Alcohol consumption, high-sensitivity C-reactive protein, and estimated glomerular filtration rate: tripartite predictors of 10-year cardiovascular risk progression in patients wit... by Yizhe Wang, Yizhe Wang, Yu Duan, Yongcheng Zhang, Yongcheng Zhang, Na Li, Ying Hu, Liping Gu, Yanfang Hou, Yuhang Ma

“…Finally, the predictive performance of various factor combinations for 10-year CVD risk progression during the post-acute COVID-19 phase in type 2 diabetes mellitus cohorts was measured by area under roc curve (AUC).ResultsAfter infection with COVID-19, 12.2% (n=46) experienced progression in their 10-year CVD risk category. …”
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Effects and neural mechanisms of a brain–computer interface-controlled soft robotic glove on upper limb function in patients with subacute stroke: a randomized controlled fNIRS stu... by Xiang Ji, Xia Lu, Yi Xu, Wenbin Zhang, Han Yang, Chenghui Yin, Hewei Wang, Caili Ren, Yingying Ji, Yongqiang Li, Guilan Huang, Ying Shen

“…Moreover, changes in prefrontal activation (post–pre) were positively correlated with improvements in ARAT scores, with significant correlations observed in the left dorsal lateral prefrontal cortex (LDLPFC) (Ch9, r = 0.592, P = 0.012; Ch25, r = 0.488, P = 0.047) and right dorsal lateral prefrontal cortex (RDLPFC) (Ch19, r = 0.671, P = 0.003). …”
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The association between hepatic steatosis, vitamin D status, and insulin resistance in adolescents with obesity by Emir Tas, Amanda Flint, Ingrid Libman, Radhika Muzumdar, Xiawei Ou, David K. Williams, Elisabet Børsheim, Eva C. Diaz

“…This study examined the relationship between changes in vitamin D status and markers of IR in adolescents, with a focus on the modifying effect of liver fat. Methods: A post-hoc analysis was performed using data from 44 adolescents participating in a 6-month observational study evaluating biomarkers of hepatosteatosis. …”
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Enhanced efficacy of Helicoverpa armigera nucleopolyhedrovirus against Spodoptera litura larvae using zeolite and chitosan nanoparticle formulations by Mia Miranti, Iqbal Nur Iskandar, Melanie Melanie, Desak Made Malini, Camelia Panatarani, I Made Joni, Dedat Prismantoro, Febri Doni, Ravindra Chandra Joshi, Wawan Hermawan

“…Notably, even the lowest concentration tested (0.125 %) of both chitosan and zeolite nanoparticles achieved 66.67 % larval mortality within seven days post-infection. However, no significant differences in lethal time were observed among treatments, regardless of nanoparticle type or concentration. …”
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A protocol for estimating health burden posed by early life exposure to ambient fine particulate matter and its heavy metal composition: a mother–child birth (ELitE) cohort from Ce... by Tanwi Trushna, Vikas Yadav, Vikas Yadav, Uday Kumar Mandal, Vishal Diwan, Vishal Diwan, Rajnarayan R. Tiwari, Rajnarayan R. Tiwari, Rajesh Ahirwar, Rajesh Ahirwar, Dharma Raj, Sindhuprava Rana, Sindhuprava Rana, Suchitra Vishwambhar Surve, Sagnik Dey, Sagnik Dey, Yogesh Damodar Sabde, Yogesh Damodar Sabde

“…We will also estimate the incidence of Acute Respiratory Infections (ARI) during infancy.DiscussionThis manuscript describes the protocol for an Indian mother–child air pollution birth cohort study that aims to generate comprehensive evidence regarding the adverse effects of early-life (i.e., both pre- and post-natal) exposure to air PM and its constituent heavy metals among Indian children. …”
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Risk factors and adverse outcomes of extubation failure in preterm infants ≤32 weeks with neonatal respiratory distress syndrome by Chen Zhu, Chen Zhu, Zhengli Wang, Zhengli Wang, Kaizhen Liu, Kaizhen Liu, Jiacheng Li, Wenyan Tang, Wenyan Tang, Yuan Shi, Qingxiong Zhu, Qingxiong Zhu

“…Patients were stratified into a success group (n = 228) and a failure (n = 62) group based on whether reintubation was required within 72 h post-extubation. Multivariable logistic regression and nomogram modeling were employed to analyze independent risk factors.ResultsA total of 290 cases were included, comprising 228 in the successful extubation group and 62 in the failed extubation group, yielding an extubation failure rate of 21.4%. …”
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Preparation of photo-crosslinked hyaluronic acid/silk fibroin hydrogel for promoting wound healing by Shujing Li, Wensheng Pan, Maohu Chen, Ruyue Wang, Feng Chen

“…The appropriate incorporation of SF was shown to enhance cellular proliferation. On day 3 post-wounding, the HASF hydrogel group demonstrated a wound closure rate of 41.7%, outperforming commercial products under identical conditions. …”
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The TgAMPK-TgPFKII axis essentially regulates protein lactylation in the zoonotic parasite Toxoplasma gondii by Chenghuan Li, Yang Zhao, Qilong Li, Ran Chen, Ying Feng, Xiaoyu Sang, Xiangrui Li, Bang Shen, Ning Jiang, Qijun Chen

“…Lysine lactylation, as a novel post-translational modification, is essential for epigenetic regulation and cellular processes, and proteomic analyses have shown that lactylated proteins are involved in a wide range of biological processes including energy metabolism, gene regulation, and protein biosynthesis. …”
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An antisense oligonucleotide-based strategy to ameliorate cognitive dysfunction in the 22q11.2 Deletion Syndrome by Pratibha Thakur, Martin Lackinger, Anastasia Diamantopoulou, Sneha Rao, Yijing Chen, Khakima Khalizova, Annie Ferng, Curt Mazur, Holly Kordasiewicz, Robert J Shprintzen, Sander Markx, Bin Xu, Joseph A Gogos

“…Furthermore, antisense oligonucleotide administration and normalization of Emc10 in the adult mouse brain not only alleviates cognitive deficits in social and spatial memory but remarkably sustains these improvements for over 2 months post-injection, indicating its therapeutic potential. …”
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Effect of Faricimab versus Aflibercept on Hyperreflective Foci in Patients with Diabetic Macular Edema from the YOSEMITE/RHINE Trials by Usha Chakravarthy, FRCOphth, PhD, Varun Chaudhary, MD, FRCS(C), Srinivas R. Sadda, MD, Colin S. Tan, FRCOphth, FRCSEd (Ophth), Stela Vujosevic, MD, PhD, Sascha Fauser, MD, Kara Gibson, PhD, Carl Glittenberg, MD, Nancy Holekamp, MD, FASRS, Ben Lanza, PhD, Andreas Maunz, PhD, Jeffrey R. Willis, MD, PhD, Rishi P. Singh, MD

“…Purpose: To compare the effect of faricimab, a dual angiopoietin-2 (Ang-2) and VEGF-A inhibitor, with aflibercept on resolution of hyperreflective foci (HRF) in patients with diabetic macular edema (DME). Design: A post hoc analysis of the randomized, double-masked, noninferiority YOSEMITE/RHINE (NCT03622580/NCT03622593) phase III trials. …”
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Individual responses to encapsulated caffeine and caffeine chewing gum on strength and power in strength-trained males by Hamed Teimouri-Korani, Mohammad Hemmatinafar, Mark ET Willems, Rasoul Rezaei, Babak Imanian

“…Data were analyzed using one-way repeated measures ANOVA and Bonferroni post hoc tests, with significance set at p ≤ 0.05. …”
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Effect of different blood transfusion threshold on the prognosis of elderly patients with anemia in intensive care unit by HU Feihuan, YANG Heng, ZHANG Pushan, LI Jun, YE Hanshen

“…Blood transfusion details of these patients in the ICU were collected and documented, including pre-transfusion Hb levels, volume and number of red blood cell transfusion, and post- transfusion Hb levels. Propensity score matching (PSM) was used to match the baseline data of the two groups of patients, and the clinical outcomes were compared and analyzed after matching. …”
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A Randomized Controlled Pilot Study Evaluating the Safety and Efficacy of Nifuroxazide in Patients with Ulcerative Colitis by AlRasheed HA, Abdallah MS, El-Khateeb E, Kamal M, Alrubia S, Alsegiani AS, Ahmed TI, Bahaa MM

“…Secondary outcomes: change in IBDQ-32 and in the level of measured biomarkers.Results: Baseline measurements were comparable between groups (p > 0.05). Post-treatment values showed significant improvements within both groups compared to baseline. …”
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Comprehensive Analysis of the Effects of Sacubitril/Valsartan According to Sex Among Patients With Heart Failure and Reduced Ejection Fraction in PARADIGM‐HF by Misato Chimura, Jawad H. Butt, Shingo Matsumoto, Eoghan G. M. McMurray, Alasdair D. Henderson, Atefeh Talebi, Akshay S. Desai, Martin P. Lefkowitz, Adel R. Rizkala, Jean L. Rouleau, Scott D. Solomon, Karl Swedberg, Michael R. Zile, Milton Packer, Pardeep S. Jhund, John J. V. McMurray

“…Methods and Results This post hoc analysis of PARADIGM‐HF examined sex‐based outcomes in patients with HF and reduced ejection fraction randomized to sacubitril/valsartan or enalapril. …”
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Estandarización de zimosán opsonizado como estímulo en la técnica de la 1,2,3-dihidrorrodamina para evaluar el estallido respiratorio del neutrófilo by Uriel Pérez-Blanco, Jenniffer Yissel Girón, Guillermo Juárez -Vega, María Jiménez, Carlos Sánchez, Ricardo Rioja, Sara Espinosa-Padilla, Lizbeth Blancas-Galicia

“…Se utilizaron las pruebas de Kolmogorov-Smirnov, ANOVA y el análisis post-hoc de Tukey. Se consideró un valor de p ≤ 0,05 como estadísticamente significativo. …”
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Chikungunya intra-vector dynamics in Aedes albopictus from Lyon (France) upon exposure to a human viremia-like dose range reveals vector barrier’s permissiveness and supports local... by Viginier, Barbara, Cappuccio, Lucie, Garnier, Céline, Martin, Edwige, Maisse, Carine, Valiente Moro, Claire, Minard, Guillaume, Fontaine, Albin, Lequime, Sébastian, Ratinier, Maxime, Arnaud, Frédérick, Raquin, Vincent

“…Transmission rate data revealed a time-dependent, but overall weak, transmission barrier, with individuals transmitting as soon as 2 days post-exposure (dpe) and >50% infectious mosquitoes at 6 dpe for the highest dose. …”
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Shifts in bla genes and Class 1 integron prevalence in beta-lactamase-producing bacteria before and after the COVID-19 pandemic in Mendoza, Argentina by F. Márquez-Friedrichs, M. B. Nolly, A. Ferreyra, L. Zuloaga, S. Dominguez, A. Secotaro, V. S. Rathour, M. T. Damiani, L. Contreras, D. G. Sánchez

“…Our findings reveal a significant increase in bacteria with the ESBL phenotype, particularly among ambulatory populations post-pandemic, suggesting a concerning spread of multidrug-resistant bacteria outside hospital environments. …”
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Can Biomarkers Predict Kidney Function Recovery and Mortality in Patients with Critical COVID-19 and Acute Kidney Injury? by Noemí Del Toro-Cisneros, José C. Páez-Franco, Miguel A. Martínez-Rojas, Isaac González-Soria, Juan Antonio Ortega-Trejo, Hilda Sánchez-Vidal, Norma A. Bobadilla, Alfredo Ulloa-Aguirre, Olynka Vega-Vega

“…Blood and urine samples were obtained when KRT was initiated (day zero), and thereafter on days 1, 3, 7, and 14 post-replacement. uSerpinA3, kidney injury molecule-1 (uKIM-1), and neutrophil gelatinase-associated lipocalin (uNGAL) were measured in urine, and interleukin-6 (IL-6), interleukin-10 (IL-10), and tumor necrosis factor alpha (TNF-α) in peripheral blood. …”
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Preoperative partial breast reirradiation and repeat breast-conserving surgery in patients with recurrent breast cancer: the prospective single-arm REPEAT trial – a study protocol... by Ellis Barbé, Joost Verhoeff, Nina Bijker, Philip Meijnen, Yasmin Civil, Lisca Wurfbain, Lysanne Jonker, Maurice van der Sangen, Arlene Oei, Katya Duvivier, Zdenko van Kesteren, Miguel Palacios, Willemien Menke-van der Houven van Oordt, Gwen Diepenhorst, Victor Thijssen, Berend Slotman, Robert-Jan Schipper, Desirée van den Bongard

“…BCS will be performed 3 (±one) weeks post PBI. The primary endpoint is the incidence of grade 2 or higher treatment-associated acute toxicity within 90 days. …”
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TSLP pretreatment inhibits M1 macrophage polarization and attenuates LPS-induced iNKT cell-dependent acute lung injury by Ting Zhou, Ziyao Zhang, Yawen Zhan, Meiying Wang, Meiying Wang, Meiying Wang, Mi Wu, Xiufang Weng, Xiufang Weng, Xiufang Weng, Xiufang Weng, Younian Xu, Younian Xu, Younian Xu

“…Thymic stromal lymphopoietin (TSLP) is known to promote Th2 responses in allergic disease, however, its role in sepsis associated ARDS remains limited.MethodsTo investigate the role of TSLP in sepsis associated lung injury, we administered exogenous recombinant TSLP to wild-type mice, followed by lipopolysaccharide (LPS) challenge. At 24 hours post-treatment, bronchoalveolar lavage fluid (BALF) and lung tissues were collected for analysis. …”
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