITORS, AN... by M. M. Loukianov, A. N. Kozminsky, S. Yu. Martsevich, S. S. Yakushin, A. N. Vorobyev, A. V. Zagrebelnyy, R. P. Myasnikov, K. G. Pereverzeva, E. A. Pravkina, E. Yu. Andreenko, E. N. Belova, A. D. Deev, V. G. Klyashtorny, E. V. Kudryashov, S. A. Boytsov

“…Patients with a combination of CHF, HT and post-infarction cardiosclerosis (PICS) compared with patients without PICS significantly more often had CHF class 3-4 NYHA (62% vs 47.9%, respectively), HT of degree 3 (92.5% vs 84.2%, respectively), stable angina class 3-4 (84.4% vs 66.4%, respectively). …”
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Factors associated with PEP awareness among adolescent girls and young women in Eswatini by Anne Laterra, Stephanie Spaid Miedema, Michelle Li, Phumzile Mndzebele, Nozipho Nzuza‐Motsa, Sana Nasir Charania, Katherine Ong, Meagan Cain, Udhayashankar Kanagasabai, Thobile Mkhonta, Laura Chiang, Francis Boateng Annor, Michelle R. Adler

“…Despite the World Health Organization's 2014 recommendation for post‐exposure prophylaxis (PEP) to be available for all HIV exposures, it has been underutilized among youth. …”
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Dinamika Ekosistem Seni Paduan Suara Voice of Bali dalam Perspektif Pierre Bourdieu by Alfin Syahrian, I Ketut Sariada, I Wayan Mudra

“…This research aims to explain how the Voice of Bali choir community manages interactions between capital structures, habitus, arena, pre-production and post-production, and event management to become an example for other groups developing choirs in Indonesia. …”
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Complete genomic characterization of global pathogens respiratory syntical virus and human norovirus using probe based capture enrichment by Sravya V Bhamidipati, Anil Surathu, Hsu Chao, Daniel P. Agustinho, Qin Xiang, Kavya Kottapalli, Abirami Santhanam, Zeineen Momin, Kimberly Walker, Vipin K. Menon, George Weissenberger, Nathanael Emerick, Faria Mahjabeen, Qingchang Meng, Jianhong Hu, Richard Sucgang, David Henke, Fritz J. Sedlazeck, Ziad M. Khan, Ginger A. Metcalf, Vasanthi Avadhanula, Pedro A. Piedra, Sasirekha Ramani, Robert L. Atmar, Mary K. Estes, Joseph F. Petrosino, Richard A. Gibbs, Donna M. Muzny, Sara Cregeen Javornik, Harsha Doddapaneni

“…The percentage of reads mapped to viral genomes was 85.1% for RSV and 40.8% for HuNoV post-capture, compared to 0.08% and 1.15% in pre-capture libraries. …”
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Differential Effects of Human Immunodeficiency Virus Nef Variants on Pulmonary Vascular Endothelial Cell Dysfunction by Amanda K. Garcia, Noelia C. Lujea, Javaria Baig, Eli Heath, Minh T. Nguyen, Mario Rodriguez, Preston Campbell, Isabel Castro Piedras, Edu Suarez Martinez, Sharilyn Almodovar

“…<b>Methods:</b> We utilized well-characterized Nef molecular constructs to examine their effects on cell adhesion molecule gene expression (<i>ICAM1</i>, <i>VCAM1</i>, and <i>SELE</i>), pro-apoptotic gene expression (<i>BAX</i>, <i>BAK</i>), and vasoconstrictive endothelin-1 (<i>EDN1</i>) gene expression in endothelial nitric oxide synthase (eNOS) nitric oxide and the production and secretion of pro-inflammatory cytokines over 24, 48, and 72 h post-transfections with Nef variants. <b>Results:</b> HIV Nef variants SF2, NA7, and PH-associated Fr17 and 3236 induced a significant increase in adhesion molecule gene expression of <i>ICAM1</i>, <i>VCAM1</i>, and <i>SELE</i>. …”
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CYTOMETRIC FEATURES OF THE CELLULAR COMPARTMENT OF THE IMMUNE SYSTEM OF PARTICIPANTS IN MODERN MILITARY CONFLICTS by S. L. Pashnin, E. V. Davydova, D. Sh. Altman, V. A. Zurochka, I. Yu. Zhuravlev, Ya. T. Zhakupova

“…A significant amount of knowledge has been accumulated about the mechanisms of immune-mediated reactions in the development of neuropsychiatric pathology, in particular post-traumatic stress disorder (PTSD). Activated T-regulatory cells play an important role in the development of neuroinflammation under stress.Purpose of the study: to study the indicators of the blood system, cytometric features of the cellular compartment of the immune system in participants in modern military conflicts with the presence of adaptation disorders associated with stress.Materials and methods. …”
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Substantia nigra related gene polymorphisms associated with antipsychotic-induced acute movement disorders: a genome-wide association study and multi-ancestry validation in schizop... by Zhe Lu, Yao-Yao Sun, Zhe-Wei Kang, Guo-Rui Zhao, Yu-Yanan Zhang, Jun-Yuan Sun, Rui Yuan, Wei-Hua Yue

“…Methods GWASs on AIMDs were conducted in 3 independent cohorts: a discovery cohort of 3067 patients (2016 subjects were reserved after quality control), a validation cohort of 277 patients, and a multi-ancestry validation cohort of 766 patients. Subsequent post-GWAS analyses included gene-based analyses, transcriptome-wide association studies (TWASs), and polygenic risk score (PRS) profiling. …”
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