The CXCL16/CXCR6 axis is linked to immune effector cell-associated neurotoxicity in chimeric antigen receptor (CAR) T cell therapy by I-Na Lu, Louisa Müller-Miny, Carolin Krekeler, Phyllis Fung-Yi Cheung, Georgia Antonopoulou, Astrid Jeibmann, Andreas Schulte-Mecklenbeck, Kornelius Kerl, Simon Call, Christian Reicherts, Annalen Bleckmann, Matthias Stelljes, Georg Lenz, Heinz Wiendl, Gerd Meyer zu Hörste, Oliver M. Grauer

“…Methods We analyzed paired peripheral blood and cerebrospinal fluid (CSF) samples from CAR T cell–treated patients who developed ICANS (n = 11) within 5–21 days post-infusion. ICANS severity was graded as follows: grade 1 (n = 3), grade 2 (n = 4), grade 3 (n = 1), and grade 4 (n = 3). …”
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Comparative Analysis of Differentially Expressed Genes and Metabolites in Waxy Maize Inbred Lines with Distinct Twin-Shoot Phenotypes by Mengfan Qin, Guangyu Li, Kun Li, Jing Gao, Meng Li, Hao Liu, Yifeng Wang, Keke Kang, Da Zhang, Wu Li

“…<i>sinensis</i> Kulesh) inbred lines, D35 (a polyembryonic line with twin shoots) and N6110 (single-shoot), exhibited similar relative growth rates during 1 to 5 days post-germination. UPLC-MS/MS profiling of 3- to 5-day-old seedling roots and shoots revealed that H2JA, MeSAG, and IAA-Val-Me were the common differentially accumulated metabolites (DAMs) of the 3-day-old vs. 5-day-old seedlings of D35 and N6110 in the same tissues, and MeSAG, tZ9G, cZROG, and DHZROG were identified in D35 vs. …”
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Preliminary research indicates that mechanical force through Pioze1 enhances local immunity during NPWT treatment for spinal infections by Hao Xing, Junlin Pan, Huan Liu, Yanan Wang, Zhengqi Chang

“…Additionally, healing times and recurrence rates within two years post-surgery were assessed. In addition, lesion specimens were retained during surgery and changes in Piezo1, Interleukin-1β (IL-1β), IL-6, IL-8, and Tumor Necrosis Factor-α (TNF-α) in lesion tissues were observed before and after immunohistochemical analysis.ResultsAll 7 patients with spinal infections successfully underwent NPWT treatment and were ultimately cured. …”
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Evaluation of Functional and Radiological Outcome of Different Cephalomedullary Nail Designs in Intertrochanteric Fractures of Femur by Adarsh U Thuppad, Harsh Kirthi Rao, Gaurav C Mendon, Santosha Manjunatha, Suraj M Revankar, Kaveesh P Shetty

“…Patients are followed up till 1-year post-operative period, in different intervals. Functional outcome using Harris hip score, fracture union, complications are assessed and compared. …”
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Impaired K48-polyubiquitination downmodulates mouse norovirus propagation by Emmrich Wakeford, Elisabeth Werkmeister, Delphine Cayet, Sabine Poiret, Catherine Daniel, Jason Mackenzie, Jean-Claude Sirard, Frank Lafont, Ghaffar Muharram

“…Due to a lack of approved preventive or curative therapy options, intensive research effort is ongoing to better understand the pathogenesis mechanisms of noroviruses.MethodsIn this study, using the persistent murine norovirus S99 strain (MNoV_S99), we have investigated the role in the regulation of anti-noroviral responses of ubiquitination, a post-translational modification that covalently adds one or multiple ubiquitin molecules onto lysine residues of target proteins. …”
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Involvement of Nuclear Receptors PPAR-α, PPAR-γ, and the Transcription Factor Nrf2 in Cellular Protection Against Oxidative Stress Regulated by H₂S and Induced by Hypoxi... by Luz Ibarra-Lara, Araceli Sánchez-López, Leonardo del Valle-Mondragon, Elizabeth Soria-Castro, Gabriela Zarco-Olvera, Mariana Patlán, Verónica Guarner-Lans, Juan Carlos Torres-Narváez, Angélica Ruiz-Ramírez, Fernando Díaz de León-Sánchez, Víctor Hugo Oidor-Chan, Vicente Castrejón-Téllez

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Dietary Tithonia diversifolia improves hematology, antioxidant capacity, liver health, and disease resistance in hybrid of Oreochromis mossambicus × Oreochromis niloticus by Yuniel MÉNDEZ-MARTÍNEZ, Pedro D. MENDOZA-CARRANZA, Juan P. ORDÓÑEZ-IGLESIA, Veronica del C. SEGOVIA-MONTESDEOCA, Ana N. MORENO-VERA, Melanie A. CASANOVA-ERAZO, Mishel E. MÉNDEZ-SEGOVIA

“…At the end of the feeding trial, 18 fish from each group were given intraperitoneal injections with a pathogenic strain of Aeromonas hydrophila to test the protective efficacy of TD against bacterial infection for seven days (post-challenge period). The results after eight weeks revealed significant differences (P < 0.05), with an increase in haematological variables and antioxidant activity, low levels of transaminases and an adequate hepatic histological response in the TD-fed fish. …”
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First results of long-term follow-up of children in Russia after gene therapy for hereditary retinal dystrophies associated with biallelic mutations in the RPE65 gene by V. V. Neroev, L. A. Katargina, M. P. Kharlampidi, L. V. Kogoleva, I. V. Zolnikova, P. A. Ilyukhin, E. V. Denisova, S. V. Milash, N. A. Osipova, S. I. Kutsev, A. V. Polyakov, R. A. Zinchenko, V. V. Kadyshev, Yu. A. Bobrovskaya

“…The results of a one-year post VN treatment follow-up of Russian patients with RPE65-associated inherited retinal disease demonstrate stabilization and improvement of visual functions, which is especially important for otherwise incurable patients with a progressive course of the disease.…”
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Drug tapering in animal research: current practices and challenges by Yatong Zhang, Yatong Zhang, Mengrui Chen, Mengrui Chen, Tongtong Jiang, Tongtong Jiang, Qianfang Fu, Qianfang Fu, Rong Ma, Rong Ma, Lianghui Nie, Lianghui Nie, Yuqiong You, Yuqiong You, Shuqi Gao, Shuqi Gao, Ping Rong, Ping Rong

“…The outcomes of tapering were classified into drug discontinuation, low-dose maintenance, and drug substitution, with all studies reporting the effects post-tapering.ConclusionThe methods of drug tapering in animal studies are influenced by multiple factors, including disease characteristics, treatment duration, animal tolerance, and specific goals. …”
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Key geological and engineering technologies and research directions for shale gas exploration and development in western Hubei Province, China by Guangyou Zhu, Jineng Jin, Qilin Xiao, Lei Wang, Guanglong Sheng, Jun Tang, Jianghui Meng, Zhiyuan Lu, Can Chen

“…For seismic data interpretation, pre-stack elastic inversion and azimuthal anisotropy inversion can be employed as core techniques, overcoming the limitation of individual post-stack attributes in typically detecting only major faults. …”
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Are Urethral Pressure Profile Measurements Effective in Diagnosing Urodynamic Stress Incontinence in Women Presenting with Stress or Mixed Urinary Incontinence? Results from a Cros... by Konstantinos Pantazis, Themistoklis Mikos, Sofia Tsiapakidou, Iakovos Theodoulidis, Stamatios Petousis, Konstantinos Dinas, Antonio Schiattarella, Antonio Simone Laganà, Apostolos P. Athanasiadis

“…However, the women in Group 2 had a significantly lower MUCP, FUL, and post-void residual after pressure flow compared to the women in Group 1 (<i>p</i> = 0.038, 0.003, and 0.04, respectively, upon Student’s <i>t</i> test for independent parameters). …”
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Involvement of ionomic metabolism of both the cerebrospinal fluid and the spinal cord in the analgesic efficacy of matrine in rats by Jin-Lu Huang, Chen-Yue Tang, Yao Fu, Li-Li Wan, Jie Li, Xi-Peng Sun, Jia-Lu Hu, Yue-Yi Zhang, Li-Ying Qu, Miao-Jia Fu, Yuan-Yuan Zhang, Le Ma, Cheng Guo, Jiu-Geng Chen

“…Matrine also dose-dependently yielded analgesia against formalin-induced biphasic pain, with an onset at around 10 min post-injection and a duration of 100 min. The ED50 and Emax values were 19.01 mg/kg and 71.86% for phase I and 40.30 mg/kg and 81.51% for phase II, respectively. …”
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The characterization of uterine calcium transport and metabolism during eggshell calcification of hens laying high or low breaking strength eggshell by Ying-ying Yang, Dong Dai, Hai-jun Zhang, Shu-geng Wu, Guang-hai Qi, Jing Wang

“…Laying hens were sampled at 1 h, 7 h (the initiation stage of eggshell calcification), and 17 h (the growth stage of eggshell calcification) post-oviposition (PO). The LS group showed a decreased thickness, weight and weight ratio of eggshells, accompanied with ultrastructural deterioration and total Ca reduction. …”
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Multisession transcranial direct current stimulation and aerobic exercise synergistically improve food craving symptoms, impulsivity, and cognitive flexibility in women with overwe... by Sahar Malek Khataei, Ehsan Amiri, Daniel Gomes da Silva Machado

“…Follow-up measurements for FC and CF were also conducted one month post-intervention. Results FC was lower in the a-tDCS + AE group compared to Sham + AE and Control groups in Phase 1 (Cohen’s d = 1.4 and 1.9, respectively). …”
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Genome-scale mRNA and miRNA transcriptomic insights into the regulatory mechanism of cucumber corolla opening by Xiao-fei SONG, Dan-feng GE, Yang XIE, Xiao-li LI, Cheng-zhen SUN, Hao-nan CUI, Xue-yun ZHU, Ren-yi LIU, Li-ying YAN

“…This integrated study on the transcriptional and post-transcriptional profiles can provide insights into the molecular regulatory mechanism underlying corolla opening in the cucumber.…”
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Maternal nitrate supplementation improves offspring cardiometabolic outcomes in obese pregnancies by Kristi M. Crowe-White, Katelyn E. Senkus, Janie C. DiNatale, Arlin B. Blood, Taiming Liu, Meijuan Zhang, Khondoker Adeba Ferdous, Rebecca Bloch, Han-A Park

“…NFD (n = 4), HFD (n = 3), and HFDN (n = 4) maintained their respective diets, yet all weanling pups were transitioned to NFD at post-natal day 21 (P21). Body composition was assessed by bioimpedance spectroscopy along with assessment of body weight (BW), and abdominal circumference as well as brown adipose tissue (BAT) and white adipose tissue (WAT) mass. …”
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Global trends and interdisciplinary insights in Tai Chi research: a bibliometric analysis (2004–2024) by Bei Li, Xiwei Zhu, Xiwei Zhu, Xiwei Zhu, Haoli Zhang, Su Zhang, Yanwei Li, Shuxi Wu, Shuxi Wu, Shuxi Wu, Jie Han, Jie Han, Jie Han

“…Disciplinary distribution was analyzed using Web of Science subject categories, and visualized through VOSviewer’s clustering algorithm.ResultsFrom 2004 to 2023, the number of research papers related to Tai Chi showed an overall upward trend, with a 12.3% average annual growth rate post-2012. China contributed 68.5% of publications (n = 645/941), followed by the United States (15.2%, n = 143). …”
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Population immunity to SARS-CoV-2 virus in residents of the Irkutsk Region in the dynamics of the epidemic by S. V. Balakhonov, V. I. Dubrovina, M. V. Chesnokova, D. D. Bryukhova, N. O. Kiseleva, A. B. Pyatidesyatnikova, K. M. Korytov, V. V. Voitkova, A. N. Perezhogin, T. A. Gavrilova, A. A. Seledtsov

“…In the fight against this viral disease, an important role is assigned to the study of the development of population immunity to the SARSCoV-2 virus, which will make it possible to assess the dynamics of seroprevalence and the formation of post-infectious humoral immunity, forecasting the development of the epidemiological situation, elucidating the characteristics of the epidemic process, and will also contribute to planning activities for specific and non-specific prevention of the disease.The aim: to determine the dynamics of population immunity to SARS-CoV-2 among the population of the Irkutsk region during the COVID-19 pandemic.Materials and methods. …”
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The effect of antimicrobial stewardship interventions upon antimicrobial consumption and appropriateness in Vietnamese district hospitals: a cluster randomised trialResearch in con... by Jaslyn Doshi, Yen Pham Ngoc, Thu Thuy Ma, Linh Thuy Duong, Van Thi Thuy Pham, Van Giap Vu, Rodney James, Qingbin Li, Quy Trinh Van, Tu Son Nguyen, Thi Thu Trang Tran, Pham Minh Thu Vo, Van An Ngo, Huu Phuc Phan, Ngoc Canh Hoang, Justin Beardsley, Thu Anh Nguyen, Greg J. Fox

“…Findings: A total of 877 and 1220 antimicrobial prescriptions were reviewed in intervention hospitals, and 1277 and 1454 prescriptions in control hospitals at baseline and post-intervention. Inappropriate antimicrobial prescribing exceeded 60% in each hospital at baseline. …”
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4D-CTA image and geometry dataset for kinematic analysis of abdominal aortic aneurysmsZenodo by Mostafa Jamshidian, Adam Wittek, Saeideh Sekhavat, Farah Alkhatib, Jens Carsten Ritter, Paul M. Parizel, Donatien Le Liepvre, Florian Bernard, Ludovic Minvielle, Antoine Fondanèche, Jane Polce, Christopher Wood, Karol Miller

“…The AAA geometries were extracted using an automated image processing pipeline comprising AI-based segmentation with PRAEVAorta software by NUREA (https://www.nurea-soft.com/), automated post-processing with the ISML-UWA in-house code (https://arxiv.org/abs/2403.07238), and surface model extraction using the freely available BioPARR (Biomechanics-based Prediction of Aneurysm Rupture Risk) (https://bioparr.mech.uwa.edu.au/) and 3D Slicer (https://www.slicer.org/) software packages [2,3]. …”
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