Novel Antigen-Presenting Cell-Targeted Nanoparticles Enhance Split Vaccine Immunity Through Microneedles Inoculation by Xiu X, Fu H, Zhang R, Ma S, Guo P, Li Z, Zhu Y, Ma F

“…The increase in HAI titers and total IgG antibody levels in rat serum indicates the effectiveness of humoral immunity, and this effect only occurs after NPs formed post-crosslinking, rather than directly using raw nanomaterials, highlighting the critical role of the nanoparticle structure.Conclusion: This study confirms that the delivery of Man-N-HACC NPs via dMAs provides a novel and promising approach for the administration of split influenza vaccines. …”
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Inguinodynia following inguinal hernia repair: a comparative analysis of open Lichtenstein and laparoscopic TAPP techniques in a two-center cohort by Anas Aljaiuossi, Saleh A. Ba-shammakh, Mohammad Bani Hani, Musab Al-A'athal, Mohammad Abu-Hussein, Mohammed Sobh, Mohammad Yousef, Zaid Mesmar, Raad Dowais, Aseel W. Ababneh, Ahmad Kenani, Mohammad Ababneh, Sameh Alawneh, Rawa'a Al-Ibrahim, Saja Al-Shdooh, Thikrayat Daoud

“…The primary endpoint was inguinodynia, defined as pain persisting ≥3 months post-operatively. Secondary endpoints included length of stay (LOS) and surgical complications. …”
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Cannabinoid-2 Receptor Activation Attenuates Sulfur Mustard Analog 2-Chloroethyl-Ethyl-Sulfide-Induced Acute Lung Injury in Mice by Gregory Nicholson, Nicholas Richards, Janette Lockett, My Boi Ly, Raj V. Nair, Woong-Ki Kim, K. Yaragudri Vinod, Nagaraja Nagre

“…ALI and inflammation were evaluated at 48 h post-exposure to CEES. Bronchoalveolar lavage fluid (BALF) was collected to measure total cells, protein, and cytokines. …”
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Tele-SPACE: group parent-based treatment for pediatric anxiety via telemedicine in a public health clinic by Naama de la Fontaine, Naama de la Fontaine, Tal Cohen, Tal Cohen, Nimrod Hertz-Palmor, Shirel Dorman-Ilan, Shirel Dorman-Ilan, Shirel Dorman-Ilan, Noa Rubin, Gal Itav, Shlomit Tsafrir, Shlomit Tsafrir, Yael Carmel, Hana Weisman, Doron Gothelf, Doron Gothelf, Doron Gothelf, Eli R. Lebowitz

“…Treatment feasibility, acceptability and satisfaction were assessed.ResultsPost treatment, significant reductions were evident in child self-reported separation anxiety symptoms (p =0.008), mother-reported child anxiety symptoms (p=0.002), maternal accommodation (p=0.006), anxiety (p=0.004) and depressive symptoms (p=0.011). …”
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Comparative Analysis of Ratoon-Competent and Ratoon-Deficient Sugarcane by Hormonal and Transcriptome Profiling by Liping Zhao, Maoyong Ran, Jing Zhang, Peifang Zhao, Fenggang Zan, Jun Zhao, Wei Qin, Qibin Wu, Jiayong Liu, Xinlong Liu

“…Additionally, GT29 exhibited notable reductions in gibberellins (GA3 and GA5) and strigolactone (5-DS) post-stem-excision, while Badila displayed stable or distinct hormonal changes. …”
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Inhaled ciclesonide in adults hospitalised with COVID-19: a randomised controlled open-label trial (HALT COVID-19) by Peter Ueda, Johan Hansson, Johan Ljungberg, Anders Krifors, Björn Johansson, Martin Larsson, Per Tornhammar, Daniel Peter Andersson, Daniel Brodin, Eli Westerlund, Simon Athlin, Sandra Wojt, Olof Elvstam, Anca Neumann, Arsim Elshani, Julia Giesecke, Jens Edvardsson-Källkvist, Sayam Bunpuckdee, Christian Unge, Jonas Lindell, Ola Blennow

“…Median (IQR) duration of oxygen therapy was 5.5 (3–9) days in the ciclesonide group and 4 (2–7) days in the standard care group (HR for termination of oxygen therapy 0.73 (95% CI 0.47 to 1.11), with the upper 95% CI being compatible with a 10% relative reduction in oxygen therapy duration, corresponding to a <1 day absolute reduction in a post-hoc calculation). Three participants in each group died/received invasive mechanical ventilation (HR 0.90 (95% CI 0.15 to 5.32)). …”
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Navigating the shadows: the impact of mindfulness, cognitive fusion, and coping strategies on psychological distress among mental health workers in Timor Leste by Gaspar Quintao, Noviyanti Carla Tilman Leite, Nicholas Tze Ping Pang, Eugene Boon Yau Koh, Jhia Mae Woo, Marina Abdul Rahman Sabri, Kah Mun Wan, Noor Melissa Noor Hadi, Ming Gui Tan, Assis Kamu, Chong Mun Ho

“…Abstract Background Mental health workers in post-conflict settings such as Timor Leste face distinct stressors stemming from limited human resources, underdeveloped systems, and ongoing socio-political instability, all of which increase the risk of psychological distress among these professionals. …”
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Assessment of pit viper associated subclinical myocardial injury by speckle tracking imaging by Jing Chen, Yang Feng, Jiaqi Chen, Chunmei Yin, Jiaming Xia, Li Fan, Liqun Sun, Chunjiang Yang

“…Abstract In post-snakebite patient care, cardiac function is chiefly monitored through Left Ventricular Ejection Fraction (LVEF) via traditional echocardiography. …”
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Abstract 013: Infarct density: a novel imaging biomarker of long‐term functional outcome after endovascular thrombectomy by Christopher G. Favilla, Heta Patel, Mohammad Hossein Abassi, Jesse Thon, Michael T. Mullen, Scott E. Kasner, Jae W. Song, Stephanie Cummings, Steven R. Messe

“…Here we aimed to quantify the relationship between functional outcome and a range of ADC thresholds on post‐EVT MRI. Methods A single‐center cohort of consecutive acute stroke patients with anterior circulation large vessel occlusion, successful recanalization via EVT (mTICI ≥ 2b), and MRI of the brain between 12 hours and 7 days after EVT was evaluated. …”
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Six‐Minute Walk Test Is Superior to Grip Strength as a Marker of Functional Recovery During Cancer Cachexia Rehabilitation by Addison Barber, Amber Willbanks, Kathryn Abplanalp, Christopher W. Lewis, Ben Binder‐Markey, Prakash Jayabalan, Richard L. Lieber, Ishan Roy

“…In a multivariate logistic regression model, discharge from IRF to home with independence was predicted by change in 6MWT (p = 0.0007) but not hGS (p = 0.8075). Six‐month survival post‐rehabilitation was predicted by change in 6MWT (p = 0.0345) but not hGS (p = 0.9025) in a multivariate Cox proportional hazards model. …”
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Development and internal validation of a depressive symptoms prediction model among the patients with cardiovascular disease who have recovered from SARS-CoV-2 infection in Wuhan,... by Zhenwei Dai, Xin Liu, Shu Jing, Hao Wang, Yiman Huang, Jiaqi Fu, Yijin Wu, Ling Zhang, Bicheng Han, Xiaoyou Su

“…The prediction model included age, stethalgia after recovery, insomnia after recovery, post-traumatic stress disorder (PTSD), anxiety, fatigue, and perceived social support as predictors. …”
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AVATAR Virtual Reality Social therapy (AVATAR_VRSocial) for distressing voices and their interference in social everyday life in early psychosis: protocol of a single-blind paralle... by Tom K J Craig, Silvia Schneider, Philippa Garety, Thomas Ward, Mar Rus-Calafell, Melina Luker, Maren Marzinzik, Phuong-Mi Nguyen, Tobias Teismann, Nils Ehrbar, Ekincan Tas, Xiao Chi Zhang, Clementine Edwards, Mark Huckvale

“…Assessor-blinded assessments will be conducted at baseline, 3 months (post-intervention) and 6 months (follow­-up). Key therapeutic targets of AVATAR_VRSocial will be those established by the previous evidence of this approach (ie, power and control, self-esteem and future focus), while introducing exposure and management of distressing voices during social interactions. …”
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Low-dose Esketamine combined with Propofol in microscopic pediatric strabismus surgery: a randomized controlled study by Yaping Shen, Bo Shi, Yu Mo, Junhe Wu, Zhentao Sun

“…HR and MAP were recorded in the two groups at 5 min before induction, after induction, at the start of the procedure, and at the end of the procedure. operative time, extubation time and post-anesthesia care unit (PACU) stay were recorded. …”
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Random vibration study of cold rolling mill excited by different hardness of strip steel by Weiquan Sun, Xiaoqiang Yan, Shen Wang, Lu Zhang, Weijing Yun, Yuchen Chen

“…Finite element simulations were conducted to resolve the probability density distributions of mill vibration responses under varying strip hardness conditions. Post-processing in MATLAB enabled a quantitative analysis of power spectral density (PSD) responses, establishing correlations between strip surface hardness parameters and dynamic vibration characteristics. …”
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Europe's adaptation to the energy crisis: reshaped gas supply–transmission–consumption structures and driving factors from 2022 to 2024 by C. Zhou, B. Zhu, A. Halff, A. Halff, S. J. Davis, Z. Liu, S. Bowring, S. B. Arous, P. Ciais

“…On the supply side, Russian gas supply to the EU27&UK was cut by 87.8 % (976.8 TW h per winter) during the post-invasion winters compared to the previous winters. …”
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Transcriptomic and histological characteristics of innate immune activation in brain parenchyma in a rat model of neonatal intraventricular hemorrhage by Miriam Zamorano, Sanjna Udtha, Aidan M. Collier, Erica Underwood, Razan El Sayed, Ankit Agarwal, Devin S. Hatchell, Chunfeng Tan, Paul J. Nietert, Scott D. Olson, Brandon A. Miller

“…There is no effective treatment for IVH other than supportive care and surgery for post-hemorrhagic hydrocephalus. We previously reported that the innate neuroimmune response in an animal model of IVH was dependent on developmental stage, only occurring in older animals. …”
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Reversal of Rocuronium Induced Muscle Relaxation with Sugammadex versus Neostigmine in Patients Undergoing General Anaesthesia: A Randomised Controlled Trial by Ankur Garg, Kirti Gupta, Richa Chandra, Jyoti Pathania, Malti Agrawal

“…Significant changes in Heart Rate (HR), Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP) and Mean Arterial Pressure (MAP) were observed post-extubation at 0, 5, and 10 minutes (p<0.05). group 1 had a lower incidence of postoperative nausea compared to group 2 (p<0.05). …”
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Epitope Variation in Hemagglutinin and Antibody Responses to Successive A/Victoria A(H1N1) Strains in Young and Older Adults Following Seasonal Influenza Vaccination: A Pilot Study by Mónica Espinar-García, Isabel María Vallejo-Bermúdez, María Ángeles Onieva-García, Irene Reina-Alfonso, Luis Llapa-Chino, Pablo Álvarez-Heredia, Inmaculada Salcedo, Rafael Solana, Alejandra Pera, Alexander Batista-Duharte

“…Antibody responses were measured pre- and 28 days post-Vaxigrip Tetra vaccination in young (18–35) and older (>65) adults, stratified by cytomegalovirus (CMV) serostatus. …”
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External validation of a prediction model for disability and pain after lumbar disc herniation surgery: a prospective international registry-based cohort study by Allan Abbott, Casper Friis Pedersen, Henrik Hedevik, Catharina Parai, Martin A Gorosito, Mikkel Andersen, Tor Ingebrigtsen, Tore K Solberg, Margreth Grotle, Bjørnar Berg

“…Conclusion: Predictive performance of machine learning models for treatment success/non-success in disability and pain at 12 months post-surgery for lumbar disc herniation showed acceptable discrimination ability, calibration, overall fit, and net benefit reproducible in similar international contexts. …”
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Colistin Sulfate-Based Combination Therapy for Infections Caused by Carbapenem-Resistant Organisms in Intensive Care Units: A Multicenter, Prospective, Observational Clinical Trial by Fan Zhang, Danyang Peng, Faming He, Ying Liu, Binbin Zang, Yanqiu Gao, Chao Qin, Suping Guo, Yawei Qi, Xisheng Zheng, Lin Guo, Tingting Zhao, Yue Jin, Rongqi Su, Juan Du, Jiazhan Pan, Bingyu Qin, Huanzhang Shao

“…Nephrotoxicity was reported in 13.1% of patients not receiving continuous renal replacement therapy (CRRT), with no significant duration-dependent increase. Post-treatment serum creatinine (Scr) levels remained stable or improved across all renal function subgroups. …”
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