Effectiveness of clopidogrel vs. ticagrelor based on the ABCD-GENE score in acute coronary syndrome patients following percutaneous coronary intervention by Xiaotong Xu, Xiaotong Xu, Kun Na, Miaohan Qiu, Xueqing Yang, Xueqing Yang, Zizhao Qi, Zizhao Qi, Jing Li, Kai Xu, Xiaozeng Wang, Yi Li, Yaling Han

“…AimThis study employs the ABCD-GENE score (age, body mass index, chronic kidney disease, diabetes, and CYP2C19 variants) to compare the effectiveness and safety of clopidogrel versus ticagrelor-based DAPT in ACS patients post-PCI.MethodsA total of consecutive 21,705 ACS patients who underwent PCI between March 2016 and March 2023 and survived at discharge were included. …”
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Effect of IL4-589C>T, FCGR2A-166His>Arg, DEFB1-20G>A, DEFB1-52G>A gene polymorphisms on TNFα, IL-1β, IL-4, and IL-10 contents in the patients with primary hip osteoarthrosis by A. M. Miromanov, T. V. Zabello, N. A. Miromanova

“…The exclusion criteria were as follows: close relationship; other types of osteoarthritis (post-traumatic, rheumatoid, metabolic, etc.); dysplastic syndromes and phenotypes; acute and chronic inflammatory diseases at the exacerbation stage; diabetes mellitus; osteoporosis; vascular diseases; obesity; malignant neoplasia; alcohol abuse. …”
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Role of Amide Proton Transfer Weighted MRI in Predicting MGMTp Methylation Status, p53-Status, Ki-67 Index, IDH-Status, and ATRX Expression in WHO Grade 4 High Grade Glioma by Faris Durmo, Jimmy Lätt, Anna Rydelius, Elisabet Englund, Tim Salomonsson, Patrick Liebig, Johan Bengzon, Peter C. M. van Zijl, Linda Knutsson, Pia C. Sundgren

“…All patients were examined using conventional MRI, including the following: T1w-MPRAGE pre- and post-contrast administration, conventional T2w and 3D FLAIR, and APTw imaging with a 3T MR scanner. …”
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Identification of CaVβ1 Isoforms Required for Neuromuscular Junction Formation and Maintenance by Amélie Vergnol, Aly Bourguiba, Stephanie Bauché, Massiré Traoré, Maxime Gelin, Christel Gentil, Sonia Pezet, Lucile Saillard, Pierre Meunier, Mégane Lemaitre, Julianne Perronnet, Frederic Tores, Candice Gautier, Zoheir Guesmia, Eric Allemand, Eric Batsché, France Pietri-Rouxel, Sestina Falcone

“…Additionally, their expression during early post-natal development is essential for NMJ maturation and long-term maintenance. …”
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Pragmatic clustered randomised control trial to evaluate a self-regulated learning intervention to be implemented in South Australian primary schools—study protocol by S.A Brinkman, B. Lam, S. Dawson, R. Marrone, D. Schunk, K. Winkel, H. Hermes, F. Gabriel, S. Fowler, D. Engelhardt

“…The primary outcome will be improved self-regulation assessed at 6 weeks, 6 months and 12 months post the intervention. Longer-term secondary outcomes will include academic and wellbeing measures obtained through administrative data linkage to the National Assessment Program in Literacy and Numeracy (NAPLAN) outcomes and the Wellbeing and Engagement Collection (WEC) outcomes measures in the year following implementation (grades 3, 5, and 7). …”
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A New Strategy for the Treatment of Patients With Prolonged Impairment of Consciousness Using Xenon. Prospective Pilot Study by A. I. Shpichko, A. N. Kuzovlev, R. A. Cherpakov, N. P. Shpichko, O. A. Grebenchikov, A. K. Yevseyev, A. K. Shabanov, S. S. Petrikov

“…The anti-inflammatory effects of xenon inhalation anesthetic, which have been repeatedly shown in previous studies, have the potential to beneficially affect the level of consciousness in these patients by targeting key links of neuroinflammation.AIM OF STUDY To evaluate the effect of oxygen-xenon mixture inhalation on the level of consciousness recovery and the severity of spastic activity in patients after traumatic brain injury.MATERIAL AND METHODS A prospective randomized clinical trial of the effect of inhaled xenon sedation on the level of consciousness and spastic activity in patients with post-coma long-term impairment of consciousness was conducted. …”
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Impact of a Novel Pretreatment on Bond Strength of Universal Adhesive to Conventional and CAD/CAM Resin Composites: In Vitro Study by Ali A. Elkaffas, Abdullah Alshehri, Feras Alhalabi, Rania Bayoumi, Abdullah Ali Alqahtani, Abdulellah Almudahi, Abdulaziz Fahd Alsubaie, Abdulaziz Fahd Alharbi

“…A three-way analysis of variance (ANOVA) was used to analyze the μTBS data, followed by Tukey’s post hoc test. The μTBS values were not significantly affected by either the resin composite type (<i>p</i> > 0.05) or the adhesive strategy (<i>p</i> > 0.05) according to the three-way ANOVA results. …”
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Efficacy and safety analysis of combined resection and reconstruction of multi-organ and vital vascular in colorectal cancer surgery by Wang Shenfan, Wu Zhenjie, Shi Ting, Wu Yuxuan, Feng Xiang

“…[Conclusion] Combined resection and reconstruction of multi-organ and vital vascular in colorectal cancer surgery, demonstrate a high rate of R0 resections and manageable post-operative complications. Overall, this approach is deemed safe and viable.…”
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Peripheral Circulation and Astrocytes Contribute to the MSC-Mediated Increase in IGF-1 Levels in the Infarct Cortex in a dMCAO Rat Model by Xiaobo Li, Wenxiu Yu, Yunqian Guan, Haiqiang Zou, Zhaohui Liang, Min Huang, Renchao Zhao, Chunsong Zhao, Zhenhua Ren, Zhiguo Chen

“…In total, only 5-6% of Iba-1+ microglia were colabeled with IGF-1 in the infarct cortex, corpus callosum, and striatum at day 2 post-dMCAO. MSC transplantation did not lead to a higher proportion of Iba-1+ cells that coexpressed IGF-1. …”
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Precision laser acupuncture at back-shu points enhances growth performance, feed efficiency, and hormonal regulation in rabbits by Mudhita Zikkrullah Ritonga, Ertika Fitri Lisnanti, Widya Pramita Lokapirnasari, Sri Hidanah, Saifur Rehman, Muhammad Fajar Amrullah, Rico Anggriawan, Mutasem Abuzahra, Denny Irmawati Hasan, Aamir Shehzad, Siti Rani Ayuti

“…Data were statistically evaluated using a one-way analysis of variance followed by Duncan’s post hoc test. Results: Group B showed significantly higher final body weight (1.97 ± 0.07 kg), weight gain (919 ± 128 g), GH levels (1.75 ± 0.12 ng/mL), improved FCR (2.67 ± 0.07), and greater FE (37.45% ± 1.09%) compared to Groups A and C (p < 0.05). …”
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Exploiting phKL-mediated homoeologous recombinants to map stripe rust resistance gene YrAev from Aegilops variabilis by Ming Hao, Yazhou Li, Chaolan Fan, Hong Chen, Yongxin Nie, Fang Wang, Jiangtao Luo, Bo Jiang, Xue Chen, Xuejiao Chen, Zhongwei Yuan, Shunzong Ning, Lianquan Zhang, Zongjun Pu, Dong Cao, Shisheng Chen, Lin Huang, Baolong Liu, Dengcai Liu

“…Differential gene expression analysis of post-inoculation with the Pst race has indicated two disease-resistance-related genes (annotated as mixed lineage kinase domain-like protein and nucleotide-binding leucine-rich repeat like protein, respectively) as promising candidates for YrAev. …”
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Combination of Ketorolac Tromethamine and Prednisolone-Loaded PLGA Nanocomposite for Effective Chronic Pain Relief in Mice by Do TN, Liu YC, Chuang YC, Tsai TL, Wu PC

“…Tuyet-Nhi Do,1 Yen-Chin Liu,2– 4 Yu-Che Chuang,5 Tsung-Lin Tsai,1,6,7 Ping-Ching Wu1,6,8– 10 1Department of Biomedical Engineering, College of Engineering, National Cheng Kung University, Tainan, 701, Taiwan; 2School of Post-Baccalaureate, College of Medicine, Kaohsiung Medical University, Kaohsiung, 812, Taiwan; 3Department of Anesthesiology, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, 812, Taiwan; 4Department of Anesthesiology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, 701, Taiwan; 5Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, 112, Taiwan; 6Center of Applied Nanomedicine, National Cheng Kung University, Tainan, 701, Taiwan; 7Department of Oncology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, 701, Taiwan; 8Institute of Oral Medicine and Department of Stomatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, 701, Taiwan; 9Medical Device Innovation Center, Taiwan Innovation Center of Medical Devices and Technology, National Cheng Kung University Hospital, National Cheng Kung University, Tainan, 701, Taiwan; 10University Center of Bioscience and Biotechnology, National Cheng Kung University, Tainan, 701, TaiwanCorrespondence: Ping-Ching Wu, Department of Biomedical Engineering, National Cheng Kung University, Tainan, 701, Taiwan, Email wbcxyz@gmail.com Tsung-Lin Tsai, Department of Oncology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, 701, Taiwan, Email sloantsai@mail.ncku.edu.twIntroduction: Chronic pain is a complex condition that requires timely and effective management to prevent long-term emotional, social, and economic consequences. …”
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[Translated article] Complications of intraosseous administration of vancomycin in total hip arthroplasty by W.F. Martínez, L. Camacho Terceros, F. Garbini, E.J. Bochatey, F.A. Lopreite

“…Detailed records and documentation of complications during hospitalisation and the first three months post-surgery were maintained. As a secondary outcome measure, the incidence of PJI was explored. …”
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Impact of Storage Conditions on Bronchoalveolar Lavage Fluid Analysis: A Human Study by Yu Shionoya, Kanae Maruyama, Takeshi Kawasaki, Mayumi Ono, Yushi Murai, Ryutaro Hirama, Dai Horiuchi, Noriko Sakuma, Shinsuke Kitahara, Shun Sato, Kohei Takahashi, Yoshihito Ozawa, Takuji Suzuki

“…Notably, neutrophil percentages showed a significant decline over time under both storage conditions—at 4 °C (<i>p</i> = 0.02) and at room temperature (<i>p</i> < 0.01). Post hoc tests revealed a notable decreasing trend at 6 h and significant reductions by 24 h at 4 °C (<i>p</i> = 0.09 and <i>p</i> = 0.02, respectively), and significant decreases at both 6 and 24 h at RT (<i>p</i> = 0.01, <0.01). …”
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The role of prefrontal cortex in chronic low back pain with comorbid depression: A resting-state fMRI study by Yanqiao Zhao, Chen Gong, Pan Zhu, Suimin Guo, Yangyang Lin, Yafei Wang, Beibei Feng, Xiaochun Meng, Yuling Wang

“…Analysis of variance and post hoc analyses among groups were conducted. Correlational analyses were performed between neuroplasticity and clinical variables. …”
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Extracorporeal carbon dioxide removal compared to ventilation alone in patients with acute hypoxaemic respiratory failure: cost-utility analysis of the REST RCT by Ashley Agus, James J. McNamee, Colette Jackson, Danny F. McAuley

“…The cost per quality-adjusted life-year was estimated at 12 months post randomisation. Results Mean EuroQol-5 Dimensions, five-level version utility scores were low and similar for each group. …”
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Influence of body mass index on cardiovascular risk in rheumatoid arthritis varies across anti-citrullinated protein antibody status and biologic use by George Athanasios Karpouzas, Anne Grete Semb, Ellen-Margrethe Hauge, Dionicio Angel Galarza-Delgado, Miguel A González-Gay, Solbritt Rantapää-Dahlqvist, Petros P Sfikakis, Virginia Pascual-Ramos, Irazú Contreras-Yáñez, Carol Hitchon, Elena Myasoedova, Durga Prasanna Misra, Iris J Colunga-Pedraza, Alfonso Corrales, George Kitas, José Ramón Azpiri-lópez, Sarah R Ormseth, Patrick Dessein, Piet Leonardus Cornelis Maria van Riel, Durez Patrick, Brian Bridal Logstrup

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Transcatheter Aortic Valve Replacement in Patients With Small Aortic Annulus: An Observational Study by Hanad Bashir, MD, Christian W. Schmidt, MS, Kofi Ansah, MD, Gustavo Mendez-Hirata, MD, Geoffrey A. Answini, MD, J. Michael Smith, MD, Saad Hasan, MD, Jeffrey Griffin, MD, Robert Dowling, MD, Dean J. Kereiakes, MD, Puvi Seshiah, MD, Joseph Choo, MD, Zaid Alirhayim, MD, Santiago Garcia, MD

“…Comorbidities and risk profiles were well balanced between groups. At 30 days post-transcatheter aortic valve replacement, SEV had lower aortic valve mean gradients (8 mmHg [6, 11] vs. …”
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Hepatic resection for recurrent hepatocellular carcinoma during pregnancy: a case report by Takashi Maeda, Daisuke Imai, Huanlin Wang, Kyohei Yugawa, Nao Kinjo, Koto Kawata, Shinichiro Ikeda, Keitaro Edahiro, Kazuki Takeishi, Tomohiro Iguchi, Hiroto Kayashima, Noboru Harada, Mizuki Ninomiya, Shohei Yamaguchi, Kozo Konishi, Shinichi Tsutsui, Hiroyuki Matsuda

“…Case presentation A 36-year-old woman underwent laparoscopic partial hepatectomy for HCC (20 mm in diameter) in segment 5 of the liver during follow-up after being determined as a hepatitis B virus carrier two and a half years ago. Post-surgery follow-up abdominal ultrasonography revealed a 36-mm tumor in segment 7 of the liver. …”
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Efficacy and mechanism of action of cipargamin as an antibabesial drug candidate by Hang Li, Shengwei Ji, Nanang R Ariefta, Eloiza May S Galon, Shimaa AES El-Sayed, Thom Do, Lijun Jia, Miako Sakaguchi, Masahito Asada, Yoshifumi Nishikawa, Xin Qin, Mingming Liu, Xuenan Xuan

“…Combining CIP with TQ effectively eliminated B. microti infection in SCID mice with no relapse, and parasite DNA was not detected by qPCR within 90 days post-infection. Our findings reveal the efficacy of CIP as an antibabesial agent, its limitations as a monotherapy due to resistance development, and the potential of combination therapy with TQ to overcome said resistance and achieve complete parasite clearance.…”
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