Clinical investigation on nebulized human umbilical cord MSC-derived extracellular vesicles for pulmonary fibrosis treatment by Meng Li, Huaping Huang, Xiaofei Wei, Huajuan Li, Jun Li, Bingchen Xie, Yuze Yang, Xingyue Fang, Lei Wang, Xiaona Zhang, Heyu Wang, Mengdi Li, Yuting Lin, Dezhi Wang, Yinyin Wang, Tongbiao Zhao, Jianqiu Sheng, Xinbao Hao, Muyang Yan, Lu Xu, Zhijie Chang

“…Remarkably, two patients with advanced post-inflammatory pulmonary fibrosis exhibited clinically significant regression on serial CT scans after hUCMSC-EVs therapy. …”
Get full text

Mesenchymal stromal cells conditioned by peripheral blood mononuclear cells exert enhanced immunomodulation capacities and alleviate a model of Myasthenia Gravis by Alexandra C. Bayer, Natalia Pinzón, Axel You, Cinthia Bergman, Nadine Dragin, Aurélien Corneau, Frédérique Truffault, Danièle Noël, Christophe Martinaud, Rozen Le Panse, Sonia Berrih-Aknin, Jean-Thomas Vilquin

“…To confirm immunomodulation efficacy in vivo, cMSC were administrated to our humanized mouse model of Myasthenia Gravis and the treatment significantly halved disease severity from 2 weeks post-injection. Conclusions This integrative study establishes distinct conditioning signatures, suggests molecular mechanisms, and underscores the therapeutic potential of cMSC, offering a robust framework for advancing cell-based therapies in autoimmune diseases.…”
Get full text

Epigenetic silencing and CRISPR-mediated reactivation of tight junction protein claudin10b (CLDN10B) in renal cancer by Sarah Arroyo Villora, Yufen Zhao, Paula Castellanos Silva, Alba A. Hahn, Vivien Olanin, David Groll, Sandra Maurer, Vera Roetzer, Witold Szymanski, Tara Procida-Kowalski, Niklas Philipp, Aline Koch, Marek Bartkuhn, Johannes Graumann, Richard Volckmann, Jan Koster, Oliver Rossbach, Denise Salzig, Reinhard Dammann, Cornelia Sigges, Jan Halbritter, Silke Haerteis, Antje Maria Richter

“…We identified the epigenetic silencing of the Claudin 10 gene isoform B (CLDN10B) through DNA hypermethylation in renal cancers, including clear cell (ccRCC), papillary (pRCC) and post-transplantation renal carcinoma (PT-ccRCC). …”
Get full text

A New Risk Prediction Tool for Bleeding and Adverse Cardiovascular Events in Patients with Pre-Existing Coronary Stents Undergoing Gastrointestinal Cancer Surgery by Xu ZY, Hao XY, Zhang Z, Zhang J, Gao L, Li T, Wang XX

“…Net reclassification index (NRI) and integrated discrimination improvement (IDI) were used to interpret the strengths. Within 30 days post-surgery, we compared the bleeding events and MACEs.Results: Among 3127 patients, 437 (13.9%) developed MACEs and 565 (18.1%) developed bleeding events. …”
Get full text

Novel variants of tick-borne encephalitis virus from patient and tick samples in Norway by Urusha Maharjan, Hilde Kristin Skudal, Naveed Asghar, Arnulf Soleng, Magnus Johansson, Heidi Elisabeth Heggen Lindstedt, Anita Koskela von Sydow, John H.-O. Pettersson, Wenche Johansen, Børre Fevang, Randi Bjerkreim, Suyog Basnet, Rose Vikse, Åshild K. Andreassen, Kristian Alfsnes

“…However, clinical samples with intact virus are rare because TBE is usually diagnosed by serology in the post-viremic phase, when the viral load is low and undetectable by molecular methods such as polymerase chain reaction (PCR). …”
Get full text

Investigation on current situation of Chinese patent medicines for children in China based on the national drug coding database by Hui Liu, Hui Liu, Ping Rong, Ping Rong, Yatong Zhang, Yatong Zhang, Yuqiong You, Yuqiong You, Qianfang Fu, Qianfang Fu, Lili Cai, Lili Cai, Juan Wei, Juan Wei, Rong Ma, Rong Ma

“…Recommendations include developing new Chinese patent medicines for children, improving drug suitability, conducting post-marketing evaluations, and refining drug labeling to ensure safe and rational pediatric medication use.…”
Get full text

Abstract 109: Endonasal Endoscopic Approach Associated Cerebral Vasospasm and Management: A Case Report by Nefize P. Turan, Matthew Bower, Abdullah Bin Zahid, Ryan P. Lee, Shih‐Chun Lin, Murugappan Ramanathan Jr, Adam Schiavi, Justin M. Caplan

“…Introduction Endoscopic endonasal approach(EEA) techniques have been increasingly utilized and have been associated with development of cerebrospinal fluid(CSF) leak, meningitis, diabetes insipidus post‐operatively. Cerebral vasospasm following EEA has rarely been described. …”
Get full text

Organizing pneumonia in hospitalized COVID-19 patients: risk factors and long-term outcomes by Sandra Cuerpo, Fernanda Hernandez-Gonzalez, Mariana Benegas, Nuria Albacar, Alejandra Lopez-Giraldo, Inés Cobo, Samara Suarez, Verónica Torres, Adelaido Salazar, Nestor Soler, María Noboa-Sevilla, Alejandro Frino-García, Nancy Pérez-Rodas, Joel Francesqui, Xavier Alsina-Restoy, Ana María Muñoz Fernández, Nuria Roger, Sergio Prieto, Alexandru Vlagea, Estibaliz Ruiz, Rosa Faner, Joan Albert Barberà, Alex Soriano, Joan Ramon Badia, María Molina-Molina, Oriol Sibila, Marcelo Sánchez, Alvar Agustí, Judith Garcia-Aymerich, Jacobo Sellares

“…Abstract Background Some patients develop post-COVID-19 organizing pneumonia (OP) that is responsive to corticosteroid treatment. …”
Get full text

Melatonin Implantation Improves the Reproductive Performance of Estrus-Synchronized Ewes During Seasonal Anestrus and Enhances the Antioxidant and Steroidogenic Capacities of Granu... by Zengyi Duan, Menghao Liu, Junjin Li, Kexiong Liu, Qi Qi, Zhixuan Yu, Hadia Akber Samoo, Chunxin Wang, Jian Hou

“…The results demonstrated that MT implantation significantly improved serum levels of total antioxidant capacity (T-AOC), superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), and glutathione peroxidase (GSH-Px), increased post-ovulatory luteal diameter and serum P4 levels, and reduced ovarian apoptosis. …”
Get full text

A Cyclic-di-AMP Adjuvanted CPAF Protein Vaccine Is Immunogenic in Swine, but It Fails to Reduce Genital <i>Chlamydia trachomatis</i> Burden by Leonie Bettin, Maria Stadler, Christine Unterweger, Maximiliane Dippel, Jonathan M. Harris, Andrea Buzanich-Ladinig, Taylor B. Poston, Toni Darville, Tobias Käser

“…Each week, the systemic T cell response was assessed via IFN-γ and IL-17 ELISpots, as well as multi-parameter flow cytometry on 0, 14, and 28 days post vaccination (dpv). The humoral immune response was analyzed by measuring CPAF-specific antibody levels and avidity via ELISAs. …”
Get full text

Our experience with management of congenital urological pathologies in adulthood: What pediatric urologists should know and adult urologists adopt in pediatric practice experience by Leon Chertin, Binyamin B. Neeman, Jawdat Jaber, Guy Verhovsky, Amnon Zisman, Ariel Mamber, Ilan Kafka, Ala Eddin Natsheh, Dmitry Koulikov, Ofer Z. Shenfeld, Boris Chertin, Stanislav Koucherov, Amos Neheman

“…The median follow-up period after surgery was 33 months (interquartile range, 12–54). Post-operative complications occurred in 5 patients (Clavien-Dindo 1–2). …”
Get full text

Exosomal BMPR2 Macromolecule Facilitates Alveolar Epithelial Cell Repair Through Functional Complex Formation with BMPR1B in Acute Lung Injury by Yun X, Chen Z, Li F, Shen F, Zhang L, Yuan J

“…The characterized macrophage-derived exosomes (163.6 ± 70.2 nm) demonstrated efficient pulmonary targeting, with peak accumulation occurring at 4 hours post-administration. Mechanistically, the formation of the BMPR2-BMPR1B complex activated SMAD1-dependent signaling pathways, as evidenced by strong BMPR1B-SMAD1 colocalization (correlation coefficient 0.94 ± 0.02) and enhanced ID1 expression.Conclusion: The BMPR2-BMPR1B interaction was demonstrated to accelerate type II to type I alveolar epithelial cell transdifferentiation, thereby facilitating tissue repair in ALI. …”
Get full text

Impact on Outcome of Different Mechanisms, Baseline Degree and Changes of Mitral Regurgitation in Patients With Aortic Stenosis Who Underwent Transcatheter Aortic Valve Replacement by Francesco Melillo, Annamaria Tavernese, Vincenzo Rizza, Francesco Putortì, Alberto Preda, Francesco Ancona, Giacomo Ingallina, Stefano Stella, Antonio Colombo, Marco Ancona, Alaide Chieffo, Nicola Buzzatti, Alessandro Castiglioni, Michele De Bonis, Francesco Maisano, Matteo Montorfano, Eustachio Agricola

“…Echocardiographic comprehensive MR assessment was performed at baseline and within 3 months post TAVR. The study population was divided into 4 groups according to MR mechanism: Group I: fibro‐calcific leaflet degeneration; Group II: prolapse/flail; Group III: ventricular secondary MR (functional MR); and Group IV: atrial functional MR. …”
Get full text

Women’s health and maternal care services: seizing missed opportunities to prevent and manage preterm birth by Bo Jacobsson, Jennifer Harris Requejo, Teesta Dey, Tina Lavin, Margaret Titty Mannah, Ramkumar Menon, Catalina Valencia, Gaurav Sharma, Andrew Shennan, Elham Shakibazadeh, Pisake Lumbiganon, Sarah Bar-Zeev, Sue Steen, Angela Nguku, Hiromi Obara, Lisa Noguchi, Pius Okong, Sanjukta Amrita Singh, Jane Sandall, Anna Gruending, Zahida Qureshi, Joshua P. Vogel

Get full text

Perda hemática e sinais ou sintomas durante avaliação puerperal: implicações para a assistência de enfermagem [Blood loss and signs or symptoms during puerperal assessment: implica... by Mariana Torreglosa Ruiz, Natália Alves Paraiso, Ana Rita Marinho Machado, Maria Beatriz Guimarães Ferreira, Anneliese Domingues Wysocki, Marli Villela Mamede

“…RESUMEN Objetivo: relacionar pérdida hemática con quejas, signos o síntomas de alteraciones de sangre en período post-parto, mediante medición del nivel de hemoglobina (Hb) y hematocrito (Ht). …”
Get full text

Flow-Diverting Stents During Mechanical Thrombectomy for Carotid Artery Dissection-Related Stroke: Analysis from a Multicentre Cohort by Osama Elshafei, Jonathan Cortese, Nidhal Ben Achour, Eimad Shotar, Jildaz Caroff, Léon Ikka, Cristian Mihalea, Vanessa Chalumeau, Maria Fernanda Rodriguez Erazu, Mariana Sarov, Nicolas Legris, Jean-Christophe Gentric, Frederic Clarençon, Laurent Spelle

“…Patient records, procedural details, and post-procedural outcomes, including follow-up data, were reviewed. …”
Get full text

What drives clinic follow-up after traumatic spinal injury? An observational cohort study from Tanzania by Julie Woodfield, Hamisi K Shabani, Scott L Zuckerman, Roger Hartl, Halinder S Mangat, Sean Inzerillo, Chibuikem A Ikwuegbuenyi, Romani Roman Sabas, Noah Willett, Magalie Cadieux, Francois Waterkeyn

“…Patients with missing data were excluded.Primary and secondary outcome measures Primary outcomes were any clinic follow-up and 1-year follow-up post-discharge. Secondary outcome was time to loss of follow-up. …”
Get full text

High-dimensional single-cell phenotyping unveils persistent differences in immune cell profiles between severe and moderate seasonal influenza by Johanna Bodin, Gro Tunheim, Anja B. Kristoffersen, Tove K. Herstad, Eleonora Vianello, Mariëlle C. Haks, Suzanne van Veen, Torgun Wæhre, Anne-Marte B. Kran, Anne-Marte B. Kran, Sarah L. Lartey, Fan Zhou, Rebecca J. Cox, Rebecca J. Cox, Tom H. M. Ottenhoff, Anne M. Dyrhol-Riise, Anne M. Dyrhol-Riise, Unni C. Nygaard, Fredrik Oftung, Siri Mjaaland

“…BackgroundInfluenza viruses with pandemic potential and possible burden of post-viral sequelae are a global concern. To prepare for future pandemics and the development of improved vaccines, it is vital to identify the immunological changes underlying influenza disease severity.MethodsWe combined unsupervised high-dimensional single-cell mass cytometry with gene expression analyses, plasma CXCL13 measurements, and antigen-specific immune cell assays to characterize the immune profiles of hospitalized patients with severe and moderate seasonal influenza disease during active infection and at 6-month follow-up. …”
Get full text

Early Rituximab as an Add-On Therapy in Children With the Initial Episode of Nephrotic Syndrome by Jialu Liu, Fang Deng, Xiaowen Wang, Cuihua Liu, Shuzhen Sun, Ruifeng Zhang, Aihua Zhang, Xiaoyun Jiang, Weili Yan, Yalan Dou, Yi Zhang, Li Xie, Biyun Qian, Qian Shen, Hong Xu

“…In the rituximab group, the 12-month relapse-free survival was significantly higher compared to historical controls (32 of 43 [74.4%] vs. 10 of 33 [30.3%]; P < 0.001; hazard ratio [HR], 3.76; 95% confidence interval [CI], 1.80–7.81). The post hoc analysis revealed a higher 24-month relapse-free survival and a lower incidence of FRNS/SDNS at the 12-month follow-up. …”
Get full text

Effect of Acupuncture on Functional Connectivity of the Limbic Network in Patients with Knee Osteoarthritis: A Resting State Functional Magnetic Resonance Imaging Study by Wu N, Lou XS, Chang YN, Li JY, Zhang ZH, Hu JH, Fan Y, Feng XD, Yin S

“…Neuroimaging revealed that only the acupuncture group demonstrated significantly increased FC post-intervention in key limbic regions, including the anterior cingulate gyrus, lenticular putamen, amygdala, temporal pole, hippocampus, pallidum, parahippocampal gyrus and caudate nucleus.Conclusion: Reduced limbic network functional connectivity is a central pathological feature in knee osteoarthritis. …”
Get full text