Mixed methods evaluation of a digital resource to build students’ skills in ASsessing cardiovascular risk, MOtivating change, and SUStaining a healthier lifestyle in themselves and... by L. Creighton, G. Caughers, G. Thompson, G. Mitchell, B. Forrest, S. McHale, N. McKenna, B. J. Rice, A. Smart, S. Gilhooly, P. Gordon-Wright, D. Fraser, S. Gray, Y. Eom, E. Kennedy, C. McLaughlin, J. McMahon, C. L. Hanson, L. Neubeck, D. Fitzsimons

“…Phase one will use two questionnaires to investigate student knowledge on CVD risk and self-efficacy, using a pre-post test design. Phase two will explore the experience of the students in using the resource and the impact on their skills and self-efficacy using focus groups. …”
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Machine learning-assisted assessment of extracellular vesicles can monitor cellular rejection after heart transplant by Jacopo Burrello, Stefano Panella, Ilaria Barison, Chiara Castellani, Alessio Burrello, Lorenzo Airale, Jessica Goi, Veronica Dusi, Roberto Frigerio, Gino Gerosa, Chiara Tessari, Nicola Pradegan, Giuseppe Toscano, Giovanni Pedrazzini, Mattia Corianò, Francesco Tona, Sara Bolis, Alessandro Gori, Marina Cretich, Marny Fedrigo, Annalisa Angelini, Lucio Barile

“…Abstract Background Heart transplant rejection, particularly acute cellular rejection (ACR), remains a critical post-operative concern, despite declining incidence rates. …”
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Autismo in età adulta Uomini e donne autistici tra criticità e risorse by 1 Rosaria Ferrara, 2 Leonardo Iovino, 1 Pasquale Ricci, 1 Lidia Ricci, 3 Roberto Latina, 4 Gianni Carbone, 1 Serafino Ricci

“…Infatti, in termini di prospettive educative e occupazionali post-scolastiche, gli individui con autismo tendono a cavarsela ancora meno bene degli individui con altri disturbi, come disabilità intellettiva, difficoltà specifiche di apprendimento, disturbi della parola e del linguaggio. …”
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A Bayesian re-analysis of the DANFLU-1 trial by Daniel Modin, Niklas Dyrby Johansen, Anders Granholm, Brian L. Claggett, Joshua Nealon, Sandrine Samson, Matthew M. Loiacono, Rebecca C. Harris, Carsten Schade Larsen, Anne Marie Reimer Jensen, Nino Emanuel Landler, Scott D. Solomon, Martin J. Landray, Gunnar H. Gislason, Lars Køber, Pradeesh Sivapalan, Jens Ulrik Stæhr Jensen, Tor Biering-Sørensen

“…This study presents a post-hoc, Bayesian re-analysis of the DANFLU-1 trial. …”
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A mechanism-based group psychotherapy approach to aggressive behavior (MAAP) in borderline personality disorder: a multicenter randomized controlled clinical trial by Christine Sigrist, Andreas Bechdolf, Katja Bertsch, Robin Bullenkamp, Martin Busse, Ute gr. Darrelmann, Astrid Dempfle, Martin Driessen, Thomas Frodl, Jan-Michael Kersting, Jessica Kesik, Burkhart Matzke, Corinne Neukel, Eva Niessen, Svenja Nückel, Viola Oertel, Frank Padberg, Alexandra Philipsen, Dorothee Pink, Andreas Reif, Matthias Reinhard, Carolin Steuwe, Larissa Wolkenstein, Sabine C. Herpertz, the MAAP Consortium

“…Outcomes are assessed at baseline, immediately, and 4, 12, 20, and 24 weeks post-treatment using ecological momentary assessment, clinical interviews, questionnaires, and online tasks. …”
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Comparison of eight weeks of resistance training and high-intensity intermittent aerobic training on the expression of microRNAs associated with adipose tissue angiogenesis and ant... by Hamid Sadeghian, Marefat Siahkohian, Mohsen Akbarpour Beni, Lotfali Bolboli

“…Data analysis was performed using independent t-test, one-way and two-way ANOVA at the significant level (P ≥ 0.05). Scheffe post hoc test was used to compare the pairwise .Results: The miR-221, miR-222 and VEGF in the Normal diet + Resistance training, Normal diet + HIIT and High-fat diet + Resistance training groups a significant increase was observed compared to the control group (P ≥ 0.01). …”
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Treatment optimization for iron deficiency anemia in pregnant women as a resource to prevent perinatal complications by T. P. Zefirova, R. R. Mukhametova, E. Iu. Iupatov, A. T. Khaertdinov

“…Inter-group perinatal complications differed as well: in comparison vs. main group more often were observed untimely discharge of amniotic fluid (54.5 % vs. 28.1 %; p = 0.031), injuries to the soft tissues of the birth canal (28.1 % vs. 9.1 %; p = 0.048), obstetric bleeding (21.2% vs. 3.1%; p = 0.027), post-delivery infectious complications (24.2 % vs. 6.25 %; p = 0.045). …”
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TRIM21 promotes type I interferon by inhibiting the autophagic degradation of STING via p62/SQSTM1 ubiquitination in systemic lupus erythematosus by Li Chen, Ma Ang, Bai Yu, Liu Zitao, Tian Linghan, Wang Ziyuan, Ma Huaishun, Chen Zhengpu, Gao Zhengheng, Feng Shijie, Fu Ping

“…Mechanistically, TRIM21 catalyzes the K63-linked polyubiquitylation of the selective autophagy receptor p62/SQSTM1, disrupting its interaction with STING. This post-translational modification prevents the sequestration of STING into autophagosomes, thereby stabilizing the adaptor protein and amplifying downstream type I interferon responses. …”
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Medical follow-up and long-term survival of patients with cerebrovascular accident: data from the REGION-M registry by S. N. Tolpygina, M. I. Chernysheva, A. V. Zagrebelny, V. P. Voronina, N. P. Kutishenko, N. A. Dmitrieva, O. V. Lerman, Yu. V. Lukina, M. M. Lukyanov, E. Yu. Okshina, N. E. Parsadanyan, S. Yu. Martsevich, O. M. Drapkina

“…The lower mortality among those visited the local clinic in the first year after CVA and among those who were visited by a doctor at home, compared with patients who were not observed, confirms the important role of medical supervision in the post-hospital period.…”
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Assessment of body composition in adolescents with obesity undergoing avocado oil supplementation by Aline Peres Leite Filizzola, Clara Korukian Freiberg, Priscila Sala Kobal, Sandra Maria Chemin Seabra da Silva, Adriana Garcia Peloggia de Castro, Deborah Cristina Landi Masquio, Yasmin Hany Saied, José Osmar Cardoso Filho, Aline de Piano Ganen

“…A randomized, double-blind, placebo-controlled clinical trial was conducted at a school clinic in the municipality of São Paulo. Thirty post-pubertal adolescents aged between 12 and 19 years were selected. …”
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A multinational cross-sectional study on the prevalence and predictors of long COVID across 33 countries by Mohamed Sayed Zaazouee, Eman Ayman Nada, Mohammed Al-kafarna, Ahmed Shaheen, Shivabalan Kathavarayan Ramu, Abdelrahman H. Hafez, Sajeda Ghassan Matar, Ahmed Assar, Mohamed Elshennawy, Hazem Abu El-Enien, Hala Jamal Redwan, Sarah Makram Elsayed, Maha Jabir Omran, Omar Hammam Salloum, Hossam Almadhoon, Mohamed Mamdouh, Engy A. Wahsh, Anas Zakarya Nourelden, Alaa Ahmed Elshanbary, Walid Abdel-Aziz, Hivan Haji Rashid, Iman Basheti, Khaled Mohamed Ragab, Ahmed Taher Masoud, Abdelrahman I. Abushouk, Long-COVID International Team (LCIT)

“…We collected demographic data, past medical history, infection details, post-COVID-19 symptoms, and quality of life. Responses were then translated into English. …”
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Faster efficacy and reduced nodule occurrence with PLLA (poly-l-lactic acid) porous microspheres by Qihua Cao, Qihua Cao, Qihua Cao, Jiayu Chen, Jiayu Chen, Jiayu Chen, Jiayu Chen, Zijun Zhang, Yufei Xiong, Jinxia Ma, Wei Sun, Xin Chen, Qilei Lou, Kaijia Tang, Kaijia Tang, Kaijia Tang, Kaijia Tang, Feng Lin, Feng Lin, Feng Lin, Yueliang Zhu, Yueliang Zhu, Yueliang Zhu, Xiaohua Yu, Xiaohua Yu, Xiaohua Yu, Xiaohua Yu

“…At predetermined experimental time points, subjects were humanely euthanized. Post-euthanasia, tissue sections underwent histological examination through hematoxylin and eosin (H&E) staining and Masson’s trichrome technique, with subsequent statistical analysis of the observational data.ResultsThe PLLA porous microsphere group demonstrated significantly faster onset of action compared to the control, with observable collagen deposition as early as week 2, enhanced inflammatory cell infiltration, more homogeneous tissue distribution, and substantially fewer microaggregates upon histological examination.DiscussionStructural modification of PLLA microspheres has successfully accelerated their onset of action while reducing nodule formation, thereby providing novel insights for clinical applications.…”
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A retrospective study on beta-blocker use and outcomes in hematopoietic stem cell transplant patients by Matthew A. Bergens, John T. Bokman, Ernaya J. Johnson, Matthew L. Braun, Yan Li, Amy T. Bush, Lauren Hill, Jolien Van Opstal, Alessandro Racioppi, Rebecca Fan, Sejal Kaushik, Edwin Alyea, Nelson Chao, Taewoong Choi, Cristina Gasparetto, Mitchell Horwitz, Richard Lopez, Sendhilnathan Ramalingam, Keith Sullivan, Paul Wischmeyer, Anthony D. Sung

“…When stratified by BB mechanism, outcomes varied: non-selective BBs were associated with lower post-HCT weight (p = 0.034), and vasodilating BBs showed a borderline reduction in length of stay (LOS) (p = 0.054). …”
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Isolation of a SARS-CoV-2 strain from pediatric patients in South Korea: biologic and genetic characterization by Hee Chun Chung, Sung Jae Kim, Su Jin Hwang, Su Jin Hwang, Sung Hoon Park, Sung Hoon Park, Kyoung Min Park, Hyeon Woo Chung, Hyeon Woo Chung, Si Hwan Ko, Dong il Park, Jun-Yeop Shim, Van Giap Nguyen, Jae Myun Lee, Jae Myun Lee

“…Cytopathic effects appeared within 48 h post-infection, marked by aggregates of dead cells. …”
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Oxidative genomic damage in pediatric patients exposed to mercury released by dental amalgam by Guadalupe Nalleli Macías-Lamas, Yveth Marlene Ortiz-García, Blanca Patricia Lazalde-Ramos, Guillermo Moisés Zúñiga-González, Belinda Claudia Gómez-Meda, Cristina Hermila Martínez-Bugarín, Susana Vanessa Sánchez-De-La-Rosa, Saulo Oswaldo Sánchez-Rivera, Gabriela Morales-Velazquez, Celia Guerrero-Velázquez, Ana Lourdes Zamora-Perez

“…Oral epithelial cell and whole saliva samples were taken at baseline and 30 days later for group 1, while for group 2, samples were obtained at different pre-treatment (baseline) and post-amalgam placement time points at 15 and 30 days. …”
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Immune profiling of uveal melanoma identifies a potential signature associated with response to immunotherapy by Wei-Lien Wang, Bita Esmaeli, Patrick Hwu, Alexandre Reuben, Michael T Tetzlaff, Jason Roszik, Mariana Petaccia De Macedo, Yong Qin, Kathryn Bollin, Fernando Carapeto, Kevin B Kim, Khalida M Wani, Sujan T Reddy, Michelle D Williams, Dan S Gombos, Alexander J Lazar, Sapna P Patel

“…Immune gene expression profiling was conducted by NanoString analysis on pre-treatment and post-treatment tumors from patients (n=6) receiving immune checkpoint blockade or 4-1BB and OX40 dual costimulation. …”
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Real-Time FTM-Based Victim Positioning System Using Heterogeneous Robots in Remote and Outdoor Scenarios by Juan Bravo-Arrabal, Carlos Simon Alvarez-Merino, Manuel Toscano-Moreno, Javier Seron-Barba, J. J. Fernandez-Lozano, Jose Antonio Gomez-Ruiz, Emil J. Khatib, Raquel Barco, Alfonso Garcia-Cerezo

“…The system was validated during a large-scale SAR drill, successfully locating two types of victims—a semi-hidden surface victim and a buried victim—within a 2000 m2 area in under 7 minutes, without any filtering or post-processing. The maximum positioning error was 22.87 m for the buried victim and 17.14 m for the surface one. …”
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Outcomes of Implementing a Multidimensional Antimicrobial Stewardship Program in a Medical Ward in a Third-Level University Hospital in Northern Italy by Maria Mazzitelli, Daniele Mengato, Gianmaria Barbato, Sara Lo Menzo, Fabio Dalla Valle, Margherita Boschetto, Paola Stano, Cristina Contessa, Daniele Donà, Vincenzo Scaglione, Giacomo Berti, Elisabetta Mariavittoria Giunco, Tiziano Martello, Francesca Venturini, Ignazio Castagliuolo, Michele Tessarin, Paolo Simioni, Annamaria Cattelan

“…<b>Methods</b>: A pre/post quasi-experimental study was conducted in an internal medicine ward at a tertiary hospital in Padua, Italy. …”
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Leishmaniases in Ethiopia: a scoping review by Ermias Diro, Fiona Wallace, Mezgebu Silamsaw Asres, Richard Wamai, Hugh Shirley, Grace Grifferty, Eleni Ayele, Katherine O’Brien, Adriana Totten, Philip Coombs, Adrienne M Orriols, Shreyas Mosurkal, Ellie Krulwich, Leah Oruko, Isabel C Roman, Prapti Shah, Riley Fanning-Hughes, Abigail L Williams, Morgan G Wong, Sophia Roe, Khushi Gandhi, Laith Matari, Sara Shaikh, Abigail Binkley, Benjamin J D Boutselis, Amer Chaudhry, Mahlet Haile

“…Research on prevention and control, health systems/policies and post-kala-azar dermal leishmaniasis, as well as randomised controlled trials, was lacking. …”
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Comparison of [99mTc]Tc-FAPI SPECT/CT and [18F]FDG PET/CT as predictive biomarkers for immunotherapy response in gastrointestinal cancer by Yu Zhang, Hong Chen, Dajia Lin, Zhiyi Lin, Jiyun Shi, Hannan Gao, Chenshen Huang, Fangqing Xue, Fan Wang, Wenxin Chen

“…TBR-FDG/TBR-FAPI was the main predictor of better prognosis post-immunotherapy ([stable disease, SD]+[partial response, PR]), with an optimal cut-off of 3.82. [99mTc]Tc-FAPI SPECT/CT can better evaluate peritoneal spread and liver metastases in gastrointestinal cancer. …”
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